Abstract:
BACKGROUND:Inflammatory and vascular markers have proved to be predictors of outcome in myocardial infarction and heart failure. We evaluated several circulating markers of cardiac stress, inflammation, and endothelial function to investigate their ability to predict short-term functional recovery and long-term clinical outcome in heart surgery patients undergoing inpatient rehabilitation. METHODS:This prospective, multicenter study enrolled 223 patients after heart surgery, included in a 3-week program of standardized and supervised physical training. The association between biomarkers (pentraxin-3 [PTX3], brain natriuretic peptide, high-sensitivity cardiac troponin-T [hs-cTnT] and C-reactive protein [hsCRP], creatine kinase, myoglobin, and urinary albumin excretion [UACR]) and exercise capacity (6-minute walk test, 6MWT) or 1-year incidence of major adverse cardiovascular events (MACE) was tested in models that included biohumoral markers, and clinical and instrumental variables. RESULTS:The patients (69.5% men, mean age of 67 ± 11 years) were enrolled after valvular surgery (52.7%) and 58.6% after coronary artery bypass grafting (CABG). Exercise capacity improved during rehabilitation (6MWT distance from 279 ± 95 to 386 ± 91 m; P < .0001); concentrations of most biomarkers decreased (hsCRP: 79% [P < .0001]; hs-cTnT: 57% [P < .0001]; UACR: 36% [P = .05]). Among the tested markers, PTX3 showed the closest association with 6MWT distance (P = .01) and was the only predictor of MACE, also in the subgroup of CABG patients (OR [95% CI] = 1.14 [1.03-1.27]; P = .015). CONCLUSION:PTX3, a marker of vascular inflammation and cardiovascular damage, is a predictor of short-term functional recovery and 1-year MACE in patients undergoing rehabilitation after cardiac surgery, regardless of clinical and instrumental parameters.
journal_name
J Cardiopulm Rehabil Prevjournal_title
Journal of cardiopulmonary rehabilitation and preventionauthors
Ferratini M,Ripamonti V,Masson S,Grati P,Racca V,Cuccovillo I,Raimondi E,Capomolla S,Macchi C,Coruzzi P,Vago T,Calvo M,Mantovani A,Latini Rdoi
10.1097/HCR.0b013e31823be0f4subject
Has Abstractpub_date
2012-01-01 00:00:00pages
17-24issue
1eissn
1932-7501issn
1932-751Xjournal_volume
32pub_type
杂志文章,多中心研究abstract:PURPOSE:Patients hospitalized with a cardiac condition are less likely to attend cardiac rehabilitation (CR) if they are smokers despite the benefits of doing so. The present study sought to investigate how, if at all, a patient's decision to attend CR was influenced by his or her tobacco use post-discharge. METHODS:W...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000366
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:The objective of this study was to use a modified Philadelphia Panel rating method to evaluate the evidence supporting the use of therapeutic exercise interventions in patients with congestive heart failure (CHF). METHODS:A computerized literature search was conducted. Inclusion criteria included studies using...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,评审
doi:10.1097/01.HCR.0000300263.07764.4a
更新日期:2007-11-01 00:00:00
abstract:PURPOSE:Best practice guidelines for cardiac rehabilitation (CR) suggest routine screening for anxiety and depression, yet many patients are not screened nor do they receive mental health treatment. Protocols are required to identify those in need of care and to ensure that appropriate assistance is provided. METHODS:...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
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doi:10.1097/HCR.0000000000000276
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abstract:PURPOSE:The purposes of this systematic review were to (1) review the literature related to the demographic and biopsychosocial-spiritual factors impacting cardiac rehabilitation (CR) referral and participation of African American patients with cardiovascular disease (CVD); (2) identify barriers and facilitators to CR ...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,评审
doi:10.1097/HCR.0000000000000183
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Hospitalization with acute exacerbation of chronic obstructive pulmonary disease (COPD) is common and costly to the health care system. Pulmonary rehabilitation (PR) can improve symptom burden and morbidity associated with COPD. The use of PR among Medicare beneficiaries is poor, and the use by Veterans Heal...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000357
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:Body mass index (BMI) has prognostic value in patients with chronic lung disease. Pulmonary rehabilitation improves quality of life. This study investigated whether BMI predicts change in disease-specific quality of life following pulmonary rehabilitation. METHODS:Subjects (N = 61), who completed pulmonary reh...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0b013e3181e17607
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:The purpose of this study was to examine emotional distress, alexithymia, and coping styles as predictors of cardiac rehabilitation (CR) outcomes and attendance. METHODS:Participants included 56 patients in an outpatient CR program (65% male, 59% white, M = 61.1 years) who completed self-report measures of emo...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0b013e318276864c
更新日期:2013-01-01 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000350
更新日期:2018-11-01 00:00:00
abstract:PURPOSE:The aim of this study was to assess the effects on exercise performance of supplementing a standard cardiac rehabilitation program with additional exercise programming compared to the standard cardiac rehabilitation program alone in elderly patients after heart surgery. METHODS:In this prospective, randomized ...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,随机对照试验
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更新日期:2010-03-01 00:00:00
abstract:PURPOSE:Although cardiac rehabilitation programs have been shown to decrease cardiovascular risk, morbidity, and mortality, few programs have integrated a balanced mind/body approach in which patients are taught the relaxation response and utilize cognitive behavior skills for stress management, along with diet and exe...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0b013e3181a33352
更新日期:2009-07-01 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,随机对照试验
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更新日期:2019-03-01 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/01.HCR.0000311508.39096.a5
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To determine whether individuals with chronic obstructive pulmonary disease (COPD) have decreased arm activity during daily life compared with healthy controls and explore the relationships between arm activity during daily life and arm functional measures in individuals with COPD. METHODS:This was a prospecti...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
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doi:10.1097/HCR.0000000000000153
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:We compared the prevalence of participants with and without symptomatic peripheral artery disease (PAD) who met the goals of attaining >7000 and 10 000 steps/d, and we determined whether PAD status was significantly associated with meeting the daily step count goals before and after adjusting for demographic va...
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更新日期:2020-11-11 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,随机对照试验
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更新日期:2016-03-01 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0b013e3181c8594b
更新日期:2010-01-01 00:00:00
abstract::Symptom-limited (maximal) exercise testing before cardiac rehabilitation (CR) was once an unambiguous standard of care. In particular, it served as an important screen for residual ischemia and instability before initiating a progressive exercise training regimen. However, improved revascularization and therapy for co...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
abstract:PURPOSE:To determine the effect of inspiratory muscle training (IMT) (alone or combined with exercise and/or pulmonary rehabilitation) and compare with other rehabilitation interventions among adults with chronic obstructive pulmonary disease (COPD). METHODS:We conducted a systematic review, using Cochrane Collaborati...
journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,meta分析,评审
doi:10.1097/01.HCR.0000314208.40170.00
更新日期:2008-03-01 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,评审
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更新日期:2015-11-01 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0b013e31818c3b6d
更新日期:2008-11-01 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000164
更新日期:2016-07-01 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/01.HCR.0000336141.94439.b8
更新日期:2008-09-01 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,评审
doi:10.1097/HCR.0b013e318199ff69
更新日期:2009-03-01 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
doi:10.1097/HCR.0000000000000087
更新日期:2015-01-01 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 临床试验,杂志文章
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更新日期:2007-05-01 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章,meta分析,评审
doi:10.1097/HCR.0b013e318220a7c9
更新日期:2011-09-01 00:00:00
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journal_title:Journal of cardiopulmonary rehabilitation and prevention
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00