当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > PET/MRI of inflammation in myocardial infarction.

PET/MRI of inflammation in myocardial infarction.

Abstract：

OBJECTIVES:The aim of this study was to explore post-myocardial infarction (MI) myocardial inflammation. BACKGROUND:Innate immune cells are centrally involved in infarct healing and are emerging therapeutic targets in cardiovascular disease; however, clinical tools to assess their presence in tissue are scarce. Furthermore, it is currently not known if the nonischemic remote zone recruits monocytes. METHODS:Acute inflammation was followed in mice with coronary ligation by 18-fluorodeoxyglucose ((18)FDG) positron emission tomography/magnetic resonance imaging, fluorescence-activated cell sorting, polymerase chain reaction, and histology. RESULTS:Gd-DTPA-enhanced infarcts showed high (18)FDG uptake on day 5 after MI. Cell depletion and isolation data confirmed that this largely reflected inflammation; CD11b(+) cells had 4-fold higher (18)FDG uptake than the infarct tissue from which they were isolated (p < 0.01). Surprisingly, there was considerable monocyte recruitment in the remote myocardium (approximately 10(4)/mg of myocardium, 5.6-fold increase; p < 0.01), a finding mirrored by macrophage infiltration in the remote myocardium of patients with acute MI. Temporal kinetics of cell recruitment were slower than in the infarct, with peak numbers on day 10 after ischemia. Quantitative polymerase chain reaction showed a robust increase of recruiting adhesion molecules and chemokines in the remote myocardium (e.g., 12-fold increase of monocyte chemoattractant protein-1), although levels were always lower than in the infarct. Finally, matrix metalloproteinase activity was significantly increased in noninfarcted myocardium, suggesting that monocyte recruitment to the remote zone may contribute to post-MI dilation. CONCLUSIONS:This study shed light on the innate inflammatory response in remote myocardium after MI.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Lee WW,Marinelli B,van der Laan AM,Sena BF,Gorbatov R,Leuschner F,Dutta P,Iwamoto Y,Ueno T,Begieneman MP,Niessen HW,Piek JJ,Vinegoni C,Pittet MJ,Swirski FK,Tawakol A,Di Carli M,Weissleder R,Nahrendorf M

doi

10.1016/j.jacc.2011.08.066

subject

Has Abstract

pub_date

2012-01-10 00:00:00

pages

153-63

issue

2

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(11)04600-6

journal_volume

59

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY文献大全
  • Cardiovascular Magnetic Resonance to Evaluate Aortic Regurgitation After Transcatheter Aortic Valve Replacement.

    abstract：BACKGROUND:Residual aortic regurgitation (AR) following transcatheter aortic valve replacement (TAVR) is associated with greater mortality; yet, determining AR severity post-TAVR using Doppler echocardiography remains challenging. Cardiovascular magnetic resonance (CMR) is purported as a more accurate means of quantify...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2016.05.059

    authors： Ribeiro HB,Orwat S,Hayek SS,Larose É,Babaliaros V,Dahou A,Le Ven F,Pasian S,Puri R,Abdul-Jawad Altisent O,Campelo-Parada F,Clavel MA,Pibarot P,Lerakis S,Baumgartner H,Rodés-Cabau J

    更新日期：2016-08-09 00:00:00

  • Systemic and pulmonary hemodynamic responses to nicardipine during graded ergometric exercise in patients with moderate to severe essential hypertension.

    abstract：:In 10 patients with moderate to severe hypertension, the hemodynamic effects of ergometric exercise and nicardipine, a dihydropyridine calcium channel antagonist, were characterized under basal conditions and after 1 week of therapy. The responses of plasma renin activity and catecholamines were also assessed. Nicardi...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(87)80209-7

    authors： Cody RJ,Kubo SH,Ryman KS,Shaknovich A,Laragh JH

    更新日期：1987-09-01 00:00:00

  • Nicotine inhibits cardiac apoptosis induced by lipopolysaccharide in rats.

    abstract：OBJECTIVES:Apoptosis develops in several heart diseases, but the therapeutic options are limited. It was hypothesized that nicotine, which inhibits apoptosis in several cells, inhibits cardiac apoptosis induced by lipopolysaccharide (LPS). BACKGROUND:Over-the-counter nicotine produces sustained levels (10 to 25 ng/ml)...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(02)02820-6

    authors： Suzuki J,Bayna E,Dalle Molle E,Lew WY

    更新日期：2003-02-05 00:00:00

  • Clinical anatomy of the atrioventricular junctions.

    abstract：OBJECTIVES:This study reevaluated the anatomy of the areas anterior and posterior to the atrioventricular (AV) septal structures, previously said to represent anterior and posterior septal areas. BACKGROUND:In descriptions of the locations of accessory AV pathways within the AV junctions, four regions have been recogn...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(94)90179-1

    authors： Dean JW,Ho SY,Rowland E,Mann J,Anderson RH

    更新日期：1994-12-01 00:00:00

  • Acute hemodynamic effects of adjustable atrial septal defect closure in the lateral tunnel Fontan procedure.

    abstract：OBJECTIVES:This study evaluated the acute hemodynamic changes with atrial septal defect closure in the postoperative period in patients undergoing the Fontan procedure. BACKGROUND:The adjustable atrial septal defect is a modification of the Fontan procedure designed to improve cardiac output and reduce systemic venous...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(94)90673-4

    authors： Harake B,Kuhn MA,Jarmakani JM,Laks H,al-Khatib Y,Elami A,Williams RG

    更新日期：1994-06-01 00:00:00

  • The relative safety and efficacy of abciximab and eptifibatide in patients undergoing primary percutaneous coronary intervention: insights from a large regional registry of contemporary percutaneous coronary intervention.

    abstract：OBJECTIVES:This study sought to assess whether the use of eptifibatide instead of abciximab is associated with a difference in outcomes of patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). BACKGROUND:Pooled data from randomized controlled trial...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2007.09.053

    authors： Gurm HS,Smith DE,Collins JS,Share D,Riba A,Carter AJ,LaLonde T,Kline-Rogers E,O'Donnell M,Changezi H,Zughaib M,Safian R,Moscucci M,Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2).

    更新日期：2008-02-05 00:00:00

  • Myocardial infarction after vascular surgery: the role of prolonged stress-induced, ST depression-type ischemia.

    abstract：OBJECTIVES:The goal of this study was to investigate the nature of the association between silent ischemia and postoperative myocardial infarction (PMI). BACKGROUND:Silent ischemia predicts cardiac morbidity and mortality in both ambulatory and postoperative patients. Whether silent stress-induced ischemia is merely a...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(01)01265-7

    authors： Landesberg G,Mosseri M,Zahger D,Wolf Y,Perouansky M,Anner H,Drenger B,Hasin Y,Berlatzky Y,Weissman C

    更新日期：2001-06-01 00:00:00

  • Morphologic comparison of patients with mitral valve prolapse who died suddenly with patients who died from severe valvular dysfunction or other conditions.

    abstract：:Clinical and necropsy findings are described in 56 patients with mitral valve prolapse: 15 patients, aged 16 to 69 years (mean 39), died suddenly and mitral valve prolapse was the only cardiac condition found at necropsy (hereafter called isolated mitral valve prolapse); the remaining 41 patients had other conditions ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(91)90875-a

    authors： Dollar AL,Roberts WC

    更新日期：1991-03-15 00:00:00

  • Does angiography six months after coronary intervention influence management and outcome? Benestent II Investigators.

    abstract：OBJECTIVES:This study was performed to assess whether angiography six months after coronary balloon angioplasty or stent implantation has an influence on clinical management and one-year outcome. BACKGROUND:The Benestent II study randomized 827 patients to balloon angioplasty or stent implantation. A subrandomization ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0735-1097(99)00380-0

    authors： Ruygrok PN,Melkert R,Morel MA,Ormiston JA,Bär FW,Fernandez-Avilès F,Suryapranata H,Dawkins KD,Hanet C,Serruys PW

    更新日期：1999-11-01 00:00:00

  • Role of surrogate end points in the evaluation of drugs for heart failure.

    abstract：:To be of clinical value in the treatment of heart failure, a drug must permit patients either to feel better or to live longer, or both. Yet, because the assessment of both quality and quantity of life is difficult, many investigators have proposed using alternate measures (namely, surrogate end points) that may indic...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(93)90487-l

    authors： Lipicky RJ,Packer M

    更新日期：1993-10-01 00:00:00

  • Estimation of circumferential fiber shortening velocity by echocardiography.

    abstract：:The M-mode and two-dimensional echocardiograms of 40 young patients were analyzed to compare the mean circumferential fiber shortening velocity (Vcf) of the left ventricle calculated separately by two methods. The mean circumferential fiber shortening velocity was derived from the M-mode echocardiogram as minor axis s...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(83)80379-9

    authors： Ruschhaupt DG,Sodt PC,Hutcheon NA,Arcilla RA

    更新日期：1983-07-01 00:00:00

  • Antithrombotic therapy in patients with valvular heart disease and prosthetic heart valves.

    abstract：:Indications and the type of antithrombotic therapy for the prevention of thromboembolism in patients with valvular heart disease, mechanical prosthetic heart valves and bioprosthetic heart valves are discussed. The evidence for these clinical recommendations is described and graded into five levels. The indications fo...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/s0735-1097(86)80006-7

    authors： Chesebro JH,Adams PC,Fuster V

    更新日期：1986-12-01 00:00:00

  • Aortic Valve Sparing in Different Aortic Valve and Aortic Root Conditions.

    abstract：:The development of aortic valve-sparing operations (reimplantation of the aortic valve and remodeling of the aortic root) expanded the surgical armamentarium for treating patients with aortic root dilation caused by a variety of disorders. Young adults with aortic root aneurysms associated with genetic syndromes are i...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2016.04.062

    authors： David TE

    更新日期：2016-08-09 00:00:00

  • Disposition of the atrioventricular conduction tissues in the heart with isomerism of the atrial appendages: its relation to congenital complete heart block.

    abstract：OBJECTIVES:Our goal was to compare histologically the mechanisms producing congenital complete heart block in normally structured hearts and in hearts with isomerism of the atrial appendages. BACKGROUND:It is known that several different histologic patterns can underscore the existence of congenital complete heart blo...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(92)90191-o

    authors： Ho SY,Fagg N,Anderson RH,Cook A,Allan L

    更新日期：1992-10-01 00:00:00

  • Clinical correlates of PR-segment depression in asymptomatic patients with pericardial effusion.

    abstract：OBJECTIVES:The purpose of this study was to determine the clinical correlates of PR-segment depression among consecutive asymptomatic patients with pericardial effusion (PE) detected by routine echocardiography. BACKGROUND:Pericardial effusion is a relatively common finding in clinical practice, but not many studies h...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(02)01889-2

    authors： Kudo Y,Yamasaki F,Doi Y,Sugiura T

    更新日期：2002-06-19 00:00:00

  • Outcomes in critically ill neonates with pulmonary stenosis and intact ventricular septum: a multiinstitutional study. Congenital Heart Surgeons Society.

    abstract：OBJECTIVE:This study attempted to determine the optimal therapeutic interventions by risk-adjusted comparisons of early and intermediate-term outcomes. BACKGROUND:The variety of interventions and the small case load at individual institutions have delayed the generation of reliable information concerning therapy for t...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/0735-1097(93)90833-m

    authors： Hanley FL,Sade RM,Freedom RM,Blackstone EH,Kirklin JW

    更新日期：1993-07-01 00:00:00

  • Association of chronic kidney disease with the spectrum of ankle brachial index the CHS (Cardiovascular Health Study).

    abstract：OBJECTIVES:This study sought to determine the association of chronic kidney disease (CKD) with high ankle brachial index (ABI) measurement and to compare its strength with that of CKD with a low ABI. BACKGROUND:CKD is an important risk factor for cardiovascular disease (CVD) events. A high ABI, a marker of lower extre...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2009.06.017

    authors： Ix JH,Katz R,De Boer IH,Kestenbaum BR,Allison MA,Siscovick DS,Newman AB,Sarnak MJ,Shlipak MG,Criqui MH

    更新日期：2009-09-22 00:00:00

  • Discovery of a new role of human resistin in hepatocyte low-density lipoprotein receptor suppression mediated in part by proprotein convertase subtilisin/kexin type 9.

    abstract：OBJECTIVES:In this study, our goal was to determine if human resistin plays a role in regulating the uptake of atherogenic low-density lipoproteins in human hepatocytes. BACKGROUND:Serum levels of resistin, an adipose tissue-derived adipokine, are increased in human obesity and are positively correlated with atheroscl...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2011.11.064

    authors： Melone M,Wilsie L,Palyha O,Strack A,Rashid S

    更新日期：2012-05-08 00:00:00

  • Role of the endothelium in the vascular effects of the thrombin receptor (protease-activated receptor type 1) in humans.

    abstract：OBJECTIVES:The purpose of this study was to determine the role of the endothelium in the vascular actions of protease-activated receptor type 1 (PAR-1) activation in vivo in man. BACKGROUND:Thrombin is central to the pathophysiology of atherothrombosis. Its cellular actions are mediated via PAR-1. Protease-activated r...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2007.12.047

    authors： Gudmundsdóttir IJ,Lang NN,Boon NA,Ludlam CA,Webb DJ,Fox KA,Newby DE

    更新日期：2008-05-06 00:00:00

  • Electrophysiologic consequences of chronic experimentally induced left ventricular pressure overload.

    abstract：:Cardiac electrophysiologic alterations were evaluated 1 to 8 months after partial supracoronary aortic constriction in cats. This procedure induced left ventricular systolic hypertension and hypertrophy with marked connective tissue infiltration. In situ, premature ventricular complexes were observed during or after v...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(83)80275-7

    authors： Cameron JS,Myerburg RJ,Wong SS,Gaide MS,Epstein K,Alvarez TR,Gelband H,Guse PA,Bassett AL

    更新日期：1983-09-01 00:00:00

  • Pre-excited RR intervals during atrial fibrillation in the Wolff-Parkinson-White syndrome: influence of the atrioventricular node refractory period.

    abstract：:The ventricular rate and percent of pre-excited QRS complexes during atrial fibrillation were compared in two groups of patients with the Wolff-Parkinson-White syndrome. Group A consisted of 22 patients whose anterograde effective refractory period of the accessory pathway was longer than that of the atrioventricular ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(91)90510-g

    authors： Fujimura O,Kuo CS,Smith BA

    更新日期：1991-12-01 00:00:00

  • Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation.

    abstract：OBJECTIVES:This study tested the hypothesis that response to antiarrhythmic drugs (AADs) is modulated by 3 common loci associated with atrial fibrillation (AF). BACKGROUND:Recent genome-wide association studies have identified 3 loci, on chromosomes 4q25 (near PITX2), 16q22 (in ZFHX3), and 1q21 (in KCNN3), that associ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2012.01.070

    authors： Parvez B,Vaglio J,Rowan S,Muhammad R,Kucera G,Stubblefield T,Carter S,Roden D,Darbar D

    更新日期：2012-08-07 00:00:00

  • Diet-Derived Circulating Antioxidants and Risk of Coronary Heart Disease: A Mendelian Randomization Study.

    abstract：BACKGROUND:Previously, observational studies have identified associations between higher levels of dietary-derived antioxidants and lower risk of coronary heart disease (CHD), whereas randomized clinical trials showed no reduction in CHD risk following antioxidant supplementation. OBJECTIVES:The purpose of this study ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2020.10.048

    authors： Luo J,le Cessie S,van Heemst D,Noordam R

    更新日期：2021-01-05 00:00:00

  • Oral Fluoroquinolone and the Risk of Aortic Dissection.

    abstract：BACKGROUND:Previous studies raised safety concerns on the association between fluoroquinolone treatment and serious collagen disorders, aortic aneurysm and dissection (AA/AD). OBJECTIVES:This study sought to evaluate this association via a case-crossover analysis in a large national administrative database. METHODS:A...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2018.06.067

    authors： Lee CC,Lee MG,Hsieh R,Porta L,Lee WC,Lee SH,Chang SS

    更新日期：2018-09-18 00:00:00

  • Magnetic resonance imaging of arrhythmogenic right ventricular dysplasia: sensitivity, specificity, and observer variability of fat detection versus functional analysis of the right ventricle.

    abstract：OBJECTIVES:The purpose of this study was to determine interobserver agreement for interpretation of magnetic resonance imaging (MRI) examinations of arrhythmogenic right ventricular dysplasia (ARVD) and to determine sensitivity and specificity of fat detection versus functional parameters measured by MRI. BACKGROUND:T...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2006.07.051

    authors： Tandri H,Castillo E,Ferrari VA,Nasir K,Dalal D,Bomma C,Calkins H,Bluemke DA

    更新日期：2006-12-05 00:00:00

  • Systematic direct angioplasty and stent-supported direct angioplasty therapy for cardiogenic shock complicating acute myocardial infarction: in-hospital and long-term survival.

    abstract：OBJECTIVES:This prospective observational study was conducted to examine the apparent impact of a systematic direct percutaneous transluminal coronary angioplasty (PTCA) strategy on mortality in a series of 66 consecutive patients with acute myocardial infarction (AMI) complicated by cardiogenic shock, and to analyze t...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(97)00496-8

    authors： Antoniucci D,Valenti R,Santoro GM,Bolognese L,Trapani M,Moschi G,Fazzini PF

    更新日期：1998-02-01 00:00:00

  • Sex differences in central hemodynamics and their relationship to left ventricular diastolic function.

    abstract：OBJECTIVES:This study aimed to investigate sex differences in the association between arterial stiffness and left ventricular (LV) diastolic dysfunction. BACKGROUND:Heart failure with preserved ejection fraction is more common in women. Arterial stiffness has been suggested as a significant contributor to the developm...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2010.09.067

    authors： Shim CY,Park S,Choi D,Yang WI,Cho IJ,Choi EY,Chung N,Ha JW

    更新日期：2011-03-08 00:00:00

  • Diagnostic accuracy of computed tomography coronary angiography according to pre-test probability of coronary artery disease and severity of coronary arterial calcification. The CORE-64 (Coronary Artery Evaluation Using 64-Row Multidetector Computed Tomog

    abstract：OBJECTIVES:The purpose of this study was to assess the impact of patient population characteristics on accuracy by computed tomography angiography (CTA) to detect obstructive coronary artery disease (CAD). BACKGROUND:The ability of CTA to exclude obstructive CAD in patients of different pre-test probabilities and in p...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2011.06.079

    authors： Arbab-Zadeh A,Miller JM,Rochitte CE,Dewey M,Niinuma H,Gottlieb I,Paul N,Clouse ME,Shapiro EP,Hoe J,Lardo AC,Bush DE,de Roos A,Cox C,Brinker J,Lima JA

    更新日期：2012-01-24 00:00:00

  • Prevention of recurrent lone atrial fibrillation by the angiotensin-II converting enzyme inhibitor ramipril in normotensive patients.

    abstract：OBJECTIVES:The aim of the present study was to verify whether angiotensin-II converting enzyme (ACE) inhibition is also effective in preventing relapses of lone atrial fibrillation (LAF), that is, in the absence of hypertension and/or heart disease. BACKGROUND:Several studies have shown that ACE inhibitors are effecti...

    journal_title：Journal of the American College of Cardiology

    pub_type： 评论,杂志文章,随机对照试验

    doi：10.1016/j.jacc.2008.08.071

    authors： Belluzzi F,Sernesi L,Preti P,Salinaro F,Fonte ML,Perlini S

    更新日期：2009-01-06 00:00:00

  • A new approach for catheter ablation of atrial fibrillation: mapping of the electrophysiologic substrate.

    abstract：OBJECTIVES:We sought to test the hypothesis that complex fractionated electrograms (CFAEs) recorded during atrial fibrillation (AF) could be used as target sites for catheter ablation of AF. BACKGROUND:Mapping of AF in humans has shown that areas of CFAEs correlate with areas of slowed conduction and pivot points of r...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2003.12.054

    authors： Nademanee K,McKenzie J,Kosar E,Schwab M,Sunsaneewitayakul B,Vasavakul T,Khunnawat C,Ngarmukos T

    更新日期：2004-06-02 00:00:00