Population pharmacokinetics of rituximab in patients with chronic lymphocytic leukemia.

abstract：:An open-label study evaluated the effect of steady-state venlafaxine on the single-dose pharmacokinetic profile of risperidone, a CYP2D6 substrate; its active metabolite, 9-hydroxyrisperidone; and the total active moiety (risperidone plus 9-hydroxyrisperidone). Thirty healthy subjects received a 1 mg oral dose of risp...

journal_title：Journal of clinical pharmacology

authors： Amchin J,Zarycranski W,Taylor KP,Albano D,Klockowski PM

更新日期：1999-03-01 00:00:00

abstract：:The pharmacokinetics and pharmacodynamics of flunisolide were studied in healthy volunteers after inhalation. In the morning on the day the study began, volunteers inhaled 0.5 mg of flunisolide with and without oral administration of charcoal, or 1 mg, 2 mg, and 3 mg of flunisolide with concomitant administration of c...

journal_title：Journal of clinical pharmacology

authors： Möllmann H,Derendorf H,Barth J,Meibohm B,Wagner M,Krieg M,Weisser H,Knöller J,Möllmann A,Hochhaus G

更新日期：1997-10-01 00:00:00

abstract：:Floctafenin (FFn), 2,3-dihydroxypropyl--N--(8--trifluoromethyl--4--quinolyl) anthranilate, a new nonnarcotic analgesic drug, was studied in man, mice, and the isolated perfused rat liver. In all species the drug is rapidly hydrolyzed to floctafenic acid (FFa). In seven volunteer subjects who each received a single ora...

journal_title：Journal of clinical pharmacology

authors： Lynn RK,Holm R,Swanson BN,Smith R,Gerber N

更新日期：1979-01-01 00:00:00

abstract：:Bile acid sequestrants can potentially bind to concomitant drugs. Single-dose studies evaluated the effects of colesevelam on the pharmacokinetics of glimepiride, glipizide extended-release (ER), and olmesartan medoxomil. Each study enrolled healthy subjects aged 18-45 years. The olmesartan medoxomil study used a rand...

journal_title：Journal of clinical pharmacology

authors： He L,Wickremasingha P,Lee J,Tao B,Mendell-Harary J,Walker J,Wight D

更新日期：2014-01-01 00:00:00

abstract：:Many astronauts experience intolerance to orthostatic stress after space flight, despite the ingestion of salt tablets and water equivalent to 0.9% saline just before their return to Earth. Previous research indicates that the ingestion of 1.07% saline solution increased plasma volume more than did 0.9% saline. Theref...

journal_title：Journal of clinical pharmacology

authors： Frey MA,Lathers C,Davis J,Fortney S,Charles JB

更新日期：1994-05-01 00:00:00

abstract：:Possible effects of multiple-dose administration of atorvastatin on the pharmacokinetics of single-dose antipyrine were evaluated in this drug-drug interaction study. Twelve healthy male volunteers received three 200-mg capsules of antipyrine on days 1 and 22, and two 40-mg atorvastatin tablets in the morning on days ...

journal_title：Journal of clinical pharmacology

authors： Yang BB,Hounslow NJ,Sedman AJ,Forgue ST

更新日期：1996-04-01 00:00:00

abstract：:Evolocumab binds PCSK9, increasing low-density lipoprotein cholesterol (LDL-C) receptors and lowering LDL-C. Target-mediated evolocumab elimination is attributable to PCSK9 binding. As circulating PCSK9 and LDL-C levels are primarily regulated by the liver, we compared evolocumab pharmacokinetics, pharmacodynamics, an...

journal_title：Journal of clinical pharmacology

authors： Gibbs JP,Slatter JG,Egbuna O,Geller M,Hamilton L,Dias CS,Xu RY,Johnson J,Wasserman SM,Emery MG

更新日期：2017-04-01 00:00:00

abstract：:In the Phase I study, the new anthracycline aclacinomycin A was given to 22 advanced cancer patients on a schedule of daily intravenous administration for five days repeated every four weeks. The limiting toxicity was myelosuppression, which was severe at a dose of 30 mg/m2 per day for five days. Platelet nadirs were ...

journal_title：Journal of clinical pharmacology

authors： Woolley PV 3rd,Ayoob MJ,Levenson SM,Smith FP

更新日期：1982-08-01 00:00:00

abstract：:The most thorough and clinically relevant approach to hypnotic drug evaluation is one that balances the strengths and weaknesses of clinical trials and sleep laboratory evaluations. Advantages of clinical trials include the ability to evaluate large numbers of subjects and specific target groups and to thoroughly asse...

journal_title：Journal of clinical pharmacology

authors： Kales A,Scharf MB,Soldatos CR,Bixler EO

更新日期：1979-07-01 00:00:00

abstract：:The objective of this study was to establish effects of inhaled loxapine on the QTc interval in this randomized, placebo-controlled, double-blind crossover study. Forty-eight healthy volunteers received a single inhaled placebo or 10 mg loxapine. Plasma concentrations of loxapine increased with a median Tmax of 1 minu...

journal_title：Journal of clinical pharmacology

authors： Spyker DA,Voloshko P,Heyman ER,Cassella JV

更新日期：2014-06-01 00:00:00

abstract：:The short-term effect of the blockade of the beta-adrenergic receptors on serum lipoproteins and the plasma activities of the enzymes involved in the metabolism of the serum lipoproteins: lipoprotein lipase (LPL), hepatic lipase (HL) and lecithin: cholesterol acyltransferase (LCAT) was evaluated in ten healthy normoli...

journal_title：Journal of clinical pharmacology

authors： Harvengt C,Heller FR,Martiat P,Van Nieuwenhuyze Y

更新日期：1987-07-01 00:00:00

abstract：:Experimental interventions that activate specific components of clinical pain are necessary for characterization of underlying mechanisms and pharmacology. Cutaneous hyperalgesia has been described that uses nonpainful heat to induce secondary hyperalgesia. This study evaluated the effect of intravenous alfentanil on ...

journal_title：Journal of clinical pharmacology

authors： Schifftner C,Schulteis G,Wallace MS

更新日期：2017-09-01 00:00:00

abstract：:In vitro dissolution profile testing of 12 generic 6-propyl-2-thiouracil (PTU) formulations indicated significant differences in their solubilities in water and in 0.1N hydrochloric acid. Two products, representing the extremes of solubility, were subsequently tested for bioavailability. Bioavailability data from euth...

journal_title：Journal of clinical pharmacology

authors： Ringhand P,Maxon HR,Ritschel WA,Chen IW,Bauman DH

更新日期：1980-02-01 00:00:00

abstract：:In the development of a new controlled release preparation and its subsequent assessment there are a number of factors that need to be considered both related to the drug itself and to the pharmaceutical preparation. This review describes the biopharmaceutical and pharmacokinetic properties of metoprolol CR/ZOK, a rec...

journal_title：Journal of clinical pharmacology

authors： Sandberg A,Abrahamsson B,Regårdh CG,Wieselgren I,Bergstrand R

更新日期：1990-02-01 00:00:00

abstract：:The aim of this study was to investigate if the concomitant administration of the positive inotropic drug enoximone (100 mg tid) has any effect on the morning through levels of the cardiac glycoside digoxin in 17 patients with congestive heart failure (NYHA II-IV). Plasma concentrations of digoxin were 1.05 +/- 0.37 n...

journal_title：Journal of clinical pharmacology

authors： Trenk D,Hertrich F,Winkelmann B,Glauner T,Dieterich HA,Jähnchen E

更新日期：1990-03-01 00:00:00

abstract：:A four-week comparison of protriptyline 10 mg three times a day and perphenazine 2 mg three times a day, alone and in combination, and a placebo in a group of nonpsychotic depressed outpatients showed no significant differences among any of the treatment groups after both two and four weeks, and a slight trend in favo...

journal_title：Journal of clinical pharmacology

authors： Weinstock R,Fisher S,Spillane J,Ise C,Shaw D,Torop P

更新日期：1975-08-01 00:00:00

abstract：:Isosorbide dinitrate is one of the most commonly prescribed medications for the treatment of ischemic heart disease. It has been demonstrated to be ineffective relative to placebo when taken inappropriately. This study objectively documents the magnitude and nature of compliance in 68 ambulatory patients who were pres...

journal_title：Journal of clinical pharmacology

authors： Straka RJ,Fish JT,Benson SR,Suh JT

更新日期：1996-07-01 00:00:00

abstract：:The antihypertensive effect of enalaprilat (MK-422), an intravenous (IV), nonsulfhydryl converting-enzyme inhibitor, was evaluated in a double-blind study of 14 patients with mild to moderate hypertension. The seven patients in the treatment group initially received IV enalaprilat 1.25 mg q6h for 24 hours. Thereafter,...

journal_title：Journal of clinical pharmacology

authors： Evans RR,Henzler MA,Weber EM,DiPette DJ

更新日期：1987-05-01 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT) is a high-risk adverse drug reaction because of its associated risk of life- and limb-threatening thrombosis. Rivaroxaban may be considered as an ideal nonheparin anticoagulant alternative for the management of HIT. In this preliminary retrospective study, the efficacy and safety...

journal_title：Journal of clinical pharmacology

authors： Farasatinasab M,Zarei B,Moghtadaei M,Nasiripour S,Ansarinejad N,Zarei M

更新日期：2020-10-01 00:00:00

abstract：:Optimal design has been used in the past mainly to optimize sampling schedules for clinical trials. Optimization on design variables other than sampling times has been published in the literature only once before. This study shows, as an example, optimization on the length of treatment periods to obtain reliable estim...

journal_title：Journal of clinical pharmacology

authors： Hennig S,Nyberg J,Hooker AC,Karlsson MO

更新日期：2009-03-01 00:00:00

abstract：:The selective T-cell costimulation modulator abatacept is approved for treatment of adult rheumatoid arthritis (RA) and polyarticular juvenile idiopathic arthritis (pJIA; 6-17 years [intravenous] and 2-17 years [subcutaneous]). An extrapolation approach was taken to determine subcutaneous weight-tiered doses of abatac...

journal_title：Journal of clinical pharmacology

authors： Gandhi Y,Passarell JA,Roy A,Murthy B

更新日期：2020-12-07 00:00:00

abstract：:PRX-00023 is a novel, nonazapirone 5-HT1A agonist in clinical development for treatment of affective disorders. The objectives of the initial clinical phase I studies (a single ascending dose study and multiple dose-ascending and high-dose titration studies) were to measure the pharmacokinetics, pharmacodynamic (neuro...

journal_title：Journal of clinical pharmacology

authors： Iyer GR,Reinhard JF Jr,Oshana S,Kauffman M,Donahue S

更新日期：2007-07-01 00:00:00

abstract：:Dienogest offers pharmacological advantages for the effective treatment of endometriosis and for use in contraception and hormone replacement therapy. This pharmacodynamic study investigated the ovulation-inhibiting effects of dienogest monotherapy in healthy women. Dienogest was administered at 0.5, 1, 2, or 3 mg dai...

journal_title：Journal of clinical pharmacology

authors： Klipping C,Duijkers I,Remmers A,Faustmann T,Zurth C,Klein S,Schuett B

更新日期：2012-11-01 00:00:00

abstract：:Food and Drug Administration data show that most anti-depressant studies in youth do not show drug effect. The few positive studies used rigorous diagnostic screening procedures, suggesting major depressive disorder (MDD) may not be a persistent condition in a subgroup of youth. To investigate persistence of MDD, we s...

journal_title：Journal of clinical pharmacology

authors： Malone RP,Bennett DS,Delaney MA,Choudhury MS,Luebbert JF,Cater J

更新日期：2006-09-01 00:00:00

abstract：:The effects of long-term triple drug therapy on renal function in patients with moderate to severe essential hypertension have not been evaluated systematically. We prospectively studied fifteen male patients with moderate to severe essential hypertension receiving triple drug therapy (metolazone, atenolol or betaxolo...

journal_title：Journal of clinical pharmacology

authors： Reams GP,Bauer JH

更新日期：1989-09-01 00:00:00

abstract：:Anisotropine methyl bromide, an anticholinergic, 80 mg given orally at 8 P.M., suppresses gastric acid secretion through the night without significant side effects. Thirty patients with endoscopy-proved symptomatic duodenal ulcer disease completed a randomized, double-blind, placebo-controlled trial of nighttime aniso...

journal_title：Journal of clinical pharmacology

authors： Bowers JH,Forbes JA,Freston JW

更新日期：1978-07-01 00:00:00

abstract：:Monitoring drug levels in patients is standard practice in presentday critical care medicine. Clinical laboratories, however, are often unable to assay drug levels immediately following phlebotomy. This may result in blood samples being kept under a variety of storage conditions for nonuniform periods of time. The cur...

journal_title：Journal of clinical pharmacology

authors： Colucci RD,Halpern NA,Levy E,McElhinney AJ,Greenstein RJ

更新日期：1988-08-01 00:00:00

abstract：:The objective of this study was to establish effects of liraglutide on the QTc interval. In this randomized, placebo-controlled, double-blind crossover study, 51 healthy participants were administered placebo, 0.6, 1.2, and 1.8 mg liraglutide once daily for 7 days each. Electrocardiograms were recorded periodically ov...

journal_title：Journal of clinical pharmacology

authors： Chatterjee DJ,Khutoryansky N,Zdravkovic M,Sprenger CR,Litwin JS

更新日期：2009-11-01 00:00:00

abstract：:The effect of food on the pharmacokinetics of 15 mg oxybutynin XL was evaluated in a single-dose, randomized, crossover, open-label study in healthy volunteers. A validated, stereospecific, high-performance liquid chromatography assay was used to simultaneously determine the plasma concentrations of R- and S-oxybutyni...

journal_title：Journal of clinical pharmacology

authors： Sathyan G,Hu W,Gupta SK

更新日期：2001-02-01 00:00:00

abstract：:The increased availability of chemical intermediates and automated instrumentation has resulted in expanded use of stable isotopes for bioavailability and bioequivalence studies in recent years. Initially, stable isotopes were confined to the labeling of mass internal standard compounds for gas chromatography/mass spe...

journal_title：Journal of clinical pharmacology

authors： Wolen RL

更新日期：1986-07-01 00:00:00