Impersistence of depression in youth: Implications for drug study design.

Abstract:

:Food and Drug Administration data show that most anti-depressant studies in youth do not show drug effect. The few positive studies used rigorous diagnostic screening procedures, suggesting major depressive disorder (MDD) may not be a persistent condition in a subgroup of youth. To investigate persistence of MDD, we serially assessed a cohort of inpatients admitted to the hospital with a clinical diagnosis of MDD. Assessments included a structured diagnostic interview, the Diagnostic Interview for Children and Adolescents-Revised (DICA-R), and measures of depressive symptomatology. Of 66 subjects (40 girls; mean age, 14.4 +/- 2.2 years), 34 (51.5%) met DICA-R criteria for MDD at the initial postadmission assessment. Of these, only 8 (23.5%) met DICA-R criteria for MDD at any subsequent assessment. Similar reductions were found on other ratings of depression. In conclusion, MDD did not persist in this sample. The findings suggest a multigated assessment procedure should be employed before randomization in antidepressant clinical trials.

journal_name

J Clin Pharmacol

authors

Malone RP,Bennett DS,Delaney MA,Choudhury MS,Luebbert JF,Cater J

doi

10.1177/0091270006290334

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

1044-51

issue

9

eissn

0091-2700

issn

1552-4604

pii

46/9/1044

journal_volume

46

pub_type

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