Direct monitoring of capillary perfusion following normovolemic hemodilution in an experimental skin-flap model.

Abstract:

:The effects of normovolemic hemodilution on skin flap survival are studied in a recently developed skin-flap model (homozygous hairless mouse ear) in which nutritional capillary flow is monitored directly by means of intravital microscopy from the time of flap creation throughout the establishment of necrosis. Two diluting agents (dextran 60 and hydroxyethyl starch 200) are utilized. Our quantitative findings demonstrate that the amount of nonperfused tissue following flap creation in both the dextran (n = 23) and starch (n = 13) groups was significantly decreased as compared with controls (n = 19). Our qualitative observations suggest that improved hemorrheologic properties at the microcirculatory level are responsible for the observed decreased necrosis. Various mechanisms by which hemodilution may act to prevent necrosis are discussed.

journal_name

Plast Reconstr Surg

authors

Barker JH,Hammersen F,Galla TJ,Bondàr I,Zeller P,Menger MD,Messmer K

doi

10.1097/00006534-199011000-00018

subject

Has Abstract

pub_date

1990-11-01 00:00:00

pages

946-54

issue

5

eissn

0032-1052

issn

1529-4242

journal_volume

86

pub_type

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