Management of glioblastoma multiforme in pregnancy.

Abstract:

:Glioblastoma multiforme presenting during pregnancy presents unique challenges to the clinician. In planning treatment, potential benefits to the mother must be balanced against the risks to the fetus. In addition, evidence relating to timing of surgery and the use of radiotherapy and chemotherapy in pregnancy is limited. Management of peritumoral edema and seizures in pregnancy is also complicated by the potential for drug-related teratogenic effects and adverse neonatal outcomes on the fetus. The general anesthetic used for surgery must factor obstetric and neurosurgical considerations. In this review article, the authors seek to examine the role, safety, and timing of therapies for glioblastoma in the context of pregnancy. This covers the use of radiotherapy and chemotherapy, timing of surgery, postoperative care, anesthetic considerations, and use of anticonvulsant medications and steroids. The authors hope that this will provide a framework for clinicians treating pregnant patients with glioblastomas.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Jayasekera BA,Bacon AD,Whitfield PC

doi

10.3171/2012.2.JNS112077

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

1187-94

issue

6

eissn

0022-3085

issn

1933-0693

journal_volume

116

pub_type

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