Morphometric and qualitative analysis of congenital occipitocervical instability in children: implications for patients with Down syndrome.

Abstract:

OBJECT:Congenital occipitocervical (OC) instability is uncommon in healthy children but can occur in many children with Down syndrome. A simple morphometric method of evaluating the OC joint in children with OC instability is presented, supported by a qualitative image analysis based on computed tomography (CT). METHODS:Thin-cut CT scans of the OC joint were obtained in eight patients with Down syndrome and one patient with congenital OC instability. These patients' CT scans were compared with those of 15 healthy age-matched control individuals. Morphometric analysis was performed by measuring the depth and length of the superior articular surface (SAS) of C-1, and these values were normalized for a comparison between groups. Qualitative data were acquired using a surface-rendering technique for a visual comparison of the C-1 SAS. Morphometric analysis demonstrated an absence of the concave C-1 SAS anatomy in patients with congenital OC instability compared with age-matched control individuals (0.083 compared with 0.202, p < 0.001). Three-dimensional (3D) image analysis of the C-l SAS supported this finding. CONCLUSIONS:Congenital differences in the shape of the OC joint are highly associated with atraumatic OC instability in children with Down syndrome. High-resolution CT imaging combined with 3D rendering techniques and surface mapping provides support for this assessment. It appears that abnormal OC joint shape is a contributing factor to congenital OC instability, especially in patients with Down syndrome.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Browd S,Healy LJ,Dobie G,Johnson JT 3rd,Jones GM,Rodriguez LF,Brockmeyer DL

doi

10.3171/ped.2006.105.1.50

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

50-4

issue

1 Suppl

eissn

0022-3085

issn

1933-0693

journal_volume

105

pub_type

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