Survival and Complication Rates of Metastasectomy in Patients With Metastatic Renal Cell Carcinoma Treated Exclusively With Targeted Therapy: A Combined Population-based Analysis.

abstract：:Sirolimus, and its antiproliferative capacity, was studied in vivo in three different syngenic rat tumours in the liver. Sirolimus is an inhibitor of the cytosolic mTOR-kinase, associated with the phosphoinositide-3-kinase/Akt pathway. After one week of daily sirolimus treatment, initiated on the day of tumour-cell in...

journal_title：Anticancer research

authors： Rizell M,Lindner P

更新日期：2005-03-01 00:00:00

abstract：:Immunoreactivity of monoclonal anti-cytokeratin KL1, PKK1, K8.12 and anti-actin antibodies in 101 cases of diseased human breast lesions showed irregular keratin distribution in luminal cells of terminal ductal-lobular unit and basal layer cells of the interlobular and main duct. Actin staining was confined to myoepit...

journal_title：Anticancer research

authors： Wada T,Yasutomi M,Yamada K,Hashimura K,Kunikata M,Tanaka T,Huang JW,Mori M

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND/AIM:The combination of bevacizumab (BEV) plus interferon alpha-2a (IFN) constitutes an option for first-line treatment of metastatic renal cell carcinoma. Real-world data from routine clinical practice are rare and were, therefore, collected during this non-interventional study (NIS). PATIENTS AND METHODS:A...

journal_title：Anticancer research

authors： Schultze-Seemann W,Schulz H,Tschechne B,Häckl M

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND/AIM:The objective of this study was to determine the molecular and clinicopathological features, as well as the prognosis of patients with endometrial cancer (EC) having prior malignancy (second primary EC: SPEC) compared with those without a history of prior malignancy (first primary EC: FPEC). MATERIALS A...

journal_title：Anticancer research

authors： Haraga J,Nakamura K,Haruma T,Nyuya A,Nagasaka T,Masuyama H

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Neurofibromatosis type 1 (NF1) is an autosomal dominant hereditary disease with complete penetrance and a very variable phenotype. Recent research has shown that postzygotic NF1 gene mutations occur to a far greater extent than previously thought. The phenotype of affected individuals reflects the time of so...

journal_title：Anticancer research

authors： Friedrich RE,Hagel C,Kohlrusch FK,Schanze I,Wieland I,Zenker M

更新日期：2020-06-01 00:00:00

abstract：:Alterations in the p53 gene are frequently observed in a wide variety of human cancers. To elucidate the role of p53 in tumorigenesis of the dog, we analyzed nine mammary tumor cell lines, and the primary or metastatic tumors used for their establishment, for the presence of genomic p53 abnormalities. Possible genomic...

journal_title：Anticancer research

authors： Van Leeuwen IS,Hellmèn E,Cornelisse CJ,Van den Burgh B,Rutteman GR

更新日期：1996-11-01 00:00:00

abstract：:Between January 1996 and June 2000, 192 men with prostate cancer underwent radical retropubic prostatectomy (RP) and bilateral pelvic node dissection in 26 centers participating in the Italian randomized prospective TAP study. The reviewing pathologist evaluated 145 RP specimens. Seventy-five cases had not been treate...

journal_title：Anticancer research

authors： Mazzucchelli R,Montironi R,Prezioso D,Bono AV,Ferrari P,Manganelli A,Morelli P,De Vito ML,Santinelli A,Diamanti L,Lotti T,Polito M,Takeda Italian TAP Study Group.

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND/AIM:Secretory phospholipase-A2 (sPLA2) mediates growth and proliferation of human esophageal adenocarcinoma cells (HEAC). Two major molecular pathways of cancer growth regulation include extracellular signal-regulated kinase 1/2 (ERK 1/2) and protein kinase-B (AKT). Phospholipase enzymes have been demonstrat...

journal_title：Anticancer research

authors： Sadaria MR,Yu JA,Meng X,Fullerton DA,Reece TB,Weyant MJ

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Tumor angiogenesis is considered a multi-pathway process, while p21(WAF1/CiP1) is a CDK inhibitor involved in cell division and survivaL Herein the tumor environment effect on endothelial p21(WAF1/Cip1) expression is examined. MATERIALS AND METHODS:The EA.hy 926 endothelial cell line and tumor-conditioned m...

journal_title：Anticancer research

authors： Vrekoussis T,Stathopoulos EN,Kafousi M,Saridaki Z,Sanidas E,Zoras O

更新日期：2005-07-01 00:00:00

abstract：:Transferrin was covalently conjugated to adriamycin (Trf-adr) by the formation of a schiff base. This conjugate was found to bind to cell membrane trf receptors in a variety of human tumor cell lines. The Trf-adr conjugate was found to be active against sensitive and resistant cell lines e.g. Lovo, HL-60, H-meso and H...

journal_title：Anticancer research

authors： Singh M,Atwal H,Micetich R

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND/AIM:Bone metastases are associated with increased morbidity and poor prognosis in a variety of cancers. The present study investigated the effects of targeted radionuclide therapy with α-emitting, bone-seeking radium-224 (224Ra) on osteolytic bone metastasis of MDA-MB-231(SA)-GFP human breast cancer cells in...

journal_title：Anticancer research

authors： Juzeniene A,Bernoulli J,Suominen M,Halleen J,Larsen RH

更新日期：2018-04-01 00:00:00

abstract：AIM:The current study reports the type of salvage chemotherapy following osimertinib and its treatment efficacy in patients with non-small-cell lung carcinoma (NSCLC) who acquire resistance to osimertinib. PATIENTS AND METHODS:In this retrospective cohort study, data from the medical charts of 40 patients with NSCLC t...

journal_title：Anticancer research

authors： Tone M,Inomata M,Awano N,Kuse N,Jo T,Yoshimura H,Minami J,Takada K,Miyamoto S,Izumo T

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:In the present study, 3 cytotoxic agents were combined as front-line chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. All 3 drugs have been used in other 2-agent combinations and have been shown to be effective as first-line therapy. PATIENTS AND METHODS:Sixty-one (53 male, 8 female, me...

journal_title：Anticancer research

authors： Dimitroulis J,Toubis M,Antoniou D,Marosis C,Armenaki U,Stathopoulos GP,Giamboudakis P,Veslemes M,Michalopoulou P,Christou F,Georgatou N,Grigoratou T,Karaindros D,Katis K,SOLCA Study Group.

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Cardiac tamponade, due to bleeding in the pericardial space after esophagectomy for esophageal cancer, is an extremely rare complication and may be associated with sudden hemodynamic instability that can lead to death unless there is prompt diagnosis and appropriate treatment. CASE REPORT:A 76-year-old man ...

journal_title：Anticancer research

authors： Ito S,Morita M,Nanbara S,Nakaji Y,Ando K,Hiyoshi Y,Okamoto T,Saeki H,Oki E,Kawanaka H,Tanoue Y,Maehara Y

更新日期：2015-01-01 00:00:00

abstract：:Thymidylate synthase (TS) is a target enzyme of 5-fluorouracil (5-FU). TS has a polymorphic repeated sequence in the 5'-UTR and the polymorphism is associated with TS protein expression. TS polymorphism has been reported to link with the efficacy of 5-FU-based chemotherapy in colorectal cancer. In this study, we exami...

journal_title：Anticancer research

authors： Ishida Y,Kawakami K,Tanaka Y,Kanehira E,Omura K,Watanabe G

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:The safety and efficacy of second-line chemotherapy for treating patients with small cell lung cancer (SCLC) and interstitial lung disease (ILD) have not been elucidated to date. PATIENTS AND METHODS:Between January 2005 and September 2013, we analyzed 23 patients with SCLC and ILD who received second-line ...

journal_title：Anticancer research

authors： Fujimoto D,Shimizu R,Kato R,Sato Y,Kogo M,Ito J,Teraoka S,Otoshi T,Nagata K,Nakagawa A,Otsuka K,Katakami N,Tomii K

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the efficacy and safety of carbon-ion radiotherapy (CIRT) alone for Stage III non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS:Data of 65 patients (median age=73 years) with Stage III NSCLC who underwent CIRT alone in the QST Hospital, Chiba, Japan, between 1997 and 2015 were retros...

journal_title：Anticancer research

authors： Anzai M,Yamamoto N,Hayashi K,Nakajima M,Nomoto A,Ogawa K,Tsuji H

更新日期：2020-01-01 00:00:00

abstract：:Human papillomaviruses (HPVs) express various proteins which have been proven to interact with some cellular functions playing a role in cell cycle progression and differentiation. Therefore, these viral gene products might be candidates for interfering with IFN-mediated antiproliferative actions. Condyloma biopsies f...

journal_title：Anticancer research

authors： Arany I,Goel A,Tyring SK

更新日期：1995-11-01 00:00:00

abstract：:Radiomics, an emerging field in radiation therapy, is hypothesized to improve classification of tumour risk and prognosis. Despite encouraging results, there are issues of practicality and interpretation of radiomic data. This study investigates the emerging role of radiomics in tumour risk classification and prognosi...

journal_title：Anticancer research

authors： Li Wen Y,Leech M

更新日期：2020-07-01 00:00:00

abstract：:In the in vivo system, cancer metastasis is a complex multi-step process. We have utilized an in vitro three-dimensional system to study the initial stages of tumour cell invasion. In this communication, the sequence of events in interactions between B16 melanoma cells and normal mouse skin fibroblasts are described. ...

journal_title：Anticancer research

authors： Mok CH,Chew EC,Riches DJ

更新日期：1986-09-01 00:00:00

abstract：:The triterpenoid fraction (100 and 200 mg/kg) of the fruit bodies of Ganoderma lucidum inhibited primary solid-tumor growth in the spleen, liver metastasis and secondary metastatic tumor growth in the liver in intrasplenic Lewis lung carcinoma (LLC)-implanted mice. In addition, the triterpenoid fraction (800 microgram...

journal_title：Anticancer research

authors： Kimura Y,Taniguchi M,Baba K

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:The prognostic impact of neutrophil to lymphocyte ratio (NLR) in non-small cell lung cancer (NSCLC) was examined using patients with a follow-up period more than 5 years. PATIENTS AND METHODS:Two hundred and eighty four consecutive resected NSCLC patients were reviewed retrospectively. In this study, patien...

journal_title：Anticancer research

authors： Tomita M,Shimizu T,Ayabe T,Yonei A,Onitsuka T

更新日期：2011-09-01 00:00:00

abstract：:A female patient with stage IV-M1c (distant lymph node and breast metastases), chemotherapy-refractory melanoma was treated with the cytotoxic T-lymphocyte antigen 4 (CTLA-4)-inhibitory monoclonal antibody ipilimumab. At first evaluation following induction treatment, there was marked increase in the volume of the lym...

journal_title：Anticancer research

authors： Wilgenhof S,Morlion V,Seghers AC,Du Four S,Vanderlinden E,Hanon S,Vandenbroucke F,Everaert H,Neyns B

更新日期：2012-04-01 00:00:00

abstract：UNLABELLED:The aim of this study was to evaluate the efficacy and safety of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in Japanese patients with relapsed or recurrent advanced non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:This was a multicentre, open-label phase II study of er...

journal_title：Anticancer research

authors： Takahashi T,Yamamoto N,Nukiwa T,Mori K,Tsuboi M,Horai T,Masuda N,Eguchi K,Mitsudomi T,Yokota S,Segawa Y,Ichinose Y,Fukuoka M,Saijo N

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND/AIM:The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid. PATIENTS AND METHODS:MT-I/II and Ki-67 antigen expression was studie...

journal_title：Anticancer research

authors： Domoslawski P,Pula B,Olbromski M,Wojtczak B,Lukienczuk T,Podhorska-Okolow M,Dziegiel P

更新日期：2018-12-01 00:00:00

abstract：AIM:To investigate the clinical significance of ATP-binding cassette transporter 11 (ABCC11) protein expression in colon cancer. MATERIALS AND METHODS:One hundred thirty nine patients with colon cancer resection between 2009 and 2011 were enrolled. The relationship with immunohistochemical ABCC11 staining and clinicop...

journal_title：Anticancer research

authors： Yamada Y,Yoshimatsu K,Yokomizo H,Okayama S,Shiozawa S

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The combined effects of Human papillomavirus (HPV) and Herpes simplex type 1 (HSV-1) infections and their effects on cancer cell radioresistance are unexplored. MATERIALS AND METHODS:An HPV16-positive hypopharyngeal carcinoma cell line (UD-SCC-2) was infected with wt-HSV-1 at low multiplicity of infection (...

journal_title：Anticancer research

authors： Turunen A,Hukkanen V,Kulmala J,Syrjanen S

更新日期：2016-02-01 00:00:00

abstract：:The purpose of this study was to determine whether the degree of anchorage-independent growth of rodent or human cells in increasing concentrations of agarose correlated with successful transfection of the cells with an activated c-Ha-ras oncogene and tumorigenicity in nude mice. NIH 3T3 cells, C3H 10T1/2 fibroblasts,...

journal_title：Anticancer research

authors： Fidler IJ,Li LM,Ananthaswamy HN,Esumi N,Radinsky R,Price JE

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:The rat model of breast cancer induced by the administration of N-methyl-nitrosourea (NMU) constitutes a useful tool for dissecting the initiation, promotion and progression process of carcinogenesis. Angiogenesis, the recruitment of new blood vessels, is an essential component of the metastatic pathway. Tum...

journal_title：Anticancer research

authors： Carrera MP,Ramírez-Expósito MJ,Valenzuela MT,García MJ,Mayas MD,Martínez-Martos JM

更新日期：2004-03-01 00:00:00

abstract：:Consumption of dietary fat has been linked to the high incidence of certain cancers. However, recent research has stimulated interest in conjugated linoleic acid (CLA), a newly recognized anticarcinogenic fatty acid. Human MCF-7 breast cancer cells were incubated for 12 d in culture medium supplemented with various co...

journal_title：Anticancer research

authors： Shultz TD,Chew BP,Seaman WR

更新日期：1992-11-01 00:00:00