当前位置： SCI文献检索 > AMERICAN HEART JOURNAL期刊下所有文献 > The effect of aspirin on the hemodynamic response to nitroglycerin.

The effect of aspirin on the hemodynamic response to nitroglycerin.

Abstract：

:The role of prostaglandins in mediating the hemodynamic response to nitroglycerin in vivo is controversial. To determine the effect of inhibiting prostaglandin production on the response to nitroglycerin, either placebo or aspirin (650 mg) was administered 1 hour prior to the administration of nitroglycerin (432 micrograms) sublingually to 40 healthy volunteers in a double-blind, randomized, cross-over study. Prior to nitroglycerin administration, blood pressure and pulse rate were determined noninvasively every 2 minutes until stable conditions were reached, and then after nitroglycerin administration determinations were made every 1 minute for the first 10 minutes, every 2 minutes for the next 10 minutes, and every 5 minutes until 30 minutes had elapsed. At peak response in the placebo study, nitroglycerin lowered systolic pressure from 117 +/- 10 to 111 +/- 10 mm Hg (p less than 0.0001). Unexpectedly, nitroglycerin increased diastolic pressure from 75 +/- 8 to 80 +/- 7 mm Hg (p less than 0.005), thus reducing pulse pressure significantly. Pulse rate after nitroglycerin increased from 72 +/- 11 to 85 +/- 14 (p less than 0.001). Aspirin slightly modified the pattern of response at 1 minute but altered neither the peak hemodynamic responses nor the areas under the time-pressure and time-pulse curves. Thus nitroglycerin-induced prostaglandin production does not play a major role in the systemic hemodynamic response to nitroglycerin in vivo.

journal_name

Am Heart J

journal_title

American heart journal

authors

Levin RI,Feit F

doi

10.1016/0002-8703(88)90252-9

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

77-84

issue

1 Pt 1

eissn

0002-8703

issn

1097-6744

pii

0002-8703(88)90252-9

journal_volume

116

pub_type

临床试验,杂志文章,随机对照试验

相关文献

AMERICAN HEART JOURNAL文献大全
  • Comparison of adverse event and device problem rates for transcatheter aortic valve replacement and Mitraclip procedures as reported by the Transcatheter Valve Therapy Registry and the Food and Drug Administration postmarket surveillance data.

    abstract：BACKGROUND:Although outcomes data on transcatheter aortic valve replacement (TAVR) and transcatheter mitral valve repair (Mitraclip) are available via the Transcatheter Valve Therapy (TVT) registry, dissemination of TVT data is often delayed. The Food and Drug Administration's Manufacturer and User Facility Device Expe...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2017.10.013

    authors： Galper BZ,Beery DE,Leighton G,Englander LL

    更新日期：2018-04-01 00:00:00

  • The long-term prognosis of patients with out-of-hospital cardiac arrest but no inducible ventricular tachycardia.

    abstract：:The long-term prognosis of patients successfully resuscitated from cardiac arrest who do not have acute precipitating factors and in whom ventricular arrhythmias cannot be induced during baseline electrophysiologic testing is controversial. The purpose of this investigation was to evaluate the long-term risk of recurr...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(90)90245-s

    authors： Sager PT,Choudhary R,Leon C,Rahimtoola SH,Bhandari AK

    更新日期：1990-12-01 00:00:00

  • Normal intima-media thickness on carotid ultrasound reliably excludes an ischemic cause of cardiomyopathy.

    abstract：BACKGROUND:Coronary artery disease (CAD) is the most common cause of left ventricular systolic dysfunction (LVSD). Patients with ischemia as the cause of LVSD may warrant revascularization. Angiography is the most accurate method of CAD diagnosis but is invasive, expensive, and associated with some risk. Noninvasive im...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ahj.2010.03.026

    authors： Reynolds HR,Steckman DA,Tunick PA,Kronzon I,Lobach I,Rosenzweig BP

    更新日期：2010-06-01 00:00:00

  • Erythropoietin improves anemia exercise tolerance and renal function and reduces B-type natriuretic peptide and hospitalization in patients with heart failure and anemia.

    abstract：BACKGROUND:Anemia is now recognized as being a common finding in CHF and is associated with increased mortality and morbidity. However, it is uncertain whether the anemia is actually causing the worse prognosis or is merely a marker of more severe cardiac disease. Previous intervention studies with subcutaneous (s.c.) ...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2006.08.005

    authors： Palazzuoli A,Silverberg D,Iovine F,Capobianco S,Giannotti G,Calabrò A,Campagna SM,Nuti R

    更新日期：2006-12-01 00:00:00

  • Spatial, individual, and temporal variation of the high-frequency QRS amplitudes in the 12 standard electrocardiographic leads.

    abstract：BACKGROUND:Analysis of high-frequency QRS amplitudes (HF-QRS) may provide an additional diagnostic tool in patients with heart disease, but the basic properties of these waveforms have not been sufficiently investigated. This study describes the spatial, individual, and temporal variation at rest of HF-QRS recorded wit...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1067/mhj.2000.101782

    authors： Pettersson J,Carro E,Edenbrandt L,Maynard C,Pahlm O,Ringborn M,Sörnmo L,Warren SG,Wagner GS

    更新日期：2000-02-01 00:00:00

  • Cognitive decline and ischemic microlesions after coronary catheterization. A comparison to coronary artery bypass grafting.

    abstract：BACKGROUND:Postinterventional cognitive dysfunction (PICD) is a known complication of coronary artery bypass grafting (CABG). However, it is largely unknown whether PICD occurs after coronary catheterization. METHODS:Neuropsychologic data were obtained from 37 patients who received coronary catheterization and 47 pati...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2011.07.021

    authors： Schwarz N,Schoenburg M,Möllmann H,Kastaun S,Kaps M,Bachmann G,Sammer G,Hamm C,Walther T,Gerriets T

    更新日期：2011-10-01 00:00:00

  • A comparison between intravenous streptokinase and tissue plasminogen activator with early intravenous heparin in acute myocardial infarction.

    abstract：:To compare the effects of two thrombolytic agents, streptokinase and recombinant tissue-type plasminogen activator (rTPA) with early heparinization, on left ventricular function, coronary patency and reinfarction rates, bleeding complications, and short- and long-term mortality, we studied 122 patients with acute myoc...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-8703(92)90685-o

    authors： Cherng WJ,Chiang CW,Kuo CT,Lee CP,Lee YS

    更新日期：1992-04-01 00:00:00

  • Accuracy and reproducibility of clinically acquired two-dimensional echocardiographic mass measurements.

    abstract：:Left ventricular mass (LVM) measurements made by the truncated ellipsoid algorithm from clinical two-dimensional echocardiograms (2DE) were compared to autopsy weights in 37 patients. All six 2DE instruments were calibrated with an ultrasound phantom to standardize LVM measurements. Measurements were made by an experi...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(89)90083-5

    authors： Byrd BF 3rd,Finkbeiner W,Bouchard A,Silverman NH,Schiller NB

    更新日期：1989-07-01 00:00:00

  • Abnormal changes in transmitral flow after acute exposure to nitroglycerin and nifedipine in uncomplicated insulin-dependent diabetes mellitus: a Doppler echocardiographic study.

    abstract：:To study the left ventricular (LV) diastolic function in uncomplicated insulin-dependent diabetic patients without hypertension (n = 25) and comparable controls (n = 15), the effect of acute administration of nitroglycerin and nifedipine on cavity dimensions and transmitral flow pattern was investigated by Doppler ech...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(93)90542-h

    authors： Gøtzsche O,Sihm I,Lund S,Schmitz O

    更新日期：1993-12-01 00:00:00

  • Diagnostic coronary angiography induces a systemic inflammatory response in patients with stable angina.

    abstract：BACKGROUND:Systemic markers of inflammation increase after percutaneous coronary intervention (PCI). The rise in inflammatory markers after PCI is frequently attributed to the inflammatory stimulus associated with coronary artery injury during balloon inflation and coronary stent implantation. The aim of this study was...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章

    doi：10.1016/S0002-8703(03)00407-1

    authors： Goldberg A,Zinder O,Zdorovyak A,Diamond E,Lischinsky S,Gruberg L,Markiewicz W,Beyar R,Aronson D

    更新日期：2003-11-01 00:00:00

  • Morbidity and mortality rates in elderly patients undergoing percutaneous coronary transluminal angioplasty.

    abstract：:Although successful dilatation of a target lesion by means of percutaneous transluminal coronary angioplasty (PTCA) can be attained as frequently in elderly as in younger patients, elderly patients have a higher risk of complications. Furthermore, cohorts of patients older than 75 years and undergoing PTCA include mor...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(94)90267-4

    authors： Lindsay J Jr,Reddy VM,Pinnow EE,Little T,Pichard AD

    更新日期：1994-10-01 00:00:00

  • Comparison of the hypolipidemic effect of gemfibrozil versus simvastatin in patients with type III hyperlipoproteinemia.

    abstract：BACKGROUND:Type III hyperlipoproteinemia is characterized by the accumulation of chylomicron and very low density lipoprotein (VLDL) remnants. Individuals with this disorder have a high risk of premature atherosclerosis, and hypolipidemic drugs are useful in their management. METHODS:We compared, in a double-blind, pl...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0002-8703(99)70262-0

    authors： Civeira F,Cenarro A,Ferrando J,Puzo J,Garcia-Otín AL,Mozas P,Pocoví M

    更新日期：1999-07-01 00:00:00

  • Accuracy of flow convergence estimates of mitral regurgitant flow rates obtained by use of multiple color flow Doppler M-mode aliasing boundaries: an experimental animal study.

    abstract：:The proximal flow convergence method of multiplying color Doppler aliasing velocity by flow convergence surface area has yielded a new means of quantifying flow rate by noninvasively derived measurements. Unlike previous methods of visualizing the turbulent jet of mitral regurgitation on color flow Doppler mapping, fl...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(93)90025-5

    authors： Zhang J,Jones M,Shandas R,Valdes-Cruz LM,Murillo A,Yamada I,Kang SU,Weintraub RG,Shiota T,Sahn DJ

    更新日期：1993-02-01 00:00:00

  • Assessment of side branch predilation before a provisional T-stent strategy for bifurcation lesions. A randomized trial.

    abstract：BACKGROUND:A simple approach is the predominant strategy for the percutaneous coronary intervention of bifurcation lesions. Performing side branch (SB) predilation in this context is currently a matter of controversy. In this study, we assess the efficacy of SB predilatation before a provisional T-stent strategy for bi...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2014.05.014

    authors： Pan M,Medina A,Romero M,Ojeda S,Martin P,Suarez de Lezo J,Segura J,Mazuelos F,Novoa J,Suarez de Lezo J

    更新日期：2014-09-01 00:00:00

  • Cross-sectional echocardiographic spectrum of papillary muscle dysfunction.

    abstract：:Cross-sectional echocardiography identified two abnormal patterns of mitral valve closure in 14 patients with mitral regurgitation due to papillary muscle dysfunction: (1) in three patients with an akinetic inferior-posterior wall but normal cavity size, papillary muscle fibrosis was associated with late systolic mitr...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(79)90430-7

    authors： Ogawa S,Hubbard FE,Mardelli TJ,Dreifus LS

    更新日期：1979-03-01 00:00:00

  • Return to the workforce following infective endocarditis-A nationwide cohort study.

    abstract：BACKGROUND:The ability to return to work after infective endocarditis (IE) holds important socioeconomic consequences for both patients and society, yet data on this issue are sparse. We examined return to the workforce and associated factors in IE patients of working age. METHODS:Using Danish nationwide registries, w...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ahj.2017.09.009

    authors： Butt JH,Kragholm K,Dalager-Pedersen M,Rørth R,Kristensen SL,Chaudry MS,Valeur N,Østergaard L,Torp-Pedersen C,Gislason GH,Køber L,Fosbøl EL

    更新日期：2018-01-01 00:00:00

  • Survival after acute myocardial infarction (SAMI) study: the design and implementation of a positive deviance study.

    abstract：:Positive deviance studies combining qualitative and quantitative designs-a mixed-methods approach-can discover strategies to produce exemplary performance. We present the SAMI study, a national positive deviance study to discover hospital strategies associated with lower 30-day hospital risk-standardized mortality rat...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2011.09.004

    authors： Krumholz HM,Curry LA,Bradley EH

    更新日期：2011-12-01 00:00:00

  • Lifestyle changes and 14-year change in high-density lipoprotein cholesterol in a cohort of male physicians.

    abstract：BACKGROUND:Although cross-sectional studies have identified lifestyle factors associated with high-density lipoprotein cholesterol (HDL-C), no studies have examined the association between changes in lifestyle factors and long-term changes in HDL-C. METHODS:We examined the association between changes in lifestyle fact...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2010.12.015

    authors： Rahilly-Tierney C,Sesso HD,Djoussé L,Gaziano JM

    更新日期：2011-04-01 00:00:00

  • Cardiac transplantation for the cardiologist not trained in transplantation.

    abstract：:This review focuses on selected aspects of the treatment of patients being evaluated for and undergoing cardiac transplantation. Cardiac transplantation is a potential therapeutic option for a variety of irreversible cardiac disorders when the symptomatic status and anticipated survival after transplantation exceeds t...

    journal_title：American heart journal

    pub_type： 杂志文章,评审

    doi：10.1016/0002-8703(95)90288-0

    authors： Taylor AJ,Bergin JD

    更新日期：1995-03-01 00:00:00

  • Optimized duration of clopidogrel therapy following treatment with the Endeavor zotarolimus-eluting stent in real-world clinical practice (OPTIMIZE) trial: rationale and design of a large-scale, randomized, multicenter study.

    abstract：BACKGROUND:Current recommendations for antithrombotic therapy after drug-eluting stent (DES) implantation include prolonged dual antiplatelet therapy (DAPT) with aspirin and clopidogrel ≥12 months. However, the impact of such a regimen for all patients receiving any DES system remains unclear based on scientific eviden...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2012.09.009

    authors： Feres F,Costa RA,Bhatt DL,Leon MB,Botelho RV,King SB 3rd,de Paula JE,Mangione JA,Salvadori D Jr,Gusmão MO,Castello H Jr,Nicolela E Jr,Perin MA,Devito FS,Marin-Neto JA,Abizaid A

    更新日期：2012-12-01 00:00:00

  • The hemodynamic determinants of the isovolumic index.

    abstract：:The isovolumic index is a recently described echocardiographic parameter of left ventricular function that is calculated as the ratio between the sum of the time of isovolumic contraction and relaxation divided by the ejection time. Although the individual components of this index may be altered by heart rate and load...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(86)90476-x

    authors： Mancini GB,Friedman HZ,Hramiec JE,DeBoe SF

    更新日期：1986-10-01 00:00:00

  • Correlation between the signal-averaged electrocardiogram and electrophysiologic study findings in patients with coronary artery disease and sustained ventricular tachycardia.

    abstract：:Ventricular late potentials at the end of the surface QRS, detected on the signal-averaged electrocardiogram (SAECG) have been shown to be markers for spontaneous and/or inducible ventricular tachycardia (VT) in patients with coronary artery disease (CAD). We examined the correlations between electrophysiologic study ...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/0002-8703(88)90884-8

    authors： Borbola J,Ezri MD,Denes P

    更新日期：1988-04-01 00:00:00

  • Gender-specific outcomes after balloon aortic valvuloplasty: Inhospital and long-term outcomes.

    abstract：BACKGROUND:Increasing numbers of balloon aortic valvuloplasty (BAV) are performed in the management of symptomatic aortic stenosis as bridge and therapeutic challenge in the work-up for transcatheter aortic valve replacement. However, the significance of gender in outcomes following BAV remains controversial. METHODS:...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2015.03.013

    authors： Christodoulidis G,Yu J,Kini A,Dangas GD,Baber U,Melissa A,Sartori S,Theodoropoulos K,Bhat A,Kovacic J,Moreno P,Krishnan P,Mehran R,Sharma S

    更新日期：2015-07-01 00:00:00

  • Elevated resting heart rate is an independent risk factor for cardiovascular disease in healthy men and women.

    abstract：BACKGROUND:Elevated resting heart rate (RHR) is known to be associated with reduced survival but inconsistencies remain, including lack of significance in most studies of healthy women, lack of independence from systolic blood pressure (SBP) in some, and the suggestion that RHR is merely functioning as a marker of phys...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2009.12.029

    authors： Cooney MT,Vartiainen E,Laatikainen T,Juolevi A,Dudina A,Graham IM

    更新日期：2010-04-01 00:00:00

  • An integrated approach to diagnosis and therapeutic management of patients with systolic heart failure in the Copenhagen metropolitan area.

    abstract：BACKGROUND:Studies on the effect of heart failure clinics have been encouraging and convincing with respect to reduced hospitalizations, improved quality of life, and reduced cost. However, previous results have been derived from patient populations either recently discharged and with specific exclusion criteria or fro...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1067/mhj.2002.123841

    authors： Galatius S,Gustafsson F,Nielsen PH,Atar D,Hildebrandt PR

    更新日期：2002-08-01 00:00:00

  • A randomized controlled trial of low-dose hormone therapy on myocardial ischemia in postmenopausal women with no obstructive coronary artery disease: results from the National Institutes of Health/National Heart, Lung, and Blood Institute-sponsored Women'

    abstract：BACKGROUND:Compared with men, women have more evidence of myocardial ischemia with no obstructive coronary artery disease. Although low endogenous estrogen levels are associated with endothelial dysfunction, the role of low-dose hormone therapy has not been fully evaluated. We postulate that a 12-week duration of low-d...

    journal_title：American heart journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.ahj.2010.03.024

    authors： Merz CN,Olson MB,McClure C,Yang YC,Symons J,Sopko G,Kelsey SF,Handberg E,Johnson BD,Cooper-DeHoff RM,Sharaf B,Rogers WJ,Pepine CJ

    更新日期：2010-06-01 00:00:00

  • Rationale and design of a multicenter randomized trial to compare the graft patency between no-touch vein harvesting technique and conventional approach in coronary artery bypass graft surgery.

    abstract：BACKGROUND:Vein graft failure is a crucial challenge in coronary artery bypass graft (CABG) surgery. Previous studies have suggested a patency benefit of the No-Touch vein harvesting technique, but only with small sample sizes. MATERIALS AND METHODS:This study is a prospective, multicenter randomized clinical trial wi...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2018.11.011

    authors： Wang X,Tian M,Zheng Z,Gao H,Wang Y,Wang L,Hu S

    更新日期：2019-04-01 00:00:00

  • Primary prevention in patients with hypertension: comments on the clinical implications of the MAPHY Study. Metoprolol Atherosclerosis Prevention in Hypertensives Study.

    abstract：:The MAPHY Study was conducted to investigate whether metoprolol, a relatively beta 1-selective beta-blocker, given as initial antihypertensive treatment, would lower cardiovascular complications of high blood pressure to a greater extent than do thiazide diuretics as initial treatment at similar blood pressure control...

    journal_title：American heart journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-8703(88)90112-3

    authors： Wikstrand J

    更新日期：1988-07-01 00:00:00

  • Treatment of anxiety in patients with coronary heart disease: Rationale and design of the UNderstanding the benefits of exercise and escitalopram in anxious patients WIth coroNary heart Disease (UNWIND) randomized clinical trial.

    abstract：BACKGROUND:Anxiety is highly prevalent among patients with coronary heart disease (CHD), and there is growing evidence that high levels of anxiety are associated with worse prognosis. However, few studies have evaluated the efficacy of treating anxiety in CHD patients for reducing symptoms and improving clinical outcom...

    journal_title：American heart journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ahj.2016.03.003

    authors： Blumenthal JA,Feger BJ,Smith PJ,Watkins LL,Jiang W,Davidson J,Hoffman BM,Ashworth M,Mabe SK,Babyak MA,Kraus WE,Hinderliter A,Sherwood A

    更新日期：2016-06-01 00:00:00

  • PLN-encoded phospholamban mutation in a large cohort of hypertrophic cardiomyopathy cases: summary of the literature and implications for genetic testing.

    abstract：BACKGROUND:hypertrophic cardiomyopathy (HCM) is a major cause of sudden death in young athletes and one of the most common inherited cardiovascular diseases, affecting 1 in 500 individuals. Often viewed as a disease of the cardiac sarcomere, mutations in genes encoding myofilament proteins are associated with disease p...

    journal_title：American heart journal

    pub_type： 杂志文章

    doi：10.1016/j.ahj.2010.08.001

    authors： Landstrom AP,Adekola BA,Bos JM,Ommen SR,Ackerman MJ

    更新日期：2011-01-01 00:00:00