Abstract:
:The tissue-specific expression of immunoglobulin genes can be partially explained by a requirement for activating factors found only in B lymphocytes and their derivatives. However, loss of immunoglobulin expression upon fusion of an immunoglobulin-producing myeloma cell with a T lymphoma cell (BW5147) or fibroblast (L cell) suggests that negatively acting factors also play a role in the tissue specificity of immunoglobulin genes. Expression of a cloned immunoglobulin heavy-chain gene introduced into myeloma cells was suppressed after fusion of the myeloma transformants with BW5147. The presence of either the immunoglobulin heavy-chain enhancer or promoter conferred suppression, under similar conditions, upon a heterologous gene that is normally expressed in both B and T lymphocytes. These immunoglobulin heavy-chain gene control regions, or gene modifications induced by them, are subject to negative control by T-lymphocyte-derived factors.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
Zaller DM,Yu H,Eckhardt LAdoi
10.1128/mcb.8.5.1932subject
Has Abstractpub_date
1988-05-01 00:00:00pages
1932-9issue
5eissn
0270-7306issn
1098-5549journal_volume
8pub_type
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