Abstract:
PURPOSE:We aimed to determine whether diarrhea experienced by patients in the intensive care unit (ICU) is related to their clinical outcomes. MATERIAL AND METHODS:We performed a systematic review and meta-analysis. We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, CINAHL, and the World Health Organization International Clinical Trials Registry Platform between inception and August 2018. The primary outcome was ICU mortality, and secondary outcomes included hospital mortality, ICU length of stay, hospital length of stay. The quality of evidence was determined using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. RESULTS:Twelve studies (enrolling 13,140 patients) compared patients with diarrhea to patients without diarrhea in the ICU. Diarrhea was related to ICU mortality (relative risk [RR]: 1.43; 95% confidence interval [CI]: 1.03 to 1.98). The mean difference (MD) in ICU length of stay between patients with and without diarrhea was 8.08 days (95% CI: 5.85 to 10.32), while the MD in hospital length of stay was 9.67 (95% CI: 2.17 to 17.16). The certainty of evidence for these outcomes was low. CONCLUSIONS:The diarrhea experienced by patients may be associated with higher mortality and prolonged length of stay in the ICU and hospital.
journal_name
J Crit Carejournal_title
Journal of critical careauthors
Taito S,Kawai Y,Liu K,Ariie T,Tsujimoto Y,Banno M,Kataoka Ydoi
10.1016/j.jcrc.2019.06.014subject
Has Abstractpub_date
2019-10-01 00:00:00pages
142-148eissn
0883-9441issn
1557-8615pii
S0883-9441(19)30181-9journal_volume
53pub_type
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journal_title:Journal of critical care
pub_type: 杂志文章
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journal_title:Journal of critical care
pub_type: 杂志文章,随机对照试验
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更新日期:2018-12-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2017.10.019
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journal_title:Journal of critical care
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journal_title:Journal of critical care
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journal_title:Journal of critical care
pub_type: 杂志文章
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更新日期:2007-09-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章,随机对照试验
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更新日期:2011-10-01 00:00:00
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journal_title:Journal of critical care
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journal_title:Journal of critical care
pub_type: 临床试验,杂志文章
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journal_title:Journal of critical care
pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
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