Red blood cell transfusion in acute brain injury subtypes: An observational cohort study.


PURPOSE:Optimal red blood cell (RBC) transfusion thresholds in acute brain injury (ABI) are poorly defined. MATERIALS AND METHODS:We conducted a retrospective cohort study of adult patients with ABI and moderate anemia (Hb 7-10 g/dL) in a neurological intensive care unit (ICU) at an academic medical center between 2008 and 2015. Transfused and non-transfused patients were matched based on age, ABI subtype, pre-transfusion hemoglobin, and ICU length of stay (LOS) at the time of RBC transfusion. Multivariable regression analyses were performed to assess the relationship between RBC transfusion and hospital LOS, hospital mortality, ICU LOS, ICU mortality, and 24 h change in sequential organ failure assessment (SOFA) scores. RESULTS:2638 patients met inclusion criteria, with 225 (8.5%) receiving RBC transfusion. Acute ischemic stroke was the most prevalent ABI diagnosis (43.3%) then intracranial hemorrhage (25.6%), subarachnoid hemorrhage (16.5%), and traumatic brain injury (TBI) (14.6%). In multivariable analyses, RBC transfusion was associated with longer hospital and ICU LOS, and higher SOFA scores. Each ABI subtype had similar results, except for TBI which showed no difference in hospital LOS. Mortality was not significantly different. CONCLUSIONS:In moderately anemic patients with ABI, RBC transfusion was associated with longer hospital and ICU LOS. Prospective investigations are necessary to further assess these relationships.


J Crit Care


Journal of critical care


Moman RN,Kor DJ,Chandran A,Hanson AC,Schroeder DR,Rabinstein AA,Warner MA




Has Abstract


2019-04-01 00:00:00












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    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: White A,Bozso SJ,Moon MC

    更新日期:2018-06-01 00:00:00

  • L-canavanine, a selective inhibitor of inducible NO synthase, increases plasma endothelin-1 concentrations in dogs with endotoxic shock.

    abstract:PURPOSE:The purpose of this article is to elucidate the effect of L-canavanine, a selective inhibitor of inducible NO synthase (iNOS), on hemodynamics, blood gas parameters, and plasma concentrations of lactate and endothelin-1 (ET-1) during endotoxic shock. MATERIALS AND METHODS:Eleven mongrel dogs under pentobarbita...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Mitaka C,Hirata Y,Yokoyama K,Imai T

    更新日期:2001-03-01 00:00:00

  • Sample entropy predicts lifesaving interventions in trauma patients with normal vital signs.

    abstract:INTRODUCTION:Heart rate complexity, commonly described as a "new vital sign," has shown promise in predicting injury severity, but its use in clinical practice is not yet widely adopted. We previously demonstrated the ability of this noninvasive technology to predict lifesaving interventions (LSIs) in trauma patients. ...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Naraghi L,Mejaddam AY,Birkhan OA,Chang Y,Cropano CM,Mesar T,Larentzakis A,Peev M,Sideris AC,Van der Wilden GM,Imam AM,Hwabejire JO,Velmahos GC,Fagenholz PJ,Yeh D,de Moya MA,King DR

    更新日期:2015-08-01 00:00:00

  • Increased incidence of diuretic use in critically ill obese patients.

    abstract:OBJECTIVE:Sodium retention occurs commonly in cardiac and liver disease, requiring the administration of diuretics to restore fluid balance. Whether obesity is associated with sodium retention has not been fully evaluated. METHODS:In a large single-center cohort of critically ill patients, we evaluated whether admissi...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: de Louw EJ,Sun PO,Lee J,Feng M,Mark RG,Celi LA,Mukamal KJ,Danziger J

    更新日期:2015-06-01 00:00:00

  • Clinical impact of lung ultrasound monitoring for diagnosis of ventilator associated pneumonia: A diagnostic randomized controlled trial.

    abstract:PURPOSE:Studies have shown that lung-ultrasound may be superior to chest x-ray (CXR) in diagnosing ventilator-associated pneumonia (VAP). This study investigated whether the use of lung-ultrasound monitoring could detect VAP earlier and improve patient outcome. METHODS:This was a single-center diagnostic randomized co...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Pradhan S,Shrestha PS,Shrestha GS,Marhatta MN

    更新日期:2020-08-01 00:00:00

  • Persistent sepsis-induced hypotension without hyperlactatemia: is it really septic shock?

    abstract:PURPOSE:The prognostic value of hyperlactatemia in septic shock is unquestionable. However, as current definitions do not include hyperlactatemia as a mandatory criterion, some hypotensive patients may be diagnosed as having septic shock despite exhibiting normolactatemia. The significance of persistent sepsis-induced ...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Hernandez G,Castro R,Romero C,de la Hoz C,Angulo D,Aranguiz I,Larrondo J,Bujes A,Bruhn A

    更新日期:2011-08-01 00:00:00

  • Barbiturate coma for intracranial hypertension: clinical observations.

    abstract:PURPOSE:To determine the neurologic outcome of patients with intracranial hypertension treated with barbiturate-induced coma. MATERIALS AND METHODS:The records of 49 patients who were admitted to a 31-bed medicosurgical intensive care unit over a 5-year period in whom a barbiturate coma was induced to control intracra...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Dereeper E,Berré J,Vandesteene A,Lefranc F,Vincent JL

    更新日期:2002-03-01 00:00:00

  • High central venous pressure is associated with acute kidney injury and mortality in patients underwent cardiopulmonary bypass surgery.

    abstract:PURPOSE:We sought to investigate the relationship between high CVP, AKI, and mortality in patients undergoing cardiac surgery with cardiopulmonary bypass. MATERIALS:All patients aged 18 years or older who underwent cardiac surgery with CPB were prospectively reviewed. Patients were excluded when renal artery were invo...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Yang Y,Ma J,Zhao L

    更新日期:2018-12-01 00:00:00

  • Predictive value of plasma biomarkers for mortality and organ failure development in patients with acute respiratory distress syndrome.

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    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Cartin-Ceba R,Hubmayr RD,Qin R,Peters S,Determann RM,Schultz MJ,Gajic O

    更新日期:2015-02-01 00:00:00

  • Building safety into ICU care.

    abstract::The Institute of Medicine's (IOMs) report, "To Err is Human," recently addressed patient safety in the United States, alerting the nation to the need for improved systems of health care. Seven main findings were addressed in this report, we focus on 3: (1) patient safety is a nationwide problem, (2) health care worker...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Pronovost P,Wu AW,Dorman T,Morlock L

    更新日期:2002-06-01 00:00:00

  • Impact of positive fluid balance on critically ill surgical patients: a prospective observational study.

    abstract:PURPOSE:The purpose of this study is to determine the effect of postoperative fluid balance (FB) on subsequent outcomes in acute care surgery (ACS) patients admitted to the surgical intensive care unit (ICU). MATERIAL AND METHODS:Acute care surgery patients admitted to the surgical ICU from 06/2012 to 01/2013 were fol...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Barmparas G,Liou D,Lee D,Fierro N,Bloom M,Ley E,Salim A,Bukur M

    更新日期:2014-12-01 00:00:00

  • Intraoperative adherence to a low tidal volume ventilation strategy in critically ill patients with preexisting acute lung injury.

    abstract:PURPOSE:Low tidal volume (LTV) ventilation reduces mortality in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). This study investigates adherence of intraoperative LTV and whether patient outcomes were different with or without continued intraoperative LTV ventilation in patients wi...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Chaiwat O,Vavilala MS,Philip S,Malakouti A,Neff MJ,Deem S,Treggiari MM,Wang J,Lang JD

    更新日期:2011-04-01 00:00:00

  • Detection of invasive pulmonary aspergillosis in critically ill patients by combined use of conventional culture, galactomannan, 1-3-beta-D-glucan and Aspergillus specific nested polymerase chain reaction in a prospective pilot study.

    abstract::Invasive pulmonary aspergillosis (IPA) is an emerging and life-threatening infectious disease in patients admitted to the intensive care unit (ICU). Most diagnostic studies are conducted in hematological patients and results cannot readily be transferred to ICU patients lacking classical host factors. In a multicenter...

    journal_title:Journal of critical care

    pub_type: 杂志文章,多中心研究


    authors: Boch T,Reinwald M,Spiess B,Liebregts T,Schellongowski P,Meybohm P,Rath PM,Steinmann J,Trinkmann F,Britsch S,Michels JD,Jabbour C,Hofmann WK,Buchheidt D

    更新日期:2018-10-01 00:00:00

  • Acinetobacter baumannii infection was decreased by the structural renovation of a medical intensive care unit.

    abstract:PURPOSE:The study aimed to determine whether improvements in intensive care unit (ICU) structural environment affect the incidence of ICU-acquired infections (IAIs), particularly those caused by multidrug-resistant pathogens. METHODS:The incidence of IAI and the number of infections caused by organisms during the 6 mo...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Nah SS,Park YH,Chung JW,Yoo S,Hong SB,Lim CM,Koh Y

    更新日期:2013-08-01 00:00:00

  • Atrial and brain natriuretic peptide concentrations and the response to inhaled nitric oxide in patients with acute respiratory distress syndrome.

    abstract:PURPOSE:The response to inhaled nitric oxide (iNO) is inconsistent in patients with acute respiratory distress syndrome (ARDS). We sought to determine whether the response to iNO, defined as 20% Pao(2)/Fio(2) increase from baseline, depends on the level of cardiac natriuretic peptides. MATERIALS AND METHODS:This is a ...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Treggiari MM,Bendjelid K,Yanez ND,Heidegger CP,Suter PM,Romand JA

    更新日期:2010-03-01 00:00:00

  • Inflammatory lung edema correlates with echocardiographic estimation of capillary wedge pressure in newly diagnosed septic patients.

    abstract:PURPOSE:Lung ultrasound is an accurate and accessible tool to quantify lung edema. Furthermore, left ventricle filling pressures (LVFP) can be assessed with transthoracic echocardiography (TTE) by the E/e' ratio (E/e'). The present study aimed to assess the correlation between E/e' and lung edema quantified by a simpli...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Santos TM,Franci D,Gontijo-Coutinho CM,Ozahata TM,de Araújo Guerra Grangeia T,Matos-Souza JR,Carvalho-Filho MA

    更新日期:2018-04-01 00:00:00

  • Anti-aging factor, serum alpha-Klotho, as a marker of acute physiological stress, and a predictor of ICU mortality, in patients with septic shock.

    abstract:PURPOSE:Genetic deletions decreasing serum alpha-Klotho (alpha-KL) have been associated with rapid aging, multi-organ failure and increased mortality in experimental sepsis. We hypothesized that lower alpha-KL obtained at the onset of septic shock correlates with higher mortality. MATERIALS AND METHODS:Prospective coh...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Abdelmalik PA,Stevens RD,Singh S,Skinner J,Carhuapoma JR,Noel S,Johns R,Fuchs RJ

    更新日期:2018-04-01 00:00:00

  • Mobilization of ventilated patients in the intensive care unit: An elicitation study using the theory of planned behavior.

    abstract:PURPOSE:Early mobilization in intensive care unit (ICU) is safe, feasible, and beneficial. However, mobilization frequently does not occur in practice. The study objective was to elicit attitudinal, normative, and control beliefs (barriers and enablers) toward the mobilization of ventilated patients, to inform developm...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Holdsworth C,Haines KJ,Francis JJ,Marshall A,O'Connor D,Skinner EH

    更新日期:2015-12-01 00:00:00

  • Injection of agitated saline to detect recirculation with transthoracic echocardiography during venovenous extracorporeal oxygenation: A pilot study.

    abstract:PURPOSE:We assessed the security and efficiency of intravenously injected agitated saline in conjunction with transthoracic echocardiography to identify recirculation in patients supported with a venovenous extracorporeal membrane oxygenation (VV ECMO) device. MATERIALS AND METHODS:We injected agitated saline 4 consec...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Pierrakos C,Collot V,Van Lieshout H,De Doncker M,Delcourt S,Gottignies P,Devriendt J,De Bels D

    更新日期:2017-02-01 00:00:00

  • Risk factors for fluconazole-resistant invasive candidiasis in intensive care unit patients: An analysis from the China Survey of Candidiasis study.

    abstract:PURPOSE:To assess the risk factors for invasive Candida infection (ICI) caused by fluconazole-resistant (Flu-R) Candida species in intensive care unit (ICU) patients. MATERIALS AND METHODS:Data from China Survey of Candidiasis study were analyzed. Patients with proven ICI were classified into fluconazole-sensitive (Fl...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Liao X,Qiu H,Li R,Guo F,Liu W,Kang M,Kang Y,China-SCAN Team.

    更新日期:2015-08-01 00:00:00

  • The sieving coefficient and clearance of vasopressin during continuous renal replacement therapy in critically ill children.

    abstract:HYPOTHESIS:As vasopressin is a small peptide, its sieving coefficient (SC) and clearance (CL) during continuous renal replacement therapy may be intermediate to those for urea and β2 microglobulin (commonly used markers for small- and middle-molecular weight solutes, respectively). METHODS:A prospective, minimal-risk ...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Baird JS

    更新日期:2010-12-01 00:00:00

  • Choice of renal replacement therapy modality in intensive care units: data from a Japanese Nationwide Administrative Claim Database.

    abstract:PURPOSE:This study was undertaken to assess recent trends of the choice of renal replacement therapy (RRT) modalities in Japanese intensive care units (ICUs). MATERIALS AND METHODS:Data were extracted from the Japanese Diagnosis Procedure Combination database for 2011. We identified adult patients without end-stage re...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Iwagami M,Yasunaga H,Noiri E,Horiguchi H,Fushimi K,Matsubara T,Yahagi N,Nangaku M,Doi K

    更新日期:2015-04-01 00:00:00

  • Studying communication about end-of-life care during the ICU family conference: development of a framework.

    abstract:PURPOSE:Family-clinician communication in the intensive care unit (ICU) about withholding and withdrawing life support occurs frequently, yet few data exist to guide clinicians in its conduct. The purpose of this study was to develop an understanding of the way this communication is currently conducted. METHODS:We ide...

    journal_title:Journal of critical care

    pub_type: 杂志文章,多中心研究


    authors: Curtis JR,Engelberg RA,Wenrich MD,Nielsen EL,Shannon SE,Treece PD,Tonelli MR,Patrick DL,Robins LS,McGrath BB,Rubenfeld GD

    更新日期:2002-09-01 00:00:00

  • Phase angle assessment in critically ill cancer patients: Relationship with the nutritional status, prognostic factors and death.

    abstract:PURPOSE:To evaluate the relationship between phase angle (PA) and nutritional status and the prognostic significance of PA in critically ill cancer patients. METHODS:31 patients that had been admitted to the intensive care unit (ICU) of a center on oncology were evaluated. Their PA was obtained from their bioelectrica...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: do Amaral Paes TC,de Oliveira KCC,de Carvalho Padilha P,Peres WAF

    更新日期:2018-04-01 00:00:00

  • External validation of Acute Physiology and Chronic Health Evaluation IV in Dutch intensive care units and comparison with Acute Physiology and Chronic Health Evaluation II and Simplified Acute Physiology Score II.

    abstract:PURPOSE:The aim of this study was to validate and compare the performance of the Acute Physiology and Chronic Health Evaluation (APACHE) IV in the Dutch intensive care unit (ICU) population to the APACHE II and Simplified Acute Physiology Score (SAPS) II. MATERIALS AND METHODS:This is a prospective study based on data...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Brinkman S,Bakhshi-Raiez F,Abu-Hanna A,de Jonge E,Bosman RJ,Peelen L,de Keizer NF

    更新日期:2011-02-01 00:00:00

  • Normal saline to dilute parenteral drugs and to keep catheters open is a major and preventable source of hypernatremia acquired in the intensive care unit.

    abstract:PURPOSE:We wanted to identify modifiable risk factors for intensive care unit (ICU)-acquired hypernatremia. MATERIALS AND METHODS:We retrospectively studied sodium and fluid loads and balances up to 7 days prior to the development of hypernatremia (first serum sodium concentration, [Na+], >150 mmol/L; H) vs control (m...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Choo WP,Groeneveld AB,Driessen RH,Swart EL

    更新日期:2014-06-01 00:00:00

  • Investigation of critical care unit utilization and mortality in patients infected with Clostridium difficile.

    abstract:BACKGROUND:A nationwide increase in the rate and severity of Clostridium difficile-associated disease may reflect infection with a virulent strain characterized by polymerase chain reaction as ribotype 027 (NAP1/B1). HYPOTHESIS:The high prevalence of ribotype 027 at our institution would allow investigation of the ris...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Gasperino J,Garala M,Cohen HW,Kvetan V,Currie B

    更新日期:2010-06-01 00:00:00

  • Safety of peripheral administration of phenylephrine in a neurologic intensive care unit: A pilot study.

    abstract::Integral to the management of the neurocritically injured patient are the prevention and treatment of hypotension, maintenance of cerebral perfusion pressure, and occasionally blood pressure augmentation. When adequate volume resuscitation fails to meet perfusion needs, vasopressors are often used to restore end-organ...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Delgado T,Wolfe B,Davis G,Ansari S

    更新日期:2016-08-01 00:00:00

  • Clinical impact of pulmonary sampling site in the diagnosis of ventilator-associated pneumonia: A prospective study using bronchoscopic bronchoalveolar lavage.

    abstract:PURPOSE:It is unclear whether ventilator-associated pneumonia (VAP) is actually a bilateral and multifocal process. In addition, the diagnostic role of chest x-ray is under debate. Assuming a low microbiologic concordance between the left and right lungs, the reliability of a single pulmonary sampling becomes questiona...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Bello G,Pennisi MA,Di Muzio F,De Pascale G,Montini L,Maviglia R,Mercurio G,Spanu T,Antonelli M

    更新日期:2016-06-01 00:00:00

  • Red cell distribution width in predicting 30-day mortality in patients with pulmonary embolism.

    abstract:PURPOSE:The aim of the study was to investigate red cell distribution width (RDW) in predicting 30-day mortality in patients with pulmonary embolism (PE). METHODS:A single-center, retrospective study design was used between January 1, 2014, and February 1, 2016. The primary end point was 30-day mortality after admissi...

    journal_title:Journal of critical care

    pub_type: 杂志文章


    authors: Zhou XY,Chen HL,Ni SS

    更新日期:2017-02-01 00:00:00