Abstract:
PURPOSE:Optimal red blood cell (RBC) transfusion thresholds in acute brain injury (ABI) are poorly defined. MATERIALS AND METHODS:We conducted a retrospective cohort study of adult patients with ABI and moderate anemia (Hb 7-10 g/dL) in a neurological intensive care unit (ICU) at an academic medical center between 2008 and 2015. Transfused and non-transfused patients were matched based on age, ABI subtype, pre-transfusion hemoglobin, and ICU length of stay (LOS) at the time of RBC transfusion. Multivariable regression analyses were performed to assess the relationship between RBC transfusion and hospital LOS, hospital mortality, ICU LOS, ICU mortality, and 24 h change in sequential organ failure assessment (SOFA) scores. RESULTS:2638 patients met inclusion criteria, with 225 (8.5%) receiving RBC transfusion. Acute ischemic stroke was the most prevalent ABI diagnosis (43.3%) then intracranial hemorrhage (25.6%), subarachnoid hemorrhage (16.5%), and traumatic brain injury (TBI) (14.6%). In multivariable analyses, RBC transfusion was associated with longer hospital and ICU LOS, and higher SOFA scores. Each ABI subtype had similar results, except for TBI which showed no difference in hospital LOS. Mortality was not significantly different. CONCLUSIONS:In moderately anemic patients with ABI, RBC transfusion was associated with longer hospital and ICU LOS. Prospective investigations are necessary to further assess these relationships.
journal_name
J Crit Carejournal_title
Journal of critical careauthors
Moman RN,Kor DJ,Chandran A,Hanson AC,Schroeder DR,Rabinstein AA,Warner MAdoi
10.1016/j.jcrc.2018.11.006subject
Has Abstractpub_date
2019-04-01 00:00:00pages
44-49eissn
0883-9441issn
1557-8615pii
S0883-9441(18)30913-4journal_volume
50pub_type
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journal_title:Journal of critical care
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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journal_title:Journal of critical care
pub_type: 杂志文章
doi:10.1016/j.jcrc.2006.12.001
更新日期:2007-03-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章,评审
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2015-04-01 00:00:00
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journal_title:Journal of critical care
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更新日期:2014-12-01 00:00:00
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更新日期:2018-02-01 00:00:00
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更新日期:2020-04-01 00:00:00
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更新日期:2020-02-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-12-01 00:00:00
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journal_title:Journal of critical care
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00