Abstract:
:The authors reviewed 76 magnetic resonance (MR) images of 38 patients with osteosarcoma treated with preoperative chemotherapy (intraarterial cisplatin with or without systemic chemotherapy). Histologic maps of the surgical tumor specimens in 33 cases were correlated with either late-chemotherapy or postchemotherapy MR images. There were four MR patterns--dark, mottled or speckled, homogeneous, and cystic--that corresponded to different amounts of tumor matrix, granulation tissue, hemosiderin deposits, fluid-filled cysts, and residual viable tumor. Nested foci of residual viable tumor could not be specifically identified, although tumor progression or skip metastases were accurately depicted in four patients. Other findings included (a) peritumoral edema in the soft tissues and intramedullary space that shrank with chemotherapy, (b) chemotherapy effect in the surrounding soft tissues, (c) a dark rim around the extramedullary component of the tumors corresponding to a collagenous capsule continuous with the periosteum, (d) development of metaphyseal hemorrhages and bone marrow infarcts, and (e) intramedullary vascular channels.
journal_name
Radiologyjournal_title
Radiologyauthors
Pan G,Raymond AK,Carrasco CH,Wallace S,Kim EE,Shirkhoda A,Jaffe N,Murray JA,Benjamin RSdoi
10.1148/radiology.174.2.2296660subject
Has Abstractpub_date
1990-02-01 00:00:00pages
517-26issue
2eissn
0033-8419issn
1527-1315journal_volume
174pub_type
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