Circulating pig-specific DNA as a novel biomarker for monitoring xenograft rejection.

abstract：:We designed this study to define reference values of the cynomolgus monkey coagulation system, as the normal range of values has not been established. Measurement of coagulation function was determined by testing plasma samples from 30 healthy male cynomolgus monkeys. Prothrombin time (PT), PT activity, PT internation...

journal_title：Xenotransplantation

authors： Rhu J,Lee KW,Kim KS,Lee JS,Kim SJ,Park JB

更新日期：2019-01-01 00:00:00

abstract：AIM:To provide information on the specificity of induced anti-pig antibodies (Abs) in baboons after exposure and sensitization to pig antigens. MATERIALS AND METHODS:Baboons (n=7) received either porcine mobilized peripheral blood progenitor cells (n=3), kidney (n=3) or heart (n=1) transplants. After rejection of thes...

journal_title：Xenotransplantation

authors： Buhler L,Xu Y,Li W,Zhu A,Cooper DK

更新日期：2003-01-01 00:00:00

abstract：:Patients in whom type 1 diabetes is complicated by impaired awareness of hypoglycemia and recurrent episodes of severe hypoglycemia are candidates for islet or pancreas transplantation if severe hypoglycemia persists after completion of a structured stepped care approach or a formalized medical optimization run-in per...

journal_title：Xenotransplantation

authors： Hering BJ,O'Connell PJ

更新日期：2016-01-01 00:00:00

abstract：:Type I diabetes remains a significant clinical problem in need of a reliable, generally applicable solution. Both whole organ pancreas and islet allotransplantation have been shown to grant patients insulin independence, but organ availability has restricted these procedures to an exceptionally small subset of the dia...

journal_title：Xenotransplantation

authors： Samy KP,Martin BM,Turgeon NA,Kirk AD

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Xenotransplantation of porcine islets can reverse diabetes in non-human primates. The remaining hurdles for clinical application include safe and effective T-cell-directed immunosuppression, but protection against the innate immune system and coagulation dysfunction may be more difficult to achieve. Islet-ta...

journal_title：Xenotransplantation

authors： Wijkstrom M,Bottino R,Iwase H,Hara H,Ekser B,van der Windt D,Long C,Toledo FG,Phelps CJ,Trucco M,Cooper DK,Ayares D

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:As a step towards clinical cardiac xenotransplantation, our experimental heterotopic intrathoracic xenotransplantation model offers a beating and ejecting donor heart while retaining the recipient's native organ as a backup in case of graft failure. Clinically applicable immunosuppressive regimens (IS) were ...

journal_title：Xenotransplantation

authors： Abicht JM,Mayr T,Reichart B,Buchholz S,Werner F,Lutzmann I,Schmoeckel M,Bauer A,Thormann M,Langenmayer M,Herbach N,Pohla H,Herzog R,McGregor CG,Ayares D,Wolf E,Klymiuk N,Baehr A,Kind A,Hagl C,Ganswindt U,Belka C

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:  Various groups have reported prolonged diabetes reversal and graft function after porcine islet transplantation into diabetic macaques using different experimental designs (macaque source, islet source, type of immunosuppression): subsequently, the International Xenotransplantation Association has publishe...

journal_title：Xenotransplantation

authors： Graham ML,Schuurman HJ

更新日期：2013-01-01 00:00:00

abstract：:Complement plays a major role in hyperacute rejection of xenografts. In order to overcome this, we are developing, by minimal mutagenesis, a modified C3 molecule that, like cobra venom factor (CVF), escapes normal complement regulatory processes and inhibits complement-mediated responses by systemic depletion of C3. U...

journal_title：Xenotransplantation

authors： Fecke W,Farries TC,D'Cruz LG,Napper CM,Harrison RA

更新日期：1998-02-01 00:00:00

abstract：:The outstanding results recently obtained in islet xenotransplantation suggest that porcine islet clinical trials may soon be scientifically appropriate. Before the initiation of such clinical studies, however, it is essential that a series of key ethical and regulatory conditions are satisfied. As far as ethics is co...

journal_title：Xenotransplantation

authors： Cozzi E,Tallacchini M,Flanagan EB,Pierson RN 3rd,Sykes M,Vanderpool HY

更新日期：2009-07-01 00:00:00

abstract：:In addition to providing a large source of donor tissue, xenogeneic islet transplantation might avoid recurrent autoimmunity in patients with type 1 diabetes. To examine this possibility further, xenogeneic pig islets were transplanted into recipient mice in the presence or absence of autoimmunity. Spontaneously, non-...

journal_title：Xenotransplantation

authors： Koulmanda M,Qipo A,Smith RN,Auchincloss H Jr

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Endothelial damage is a critical step in the development of (xeno) transplantation-related and cardiovascular pathology. In humans, the amount of circulating endothelial cells (CEC) correlates to disease intensity and functions as a valuable damage marker. While (xeno) transplantation and cardiovascular rese...

journal_title：Xenotransplantation

authors： Post IC,Weenink RP,van Wijk AC,Heger M,Böing AN,van Hulst RA,van Gulik TM

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The induced antibodies against Galalpha1,3Gal (Gal) and non-Gal epitopes may contribute to delayed xenograft rejection (DXR). We asked whether blockade of the CD40/CD154 and CD28/B7 co-stimulatory pathways modulates the baboon elicited antibody response to pig Gal and non-Gal antigens. METHODS:Eighteen babo...

journal_title：Xenotransplantation

authors： Wu G,Pfeiffer S,Schröder C,Zhang T,Nguyen BN,Lea W,Kelishadi S,Atkinson JB,Schuurman HJ,White DJ,Azimzadeh AM,Pierson RN 3rd

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:In pig-to-nonhuman primate solid organ xenotransplantation using organs from donors transgenic for human decay-accelerating factor (hDAF), the main type of rejection is antibody-mediated (acute humoral xenograft rejection, AHXR). This occurs despite the complement-regulatory function of the transgene, neutra...

journal_title：Xenotransplantation

authors： Lam TT,Hausen B,Hook L,Lau M,Higgins J,Christians U,Jacobsen W,Baluom M,Duthaler R,Katopodis A,Chavez G,Cozzi E,Harrison R,Schuurman HJ,Borie D,Morris RE

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Recently, we have shown that an immunosuppression regimen including costimulation blockade via anti-CD154 antibody significantly prolongs the cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon heterotopic xenotransplantation model. Unfortunately, many coagulation disorders were observed with the use ...

journal_title：Xenotransplantation

authors： Mohiuddin MM,Singh AK,Corcoran PC,Hoyt RF,Thomas ML 3rd,Lewis BG,Eckhaus M,Dabkowski NL,Belli AJ,Reimann KA,Ayares D,Horvath KA

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Despite overcoming xenograft hyperacute rejection (HAR), Gal (galactose-alpha1,3-galactose) expression may not be completely eliminated from the alpha1,3-galactosyltransferase gene knockout (Gal KO) pig because of alternative galactosyltransferases. Whether low levels of "residual" Gal are still susceptible ...

journal_title：Xenotransplantation

authors： Murray-Segal L,Gock H,Cowan PJ,d'Apice AJ

更新日期：2008-02-01 00:00:00

abstract：:The process of islet xenograft rejection is still poorly understood. To elucidate further possible mechanism(s) involved in xenograft rejection, the effect of different immunization protocols was investigated. Fetal porcine islet-like cell clusters (ICCs) were transplanted under the kidney capsule in otherwise untreat...

journal_title：Xenotransplantation

authors： Korsgren O,Wallgren AC,Satake M,Karlsson-Parra A

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Porcine islet transplantation into diabetic non-human primates is considered most relevant in translational research supporting a clinical application. Most studies have focused on immunosuppressive protocols, while metabolic aspects have mainly been utilized in graft monitoring. We evaluated data from our g...

journal_title：Xenotransplantation

authors： Graham ML,Bellin MD,Papas KK,Hering BJ,Schuurman HJ

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Over time, the notion of public has evolved. While the concept of public was initially conceived of as a single undifferentiated entity, the common understanding is now that a variety of differentiated, multifaceted and multiple public(s) can be constructed for different purposes. This is equally true in xen...

journal_title：Xenotransplantation

authors： Sobbrio P,Jorqui M

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Human cytomegalovirus (HCMV) infection or reactivation has been linked to allograft rejection resulting from endothelial injury and immune activation. In pig-to-human xenotransplantation, currently investigated to circumvent the shortage of human organs in transplantation medicine, the porcine endothelium wi...

journal_title：Xenotransplantation

authors： Millard AL,Häberli L,Sinzger C,Ghielmetti M,Schneider MK,Bossart W,Seebach JD,Mueller NJ

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:In vivo pig liver xenotransplantation preclinical trials appear to have poor efficiency compared to heart or kidney xenotransplantation because of xenogeneic rejection, including coagulopathy, and particularly thrombocytopenia. In contrast, ex vivo pig liver (wild type) perfusion systems have been proven to ...

journal_title：Xenotransplantation

authors： Wang Q,Zhang X,Wang B,Bai G,Pan D,Yang P,Tao K,Li X,Dou K

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Activation of the clotting cascade is central in acute xenograft rejection (AHXR) that occurs when pig organs are transplanted into primates. The coagulopathy reported in this model is a very complex process that involves simultaneously coagulation factors, platelets and phospholipid-bearing cells (i.e., leu...

journal_title：Xenotransplantation

authors： Spiezia L,Boldrin M,Radu C,Bulato C,Bertini D,Bon M,Campello E,Vadori M,Galli C,Gavasso S,Nottle MB,Cowan PJ,Cozzi E,Simioni P

更新日期：2013-03-01 00:00:00

abstract：:Post-transplantation infections are common in allograft recipients and should be expected in all immunocompromised hosts. Based on the need for immunosuppression in xenotransplantation, procedures developed to enhance safety in allotransplantation can be applied in future xenotransplantation clinical trials. Standardi...

journal_title：Xenotransplantation

authors： Nellore A,Fishman JA

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:We have successfully performed heart transplantation despite the most unfavourable risk factors for graft and patient survival: the presence of a high level of antibodies (Abs) against the donor's human leukocyte antigens (HLA) class I/II and blood group A1 antigens. The present study concerns post-transplan...

journal_title：Xenotransplantation

authors： Bućin D,Johansson S,Lindberg LO

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Cell-based therapies for liver disease such as bioartificial liver rely on a large quantity and high quality of hepatocytes. Cold storage was previously shown to be a better way to preserve the viability and functionality of hepatocytes during transportation rather than freezing, but this was only p...

journal_title：Xenotransplantation

authors： Li Y,Chen HS,Shaheen M,Joo DJ,Amiot BP,Rinaldo P,Nyberg SL

更新日期：2019-07-01 00:00:00

abstract：:Xenotransplantion remains the most viable option for significant expansion of the donor organ pool in clinical transplantation. With the advent of nuclear transfer technologies, the production of transgenic swine has become a possibility. These animals have allowed transplant investigators to overcome humoral mechanis...

journal_title：Xenotransplantation

authors： Scalea J,Hanecamp I,Robson SC,Yamada K

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Whilst macrohemodynamic function of porcine xenografts transplanted into baboons has been assessed perioperatively, the ability of the xenograft to maintain systemic microcirculatory perfusion has not been investigated after pig-to-baboon xenotransplantation so far. METHODS:We investigated the sublingual mi...

journal_title：Xenotransplantation

authors： Bauer A,Renz V,Baschnegger H,Abicht JM,Beiras-Fernandez A,Brenner P,Thein E,Schmoeckel M,Reichart B,Christ F

更新日期：2011-07-01 00:00:00

abstract：:Decellularized bovine pericardium (DBP)-based biomeshes are the gold standard in reconstructive surgery. In order to prolong their stability after the transplantation, various chemical cross-linking strategies are employed. However, structural and functional properties of the biomeshes differ in dependence on the cros...

journal_title：Xenotransplantation

authors： Grebenik EA,Istranov LP,Istranova EV,Churbanov SN,Shavkuta BS,Dmitriev RI,Veryasova NN,Kotova SL,Kurkov AV,Shekhter AB,Timashev PS

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Blood group ABO-incompatible live donor (LD) renal transplantation may provide a significant source of organs. We report the results of our first 14 cases of ABO-incompatible LD renal transplantation using specific anti-A/B antibody (Ab) immunoadsorption (IA) and anti-CD20 monoclonal Ab (mAb) treatment. PATI...

journal_title：Xenotransplantation

authors： Nordén G,Briggs D,Cockwell P,Lipkin G,Mjörnstedt L,Mölne J,Ready A,Rydberg L,Samuelsson O,Svalander CT,Breimer ME

更新日期：2006-03-01 00:00:00

abstract：UNLABELLED:Xenotransplantation using porcine organs may resolve a chronic shortage of donor organs for clinical transplantation if significant immunological barriers can be overcome. To determine the potential role of T lymphocytes in Xenograft (Xg) rejection, we transplanted transgenic hCD46 porcine hearts heterotopic...

journal_title：Xenotransplantation

authors： Davila E,Byrne GW,LaBreche PT,McGregor HC,Schwab AK,Davies WR,Rao VP,Oi K,Tazelaar HD,Logan JS,McGregor CG

更新日期：2006-01-01 00:00:00

abstract：:When clinical xenotransplantation is introduced, the costs associated with acquisition of a genetically engineered pig organ are as yet unknown. How will these costs compare with those currently associated with the acquisition of deceased human organs? An understanding of the financial aspects of deceased organ and ti...

journal_title：Xenotransplantation

authors： Saari RJ,Cooper DKC

更新日期：2017-07-01 00:00:00