Abstract:
:Infantile hemangiomas (IHs) are the most common tumors of infancy. Imiquimod, an immune-response modifier, has been proven effective and safe in the treatment of superficial and mixed hemangiomas, but severe local reactions caused by imiquimod have been reported sporadically. To evaluate the safety of imiquimod 5% cream and the sequelae of severe local inflammatory reactions in the treatment of superficial IHs we performed a retrospective chart review of all children with superficial IHs who received topical imiquimod treatment in the Department of Plastic and Reconstructive Surgery of Shanghai 9th People's Hospital from March 2010 through February 2012 and selected those who had severe local reactions to topical imiquimod for further description. Nine of 224 (4.0%) children with superficial IHs who received imiquimod 5% cream treatment had severe local reactions. All four patients who had follow-up for longer than 1 year had permanent disfiguring depigmented scars after intensive inflammatory reactions. Seven of the severe reactions happened on protruding IHs and four involved the skin folds and joints, suggesting that imiquimod 5% cream should probably be avoided in IHs with either this morphology or these sites.
journal_name
Pediatr Dermatoljournal_title
Pediatric dermatologyauthors
Qiu Y,Ma G,Lin X,Jin Y,Chen H,Hu Xdoi
10.1111/pde.12002subject
Has Abstractpub_date
2013-05-01 00:00:00pages
342-7issue
3eissn
0736-8046issn
1525-1470journal_volume
30pub_type
杂志文章abstract:BACKGROUND/OBJECTIVES:Chromhidrosis is a rare condition of which there are only a few case reports in the literature. The aim of this study was to evaluate clinical, laboratory, and possible environmental factors in 13 patients with chromhidrosis to elucidate causative agents. METHODS:Data were obtained from the medic...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.13491
更新日期:2018-07-01 00:00:00
abstract::Nipple adenoma is an uncommon proliferative process of the breast and predominantly occurs in women aged 40-50. Its incidence is extremely low in men, and it has not been reported in a boy. Although nipple adenoma is rare and benign, being familiar with it is important because it clinically resembles Paget disease and...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.13430
更新日期:2018-05-01 00:00:00
abstract::Two sporadic cases of Heck disease in Polish girls were associated with human papillomavirus 13. No other children and nobody from their surroundings had similar lesions. The course of the disease was chronic in both patients. The lesions regressed spontaneously in one girl within several years after some of the papul...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.1993.tb00368.x
更新日期:1993-09-01 00:00:00
abstract::Infliximab, a chimeric antitumor necrosis factor alpha monoclonal antibody (anti-TNF alpha), has been recently shown to have a beneficial effect on pyoderma gangrenosum associated with inflammatory bowel disease. Patients with the syndromic triad of pyogenic sterile arthritis, pyoderma gangrenosum, and acne, an autoin...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2005.22320.x
更新日期:2005-05-01 00:00:00
abstract::Lichen planus is an uncommonly encountered dermatosis in children. In the present study of 50 children the limbs were the most common site of involvement (70.0%). A majority of the children (60.0%) presented with the classic form of the disease. Hypertrophic lesions were present in 26.0% of children while linear lesio...
journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1046/j.1525-1470.1999.00074.x
更新日期:1999-09-01 00:00:00
abstract::The disorders of cornification (ichthyoses) comprise acquired and inherited disorders characterized clinically by generalized scaling and histologically by hyperkeratosis. They may arise through defects in the production or maintenance of a normal cornified cell compartment, or both. The stratum corneum is composed of...
journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1525-1470.1992.tb00632.x
更新日期:1992-12-01 00:00:00
abstract::Woolly hair nevus is a rare syndrome that presents as woolly hair in restricted areas of the scalp and may be associated with pigmented macules or epidermal nevus on the body. Here, we report a case of woolly hair nevus, linear pigmentation, and multiple epidermal nevi with a somatic HRAS c.34G>A(p.G12S) mutation. ...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.13783
更新日期:2019-05-01 00:00:00
abstract::We aimed to better understand the pathogenesis, clinical features, prognosis, and treatment of neonatal autoimmune blistering diseases (AIBDs). We searched Medline, Embase, PubMed, Latin American and Caribbean Health Sciences Literature, and reference lists of identified articles. Inclusion criteria were articles publ...
journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1111/pde.12859
更新日期:2016-07-01 00:00:00
abstract::Four unrelated children with osteoma cutis and Albright hereditary osteodystrophy (pseudohypoparathyroidism and pseudopseudohypoparathyroidism) are described. All four patients were normocalcemic when they were first seen with cutaneous ossification. A diagnosis of Albright hereditary osteodystrophy was established on...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.1992.tb00318.x
更新日期:1992-03-01 00:00:00
abstract::Successful management of toxic epidermal necrolysis (TEN) with tumor necrosis factor-α inhibitors has been described in adults. We present a case of a 7-year-old boy with infection-associated TEN, diagnosed by typical clinical and histopathological features, most likely caused by Mycoplasma pneumoniae. Treatment with ...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.13778
更新日期:2019-05-01 00:00:00
abstract::Subcutaneous fat necrosis is an inflammatory disorder of adipose tissue. Although patients need long-term follow-up to prevent hypercalcemia, the prognosis is generally favorable. We herein present a case of a newborn who developed subcutaneous fat necrosis-related hypercalcemia after hypothermia treatment for hypoxic...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2011.01716.x
更新日期:2013-01-01 00:00:00
abstract::Hair casts were seen in 22 girls ranging in age from 4 to 13 years. They were localized to the frontal, vertex, and temporal areas. The number of affected hairs varied from one-tenth to one-third. Twenty of the 22 girls styled their hair in ponytails or pigtails. Compound root sheath casts were present in six of nine ...
journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1525-1470.1990.tb01023.x
更新日期:1990-12-01 00:00:00
abstract::PLACK syndrome (OMIM 616295) is a form of generalized peeling skin syndrome (GPSS; OMIM 270300). It is an autosomal recessive genodermatosis caused by pathogenic mutations in CAST, which encodes calpastatin, an endogenous specific inhibitor of calpain, a calcium-dependent cysteine protease. We present a 5-year-old gir...
journal_title:Pediatric dermatology
pub_type:
doi:10.1111/pde.14383
更新日期:2020-10-03 00:00:00
abstract::Accessory scrotum is an extremely rare congenital scrotal anomaly defined as the occurrence of scrotal skin outside of its proper location with no testicular tissue. We report a preterm twin male infant who had an accessory scrotum located on the right inguinal and proximal femoral region. ...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1046/j.1525-1470.1999.00035.x
更新日期:1999-03-01 00:00:00
abstract::We report an unusual congenital vesiculopustular eruption arising in a neonate as the result of the transient myeloproliferative disorder (TMD) associated with trisomy 21. In this instance, the neonate was phenotypically normal, making the diagnosis more elusive. Initially the lesions were clinically suspicious for he...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.0736-8046.2004.21505.x
更新日期:2004-09-01 00:00:00
abstract::The keratitis, ichthyosis, and deafness (KID) syndrome is a rare congenital disorder of the ectoderm characterized by diffuse hyperkeratotic erythroderma, keratitis with neovascularization of the cornea, and severe neurosensory hearing loss. A familial occurrence of this syndrome has been mentioned in four reports inc...
journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1046/j.1525-1470.1998.1998015219.x
更新日期:1998-05-01 00:00:00
abstract::Tuberous sclerosis complex is an autosomal dominant disorder that often manifests early in life with cutaneous features, and it is important that dermatologists who care for children remain up to date on its diagnosis and management. This article provides an update regarding the most recent guidelines for diagnosis pu...
journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1111/pde.12567
更新日期:2015-09-01 00:00:00
abstract::We report an 8-year-old boy who developed dystrophic calcinosis cutis that occurred following trauma. Multiple abrasions were observed in the inguinal folds after a soccer game. Subsequently, multiple papules with soft centers and white particles appeared in the same area. A biopsy specimen showed calcinosis cutis wit...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2005.22309.x
更新日期:2005-05-01 00:00:00
abstract::Psychologic factors may play a significant role in acne in at least three ways. First, as many patients readily report, emotional stress can exacerbate acne. Second, it is common for patients to develop psychiatric problems as a consequence of the conditions, such as those related to low self-esteem, social phobias, o...
journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1525-1470.1991.tb00856.x
更新日期:1991-09-01 00:00:00
abstract::A 3-year-old girl presented with longer hair on the left side of her scalp, coarse hair of abnormal length on her extremities, and a tuft of hair in the lumbosacral region, with all hair distributed on normally pigmented skin. Neither similar or relevant family history nor associated extracutaneous abnormalities was d...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2009.00948.x
更新日期:2009-07-01 00:00:00
abstract::A 6-month-old baby had erythema, fissuring of the skin, and craquelé due to prolonged use of a liquid soap mistakenly believed to be a moisturizer. We think these kinds of skin disorders will become increasingly common due to such misunderstandings. The proliferation of cosmetic products for baby skin care, the increa...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.1993.tb00378.x
更新日期:1993-09-01 00:00:00
abstract::Pemphigus herpetiformis (PH) is a rare autoimmune bullous condition usually seen in adults and likely underrecognized in children. We describe a 2-year-old girl who presented with a chronic, generalized, blistering rash consistent with pediatric PH based on histology and immunohistochemistry and review the literature....
journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1111/pde.13152
更新日期:2017-05-01 00:00:00
abstract::Superficial granulomatous pyoderma is a rare entity thought to be a variant of pyoderma gangrenosum and is often mistaken for classic pyoderma gangrenosum. Superficial granulomatous pyoderma has mainly been described in adults. We describe a case of Superficial granulomatous pyoderma in an 11-year-old girl and present...
journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1525-1470.2010.01271.x
更新日期:2010-09-01 00:00:00
abstract::Bascule syndrome is a recently described benign vasomotor dermatosis characterized by Bier anemic spots, cyanosis, and urticaria-like eruption. We report a case of a 13-year-old girl with cutaneous lesions consistent with Bascule syndrome who had had three exercise-related syncopal episodes. It would be recommended to...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.13425
更新日期:2018-03-01 00:00:00
abstract::The most common cause of death in blue rubber bleb nevus syndrome is gastrointestinal bleeding. Here we present a case of central nervous system bleeding that resulted in death. ...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.12718
更新日期:2016-01-01 00:00:00
abstract::Scurvy, or hypovitaminosis C, is an uncommon condition that exists today primarily within certain unique populations-particularly the elderly subjects, patients with neurodevelopmental disabilities or psychiatric illnesses, or others with unusual dietary habits. Vitamin C is an essential nutrient in the human body, an...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2010.01095.x
更新日期:2011-07-01 00:00:00
abstract::Little is known about pediatricians' counseling and clinical practices to reduce skin cancer risk among their patients. Thus our objectives were to characterize skin cancer preventive counseling and clinical practices in a sample of pediatricians and identify correlates of these practices. Physicians practicing genera...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1046/j.1525-1470.2003.03004.x
更新日期:2003-01-01 00:00:00
abstract::Identification of melanoma or worrisome moles is often taught as an important part of routine skin checks. We sought to evaluate the efficacy of gamified education vs. traditional ABCDEs education on melanoma identification and self-confidence in identifying worrisome moles. We report that in our cohort (n = 271), par...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.14158
更新日期:2020-07-01 00:00:00
abstract::We describe the clinicopathologic features of an unusual case of fibromatosis colli. The lesion was rock hard, lateral, tightly affixed to the clavicle, and with overlying hypertrichosis. ...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2010.01263.x
更新日期:2010-09-01 00:00:00
abstract::An 8-year-old girl had pseudoxanthoma elasticum (PXE) with the characteristic skin and ocular findings. She had no associated systemic symptoms and no family history of PXE. The disease was most likely inherited in an autosomal recessive fashion. It is reviewed with regard to etiology, inheritance, diagnosis, and, par...
journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1525-1470.1993.tb00005.x
更新日期:1993-03-01 00:00:00