Sexual arousal difficulties in women treated with antidepressants: a comparison between escitalopram and fluoxetine.

Abstract:

OBJECTIVE:To compare the risk of sexual arousal difficulties between two groups of depressed female patients in remission who were treated with either escitalopram or fluoxetine. Associated factors were also examined. METHODS:This was a cross-sectional study involving 112 female patients attending the psychiatric clinic, University Kebangsaan Malaysia Medical Centre (UKMMC) with depressive disorders as assessed by using the Structured Clinical Interview for DSM-IV (SCID), who had been in remission for the previous 2 months as defined by a score of < or = 10 from an assessment using the Montgomery-Asberg Depression Rating Scale (MADRS) and were treated with either fluoxetine or escitalopram. Sexual arousal difficulties were assessed using the arousal subscale of Malay Version of the Female Sexual Function Index (MVFSFI). RESULTS:The rate of sexual arousal difficulties was 41.1% for all subjects. Sexual arousal difficulties occurred in 50.0% of subjects treated with fluoxetine and 32.1% with escitalopram. However, this difference was not statistically significant (p = 0.055). Multivariate logistic regression analysis showed that higher dose of antidepressant (adjusted OR = 4.08, 95 CI = 1.70-9.81) was significantly associated with female sexual arousal difficulties. CONCLUSION:The risk of sexual arousal difficulties was higher in female patients who were treated with higher doses of either fluoxetine or escitalopram.

journal_name

Int J Psychiatry Med

authors

Midi M,Kanagasundram S,Sidi H,Asmidar D,Naing L,Guan NC

doi

10.2190/PM.43.4.h

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

405-18

issue

4

eissn

0091-2174

issn

1541-3527

journal_volume

43

pub_type

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