当前位置： SCI文献检索 > International Wound Journal期刊下所有文献 > Effect of local anaesthetic infiltration with bupivacaine and ropivacaine on wound healing: a placebo-controlled study.

Effect of local anaesthetic infiltration with bupivacaine and ropivacaine on wound healing: a placebo-controlled study.

Abstract：

:Infiltration of surgical wounds with long-acting local anaesthetics (LA) is used to reduce postoperative incisional pain. We hypothesised that infiltration with LA interferes with wound healing in rats. Seventy-two rats were allocated into nine groups. After intraperitoneal anaesthesia, the interscapular dorsal region was infiltrated with equivolumes of saline, 0·5% bupivacaine or ropivacaine, in a randomised double-blind fashion. A standardised incision was performed in the infiltrated area and sutured closed. The rats were euthanised on the 3rd or 14th day after the operation and tissue from the incision site was subjected to histochemical analyses and mechanical testing (MT). Compared with the control group, bupivacaine displayed a significant increase in the macrophage number on day 3 (+63% versus +27% for ropivacaine). The transforming growth factor β-1 expression had a significant increase in the LA (versus saline) groups, +63% in ropivacaine group and +115% in bupivacaine group on day 3 (P < 0·05). The collagen fibres as measured by dyed area were significantly higher in the bupivacaine group on day 3 (+56%, P < 0·01 versus +15% for ropivacaine). CD34 was reduced in bupivacaine group (-51%, P < 0·05 versus +3% for ropivacaine). On day 14, no statistical differences were observed in either LA group (versus saline) with respect to histopathologic or inflammatory mediators. MT on day 14 showed no differences between the LA and saline groups. The LA-induced increases in histological markers did not extend beyond the third day, suggesting that wound infiltration with long-acting LA does not impair the wound healing process in rats.

journal_name

Int Wound J

journal_title

International wound journal

authors

Abrão J,Fernandes CR,White PF,Shimano AC,Okubo R,Lima GB,Bachur JA,Garcia SB

doi

10.1111/j.1742-481X.2012.01101.x

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

379-85

issue

4

eissn

1742-4801

issn

1742-481X

journal_volume

11

pub_type

杂志文章

相关文献

International Wound Journal文献大全
  • Negative pressure wound therapy via vacuum-assisted closure following partial foot amputation: what is the role of wound chronicity?

    abstract：:Randomised clinical trials (RCTs) to evaluate diabetic foot wound therapies have systematically eliminated large acute wounds from evaluation, focusing only on smaller chronic wounds. The purpose of this study was to evaluate the proportion and rate of wound healing in acute and chronic wounds after partial foot amput...

    journal_title：International wound journal

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1111/j.1742-481X.2006.00270.x

    authors： Armstrong DG,Lavery LA,Boulton AJ

    更新日期：2007-03-01 00:00:00

  • Implementation of a successful electronic wound documentation system in rural Victoria, Australia: a subject of collaboration and community engagement.

    abstract：:To describe the steps needed for a successful implementation of an e-health programme (the Mobile Wound Care system) in rural Victoria, Australia and to provide recommendations for future e-health initiatives. Wound care is a major burden on the health care system. Optimal wound care was found to be impeded by issues ...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/iwj.12041

    authors： Khalil H,Cullen M,Chambers H,Steers N,Walker J

    更新日期：2014-06-01 00:00:00

  • The use of keratin-based wound products on refractory wounds.

    abstract：:Keratin proteins have been shown to play a key role in wound healing. Controlled keratin gene (KRT) expression promotes cell growth, migration and differentiation, and as an example of the importance of keratin proteins, absence of KRT17 has been shown to delay wound closure. In addition, downregulation of KRT6 and KR...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/iwj.12245

    authors： Batzer AT,Marsh C,Kirsner RS

    更新日期：2016-02-01 00:00:00

  • The clinical experience for treating post-burn depigmentation with tiny epidermal particles graft.

    abstract：:The critical problem of post-burn depigmentation is the lacking normal melanocytes. Auto-skin grafting and autologous non-cultured epidermal cell suspension have been used to improve the appearance. However, a large amount of skin graft is required of donor sites in the former method, while the latter method is though...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/iwj.12577

    authors： Chen B,Xu M,Li B

    更新日期：2017-02-01 00:00:00

  • Ulcerated necrobiosis lipoidica as a rare cause for chronic leg ulcers: case report series of ten patients.

    abstract：:Necrobiosis lipoidica is a rare granulomatous disorder of the skin. In up to 30% of the affected patients it can lead to ulcerations, which can impair the quality of life and are also very difficult to treat. Its pathogenesis is not fully understood. Only few studies focussing on necrobiosis lipoidica can be found, bu...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/iwj.12159

    authors： Franklin C,Stoffels-Weindorf M,Hillen U,Dissemond J

    更新日期：2015-10-01 00:00:00

  • Negative pressure wound therapy: an adjuvant to surgical reconstruction of large or difficult skin and soft tissue defects.

    abstract：:Wide and deep wound defects are a challenge to surgeons, particularly when aggressive or more radical operations are unavailable. This article introduces refined techniques, indications and the clinical experience of the application of negative pressure wound therapy (NPWT) as an easy ancillary wound dressing method f...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/j.1742-481X.2011.00813.x

    authors： Lee DL,Ryu AY,Rhee SC

    更新日期：2011-08-01 00:00:00

  • Alternative treatment of gluteofemoral fistulas using honey: a case report.

    abstract：:Perianal fistula is a common disease that affects particular patients with inflammatory bowel disease. Honey has been used as a natural remedy for centuries for the treatment of various disorders. We report a patient with persistent fistulas, in whom conventional medical and surgical therapy failed. In this case, most...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/j.1742-481X.2011.00844.x

    authors： Vlcekova P,Krutakova B,Takac P,Kozanek M,Salus J,Majtan J

    更新日期：2012-02-01 00:00:00

  • Risk of readmissions, mortality, and hospital-acquired conditions across hospital-acquired pressure injury (HAPI) stages in a US National Hospital Discharge database.

    abstract：:Pressure injuries are one of the most common and costly complications occurring in US hospitals. With up to 3 million patients affected each year, hospital-acquired pressure injuries (HAPIs) place a substantial burden on the US healthcare system. In the current study, US hospital discharge records from 9.6 million pat...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/iwj.13482

    authors： Wassel CL,Delhougne G,Gayle JA,Dreyfus J,Larson B

    更新日期：2020-12-01 00:00:00

  • Rheumatoid arthritis-associated inflammatory leg ulcers: a new treatment for recalcitrant wounds.

    abstract：:Patients with rheumatoid arthritis may develop leg ulcers of varied aetiologies, including venous disease, infection and inflammation (vasculitis or pyoderma gangrenosum). The leg ulcers in rheumatoid arthritis patients may involve several of these aetiological factors and are often difficult to heal. Both the ulcers ...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/j.1742-481x.2004.0002.x

    authors： Coelho S,Amarelo M,Ryan S,Reddy M,Sibbald RG

    更新日期：2004-04-01 00:00:00

  • Symmetrical peripheral digital gangrene following severe Plasmodium falciparum malaria-induced disseminated intravascular coagulopathy.

    abstract：:Symmetrical peripheral digital gangrene is a life-changing complication, caused by a pro-thrombotic life-threatening disease, such as disseminated intravascular coagulopathy (DIC) secondary to systemic infection. We describe the unusual case of a woman who developed symmetrical peripheral digital gangrene following DI...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/j.1742-481X.2010.00697.x

    authors： Ghafoor SZ,MacRae EA,Harding KG,Patel GK

    更新日期：2010-10-01 00:00:00

  • Nicorandil: from ulcer to fistula into adjacent organs.

    abstract：:Nicorandil is an original vasodilatator used to control angina by decreasing cardiac preload and afterload. Since 1997, many reports of single or multiple nicorandil-induced ulcerations have been published. To date, eight cases of nicorandil-induced fistula into adjacent organs have been described. The pathogeneses of...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/j.1742-481X.2012.00966.x

    authors： Trechot P,Petitpain N,Guy C,Pinzano A,Javot L,Schmutz JL,Marie B,Barbaud A

    更新日期：2013-04-01 00:00:00

  • Negative pressure surgical management after pathological scar surgical excision: a first report.

    abstract：:Wound dehiscence is a surgical complication caused by the application of opposing and distracting forces tending to pull apart the suture line. In recent years, a novel negative pressure surgical management system has been developed to prevent surgical wound complications. This system creates a closed environment that...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/iwj.12040

    authors： Bollero D,Malvasio V,Catalano F,Stella M

    更新日期：2015-02-01 00:00:00

  • A case series and a review of the literature on foreign modelling agent reaction: an emerging problem.

    abstract：:Foreign modelling agent reactions (FMAR) are the result of the injection of unapproved high-viscosity fluids with the purpose of cosmetic body modelling. Its consequences lead to ulceration, disfigurement and even death, and it has reached epidemic proportions in several regions of the world. We describe a series of p...

    journal_title：International wound journal

    pub_type： 杂志文章,评审

    doi：10.1111/iwj.12643

    authors： Martínez-Villarreal AA,Asz-Sigall D,Gutiérrez-Mendoza D,Serena TE,Lozano-Platonoff A,Sanchez-Cruz LY,Toussaint-Caire S,Domínguez-Cherit J,López-García LA,Cárdenas-Sánchez A,Contreras-Ruiz J

    更新日期：2017-06-01 00:00:00

  • Ultrasonography effectiveness of the vibration vs cryotherapy added to an eccentric exercise protocol in patients with chronic mid-portion Achilles tendinopathy: A randomised clinical trial.

    abstract：:Tendinopathy is a very common disease in the general population as well as in athletes. The aim of the present study was to examine the tendon thickness and cross-sectional area (CSA) in subjects with chronic mid-portion Achilles tendinopathy (AT) who engaged in either an eccentric exercise (EE) programme with vibrati...

    journal_title：International wound journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/iwj.13074

    authors： Romero-Morales C,Javier Martín-Llantino P,Calvo-Lobo C,Palomo-López P,López-López D,Fernández-Carnero J,Rodríguez-Sanz D

    更新日期：2019-04-01 00:00:00

  • Comparison of the efficacy and safety of povidone-iodine foam dressing (Betafoam), hydrocellular foam dressing (Allevyn), and petrolatum gauze for split-thickness skin graft donor site dressing.

    abstract：:We evaluated the efficacy and safety of a povidone-iodine (PVP-I) foam dressing (Betafoam) for donor site dressing versus a hydrocellular foam dressing (Allevyn) and petrolatum gauze. This prospective Phase 4 study was conducted between March 2016 and April 2017 at eight sites in Korea. A total of 106 consenting patie...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/iwj.13043

    authors： Pak CS,Park DH,Oh TS,Lee WJ,Jun YJ,Lee KA,Oh KS,Kwak KH,Rhie JW

    更新日期：2019-04-01 00:00:00

  • Skin grafting for the treatment of chronic leg ulcers - a systematic review in evidence-based medicine.

    abstract：:Skin grafting is one of the most common surgical procedures in the area of non-healing wounds by which skin or a skin substitute is placed over a wound to replace and regenerate the damaged skin. Chronic leg ulcers are an important problem and a major source of expense for Western countries and for which many differen...

    journal_title：International wound journal

    pub_type： 杂志文章,评审

    doi：10.1111/iwj.12575

    authors： Serra R,Rizzuto A,Rossi A,Perri P,Barbetta A,Abdalla K,Caroleo S,Longo C,Amantea B,Sammarco G,de Franciscis S

    更新日期：2017-02-01 00:00:00

  • Enteroatmospheric fistula management by endoscopic gastrostomy PEG tube.

    abstract：:Management of small-bowel fistulas which are in an open abdomen and have no soft tissue overlay or a fistula tract involves many complications and challenges. Controlling the local leakage of enteric contents has a central role in the success of medical treatment. There are several methods to deal with fistula dischar...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/iwj.12726

    authors： Miranda LE,Miranda AC

    更新日期：2017-12-01 00:00:00

  • Keloid progression: a stiffness gap hypothesis.

    abstract：:Keloids are fibroproliferative skin disorders characterised clinically by continuous horizontal progression and post-surgical recurrence and histologically by the accumulation of collagen and fibroblast ingredients. Till now, their aetiology remains clear, which may cover genetic, environmental and metabolic factors. ...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/iwj.12693

    authors： Huang C,Liu L,You Z,Wang B,Du Y,Ogawa R

    更新日期：2017-10-01 00:00:00

  • The economics of pressure relieving surfaces: an illustrative case study of the impact of high-specification surfaces on hospital finances.

    abstract：:Pressure ulcers are associated with a significant economic burden that, in many cases, is recognised as being avoidable. The effectiveness of pressure relieving surfaces is well documented and acknowledged in clinical guidelines on the prevention and management of pressure ulcers. Whilst pressure relieving surfaces ar...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/j.1742-481X.2009.00647.x

    authors： Trueman P,Whitehead SJ

    更新日期：2010-02-01 00:00:00

  • Effect of low-thermal dissection device versus conventional electrocautery in mastectomy for female-to-male transgender patients.

    abstract：:Subcutaneous mastectomy, the first step in sexual reassignment surgery of female-to-male transsexuals, is associated with high rates of complication and revision surgery. Also, conventional electrosurgery and the associated thermal tissue damage may compromise outcome. This retrospective randomised clinical study eval...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/iwj.13382

    authors： Schlosshauer T,Kiehlmann M,Riener MO,Rothenberger J,Sader R,Rieger UM

    更新日期：2020-10-01 00:00:00

  • TIME management by medicinal larvae.

    abstract：:Wound bed preparation (WBP) is an integral part of the care programme for chronic wounds. The acronym TIME is used in the context of WBP and describes four barriers to healing in chronic wounds; namely, dead Tissue, Infection and inflammation, Moisture imbalance and a non-migrating Edge. Larval debridement therapy (LD...

    journal_title：International wound journal

    pub_type： 杂志文章,评审

    doi：10.1111/iwj.12457

    authors： Pritchard DI,Čeřovský V,Nigam Y,Pickles SF,Cazander G,Nibbering PH,Bültemann A,Jung W

    更新日期：2016-08-01 00:00:00

  • Risk factors for 90-day and 180-day mortality in hospitalised patients with pressure ulcers.

    abstract：:An understanding of risk factors associated with mortality among pressure ulcer patients can inform prognostic counselling and treatment plans. This retrospective cohort study examined associations of comorbid illness, demographic characteristics and laboratory values with 90-day and 90- to 180-day mortality in adult ...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/j.1742-481X.2012.01032.x

    authors： Flattau A,Blank AE

    更新日期：2014-02-01 00:00:00

  • Cold immersion recovery responses in the diabetic foot with neuropathy.

    abstract：:The aim of this article was to investigate the effectiveness of testing cold immersion recovery responses in the diabetic foot with neuropathy using a contact thermography system based on thermochromic liquid crystals. A total of 81 subjects with no history of diabetic foot ulceration were assigned to neuropathy, non ...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/j.1742-481X.2008.00454.x

    authors： Bharara M,Viswanathan V,Cobb JE

    更新日期：2008-10-01 00:00:00

  • Understanding factors influencing venous leg ulcer guideline implementation in Australian primary care.

    abstract：:The aim of this study was to gain a better understanding of the venous leg ulcer (VLU) management in primary health care settings located in Melbourne metropolitan and rural Victoria, Australia. We explored health professionals' perspective on the use of the Australian and New Zealand Venous Leg Ulcer Clinical Practic...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/iwj.13334

    authors： Weller CD,Richards C,Turnour L,Team V

    更新日期：2020-06-01 00:00:00

  • Using image J to document healing in ulcers of the foot in diabetes.

    abstract：:The aim of the study was to assess the reliability of measuring the cross-sectional area of diabetic foot ulcers using Image J software. The inter- and intra-rater reliability of ulcer area measures were assessed using digital images of acetate tracings of ulcers of the foot affecting 31 participants in an off-loading...

    journal_title：International wound journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/iwj.12769

    authors： Jeffcoate WJ,Musgrove AJ,Lincoln NB

    更新日期：2017-12-01 00:00:00

  • Wound conditioning of a deep tissue defect including exposed bone after tumour excision using PROMOGRAN* Matrix, a protease-modulating matrix.

    abstract：:A case study reporting on the successful treatment of a patient affected by a basal cell carcinoma is submitted. Because the carcinoma had infiltrated deeply, a wide excision was necessary, including the removal of bone tissue. The deep tissue defect was treated with PROMOGRAN* Matrix, a protease-modulating matrix, to...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/j.1742-4801.2005.00120.x

    authors： Tausche AK,Sebastian G

    更新日期：2005-09-01 00:00:00

  • Cost-effectiveness of treating vascular leg ulcers with UrgoStart(®) and UrgoCell(®) Contact.

    abstract：:Although chronic wounds have a high socio-economic impact, data on comparative effectiveness of treatments are rare. UrgoStart(®) is a hydroactive dressing containing a nano-oligosaccharide factor (NOSF). This study aimed at evaluating the cost-effectiveness of this NOSF-containing wound dressing in vascular leg ulcer...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/iwj.12238

    authors： Augustin M,Herberger K,Kroeger K,Muenter KC,Goepel L,Rychlik R

    更新日期：2016-02-01 00:00:00

  • The efficacy of hydrogel dressings as a first aid measure for burn wound management in the pre-hospital setting: a systematic review of the literature.

    abstract：:The aim of this systematic review was to determine the supporting evidence for the clinical use of hydrogel dressings as a first aid measure for burn wound management in the pre-hospital setting. Two authors searched three databases (Ovid Medline, Ovid Embase and The Cochrane Library) for relevant English language art...

    journal_title：International wound journal

    pub_type： 杂志文章,评审

    doi：10.1111/iwj.12469

    authors： Goodwin NS,Spinks A,Wasiak J

    更新日期：2016-08-01 00:00:00

  • The impact of evolving V.A.C ® Therapy technology on outcomes in wound care. Prologue.

    abstract：:In May 2011, an international panel of wound care experts from multiple disciplines convened to develop this document to summarise the evolution of negative pressure wound therapy (NPWT) technology devices over the past 15 years, specifically concentrating on the V.A.C.(®) Therapy (KCI USA, Inc., San Antonio, TX) fam...

    journal_title：International wound journal

    pub_type：

    doi：10.1111/j.1742-481X.2012.00978.x

    authors： Gupta S

    更新日期：2012-08-01 00:00:00

  • Topical grape (Vitis vinifera) seed extract promotes repair of full thickness wound in rabbit.

    abstract：:In recent years, oxidative stress and free radicals have been implicated in impaired wound healing. Grape (Vitis vinifera) seed extract (GSE) possesses anti-inflammatory and antioxidant properties. The present study was undertaken to assess the potential activity of grape seed hydroalcoholic extract in wound healing i...

    journal_title：International wound journal

    pub_type： 杂志文章

    doi：10.1111/j.1742-481X.2011.00833.x

    authors： Hemmati AA,Aghel N,Rashidi I,Gholampur-Aghdami A

    更新日期：2011-10-01 00:00:00