Cost-effective choice of antimicrobial therapy for serious infections.

Abstract:

:The authors evaluated the financial and health implications of treatment choices for three serious classes of infection: hospital-acquired pneumonia, intra-abdominal infection, and sepsis of unknown origin. Data were obtained from a systematic review of clinical literature and published data bases, by written questionnaire from a panel of infectious disease authorities, and from actual costs at a tertiary-care hospital. For pneumonia and sepsis, the third-generation cephalosporin evaluated (ceftizoxime) was found to be less expensive than other regimens, when costs of dose preparation and administration, monitoring, and toxicity were added to drug acquisition costs. The lowest-cost regimen for intra-abdominal infection was metronidazole plus gentamicin. Modest differences in efficacy would easily outweigh differences in toxicity, however, and could justify the use of more expensive regimens (e.g., mezlocillin plus gentamicin for hospital-acquired pneumonia, and cefoxitin plus gentamicin for intra-abdominal infection). If all regimens are assumed to be equally efficacious, then the third-generation cephalosporin was both lowest in cost and, owing to its low toxicity, greatest in net health benefit.

journal_name

J Gen Intern Med

authors

Weinstein MC,Read JL,MacKay DN,Kresel JJ,Ashley H,Halvorsen KT,Hutchings HC

doi

10.1007/BF02596417

subject

Has Abstract

pub_date

1986-11-01 00:00:00

pages

351-63

issue

6

eissn

0884-8734

issn

1525-1497

journal_volume

1

pub_type

杂志文章
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    doi:10.1007/BF02599811

    authors: Brown JT,Fulkerson CC,Delong ER

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    更新日期:1997-09-01 00:00:00

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    authors: Dunn PM,Parker DF,Levinson W,Mullooly JP

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    authors: Aucott JN,Pelecanos E,Dombrowski R,Fuehrer SM,Laich J,Aron DC

    更新日期:1996-03-01 00:00:00

  • Using Peer Feedback to Promote Clinical Excellence in Hospital Medicine.

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  • A practical guide to developing effective web-based learning.

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    更新日期:2009-11-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    authors: Rigsby MO,Rosen MI,Beauvais JE,Cramer JA,Rainey PM,O'Malley SS,Dieckhaus KD,Rounsaville BJ

    更新日期:2000-12-01 00:00:00

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    更新日期:2006-11-01 00:00:00

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    更新日期:2015-06-01 00:00:00

  • Potential unintended consequences due to Medicare's "no pay for errors" rule? A randomized controlled trial of an educational intervention with internal medicine residents.

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    pub_type: 杂志文章,随机对照试验

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    更新日期:2010-10-01 00:00:00

  • AIDS-related Pneumocystis carinii pneumonia in older patients.

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    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

    doi:10.1007/BF02599026

    authors: Keitz SA,Bastian LA,Bennett CL,Oddone EZ,DeHovitz JA,Weinstein RA

    更新日期:1996-10-01 00:00:00

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  • The value of serum iron studies as a test for iron-deficiency anemia in a county hospital.

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    journal_title:Journal of general internal medicine

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    doi:10.1007/BF02596144

    authors: Psaty BM,Tierney WM,Martin DK,McDonald CJ

    更新日期:1987-05-01 00:00:00

  • Efficacy of a one-month training block in psychosocial medicine for residents: a controlled study.

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    pub_type: 杂志文章

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    更新日期:1991-11-01 00:00:00

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    journal_title:Journal of general internal medicine

    pub_type: 杂志文章

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    更新日期:2010-08-01 00:00:00

  • Pharmaceutical industry gifts to physicians: patient beliefs and trust in physicians and the health care system.

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    pub_type: 杂志文章

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    更新日期:2012-03-01 00:00:00

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    更新日期:1993-10-01 00:00:00

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    pub_type: 杂志文章,多中心研究

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    更新日期:2014-08-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2007-07-01 00:00:00

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    pub_type: 杂志文章

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