Anti-NMDA-receptor encephalitis: case report and literature review of an under-recognized condition.

Abstract:

:Anti-N-methyl-D-aspartate receptor (anti-NMDA-R) encephalitis is an immune-mediated syndrome that remains under-recognized despite a growing body of literature. This syndrome has been predominantly described in young females with a constellation of symptoms, including personality changes, autonomic dysfunction and neurologic decompensation. It is commonly associated with mature ovarian teratomas. We describe the classic presentation of anti-NMDA-R encephalitis in three dramatically different patients: Case A, a young woman with ovarian teratoma; Case B, the eldest case reported to date; and Case C, a young male with no identifiable tumor. We review the literature summarizing the differential diagnosis, investigative approach, treatment options and challenges inherent to this disorder. We advocate good supportive care, involvement of multiple health disciplines and use of immune-modulating therapies in patient management. These cases underscore the need for increased awareness and high diagnostic suspicion when approaching the patient with suspected viral encephalitis.

journal_name

J Gen Intern Med

authors

Day GS,High SM,Cot B,Tang-Wai DF

doi

10.1007/s11606-011-1641-9

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

811-6

issue

7

eissn

0884-8734

issn

1525-1497

journal_volume

26

pub_type

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