Selective internal radiation therapy: validation of intraoperative dosimetry.

Abstract:

:In selective internal radiation (SIR) therapy of hepatic metastases, tumor vasculature is preferentially embolized with high-energy beta-emitting yttrium-90-labeled microspheres. To enable accurate estimation of the resultant absorbed radiation doses to tissues, an intraoperative beta detection probe is used to scan the liver surface. The validity of the response of this probe to Y-90 and its clinical application were assessed with a phantom containing varying activities and with biopsy samples obtained from patients being treated with SIR therapy. A linear relationship was found between the probe counts taken from the biopsy samples and the calculated tissue radiation doses from the specific activities of each sample. This relationship was repeated with probe counts determined against a water phantom containing various activities of Y-90. The probe was shown to respond minimally to bremsstrahlung. The use of the probe in measuring tissue radiation doses at laparotomy provides the opportunity to control dose administration during SIR therapy. In this way, subtherapeutic exposure of normal tissue can be assured while tumor tissue receives maximal radiation levels.

journal_name

Radiology

journal_title

Radiology

authors

Burton MA,Gray BN,Kelleher DK,Klemp PF

doi

10.1148/radiology.175.1.2315490

subject

Has Abstract

pub_date

1990-04-01 00:00:00

pages

253-5

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

175

pub_type

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