Cerebral Microhemorrhage at MRI in Mild Cognitive Impairment and Early Alzheimer Disease: Association with Tau and Amyloid β at PET Imaging.

Abstract:

:Background Growing evidence indicates an association between cerebral microhemorrhages (MHs) and amyloid β accumulation in Alzheimer disease (AD), but to the knowledge of the authors the association with tau burden is unknown. Purpose To investigate the association between cerebral MH load and tau pathologic structure measured in healthy older individuals and individuals along the AD spectrum, stratified by using the A (amyloid β)/T (tau)/N (neurodegeneration) biomarker classification system. Materials and methods In this prospective cohort study, participants from the AD Neuroimaging Initiative were included (healthy control participants, participants with mild cognitive impairment, and participants with AD dementia; data from October 2005 to January 2019). T2*-weighted gradient-echo MRI was performed to quantify MH, fluorine 18 (18F) flortaucipir (AV-1451) PET was performed to quantify tau, and 18F-florbetaben/18F- florbetapir (AV45) PET was performed to quantify amyloid β to study associations of MH with regional and global tau and amyloid β load. Associations with cerebrospinal fluid (CSF) biomarkers (amyloid β1-42, total tau, phosphorylated tau 181) were also assessed. Analysis of covariance and Spearman rank correlation test for cross-sectional analysis and Wilcoxon signed rank test for longitudinal analyses were used, controlling for multiple comparisons (Bonferroni significance threshold, P < .008). Results Evaluated were 343 participants (mean age, 75 years ± 7; 186 women), including 205 participants who were A-TN- (mean age, 73 years ± 7; 115 women), 80 participants who were A+TN- (mean age, 76 years ± 7; 38 women), and 58 participants who were A+TN+ (mean age, 77 ± 8; 34 women). MH count was associated with global (Spearman ρ = 0.27; P = .004) and frontal (ρ = 0.27; P = .005) amyloid β load and global tau load (ρ = 0.31; P = .001). In a longitudinal analysis, MH count increased significantly over approximately 5 years in the entire cohort (T-1, 81 [range, 0-6 participants]; T0, 214 [range, 0-58 participants]; P < .001), in A+TN+ (T-1, 20 [range, 0-5 participants]; T0, 119 [range, 1-58 participants]; P < .001), A+TN- (T-1, 31 [range, 0-6 participants]; T0, 43 [range, 0-8 participants]; P = .03), and A-TN- (T-1, 30 [range, 0-4 participants]; T0, 52 [range, 0-6 participants]; P = .007). A higher MH count was associated with higher future global (ρ = 0.29; P = .008) and parietal (ρ = 0.31; P = .005) amyloid β and parietal tau load (ρ = 0.31; P = .005). Conclusion Cerebral microhemorrhage load is associated spatially with tau accumulation, both cross-sectionally and longitudinally. © RSNA, 2020 Online supplemental material is available for this article.

journal_name

Radiology

journal_title

Radiology

authors

Rauchmann BS,Ghaseminejad F,Mekala S,Perneczky R,Alzheimer’s Disease Neuroimaging Initiative.

doi

10.1148/radiol.2020191904

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

134-142

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

296

pub_type

杂志文章
  • Nonalcoholic fatty liver disease: portal hypertension due to outflow block in patients without cirrhosis.

    abstract:PURPOSE:To prospectively evaluate whether the characteristics of hepatic blood flow change during the early stages of fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS:All participants provided written informed consent, and the study protocols were approved by the institutional ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.14132952

    authors: Hirooka M,Koizumi Y,Miyake T,Ochi H,Tokumoto Y,Tada F,Matsuura B,Abe M,Hiasa Y

    更新日期:2015-02-01 00:00:00

  • CT colonography: a systematic review of standard of reporting for studies of computer-aided detection.

    abstract:PURPOSE:To determine objectively the current standard of reporting for studies of computer-aided detection (CAD) for computed tomographic (CT) colonography by systematically reviewing published articles. MATERIALS AND METHODS:MEDLINE was searched to identify study articles meeting the inclusion criteria for describing...

    journal_title:Radiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1148/radiol.2461070121

    authors: Robinson C,Halligan S,Taylor SA,Mallett S,Altman DG

    更新日期:2008-02-01 00:00:00

  • Pulmonary Hypertension: A Nomogram Based on CT Pulmonary Angiographic Data for Prediction in Patients without Pulmonary Embolism.

    abstract:PURPOSE:To use cardiovascular data from computerized tomographic (CT) pulmonary angiography for facilitating the identification of pulmonary hypertension (PH) in patients without acute pulmonary embolism. MATERIALS AND METHODS:The institutional human research committee approved this retrospective study; informed conse...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.15141269

    authors: Aviram G,Shmueli H,Adam SZ,Bendet A,Ziv-Baran T,Steinvil A,Berliner AS,Nesher N,Ben-Gal Y,Topilsky Y

    更新日期:2015-10-01 00:00:00

  • Thin-walled cystic lesions in bronchioalveolar carcinoma.

    abstract::In a retrospective study, thin-walled cystic lesions were identified in four patients with proved bronchioalveolar carcinoma (BAC). The radiographic appearances are described, and possible mechanisms of formation of the lesions are discussed. Although such appearances due to BAC have rarely been described in the liter...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.185.2.1329140

    authors: Weisbrod GL,Towers MJ,Chamberlain DW,Herman SJ,Matzinger FR

    更新日期:1992-11-01 00:00:00

  • Noninvasive Characterization of Tumor Angiogenesis and Oxygenation in Bevacizumab-treated Recurrent Glioblastoma by Using Dynamic Susceptibility MRI: Secondary Analysis of the European Organization for Research and Treatment of Cancer 26101 Trial.

    abstract::Background Relevance of antiangiogenic treatment with bevacizumab in patients with glioblastoma is controversial because progression-free survival benefit did not translate into an overall survival (OS) benefit in randomized phase III trials. Purpose To perform longitudinal characterization of intratumoral angiogenesi...

    journal_title:Radiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1148/radiol.2020200978

    authors: Kickingereder P,Brugnara G,Hansen MB,Nowosielski M,Pflüger I,Schell M,Isensee F,Foltyn M,Neuberger U,Kessler T,Sahm F,Wick A,Heiland S,Weller M,Platten M,von Deimling A,Maier-Hein KH,Østergaard L,van den Bent MJ,Gor

    更新日期:2020-10-01 00:00:00

  • Application of image-guided surface coil P-31 MR spectroscopy to human liver, heart, and kidney.

    abstract::Localized phosphorus-31 magnetic resonance (MR) spectroscopy in humans has previously been accomplished with surface coils by means of depth-resolved surface coil spectroscopy or rotating frame experiments, in which the extent of tissue sampled critically depends on surface coil placement. The authors' goal was to mod...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.169.2.3051120

    authors: Matson GB,Twieg DB,Karczmar GS,Lawry TJ,Gober JR,Valenza M,Boska MD,Weiner MW

    更新日期:1988-11-01 00:00:00

  • Relationship between Overall Survival of Patients with Non-Small Cell Lung Cancer and Whole-Body Metabolic Tumor Burden Seen on Postsurgical Fluorodeoxyglucose PET Images.

    abstract:PURPOSE:To test the hypothesis that whole-body metabolic tumor burden (MTBWB) on postsurgical fluorodeoxyglucose (FDG) positron emission tomographic (PET)/computed tomographic (CT) images in patients with non-small cell lung cancer (NSCLC) is associated with their overall survival (OS). MATERIALS AND METHODS:The insti...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.14141398

    authors: Zhang C,Liao C,Penney BC,Appelbaum DE,Simon CA,Pu Y

    更新日期:2015-06-01 00:00:00

  • "Missing" femoral condyle: an unusual sequela to neonatal osteomyelitis and septic arthritis.

    abstract::Growth deformities of the distal femur and unusual gait disturbances were observed in four girls who had had neonatal osteomyelitis and septic arthritis. In each case apparent absence or hypoplasia of one of the femoral condyles, as seen on plain radiographs, was associated with marked genu varum or genu valgum. Arthr...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.161.2.3763900

    authors: Singson RD,Berdon WE,Feldman F,Denton JR,Abramson S,Baker DH

    更新日期:1986-11-01 00:00:00

  • Epinephrine enhanced renal angiography in the diagnosis of hamartoma (angiomyolipoma): a reevaluation.

    abstract::The vlue of epinephrine enhanced angiography in the preoperative distinction of isolated hamartoma (angiomyolipoma without stigma of tuberous sclerosis) from hypernephroma has been largely discounted in the past. The authors performed this procedure in 6 patients (4 with isolated hamartoma and 2 with tuberous sclerosi...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/132.1.61

    authors: Jander HP,Tonkin IL

    更新日期:1979-07-01 00:00:00

  • MR imaging of the cochlear modiolus: area measurement in healthy subjects and in patients with a large endolymphatic duct and sac.

    abstract:PURPOSE:To evaluate the cochlear modiolus with thin-section magnetic resonance (MR) imaging in healthy subjects and patients with a large endolymphatic duct and sac, and to assess whether the cochlea is normal or abnormal in patients with a large endolymphatic duct and sac. MATERIALS AND METHODS:MR images were obtaine...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.213.3.r99dc05819

    authors: Naganawa S,Ito T,Iwayama E,Fukatsu H,Ishigaki T,Nakashima T,Ichinose N

    更新日期:1999-12-01 00:00:00

  • Sarcoidosis: correlation of extent of disease at CT with clinical, functional, and radiographic findings.

    abstract::Computed tomography (CT) was compared with chest radiography in the assessment of disease severity in 27 patients with sarcoidosis. The CT scans and radiographs were each read twice by two independent observers. Disease extent was assessed on CT scans by visual scoring (0%-100% involvement of the lung parenchyma) and ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.171.3.2717730

    authors: Müller NL,Mawson JB,Mathieson JR,Abboud R,Ostrow DN,Champion P

    更新日期:1989-06-01 00:00:00

  • Up to 50-fold increase in urine viscosity with iso-osmolar contrast media in the rat.

    abstract:PURPOSE:To compare changes in urinary viscosity in the renal tubules following administration of a high-viscosity iso-osmolar contrast agent (iodixanol) to that observed following administration of a less viscous, higher osmolar contrast agent (iopromide) in anesthetized rats. MATERIALS AND METHODS:A total of 43 rats ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.10091485

    authors: Seeliger E,Becker K,Ladwig M,Wronski T,Persson PB,Flemming B

    更新日期:2010-08-01 00:00:00

  • Doppler US. Part II. Clinical applications.

    abstract::Duplex and color Doppler ultrasound (US) are noninvasive techniques capable of providing much information about the condition of blood vessels and flow within them throughout the body. Doppler US provides more than noninvasive angiography. Besides assessment of blood vessel patency and direction of flow, analysis of t...

    journal_title:Radiology

    pub_type: 杂志文章,评审

    doi:10.1148/radiology.174.2.2404310

    authors: Scoutt LM,Zawin ML,Taylor KJ

    更新日期:1990-02-01 00:00:00

  • Recurrent colorectal carcinoma: evaluation with barium enema examination and CT.

    abstract::The efficacy of the barium enema examination and abdominal computed tomography (CT) was investigated in 81 patients who had undergone operation for colorectal carcinoma. Recurrent disease was found in 52 patients and was divided into local (anastomotic and perianastomotic) and remote (distant and hepatic metastases) t...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.163.2.3562810

    authors: Chen YM,Ott DJ,Wolfman NT,Gelfand DW,Karsteadt N,Bechtold RE

    更新日期:1987-05-01 00:00:00

  • Chronic diffuse infiltrative lung disease: determination of the diagnostic value of clinical data, chest radiography, and CT and Bayesian analysis.

    abstract:PURPOSE:To assess the value of clinical, chest radiographic, and computed tomographic (CT) findings in classifying chronic diffuse infiltrative lung disease (CDILD) MATERIALS AND METHODS: Two samples from the same population were consecutively studied: the training set (group A, n = 208) for the development of the deci...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.191.2.8153310

    authors: Grenier P,Chevret S,Beigelman C,Brauner MW,Chastang C,Valeyre D

    更新日期:1994-05-01 00:00:00

  • Chronic obstructive pulmonary disease: thin-section CT measurement of airway wall thickness and lung attenuation.

    abstract:PURPOSE:To prospectively evaluate airway wall thickness and lung attenuation at spirometrically gated thin-section computed tomography (CT) in patients with chronic obstructive pulmonary disease (COPD) and to correlate gated CT findings with pulmonary function test (PFT) results. MATERIALS AND METHODS:The ethical comm...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2342040013

    authors: Orlandi I,Moroni C,Camiciottoli G,Bartolucci M,Pistolesi M,Villari N,Mascalchi M

    更新日期:2005-02-01 00:00:00

  • Ultrasonic evaluation of normal pancreatic echogenicity and its relationship to fat deposition.

    abstract::Normal pancreatic ultrasound studies of 28 patients were evaluated as to pancreatic echogenicity and correlated with the morphologic appearance of the pancreas on CT to test the hypothesis that increasing pancreatic echogenicity is related to greater fat infiltration. Statistical analysis indicates that fat is a major...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.137.2.7433680

    authors: Marks WM,Filly RA,Callen PW

    更新日期:1980-11-01 00:00:00

  • Gender Differences in Academic Rank of Radiologists in U.S. Medical Schools.

    abstract::Purpose To determine whether there were gender differences in full professorship after accounting for factors known to influence academic advancement. Materials and Methods Institutional review board approval was obtained for this HIPAA-compliant study, with waiver of informed consent. In this cross-sectional study, t...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2016160950

    authors: Kapoor N,Blumenthal DM,Smith SE,Ip IK,Khorasani R

    更新日期:2017-04-01 00:00:00

  • The Alzheimer structural connectome: changes in cortical network topology with increased amyloid plaque burden.

    abstract:PURPOSE:To evaluate differences in the structural connectome among patients with normal cognition (NC), mild cognitive impairment (MCI), and Alzheimer disease (AD) and to determine associations between the structural connectome and cortical amyloid deposition. MATERIALS AND METHODS:Patients enrolled in a multicenter b...

    journal_title:Radiology

    pub_type: 杂志文章,多中心研究

    doi:10.1148/radiol.14132593

    authors: Prescott JW,Guidon A,Doraiswamy PM,Roy Choudhury K,Liu C,Petrella JR,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2014-10-01 00:00:00

  • Peritoneocele: visualization with defecography and peritoneography performed simultaneously.

    abstract:PURPOSE:To evaluate the use of simultaneous defecography and peritoneography (defecoperitoneography) in patients with an unexplained widening of the rectovaginal space noted at defecography. MATERIALS AND METHODS:Twenty-two patients with unexplained widening of the rectovaginal space noted at defecography were studied...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.202.2.9015060

    authors: Bremmer S,Mellgren A,Holmström B,López A,Udén R

    更新日期:1997-02-01 00:00:00

  • Colorectal cancer overlooked at barium enema examination and colonoscopy: a continuing perceptual problem.

    abstract:PURPOSE:To evaluate reasons for missed diagnosis of colorectal carcinoma at barium enema (BE) examination and colonoscopy and determine if standards have improved since a similar study in 1981. MATERIALS AND METHODS:Relevant studies obtained within 3 years of diagnosis in 161 patients with colorectal carcinoma treated...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.192.2.8029400

    authors: Brady AP,Stevenson GW,Stevenson I

    更新日期:1994-08-01 00:00:00

  • Gallbladder ablation through radiologic intervention: an experimental alternative to cholecystectomy.

    abstract::Twenty pigs underwent (a) cystic duct occlusion by means of fluoroscopically guided transcatheter endoluminal bipolar radio-frequency (RF) electrocoagulation and (b) gallbladder sclerotherapy with one of two different regimens of ethanol and sodium tetradecyl-sulfate (STS). Serum ethanol levels and hepatic enzyme test...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.171.1.2928530

    authors: Becker CD,Quenville NF,Burhenne HJ

    更新日期:1989-04-01 00:00:00

  • Computer-aided detection in screening mammography: variability in cues.

    abstract:PURPOSE:To evaluate the variability of true-positive and false-positive cues by using a commercially available computer-aided detection (CAD) system for analysis of 50 malignancies in a screening population. MATERIALS AND METHODS:Fifty breast cancers detected at screening were analyzed by using a commercially availabl...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2332031200

    authors: Baker JA,Lo JY,Delong DM,Floyd CE

    更新日期:2004-11-01 00:00:00

  • Influence of image acquisition parameters on CT artifacts and polyp depiction in spiral CT colonography: in vitro evaluation.

    abstract:PURPOSE:To quantify the effects of spiral computed tomographic (CT) acquisition parameters on the magnitude of three-dimensional (3D) rippling artifacts and polyp depiction. MATERIALS AND METHODS:An in vitro colon phantom was constructed with air-filled acrylic cylinders that contained synthetic polyps of 3-13 mm. The...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.217.1.r00oc13165

    authors: Whiting BR,McFarland EG,Brink JA

    更新日期:2000-10-01 00:00:00

  • Vertebral sarcoidosis in adolescents.

    abstract::Two cases of vertebral sarcoidosis in pediatric patients are presented. All such patients reported have been black, 13-15 years old, and have a history of back pain. Radiographs of the involved vertebrae show primarily lytic destruction with sclerotic borders in some of the lesions. Fungal infections, tuberculosis, py...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/121.1.153

    authors: Stump D,Spock A,Grossman H

    更新日期:1976-10-01 00:00:00

  • Plastic bowing, torus and greenstick supracondylar fractures of the humerus: radiographic clues to obscure fractures of the elbow in children.

    abstract::The anterior humeral line is a valuable aid in the search for supracondylar fractures in children. When it is abnormal other signs of fracture should be carefully sought. The AHL was normal in only 5.8% of the cases reviewed (4 of 68 cases). There was other evidence of fracture in each case. Comparison of the AHLs on ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/128.1.145

    authors: Rogers LF,Malave S Jr,White H,Tachdjian MO

    更新日期:1978-07-01 00:00:00

  • Effect of contrast material injection duration and rate on aortic peak time and peak enhancement at dynamic CT involving injection protocol with dose tailored to patient weight.

    abstract:PURPOSE:To investigate the effect of duration and rate of contrast material injection on aortic peak time and peak enhancement in an injection protocol in which the contrast material dose is adjusted according to patient weight. MATERIALS AND METHODS:One hundred ninety-nine patients were randomly divided into three gr...

    journal_title:Radiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1148/radiol.2301021008

    authors: Awai K,Hiraishi K,Hori S

    更新日期:2004-01-01 00:00:00

  • Respiratory motion artifact affecting hepatic arterial phase MR imaging with gadoxetate disodium is more common in patients with a prior episode of arterial phase motion associated with gadoxetate disodium.

    abstract:PURPOSE:To determine, in a dual-center setting, whether patients who experience transient severe motion ( TSM transient severe motion ) in the arterial phase during gadoxetate disodium-enhanced magnetic resonance (MR) imaging are at higher risk for a subsequent episode of TSM transient severe motion than patients who d...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.14140386

    authors: Bashir MR,Castelli P,Davenport MS,Larson D,Marin D,Hussain HK,Jaffe TA

    更新日期:2015-01-01 00:00:00

  • The sonographically patent umbilical vein in portal hypertension.

    abstract::A patent umbilical vein is a sonographic sign of portal hypertension. The specificity of the sign is not known. In a review of 12 patients with sonographically demonstrated patency of the umbilical vein, we found two patients in whom no clinical evidence existed to suggest the presence of portal hypertension. In six o...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.145.2.7134450

    authors: Saddekni S,Hutchinson DE,Cooperberg PL

    更新日期:1982-11-01 00:00:00

  • Retrievable vena caval filter percutaneously introduced.

    abstract::A vena caval filter than can be introduced percutaneously via the femoral vein is described. We placed these filters in five patients without complications. Experimental work in filter removal one to two weeks after insertion in dogs has been performed. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.155.3.4001390

    authors: Lund G,Rysavy J,Hunter DW,Castaneda-Zuniga WR,Amplatz K

    更新日期:1985-06-01 00:00:00