Expanded Preconception Carrier Screening in Clinical Practice: Review of Technology, Guidelines, Implementation Challenges, and Ethical Quandaries.

Abstract:

:In the last 10 years, expanded preconception carrier screening has become widely available and helps patients/couples make more informed decisions with regard to their reproductive options and facilitates more effective preconception planning, prenatal diagnosis, condition-specific counseling, and condition-specific care. This review provides an overview of expanded preconception carrier screening's high-throughput genotyping and sequencing approaches, current guidelines, implementation challenges and evolving ethical quandaries.

journal_name

Clin Obstet Gynecol

authors

Zhang T,Madeira J,Lu Y,Sun Y,Mertes H,Pennings G,Lindheim SR

doi

10.1097/GRF.0000000000000437

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

217-227

issue

2

eissn

0009-9201

issn

1532-5520

journal_volume

62

pub_type

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