Abstract:
BACKGROUND:Safety and efficacy of botulinum toxin A for glabellar line (GL) treatment are well established. Currently approved formulations require reconstitution before injection. OBJECTIVES:The authors sought to assess 6-month efficacy, safety, and patient satisfaction of new ready-to-use abobotulinumtoxinA solution for injection (ASI) in patients with moderate-to-severe GL at maximum frown. METHODS:The authors conducted a phase 3, double-blind, randomized, placebo-controlled trial (NCT02353871). Patients (N = 185) were randomized (2:1) to receive ASI 50 U or placebo. GL severity was evaluated at days 8, 15, 29, 57, 85, 113, 148, and 183 employing a 4-point scale for investigator's live assessment (ILA) and subject's self-assessment (SSA). Primary endpoint was ILA of GL at maximum frown at day 29, and secondary endpoints were ILA and SSA of GL at maximum frown (all time points), patient satisfaction with GL appearance, time to onset, and duration of action. RESULTS:Responder rates were significantly higher for ASI vs placebo (88.3% vs 1.4%; P < 0.0001) at day 29 by ILA and all time points by ILA (P < 0.0001-0.0441) and SSA (P < 0.0001-0.0036). Sixty percent of patients reported onset of treatment response on or before day 3 (P < 0.0001 vs placebo), and in 5% of patients, efficacy by ILA lasted 6 months (day 183; P = 0.0441 vs placebo). Patient satisfaction rates were significantly higher for ASI vs placebo at all visits (P < 0.0001). Safety was comparable with the known abobotulinumtoxinA profile. CONCLUSIONS:ASI was significantly efficacious for improving moderate or severe GL vs placebo by investigator and patient assessment. ASI was associated with high patient satisfaction, a long duration of action, and comparable safety profile to abobotulinumtoxinA. LEVEL OF EVIDENCE: 1:
journal_name
Aesthet Surg Jjournal_title
Aesthetic surgery journalauthors
Ascher B,Rzany B,Kestemont P,Hilton S,Heckmann M,Bodokh I,Noah EM,Boineau D,Kerscher M,Volteau M,Le Berre P,Picaut Pdoi
10.1093/asj/sjz003subject
Has Abstractpub_date
2020-01-01 00:00:00pages
93-104issue
1eissn
1090-820Xissn
1527-330Xpii
5407526journal_volume
40pub_type
杂志文章,随机对照试验abstract::Rhinoplasty is generally considered to be one of the most challenging, complex, and exciting of all the plastic surgery procedures. In this article, the authors discuss key concepts related to patient evaluation and analysis, as well as techniques and maneuvers that reliably lead to favorable long-term results in rhin...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,评审
doi:10.1177/1090820X10380388
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:The mechanism of breast implant rupture has continued to be an important topic throughout the plastic surgery community and regulatory agencies, such as the US Food and Drug Administration. Retrieved ruptured implants returned to Allergan (Santa Barbara, CA; formerly Inamed Corporation) for analysis exhibit ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2007.04.001
更新日期:2007-05-01 00:00:00
abstract::Efforts to improve lipoplasty results through the application of focused energy continue to arouse interest. The author's initial experience with power-assisted lipoplasty indicates that this technique is safe, fast, and capable of producing results equal or superior to those achieved through use of traditional lipopl...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1067/maj.2001.113641
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Despite the effectiveness of ablative CO(2) laser resurfacing for facial rejuvenation, its application has been limited owing to an undesirable side-effect profile, including prolonged hyperemia and potential pigmentary changes. However, newer fractional CO(2) laser technology has reduced the recovery time a...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X10386930
更新日期:2010-11-01 00:00:00
abstract::The authors recommend this brachioplasty technique for patients who have lost a significant amount of weight. The sinusoidal-shaped scar helps to avoid problems such as linear scar contracture, wound tension, and widened or hypertrophic scars. ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2004.04.010
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:In order for aesthetic surgery to participate in the movement toward evidence-based medicine, a system that quantifies aesthetic outcomes must be developed based on reliable and reproducible data. Previous studies have investigated the attractiveness of averaged (or composite) faces. Data has shown that thes...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X10369370
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:A device to assist in the delivery of dermal filler may achieve reductions in patient discomfort and adverse events, as well physician fatigue. It may also increase the accuracy of material placement. OBJECTIVES:The authors assess the safety and performance of the Artiste Assisted Injection System (Nordson ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,随机对照试验
doi:10.1177/1090820X13487372
更新日期:2013-07-01 00:00:00
abstract:Background:While recent studies have reported modest to no difference in breast aesthetics for shaped and round implant types in breast augmentations, the anatomy and biomechanics in the setting of breast reconstruction is different. Objectives:Accordingly, we endeavored to evaluate whether two implant types impacted ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjx210
更新日期:2018-05-15 00:00:00
abstract::The retaining ligaments of the face are important in understanding concepts of facial aging and rejuvenation. They are located in constant anatomic locations where they separate facial spaces and compartments. Their superficial extensions form subcutaneous septa that separate facial fat compartments. Their main signif...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,评审
doi:10.1177/1090820X13495405
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:It would be useful if existing tools or outcomes measures could predict which patients are at greater risk of revision surgery following rhinoplasty. OBJECTIVE:We aim to determine if a single question assessing nasal self-esteem could be used to predict which patients are at greatest risk of revision surger...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa252
更新日期:2020-08-28 00:00:00
abstract::Although the principles of burn management are still primarily focused on survival, as advances are realized in resuscitation, nutrition, and wound management, the functional and aesthetic outcomes following burn injury have become increasingly important. Acellular dermal matrix materials, which allow surgeons to mini...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,评审
doi:10.1177/1090820X11418202
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:The popularity of genital cosmetic procedures in women is increasing. These procedures are often assumed and promoted as having a positive effect on women's psychological well-being, particularly their self-esteem. Empirical support for these claims is lacking. OBJECTIVES:The aim of this study was to conduc...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,meta分析
doi:10.1093/asj/sjaa038
更新日期:2020-09-14 00:00:00
abstract:BACKGROUND:Adipocyte viability is affected by fat preparation and processing methods, but rigorous and objective studies of these relationships are lacking. OBJECTIVES:The authors conducted a comprehensive evaluation of variables affecting adipocyte viability prior to injection of fat at the recipient site. METHODS:L...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjw106
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Until 2001, body contouring surgery after massive weight loss was uncoordinated, with few patients achieving compete rehabilitation. OBJECTIVE:The authors report a 5-year, retrospective, 75-case clinical review to determine the effectiveness, reliability, and safety of single and multistage total body lift ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2008.03.001
更新日期:2008-05-01 00:00:00
abstract::Endoscopic forehead rejuvenation offers the advantages of greater patient acceptance and lower complication rates. The author describes technical modifications that make the endoscopic approach effective in a wide range of patients. Particular attention is paid to the problem of asymmetry. When the preoperative differ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1067/maj.2001.115258
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Previously, the problem created by overly convex, wide, and robust lower lateral cartilages (LLC) required an external or endonasal approach with delivery. Although this method has proven invaluable, it may not be indicated in all patients with large tips, specifically those with overly convex LLC or with th...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X10391779
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The nose is an important part of the face and plays a significant role in interpersonal communication and self-esteem. Dorsal preservation techniques, such as the push-down and let-down techniques, are used for dorsal hump reductions. OBJECTIVES:In this study, several approaches are defined in which the let...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa436
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND:Facial aging is a complicated process that includes volume loss and soft tissue descent. This study provides quantitative 3-dimensional (3D) data on the long-term effect of vertical vector deep-plane rhytidectomy on restoring volume to the midface. OBJECTIVE:To determine if primary vertical vector deep-plan...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sju171
更新日期:2015-07-01 00:00:00
abstract::The author analyzes the aesthetics of gluteal contouring, combining the contributions of other experts with his unique classification system that divides the gluteal region into 8 distinct aesthetic units. He advises that careful anatomic analysis and surgical technique, as well as communication with patients to deter...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2006.01.001
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Improvements in skin erythema and elasticity have been observed with topical application of platelet-rich plasma after fractional laser (FXD) treatment. Injections of nanofat via small needles into the dermis improves tissue thickness, discoloration and wrinkle depth. OBJECTIVES:The aim of this study was to...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjz240
更新日期:2020-07-13 00:00:00
abstract:BACKGROUND:Economic evaluation is important for making decisions about resource allocation. Few cost-utility or cost-effectiveness studies on breast hypertrophy have been reported in the medical literature. OBJECTIVES:The authors sought to determine the cost-utility of reduction mammaplasty in the Brazilian national h...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,随机对照试验
doi:10.1177/1090820X14539972
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Knowledge of topographic skin thickness is important to plastic surgery of the face as it may guide resection and restoration in oncologic, aesthetic, and reconstructive procedures. OBJECTIVE:The purpose of this study is to report the relative thickness of the face throughout 39 distinct subunits. METHODS:...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjv079
更新日期:2015-11-01 00:00:00
abstract::Young aesthetic surgeons may wonder, "Why care about aesthetic medicine?" The answer is based on the "five principles" of aesthetic medicine: patient acquisition, patient retention, patient optimization, patient education, and patient conversion. The explosion in new nonsurgical technologies and treatments combined wi...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjy273
更新日期:2019-06-21 00:00:00
abstract:BACKGROUND:YouTube is increasingly being utilized as a major educational resource by patients. It is important for plastic surgeons to understand the quality and characteristics of videos that patients are likely to view about procedures of interest. OBJECTIVES:The aim of this study was to evaluate the quality of the ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjz268
更新日期:2020-04-14 00:00:00
abstract:BACKGROUND:Glabellar wrinkle corrections are usually performed by injecting botulinum toxin and hyaluronic acid fillers. The glabella is one of the most dangerous locations for filler injection because of possible visual complications. OBJECTIVE:The objective of this study was to use Doppler ultrasound to determine th...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa197
更新日期:2020-07-09 00:00:00
abstract:BACKGROUND:Women tend to develop more and deeper wrinkles in the perioral region than men. Although much is known about the complex mechanisms involved in skin aging, previous studies have described histologic differences between men and women with respect to skin aging only incidentally and have not investigated the p...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2009.08.018
更新日期:2009-11-01 00:00:00
abstract::Cellulite is a common condition affecting 85% of postadolescent women. Recent advances in aesthetic techniques have initiated a new pursuit into understanding the cause and treatment of this condition. A recently introduced "roller massage therapy" device, Silhouette, was selected for evaluation in this study. Three p...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/s1090-820x(98)70037-8
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:In the subspecialty of female genital cosmetic procedures, patient satisfaction and quality of life are key outcome measures. As such, valid and reliable patient-reported outcome measures (PROMs) examining these outcomes are essential. OBJECTIVES:The authors sought to identify and scrutinize all PROMs devel...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjz325
更新日期:2020-02-17 00:00:00
abstract:BACKGROUND:Recommendations for venous thromboembolism (VTE) prophylaxis have been published in the plastic surgery literature. However, no comprehensive survey of the overall incidence of VTE among plastic surgery patients has been undertaken. OBJECTIVE:This study was performed to determine the incidence of VTE in pla...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2006.07.003
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Injections are associated with a certain amount of pain, the tolerance of which can vary between individuals. With regard to noninvasive pain control techniques in subcutaneous injections, few studies with adequate levels of evidence and design quality exist to support any specific analgesic method. OBJECTI...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,随机对照试验
doi:10.1093/asj/sjz380
更新日期:2021-01-01 00:00:00