Abstract:
BACKGROUND:The efficacy of adipose-derived stem cells (ASCs) to improve wound healing has been extensively investigated. Unfortunately, no consistent reports have described significant improvements in healing time or outcomes in large-scale clinical trials utilizing human ASCs. Primarily, these studies examined undifferentiated ASCs as opposed to specific cells differentiated from ASCs. OBJECTIVES:The authors sought to examine the properties of fibroblasts differentiated from human ASCs (dFib cells) compared with those of primary dermal fibroblasts. METHODS:ASCs were isolated from healthy female patients, differentiated into dFib cells, and compared with intra-patient primary dermal fibroblasts for morphology, extracellular matrix (ECM) marker expression, and cell migration employing qPCR, western blot, and scratch test assays. RESULTS:De novo differentiated fibroblasts produce higher levels of the healthy ECM markers Elastin, Fibronectin, and Collagen 1 compared with primary fibroblasts. In contrast, dFib cells have reduced expression of the scar tissue markers αSMA, Collagen 3, and MMP-1. Further, dFib cells close scratch defects more quickly than primary dermal fibroblasts (32 ± 12.85 hours vs 64 ± 13.85 hours, P < 0.01) in a scratch test assay. CONCLUSIONS:These data suggest that fibroblasts newly differentiated from human ASCs migrate well and produce a robust ECM, the combination of which may contribute to improved wound healing, and thus should be further investigated.
journal_name
Aesthet Surg Jjournal_title
Aesthetic surgery journalauthors
Gersch RP,Raum JC,Calvert C,Percec Idoi
10.1093/asj/sjz071subject
Has Abstractpub_date
2020-01-01 00:00:00pages
108-117issue
1eissn
1090-820Xissn
1527-330Xpii
5381094journal_volume
40pub_type
杂志文章abstract:BACKGROUND:Adipose and adipose derived regenerative cells (ADRCs) play an increasing role in androgenetic alopecia. OBJECTIVES:The authors sought to evaluate the safety and feasibility of fat grafts enriched with ADRCs in early androgenetic alopecia. METHODS:Seventy-one patients were treated: 16 with Puregraft fat an...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa037
更新日期:2020-05-16 00:00:00
abstract:BACKGROUND:Upper eyelid ectropion occurs as a post-blepharoplasty complication or involution change, and it causes dry eye symptoms that cannot be resolved with conservative management. OBJECTIVES:The aim of this study is to describe the authors' surgical technique of anatomical correction of upper eyelid ectropion, i...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa143
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:In 1971, Ribeiro isolated a segment in the inferior pole of the ptotic breast, nourished by muscular perforating vessels, and moved it cranially to the posterior region of the remaining detached breast tissue, where it was fixed to the pectoral fascia. This maneuver created a flap with autologous implant fun...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjz188
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Surgeons often advise patients with large ptotic breasts to undergo a Wise pattern reduction (WPR) mammaplasty using an inferior pedicle technique with consideration of a free-nipple graft. OBJECTIVE:We describe the Boston modification of the Robertson technique (BMRT), which allows for the elimination of t...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2006.10.010
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:The Plastic Surgery In-Service Training Exam (PSITE) is a multiple-choice examination taken by plastic surgery trainees to provide an assessment of plastic surgery knowledge. OBJECTIVE:The purpose of this study was to evaluate cosmetic questions and determine overlap with national procedural data. METHODS:...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sju151
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:There are many products approved for aesthetic soft tissue augmentation. Despite this abundance, there is limited objective data regarding safety, longevity, and complication rates. Instead, most reports rely on subjective measures to report volume changes and outcomes, making product comparison difficult. ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X12442528
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Although the anatomy of the individual pectoralis major and minor muscles has been described previously, never before has the anatomic relationship between these muscles been investigated. OBJECTIVE:The authors identify the anatomic relationship of the costal origins of the pectoralis major and minor muscle...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X13519643
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Techniques for augmentation mammaplasty commonly involve incisions through at least a portion of the pectoralis major muscle. The effects of implant position and surgical release of the muscle origin have not been thoroughly addressed. OBJECTIVE:In this study the authors report on a group of female athletes...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2004.02.005
更新日期:2004-05-01 00:00:00
abstract::Numerous surgical options for breast reduction have been described, but in the current healthcare environment, efficiency is of the utmost importance. In this Featured Operative Technique, the authors describe an efficient, reproducible, and simple method for minimal to moderate reduction mammaplasty that utilizes a s...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sju011
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Previously, the problem created by overly convex, wide, and robust lower lateral cartilages (LLC) required an external or endonasal approach with delivery. Although this method has proven invaluable, it may not be indicated in all patients with large tips, specifically those with overly convex LLC or with th...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X10391779
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Liposuction is one of the most common aesthetic procedures and a number of options are available to practitioners in terms of surgical technique. One of those options is ultrasound-assisted liposuction (UAL), which has garnered considerable attention in the literature and from patients themselves. Because th...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X10378086
更新日期:2010-09-01 00:00:00
abstract::Gluteal augmentation with fat has become one of the most common cosmetic procedures worldwide. Gluteal augmentation is designed to increase the volume and contour of the gluteal region. Intramuscular lipoinjection has been linked to multiple reports of severe complications, including death due to macro fat embolism (M...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjz151
更新日期:2019-08-22 00:00:00
abstract:BACKGROUND:The pedicled latissimus dorsi (LD) flap serves an important function in breast reconstruction, but its utility is limited by its inability to provide sufficient breast volume. OBJECTIVES:The purpose of this preliminary report was to review the techniques and outcomes of utilizing fat-grafted, volume-enhance...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjv173
更新日期:2016-02-01 00:00:00
abstract:Background:Low satisfaction rates and severe complications are two major limitations for temporal hollowing augmentation using autologous fat grafting. Despite fat compartments in temporal region have been reported, its clinical applied anatomy for fat grafting have not been the subject of studies that show its benefit...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjw257
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:In order for aesthetic surgery to participate in the movement toward evidence-based medicine, a system that quantifies aesthetic outcomes must be developed based on reliable and reproducible data. Previous studies have investigated the attractiveness of averaged (or composite) faces. Data has shown that thes...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X10369370
更新日期:2010-03-01 00:00:00
abstract:Background:Poor wound healing and scar formation remain critical problems in daily surgical practice. Generally, most attention is paid to intra- and postoperative interventions to improve wound healing after surgery, while preoperative interventions remain unsatisfactorily explored. Objectives:In this systematic revi...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjy074
更新日期:2018-10-15 00:00:00
abstract:BACKGROUND:The popularity of genital cosmetic procedures in women is increasing. These procedures are often assumed and promoted as having a positive effect on women's psychological well-being, particularly their self-esteem. Empirical support for these claims is lacking. OBJECTIVES:The aim of this study was to conduc...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,meta分析
doi:10.1093/asj/sjaa038
更新日期:2020-09-14 00:00:00
abstract:BACKGROUND:The acute columellar-labial angle is associated with a long upper lip and can promote disharmony in the adult face. The different alloplastic or biologic materials used to correct this defect all have some disadvantages. OBJECTIVE:The authors propose the concomitant treatment of the acute columellar-labial ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2008.10.003
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:The ears increase in all dimensions over the years (eg, length, helix diameter, lobe length), but the most obvious change is the elongation or ptosis of the lobe. Its correction should be considered a part of facial rejuvenation. OBJECTIVES:The authors presented the surgical procedure they have been utilizi...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjz348
更新日期:2020-07-13 00:00:00
abstract:Background:The previously described Akademikliniken (AK) method is a comprehensive approach to breast augmentation with form stable implants that has been shown to afford favorable outcomes when applied by experienced surgeons. Objectives:To evaluate outcomes of a surgeon newly adopting this method at the beginning of...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjx024
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Temple hollowing with soft tissue volume loss is well recognized in HIV lipoatrophy. Similar changes occur as part of aging, with skeletalization of the orbital rim and clipping of the eyebrow tail. OBJECTIVES:The authors report their initial experience treating temple volume loss and orbitofacial asymmetry...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1177/1090820X10374099
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:The advantages of dual-plane, partially submuscular breast implants are well documented. Standard conversion techniques to dual-plane positioning use marionette sutures and internal capsulorrhaphy sutures from the lower edge of the pectoralis major muscle to the anterior capsule or breast fascia within the s...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2008.12.005
更新日期:2009-01-01 00:00:00
abstract:Background:While recent studies have reported modest to no difference in breast aesthetics for shaped and round implant types in breast augmentations, the anatomy and biomechanics in the setting of breast reconstruction is different. Objectives:Accordingly, we endeavored to evaluate whether two implant types impacted ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjx210
更新日期:2018-05-15 00:00:00
abstract::Wrinkles are just one indicator of facial aging, but an indicator that is of prime importance in our world of facial aesthetics. Wrinkles occur where fault lines develop in aging skin. Those fault lines may be due to skin distortion resulting from facial expression or may be due to skin distortion from mechanical comp...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,评审
doi:10.1093/asj/sjw074
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Paradoxical adipose hyperplasia (PAH) is a rare, moderate-to-severe adverse event associated with cryolipolysis (Coolsculpting, CS). OBJECTIVES:Describe the incidence, diagnoses and treatment of PAH, following CS for nonsurgical fat reduction. METHODS:A multicenter evaluation of all patients who underwent ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjaa310
更新日期:2020-11-20 00:00:00
abstract:BACKGROUND:Lipoatrophy of the face negatively impacts the quality of life and body image of individuals on antiretroviral therapy. Facial fillers can minimize the stigma associated with the human immonodeficiency virus (HIV). OBJECTIVES:In this 5-year follow-up study, the author assessed the safety and efficacy of a p...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章,随机对照试验
doi:10.1093/asj/sjv036
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:The demand for minimally invasive cosmetic procedures has continued to rise, yet few studies have examined this patient population. OBJECTIVES:This study sought to define the demographics, social characteristics, and motivations of patients seeking minimally invasive facial cosmetic procedures. METHODS:A p...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjv094
更新日期:2015-11-01 00:00:00
abstract::Abdominal wall hernias are often diagnosed on clinical examination or encountered intraoperatively during an abdominoplasty. Traditional surgical techniques for abdominoplasty and umbilical hernia repair, when performed simultaneously, can potentially compromise the vascular supply to the umbilicus. The authors descri...
journal_title:Aesthetic surgery journal
pub_type: 信件
doi:10.1016/j.asj.2009.02.012
更新日期:2009-07-01 00:00:00
abstract::The superior pedicle reduction mammaplasty allows most premenopausal women to maintain lactational capabilities and nipple sensation. It is a relatively simple breast reduction technique which, according to the author, achieves an aesthetically pleasing breast shape with no "bottoming out" and a high level of patient ...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1016/j.asj.2005.05.010
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:The American Society for Aesthetic Plastic Surgery (ASAPS) sponsors an annual conference that promotes education, advocacy, and care. There, researchers deliver abstracts as podium and poster presentations. Subsequently, ASAPS encourages submitting these research findings for publication. Yet, many never bec...
journal_title:Aesthetic surgery journal
pub_type: 杂志文章
doi:10.1093/asj/sjw097
更新日期:2017-02-01 00:00:00