Neural correlates of behavioral variation in healthy adults' antisaccade performance.

Abstract:

:Cognitive control is required for correct antisaccade performance. High antisaccade error rates characterize certain psychiatric disorders, but can be highly variable, even among healthy groups. Antisaccade data were acquired from a large sample of healthy undergraduates, and error rate was quantified. Participants who reliably made few errors (good, n = 13) or many errors (poor, n = 13) were recruited back to perform antisaccades during fMRI acquisition. A data-derived model was used to compare signal between good and poor performers during blocks of antisaccade trials. Behaviorally derived regressors were used to compare signal between good and poor performers during correct and error trials. Results show differential activation in middle frontal gyrus and inferior parietal lobule between good and poor performers, suggesting that failure to recruit these top-down control regions corresponds to poor antisaccade performance in healthy young adults.

journal_name

Psychophysiology

journal_title

Psychophysiology

authors

Schaeffer DJ,Amlung MT,Li Q,Krafft CE,Austin BP,Dyckman KA,McDowell JE

doi

10.1111/psyp.12030

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

325-33

issue

4

eissn

0048-5772

issn

1540-5958

journal_volume

50

pub_type

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