Abstract:
:Two known cleistriosides and six known cleistetrosides were synthesized and evaluated for anticancer and antibacterial activity. This study, for the first time, reports anticancer activity and comprehensively the antibacterial activity for these oligosaccharide natural products. In addition, two new unnatural cleistetroside analogues were synthesized and tested. Biological activities for the ten oligosaccharides against B. subtilis were found to range between 4 and >64 µM, and for NCI-H460 human lung cancer epithelial cells between 7.5 and 90.9 µM. Similar activities were found for seven of the oligosaccharides against the NCI panel of 60 cell lines. The degree of acylation and location of the specific acetate groups had significant effects on the anticancer and antibacterial activity of both the cleistriosides and cleistetrosides.
journal_name
ACS Med Chem Lettjournal_title
ACS medicinal chemistry lettersauthors
Shi P,Silva MC,Wang HY,Wu B,Akhmedov NG,Li M,Beuning PJ,O'Doherty GAdoi
10.1021/ml300303gsubject
Has Abstractpub_date
2012-12-13 00:00:00pages
1086-1090issue
12issn
1948-5875journal_volume
3pub_type
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