Abstract:
:Amyotrophic lateral sclerosis (ALS) is a devastating disease with a lifetime risk of ∼1 in 2000. Presently, diagnosis of ALS relies on clinical assessments for upper motor neuron and lower motor neuron deficits in multiple body segments together with a history of progression of symptoms. In addition, it is common to evaluate lower motor neuron pathology in ALS by electromyography. However, upper motor neuron pathology is solely assessed on clinical grounds, thus hindering diagnosis. In the past decade magnetic resonance methods have been shown to be sensitive to the ALS disease process, namely: resting-state connectivity measured with functional MRI, cortical thickness measured by high-resolution imaging, diffusion tensor imaging (DTI) metrics such as fractional anisotropy and radial diffusivity, and more recently magnetic resonance spectroscopy (MRS) measures of gamma-aminobutyric acid concentration. In this present work we utilize independent component analysis to derive brain networks based on resting-state functional magnetic resonance imaging and use those derived networks to build a disease state classifier using machine learning (support-vector machine). We show that it is possible to achieve over 71% accuracy for disease state classification. These results are promising for the development of a clinically relevant disease state classifier. Future inclusion of other MR modalities such as high-resolution structural imaging, DTI and MRS should improve this overall accuracy.
journal_name
Front Hum Neuroscijournal_title
Frontiers in human neuroscienceauthors
Welsh RC,Jelsone-Swain LM,Foerster BRdoi
10.3389/fnhum.2013.00251subject
Has Abstractpub_date
2013-06-10 00:00:00pages
251issn
1662-5161journal_volume
7pub_type
杂志文章abstract::Recent studies suggest changes in religious cognition in a subgroup of patients with Parkinson's disease (PD e.g., Butler et al., 2011). It is unclear whether this deficit extends to both doctrinal and experiential categorization forms of religious cognition. Kapogiannis et al. (2009b) dissociated experiential and doc...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00113
更新日期:2016-03-22 00:00:00
abstract::Rapid aiming movements are typically used to study upper limb motor control and development. Despite the large corpus of work in this area, few studies have examined kinematic manual asymmetries in children who have just started formal schooling and until now, none have characterized how children coordinate their join...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2020.554378
更新日期:2020-09-16 00:00:00
abstract::At present, a healthy diet appears to be one of the suitable strategies in slowing down cognitive decline in the process of aging. A number of evidence-based studies confirm its efficacy, safety, and cost-effectiveness. The aim of this mini review is to evaluate and describe recent randomized clinical and cohort studi...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnhum.2020.00325
更新日期:2020-08-11 00:00:00
abstract::Contemporary philosophical and neurocognitive studies of the self have dissociated two distinct types of self-awareness: a "narrative" self-awareness (NS) weaving together episodic memory, future planning and self-evaluation into a coherent self-narrative and identity, and a "minimal" self-awareness (MS) focused on pr...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2013.00582
更新日期:2013-09-24 00:00:00
abstract::Transient global amnesia (TGA) is a benign memory disorder with etiologies that have been debated for a long time. The prevalence of stressful events before a TGA attack makes it hard to overlook these precipitating factors, given that stress has the potential to organically effect the brain. Cortical spreading depres...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2020.602496
更新日期:2020-12-08 00:00:00
abstract::The Default Mode Network (DMN) is a brain system that mediates internal modes of cognitive activity, showing higher neural activation when one is at rest. Nowadays, there is a lot of interest in assessing functional interactions between its key regions, but in the majority of studies only association of Blood-oxygen-l...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00014
更新日期:2016-02-01 00:00:00
abstract::Acoustic stimuli can cause a transient increase in the excitability of the motor cortex. The current study leverages this phenomenon to develop a method for testing the integrity of auditorimotor integration and the capacity for auditorimotor plasticity. We demonstrate that appropriately timed transcranial magnetic st...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2014.00398
更新日期:2014-06-03 00:00:00
abstract::The autobiographical-self refers to a mental state derived from the retrieval and assembly of memories regarding one's biography. The process of retrieval and assembly, which can focus on biographical facts or personality traits or some combination thereof, is likely to vary according to the domain chosen for an exper...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnhum.2013.00548
更新日期:2013-09-04 00:00:00
abstract::The Implicit Association Test (IAT) is a reaction time based categorization task that measures the differential associative strength between bipolar targets and evaluative attribute concepts as an approach to indexing implicit beliefs or biases. An open question exists as to what exactly the IAT measures, and here EEG...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2015.00605
更新日期:2015-11-24 00:00:00
abstract::Gait and balance impairments are frequently considered as the most significant concerns among individuals suffering from neurological diseases. Robot-assisted gait training (RAGT) has shown to be a promising neurorehabilitation intervention to improve gait recovery in patients following stroke or brain injury by poten...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnhum.2019.00172
更新日期:2019-06-05 00:00:00
abstract::[This corrects the article on p. 386 in vol. 9, PMID: 26175682.]. ...
journal_title:Frontiers in human neuroscience
pub_type: 已发布勘误
doi:10.3389/fnhum.2015.00458
更新日期:2015-08-19 00:00:00
abstract::Neurofibromatosis type I (NF1) is a neurogenetic disease marked by multiple cognitive and learning problems. Genetic variants may account for phenotypic variance in NF1. Here, we investigated the association between the catechol-O-methyltransferase (COMT) Val(158)Met polymorphism and working memory and arithmetic perf...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00334
更新日期:2016-07-05 00:00:00
abstract::Disambiguation refers to the ability to interpret ambiguous information in a sensible way, which is important in an ever-changing external environment. Disambiguation occurs when prior knowledge is given before an ambiguous stimulus is presented. For example, labeling a series of meaningless blobs as a "human body" ca...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2013.00501
更新日期:2013-08-30 00:00:00
abstract::The neural basis of progress monitoring has received relatively little attention compared to other sub-processes that are involved in goal directed behavior such as motor control and response inhibition. Studies of error-monitoring have identified the dorsal anterior cingulate cortex (dACC) as a structure that is sens...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2014.00688
更新日期:2014-09-10 00:00:00
abstract::To investigate the neural systems that contribute to the formation of complex, self-relevant emotional memories, dedicated fans of rival college basketball teams watched a competitive game while undergoing functional magnetic resonance imaging (fMRI). During a subsequent recognition memory task, participants were show...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2010.00034
更新日期:2010-05-18 00:00:00
abstract::Face processing involves a complex, multimodal brain network. While visual-perceptual face patches in posterior parts of the brain have been studied for over a decade, the existence and properties of face-selective regions in orbitofrontal cortex (OFC) is a relatively new area of research. While regions of OFC are imp...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00279
更新日期:2016-06-14 00:00:00
abstract::The brain integrates multisensory inputs coming from the body (i.e., proprioception, tactile sensations) and the world that surrounds it (e.g., visual information). In this way, it is possible to build supra-modal and coherent mental representations of our own body, in order to process sensory events and to plan movem...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2017.00617
更新日期:2018-01-04 00:00:00
abstract::Accurate estimates of the time-to-contact (TTC) of approaching objects are crucial for survival. We used an ecologically valid driving simulation to compare and contrast the neural substrates of egocentric (head-on approach) and allocentric (lateral approach) TTC tasks in a fully factorial, event-related fMRI design. ...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/neuro.09.010.2008
更新日期:2008-09-13 00:00:00
abstract::Older adults have difficulties in navigating unfamiliar environments and updating their wayfinding behavior when faced with blocked routes. This decline in navigational capabilities has traditionally been ascribed to memory impairments and dysexecutive function, whereas the impact of visual aging has often been overlo...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2020.552111
更新日期:2020-10-29 00:00:00
abstract::Real-world memories involve the integration of multiple events across time, yet the mechanisms underlying this integration is unknown. Recent rodent studies show that distinct memories encoded within a few hours, but not several days, share a common neural ensemble, and a common fate whereby later fear conditioning ca...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2019.00315
更新日期:2019-09-13 00:00:00
abstract::A RECENT OPINION ARTICLE (NEURAL OSCILLATIONS IN SPEECH: do not be enslaved by the envelope. Obleser et al., 2012) questions the validity of a class of speech perception models inspired by the possible role of neuronal oscillations in decoding speech (e.g., Ghitza, 2011; Giraud and Poeppel, 2012). The authors criticiz...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2012.00340
更新日期:2013-01-04 00:00:00
abstract::Background: Extracranial signals are the main source of noise in functional near-infrared spectroscopy (fNIRS) as light is penetrating the cortex but also skin and muscles of the head. Aim: Here we performed three experiments to investigate the contamination of fNIRS measurements by temporal muscle activity. Material ...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2017.00456
更新日期:2017-09-15 00:00:00
abstract::Previous studies using hierarchical figures (where a large global shape is composed of a series of smaller local shapes) suggest that performance is better for local features presented in the right relative to left visual field, whereas the opposite pattern is observed for global features. However, these previous stud...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2012.00028
更新日期:2012-02-22 00:00:00
abstract::The year 2009 marked the 100th anniversary of the publication of the famous brain map of Korbinian Brodmann. Although a "classic" guide to microanatomical parcellation of the cerebral cortex, it is - from today's state-of-the-art neuroimaging perspective - problematic to use Brodmann's map as a structural guide to fun...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2011.00019
更新日期:2011-02-18 00:00:00
abstract::In light of growing concerns about opioid analgesics, developing new non-pharmacologic pain control techniques has become a high priority. Adjunctive virtual reality can help reduce acute pain during painful medical procedures. However, for some especially painful medical procedures such as burn wound cleaning, clinic...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2019.00467
更新日期:2020-01-23 00:00:00
abstract::Behavioral, neuropsychological, and neuroimaging data support the idea that numbers are represented along a mental number line (MNL), an analogical, visuospatial representation of number magnitude. The MNL is left-to-right oriented in Western cultures, with small numbers on the left and larger numbers on the right. Le...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2012.00023
更新日期:2012-02-20 00:00:00
abstract::In their attempt to define discrete subcomponents of intentionality, Brass and Haggard (2008) proposed their What, When, and Whether model (www-model) which postulates that the content, the timing and the possibility of generating an action can be partially independent both at the cognitive level and at the level of t...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2017.00238
更新日期:2017-05-17 00:00:00
abstract::Individuals differ substantially in their susceptibility to distraction by irrelevant visual information. Previous research has uncovered how individual variability in the goal-driven component of attentional control influences distraction, yet it remains unknown whether other sources of variability between individual...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2012.00012
更新日期:2012-02-15 00:00:00
abstract::Behavioral and event-related potential (ERP) studies on aphasia patients showed that lexical information is not lost but rather its integration into the working context is hampered. Studies have been conducted on the processing of sentence-level information (meaningful versus meaningless) and of word-level information...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00684
更新日期:2017-01-10 00:00:00
abstract::Nearly half of all mild brain injury sufferers experience long-term cognitive impairment, so an important goal in rehabilitation is to address their multiple cognitive deficits to help them return to prior levels of functioning. Cognitive training, or the use of repeated mental exercises to enhance cognition, is one r...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2020.00229
更新日期:2020-06-24 00:00:00