Abstract：
OBJECTIVE:The aim of this study is to reveal inhibitory effect of gamma knife irradiation on angiogenesis of meningiomas using rat corneal angiogenesis assay. METHODS:A total of 72 rats were divided into three preliminary groups. Each group, consisting of 24 rats, was implanted to World Health Organization (WHO) grade I (typical), grade II (atypical), and grade III (malignant) meningioma. Each of these three preliminary groups of 24 rats, were then divided into four subgroups, each consisting of 6 rats and subsequently irradiated by gamma knife with dose prescriptions of 0, 14, 18, and 22 Gy. The numbers of vessels that developed around the micropockets of the corneas were counted and photographed on days 5, 10, 15, and 20. RESULTS:For WHO grade I meningiomas, 18 and 22 Gy doses (P < 0.001), and for grade II meningiomas, the 22-Gy (P = 0.021) dose were found to inhibit tumor-induced angiogenesis compared with the radiation-free control group. For grade III meningiomas, there was no statistical difference with the control group in any of the doses applied. Our findings demonstrate that gamma knife irradiation may suppress the angiogenic activity of WHO grades I and II meningiomas but not of the grade III meningiomas. CONCLUSIONS:For the first time, this study provides an experimental data to show the antiangiogenic effect of gamma knife irradiation on meningiomas.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Kılıç K,Avsar T,Akgün E,Özkan A,Toktaş ZO,Şeker A,Kılıç Tdoi
10.1016/j.wneu.2013.06.021subject
Has Abstractpub_date
2013-11-01 00:00:00pages
598-604issue
5eissn
1878-8750issn
1878-8769pii
S1878-8750(13)00768-7journal_volume
80pub_type
杂志文章abstract：BACKGROUND:The neurosurgical boot camp has been fully incorporated into U.S. postgraduate education. This is the first implementation of the neurosurgical boot in a developing country. To advance neurosurgical education, we developed a similar boot camp program, in collaboration with Bolivian neurosurgeons, to determin...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.05.046
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Meningiomas are more prevalent with increasing age, and there is no general consensus of surgical management for this group of tumors. The role of resection and the predictors of recurrence of meningiomas in elderly patients have not been well established. The authors reviewed their experience of surgical re...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.02.066
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:Muscle injury is inevitable during surgical exposure of the spine. This study compared paraspinal muscle injury after 4 surgical techniques: microdiscectomy (MD), percutaneous endoscopic lumbar discectomy (PELD), percutaneous endoscopic interlaminar discectomy (PEID), unilateral biportal endoscopic discectomy...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.05.085
更新日期：2018-08-01 00:00:00
abstract：OBJECTIVE:Aneurysm surgery demands precise spatial understanding of the vascular anatomy and its surroundings. We report on a decade of experience planning clipping procedures preoperatively in a virtual reality (VR) workstation and present outcomes with respect to mortality, morbidity, and aneurysm occlusion rate. ME...
journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.wneu.2016.08.124
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVE:Currently, no spinal classification system has achieved universal acceptance. Therefore, it is important to choose a reliable classification within clinical practice. The objective of this study was to determine and compare the intraobserver and interobserver agreement of the Load Sharing Classification (LSC)...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.04.138
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Since the 1980s, numerous operations have replaced posterior lumbar interbody fusion (PLIF) with human bone. These operations often involve expensive implants and complex procedures. Escalating expenditures in lumbar fusion surgery warrant re-evaluation of classical PLIF with allogeneic ilium and without ins...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.03.210
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:We retrospectively assessed the surgical outcomes of transitional meningioma (TM) in a relatively large series to evaluate the long-term outcomes and propose an appropriate treatment strategy for TM. METHODS:We included 298 patients who had undergone surgery from September 2011 to August 2013. The clinical c...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.03.104
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:The nomenclature adopted for endoscopic medial maxillectomies (EMMs) is exceedingly heterogeneous. The aim of this study was to objectively measure surgical exposure in a preclinical anatomic setting to validate a classification for modular EMMs. MATERIALS AND METHODS:Computed tomography was used to scan 6 ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.12.094
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Subcallosal artery (ScA) infarction is a well-recognized but uncommon complication of surgical treatment of anterior communicating artery aneurysms. CASE DESCRIPTION:An elderly man presented with massive subarachnoid hemorrhage due to left posterior communicating artery aneurysm with thick clots in the ante...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.07.052
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:For several variants of quasi-moyamoya disease, cerebral revascularization treatment is as effective as it is for the more typical cases of moyamoya disease. Here, we examined a case of moyamoya disease with concurrent congenital rubella syndrome (CRS). On the basis of concurrent underlying disease, the pati...
journal_title：World neurosurgery
pub_type：
doi：10.1016/j.wneu.2020.02.081
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Os odontoideum is a smooth, independent ossicle separated from a hypoplastic odontoid process located cranially in the expected position of the odontoid tip. The pathogenesis of os odontoideum remains controversial, and several etiological theories have been suggested for congenital, developmental, and traum...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.07.019
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Brain aneurysms (BAs) are the most common intracranial vascular condition, with an overall incidence of 1%-2%. Among the common causes of their initial formation and growth, the role of radiation therapy (RT) has been reported in some studies. The aim of the present study is to report the most relevant featu...
journal_title：World neurosurgery
pub_type： 杂志文章,评审
doi：10.1016/j.wneu.2019.09.157
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:It was believed that Chiari type II malformation (CM-II) was always present in a myelomeningocele (MMC). In fact, it is associated in about 80% of cases. Improvement of the hindbrain herniation after prenatal closure of MMC has challenged the idea that this condition was irreversible. Only 2 studies report as...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.08.152
更新日期：2017-12-01 00:00:00
abstract：:Transforaminal endoscopic spine surgery is an emerging technique in spine surgery, but it offers 2 distinct challenges to spine surgeons looking to adopt it: 1) targeting spine pathology and 2) understanding the endoscopic anatomy visualized through the endoscope. Intraoperative computed tomography (CT)-guided navigat...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.03.188
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:Work hour restrictions and current quality, financial, and legal concerns have reduced resident operative volume and autonomy. Although laboratory (cadaveric or animal) dissection has a rich history in neurosurgery, its current role in resident training is unclear. Recent literature suggests educators have lo...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2014.05.028
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:There has been no precise guide for treatment management of aneurysmal subarachnoid hemorrhage (aSAH) based on the patient's age and treatment method. This study clarifies each risk management for aSAH according to age and treatment method listed in a nationwide database. METHODS:We compared 2 groups of pati...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.09.015
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Cement leakage is the most common complication of vertebroplasty and kyphoplasty. So far, the reported risk factors remain conflicting because of limited data and lack of uniform measurement and evaluation. Here, we performed a systematic review and meta-analysis of potential risk factors for cement leakage ...
journal_title：World neurosurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.wneu.2017.01.124
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Lumbar arthrodesis is a surgical option for treatment of lumbar pathologies. Stability of the spinal construct partly depends on load-bearing support from back muscles. Despite the role of the psoas muscle in upright spinal stabilization, data describing its clinical significance are scarce. We evaluated the...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2015.11.022
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:The clinical decision whether and when to resume antithrombotics in patients with chronic subdural hematomas (CSDH) postoperatively is limited by a lack of quality evidence exploring this topic. Our study aims to assess the available evidence of patient complication outcomes, specifically hemorrhagic and thr...
journal_title：World neurosurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.wneu.2017.10.091
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:We explored the external ventricular drain (EVD) practices in Thailand. METHODS:We performed a survey-based study to describe EVD insertion, maintenance, quality improvement (QI) practices, and incidence of EVD infection. RESULTS:The study included 58 of 101 hospitals contacted (57.4% response rate), with ≥...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.02.144
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:This meta-analysis of published randomized controlled trials (RCTs) aimed to investigate the efficacy and safety of endovascular therapy (ET) for patients with acute ischemic stroke. METHODS:The summary relative risks (RRs) with corresponding 95% confidence intervals were calculated to measure the effectiven...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.07.156
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:The purpose of the present study was to assess for gender-based differences in the usage and cost of maximal nonoperative therapy before spinal fusion surgery in patients with symptomatic lumbar stenosis or spondylolisthesis. METHODS:A large insurance database was queried for patients with symptomatic lumbar...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.08.131
更新日期：2018-12-01 00:00:00
abstract：:Gross total resection of large intracranial meningiomas (LIMs) can be challenging and cause significant morbidity and mortality. The aim of this systematic review is to determine the clinical effectiveness and safety of stereotactic radiosurgery (SRS) either as primary or adjuvant therapy for LIMs with tumors ≥2.5 cm ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.06.064
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:To analyze the clinical impact of extubation failure (EF) in patients with good-grade subarachnoid hemorrhage (SAH), in whom a good clinical course usually is expected. PATIENTS AND METHODS:We reviewed the clinical data from 141 patients with SAH and 1) initial Hunt & Hess grade 1-3; 2) induction of general ...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.06.027
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:The petrosquamosal sinus (PSS) is clinically important as it represents a potential hemorrhagic hazard during neurosurgical procedures. This double-approach radiologic study and meta-analysis aimed to assess the imaging characteristics of the PSS on computed tomography (CT) and systematically analyze its prev...
journal_title：World neurosurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.wneu.2017.12.132
更新日期：2018-03-01 00:00:00
abstract：INTRODUCTION:Vertebral compression fractures are a common clinical occurrence in elderly individuals with osteoporosis. No current evidence exists on risk factors and clinical impact of discharge to inpatient (IP) care facility after vertebral augmentation procedures. MATERIALS AND METHODS:The 2012-2014 American Colle...
journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.wneu.2018.06.221
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:The benefit of endovascular treatment (EVT) for acute ischemic stroke patients with mild deficits is unknown. We sought to evaluate the natural history of patients with a low National Institute of Health Stroke Score (NIHSS) and an intracranial occlusion. METHODS:We included patients with a computed tomogra...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2020.09.080
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Traumatic posterior fossa subdural hemorrhage (SDH) is a rare subtype of subdural hemorrhage in head injuries. Existing data on its pathophysiology and outcome are currently limited; therefore, the condition is not yet fully understood. The present study aimed to determine the incidence, outcome, and prognos...
journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.wneu.2018.07.191
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:In vascular reconstructive surgery, intraoperative confirmation of patency is performed by angiography, Doppler, or indocyanine videoangiography, but it is sometimes insufficient. OBJECTIVE:Using the FLOW 800 system (Carl Zeiss, Oberkochen, Germany), we confirmed patency in a quantitative relative evaluatio...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2017.11.072
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Although reoperation likely confers survival benefit for glioblastoma, whether the extent of resection (EOR) of the reoperation affects survival outcome has yet to be thoroughly evaluated in the current temozolomide (TMZ) era. The aim of this meta-analysis was to pool the current literature and evaluate the ...
journal_title：World neurosurgery
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.wneu.2019.03.250
更新日期：2019-07-01 00:00:00
