Eculizumab for atypical hemolytic uremic syndrome in pregnancy.

Abstract:

BACKGROUND:Atypical hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy often caused by mutations in complement genes. During pregnancy, disease outcome is poor both for mother and fetus. Since 2009, the humanized monoclonal antibody eculizumab has been successfully used in the treatment of atypical HUS in nonpregnant patients. CASE:A 26-year-old woman with a homozygous mutation in complement factor H developed a relapse of atypical HUS at 17 weeks of gestation in her first pregnancy. Because the disease remained active despite multiple plasma exchanges, eculizumab was started at 26 weeks of gestation. It was well tolerated and has led to remission and to the delivery of a healthy neonate. CONCLUSION:Eculizumab may be useful for the treatment of atypical HUS during pregnancy.

journal_name

Obstet Gynecol

authors

Ardissino G,Wally Ossola M,Maria Baffero G,Rigotti A,Cugno M

doi

10.1097/AOG.0b013e31828e2612

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

487-489

issue

2 Pt 2

eissn

0029-7844

issn

1873-233X

pii

00006250-201308002-00021

journal_volume

122

pub_type

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