Abstract:
:Genetic incompatibilities are commonly observed between hybridizing species. Although this type of isolating mechanism has received considerable attention, we have few examples describing how genetic incompatibilities evolve. We investigated the evolution of two loci involved in a classic example of a Bateson-Dobzhansky-Muller (BDM) incompatibility in Xiphophorus, a genus of freshwater fishes from northern Central America. Hybrids develop a lethal melanoma due to the interaction of two loci, an oncogene and its repressor. We cloned and sequenced the putative repressor locus in 25 Xiphophorus species and an outgroup species, and determined the status of the oncogene in those species from the literature. Using phylogenetic analyses, we find evidence that a repeat region in the proximal promoter of the repressor is coevolving with the oncogene. The data support a hypothesis that departs from the standard BDM model: it appears the alleles that cause the incompatibilities have coevolved simultaneously within lineages, rather than in allopatric or temporal isolation.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Scarpino SV,Hunt PJ,Garcia-De-Leon FJ,Juenger TE,Schartl M,Kirkpatrick Mdoi
10.1093/molbev/mst127subject
Has Abstractpub_date
2013-10-01 00:00:00pages
2302-10issue
10eissn
0737-4038issn
1537-1719pii
mst127journal_volume
30pub_type
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