Human migration, diversity and disease association: a convergent role of established and emerging DNA markers.


:With the gradual development of intelligence, human got curious to know his origin and evolutionary background. Historical statements and anthropological findings were his primary tool for solving the puzzles of his own origin, until came the golden era of molecular markers which took no time to prove it's excellence in unveiling answers to the questions regarding the migration pattern of human across different geographical regions. As a bonus these markers proved very much beneficial in solving criminal offenses and in understanding the etiology of many dreaded diseases and to design their prevention. In this review, we have aimed to throw light on some of the promising molecular markers which are very much in application now-a-days for not only understanding the evolutionary background and ancient migratory routes of humans but also in the field of forensics and human health.


Front Genet


Frontiers in genetics


Guha P,Srivastava SK,Bhattacharjee S,Chaudhuri TK




Has Abstract


2013-08-09 00:00:00








  • Microrefugia and species persistence in the Galápagos highlands: a 26,000-year paleoecological perspective.

    abstract::The Galápagos Islands are known to have experienced significant drought during the Quaternary. The loss of mesophytic upland habitats has been suggested to underlie the relatively lower endemism of upland compared with lowland plant assemblages. A fossil pollen record spanning the last 26,000 years from an upland bog ...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Collins AF,Bush MB,Sachs JP

    更新日期:2013-12-03 00:00:00

  • Sulfite Alters the Mitochondrial Network in Molybdenum Cofactor Deficiency.

    abstract::Molybdenum cofactor deficiency (MoCD) is an autosomal recessive disorder belonging to the large family of inborn errors in metabolism. Patients typically present with encephalopathy and seizures early after birth and develop severe neurodegeneration within the first few weeks of life. The main pathomechanism underlyin...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Mellis AT,Roeper J,Misko AL,Kohl J,Schwarz G

    更新日期:2021-01-07 00:00:00

  • Genetic Susceptibility to Neurodegeneration in Amazon: Apolipoprotein E Genotyping in Vulnerable Populations Exposed to Mercury.

    abstract::Human exposure to mercury is a serious problem of public health in Amazon. As in other vulnerable populations throughout the world, Amazonian riverine populations are chronically exposed to this metal and some symptoms of mercury intoxication were already detected in these populations. However, studies on the genetic ...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Arrifano GPF,Martín-Doimeadios RCR,Jiménez-Moreno M,Fernández-Trujillo S,Augusto-Oliveira M,Souza-Monteiro JR,Macchi BM,Alvarez-Leite JI,do Nascimento JLM,Amador MT,Santos S,Ribeiro-Dos-Santos Â,Silva-Pereira LC,Oriá RB,Cresp

    更新日期:2018-07-27 00:00:00

  • Estimation of Gene Expression at Isoform Level from mRNA-Seq Data by Bayesian Hierarchical Modeling.

    abstract::mRNA-Seq is a precise and highly reproducible technique for measurement of transcripts levels and yields sequence information of a transcriptome at a single nucleotide base-level thus enabling us to determine splice junctions and alternative splicing events with high confidence. Often analysis of mRNA-Seq data does no...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Bhattacharjee M,Gupta R,Davuluri RV

    更新日期:2012-11-27 00:00:00

  • A Near-Chromosome Level Genome Assembly of Anopheles stephensi.

    abstract::Malaria remains a major healthcare risk to growing economies like India, and a chromosome-level reference genome of Anopheles stephensi is critical for successful vector management and understanding of vector evolution using comparative genomics. We report chromosome-level assemblies of an Indian strain, STE2, and a P...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Chida AR,Ravi S,Jayaprasad S,Paul K,Saha J,Suresh C,Whadgar S,Kumar N,Rao K R,Ghosh C,Choudhary B,Subramani S,Srinivasan S

    更新日期:2020-11-16 00:00:00

  • The functional consequences of relative substrate specificity in complex biochemical systems.

    abstract::A biochemical activity, that is, enzymatic reaction or molecular interaction, frequently involves a molecule, for example, an enzyme, capable of interacting with numerous substrates or partners. Specificity is a fundamental property of biochemical activities, and relative specificity refers to the situation whereby a ...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Zeng Y

    更新日期:2011-09-20 00:00:00

  • Recent Advances of Deep Learning in Bioinformatics and Computational Biology.

    abstract::Extracting inherent valuable knowledge from omics big data remains as a daunting problem in bioinformatics and computational biology. Deep learning, as an emerging branch from machine learning, has exhibited unprecedented performance in quite a few applications from academia and industry. We highlight the difference a...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章,评审


    authors: Tang B,Pan Z,Yin K,Khateeb A

    更新日期:2019-03-26 00:00:00

  • DNA Methylation Patterns of a Satellite Non-coding Sequence - FA-SAT in Cancer Cells: Its Expression Cannot Be Explained Solely by DNA Methylation.

    abstract::Satellite ncRNAs are emerging as key players in cell and cancer pathways. Cancer-linked satellite DNA hypomethylation seems to be responsible for the overexpression of satellite non-coding DNAs in several tumors. FA-SAT is the major satellite DNA of Felis catus and recently, its presence and transcription was describe...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Ferreira D,Escudeiro A,Adega F,Chaves R

    更新日期:2019-02-12 00:00:00

  • Increased Expression of TICRR Predicts Poor Clinical Outcomes: A Potential Therapeutic Target for Papillary Renal Cell Carcinoma.

    abstract::Background: Papillary renal cell carcinoma (PRCC), although the second-most common type of renal cell carcinoma, still lacks specific biomarkers for diagnosis, treatment, and prognosis. TopBP1-interacting checkpoint and replication regulator (TICRR) is a DNA replication initiation regulator upregulated in various canc...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Xia S,Lin Y,Lin J,Li X,Tan X,Huang Z

    更新日期:2021-01-11 00:00:00

  • The metamorphosis of amphibian toxicogenomics.

    abstract::Amphibians are important vertebrates in toxicology often representing both aquatic and terrestrial forms within the life history of the same species. Of the thousands of species, only two have substantial genomics resources: the recently published genome of the Pipid, Xenopus (Silurana) tropicalis, and transcript info...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Helbing CC

    更新日期:2012-03-14 00:00:00

  • Target of Rapamycin Regulates Genome Methylation Reprogramming to Control Plant Growth in Arabidopsis.

    abstract::DNA methylation is an indispensable epigenetic modification that dynamically regulates gene expression and genome stability during cell growth and development processes. The target of rapamycin (TOR) has emerged as a central regulator to regulate many fundamental cellular metabolic processes from protein synthesis to ...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Zhu T,Li L,Feng L,Mo H,Ren M

    更新日期:2020-03-03 00:00:00

  • Interaction of Scientific Knowledge and Implementation of the Multilateral Environment Agreements in Relation to Digital Sequence Information on Genetic Resources.

    abstract::Integration of scientific knowledge into negotiations of the Multilateral Environment Agreements (MEAs) is crucial to effective implementation of those MEAs by ensuring uniformity in their terminology. Recent innovations in the field of biotechnology provoked a discussion over "Digital Sequence Information" (DSI) in f...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Kobayashi K,Domon E,Watanabe KN

    更新日期:2020-09-16 00:00:00

  • Aberrant epigenetic regulators control expansion of human CD34+ hematopoietic stem/progenitor cells.

    abstract::Transcription is a tightly regulated process ensuring the proper expression of numerous genes regulating all aspects of cellular behavior. Transcription factors regulate multiple genes including other transcription factors that together control a highly complex gene network. The transcriptional machinery can be "hijac...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章,评审


    authors: Faridi F,Ponnusamy K,Quagliano-Lo Coco I,Chen-Wichmann L,Grez M,Henschler R,Wichmann C

    更新日期:2013-11-28 00:00:00

  • Genomic Analysis Revealed New Oncogenic Signatures in TP53-Mutant Hepatocellular Carcinoma.

    abstract::The TP53 gene is the most commonly mutated gene in human cancers and mutations in TP53 have been shown to have either gain-of-function or loss-of-function effects. Using the data generated by The Cancer Genome Atlas, we sought to define the spectrum of TP53 mutations in hepatocellular carcinomas (HCCs) and their assoc...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Kancherla V,Abdullazade S,Matter MS,Lanzafame M,Quagliata L,Roma G,Hoshida Y,Terracciano LM,Ng CKY,Piscuoglio S

    更新日期:2018-02-02 00:00:00

  • The Value of Mouse Models of Rare Diseases: A Spanish Experience.

    abstract::Animal models are invaluable for biomedical research, especially in the context of rare diseases, which have a very low prevalence and are often complex. Concretely mouse models provide key information on rare disease mechanisms and therapeutic strategies that cannot be obtained by using only alternative methods, and ...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Murillo-Cuesta S,Artuch R,Asensio F,de la Villa P,Dierssen M,Enríquez JA,Fillat C,Fourcade S,Ibáñez B,Montoliu L,Oliver E,Pujol A,Salido E,Vallejo M,Varela-Nieto I

    更新日期:2020-10-14 00:00:00

  • Genome Scan for Parent-of-Origin QTL Effects on Bovine Growth and Carcass Traits.

    abstract::Parent-of-origin effects (POE) such as genomic imprinting influence growth and body composition in livestock, rodents, and humans. Here, we report the results of a genome scan to detect quantitative trait loci (QTL) with POE on growth and carcass traits in Angus × Brahman cattle crossbreds. We identified 24 POE-QTL on...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Imumorin IG,Kim EH,Lee YM,De Koning DJ,van Arendonk JA,De Donato M,Taylor JF,Kim JJ

    更新日期:2011-07-12 00:00:00

  • Selection and validation of potato candidate genes for maturity corrected resistance to Phytophthora infestans based on differential expression combined with SNP association and linkage mapping.

    abstract::Late blight of potato (Solanum tuberosum L.) caused by the oomycete Phytophthora infestans (Mont.) de Bary, is one of the most important bottlenecks of potato production worldwide. Cultivars with high levels of durable, race unspecific, quantitative resistance are part of a solution to this problem. However, breeding ...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Muktar MS,Lübeck J,Strahwald J,Gebhardt C

    更新日期:2015-09-23 00:00:00

  • Function and evolution of microRNAs in eusocial Hymenoptera.

    abstract::The emergence of eusociality ("true sociality") in several insect lineages represents one of the most successful evolutionary adaptations in the animal kingdom in terms of species richness and global biomass. In contrast to solitary insects, eusocial insects evolved a set of unique behavioral and physiological traits ...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Søvik E,Bloch G,Ben-Shahar Y

    更新日期:2015-05-27 00:00:00

  • Phylogeography and Population Genetics of Vicugna vicugna: Evolution in the Arid Andean High Plateau.

    abstract::The vicuña (Vicugna vicugna) is the most representative wild ungulate of the high Andes of South America with two recognized morphological subspecies, V. v. mensalis in the north and V. v. vicugna in the south of its distribution. Current vicuña population size (460,000-520,000 animals) is the result of population rec...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: González BA,Vásquez JP,Gómez-Uchida D,Cortés J,Rivera R,Aravena N,Chero AM,Agapito AM,Varas V,Wheleer JC,Orozco-terWengel P,Marín JC

    更新日期:2019-06-06 00:00:00

  • Quantifying Gene Essentiality Based on the Context of Cellular Components.

    abstract::Different genes have their protein products localized in various subcellular compartments. The diversity in protein localization may serve as a gene characteristic, revealing gene essentiality from a subcellular perspective. To measure this diversity, we introduced a Subcellular Diversity Index (SDI) based on the Gene...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Jia K,Zhou Y,Cui Q

    更新日期:2020-01-21 00:00:00

  • The Impact of CYP3A4*22 on Tacrolimus Pharmacokinetics and Outcome in Clinical Practice at a Single Kidney Transplant Center.

    abstract::Background: Although there is evidence that the CYP3A4*22 variant should be considered in tacrolimus dosing in renal transplantation, its impact beyond tacrolimus dose requirements remains controversial. Methods: In a cohort of 121 kidney transplant recipients, we analyzed the CYP3A4*1B, CYP3A4*22, and CYP3A5*3 allele...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Abdel-Kahaar E,Winter S,Tremmel R,Schaeffeler E,Olbricht CJ,Wieland E,Schwab M,Shipkova M,Jaeger SU

    更新日期:2019-09-26 00:00:00

  • Novel Compound Heterozygous Variants of ETHE1 Causing Ethylmalonic Encephalopathy in a Chinese Patient: A Case Report.

    abstract::Ethylmalonic encephalopathy (EE) is a very rare autosomal recessive metabolic disorder that primarily affects children. Less than one hundred EE patients have been diagnosed worldwide. The clinical manifestations include chronic diarrhea, petechiae, orthostatic acrocyanosis, psychomotor delay and regression, seizures,...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Chen X,Han L,Yao H

    更新日期:2020-04-17 00:00:00

  • Exome Analysis Identified Novel Homozygous Splice Site Donor Alteration in NT5C2 Gene in a Saudi Family Associated With Spastic Diplegia Cerebral Palsy, Developmental Delay, and Intellectual Disability.

    abstract::Hereditary spastic paraplegias (HSPs) is a rare heterogeneous group of neurodegenerative diseases, with upper and lower limb spasticity motor neuron disintegration leading to paraplegias. NT5C2 gene (OMIM: 600417) encode a hydrolase enzyme 5'-nucleotidase, cytosolic II play an important role in maintaining the balance...

    journal_title:Frontiers in genetics



    authors: Naseer MI,Abdulkareem AA,Pushparaj PN,Bibi F,Chaudhary AG

    更新日期:2020-02-21 00:00:00

  • Diverse developmental disorders from the one ring: distinct molecular pathways underlie the cohesinopathies.

    abstract::The multi-subunit protein complex, cohesin, is responsible for sister chromatid cohesion during cell division. The interaction of cohesin with DNA is controlled by a number of additional regulatory proteins. Mutations in cohesin, or its regulators, cause a spectrum of human developmental syndromes known as the "cohesi...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Horsfield JA,Print CG,Mönnich M

    更新日期:2012-09-12 00:00:00

  • SUMO-Targeted Ubiquitin Ligases (STUbLs) Reduce the Toxicity and Abnormal Transcriptional Activity Associated With a Mutant, Aggregation-Prone Fragment of Huntingtin.

    abstract::Cell viability and gene expression profiles are altered in cellular models of neurodegenerative disorders such as Huntington's Disease (HD). Using the yeast model system, we show that the SUMO-targeted ubiquitin ligase (STUbL) Slx5 reduces the toxicity and abnormal transcriptional activity associated with a mutant, ag...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Ohkuni K,Pasupala N,Peek J,Holloway GL,Sclar GD,Levy-Myers R,Baker RE,Basrai MA,Kerscher O

    更新日期:2018-09-18 00:00:00

  • Network Diffusion-Based Prioritization of Autism Risk Genes Identifies Significantly Connected Gene Modules.

    abstract::Autism spectrum disorder (ASD) is marked by a strong genetic heterogeneity, which is underlined by the low overlap between ASD risk gene lists proposed in different studies. In this context, molecular networks can be used to analyze the results of several genome-wide studies in order to underline those network regions...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Mosca E,Bersanelli M,Gnocchi M,Moscatelli M,Castellani G,Milanesi L,Mezzelani A

    更新日期:2017-09-25 00:00:00

  • Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example.

    abstract:PURPOSE:Genetic risk assessment is becoming an important component of clinical decision-making. Genetic Risk Scores (GRSs) allow the composite assessment of genetic risk in complex traits. A technically and clinically pertinent question is how to most easily and effectively combine a GRS with an assessment of clinical ...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Goldstein BA,Knowles JW,Salfati E,Ioannidis JP,Assimes TL

    更新日期:2014-08-01 00:00:00

  • Redundancy of the genetic code enables translational pausing.

    abstract::The codon redundancy ("degeneracy") found in protein-coding regions of mRNA also prescribes Translational Pausing (TP). When coupled with the appropriate interpreters, multiple meanings and functions are programmed into the same sequence of configurable switch-settings. This additional layer of Ontological Prescriptiv...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章,评审


    authors: D'Onofrio DJ,Abel DL

    更新日期:2014-05-20 00:00:00

  • Y-STR Haplogroup Diversity in the Jat Population Reveals Several Different Ancient Origins.

    abstract::The Jats represent a large ethnic community that has inhabited the northwest region of India and Pakistan for several thousand years. It is estimated the community has a population of over 123 million people. Many historians and academics have asserted that the Jats are descendants of Aryans, Scythians, or other ancie...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Mahal DG,Matsoukas IG

    更新日期:2017-09-20 00:00:00

  • Potential for Genetic Improvement of the Main Slaughter Yields in Common Carp With in vivo Morphological Predictors.

    abstract::Common carp is a major aquaculture species worldwide, commonly sold alive but also as processed headless carcass or filets. However, recording of processing yields is impossible on live breeding candidates, and alternatives for genetic improvement are either sib selection based on slaughtered fish, or indirect selecti...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章


    authors: Prchal M,Bugeon J,Vandeputte M,Kause A,Vergnet A,Zhao J,Gela D,Genestout L,Bestin A,Haffray P,Kocour M

    更新日期:2018-07-30 00:00:00