Methylated DNA is over-represented in whole-genome bisulfite sequencing data.

abstract：:Our ability to overcome the challenges behind metabolic disorders will require a detailed understanding of the regulation of responses to nutrition. The Creb3 transcription factor family appears to have a unique regulatory role that links cellular secretory capacity with development, nutritional state, infection, and ...

journal_title：Frontiers in genetics

authors： Khan HA,Margulies CE

更新日期：2019-06-21 00:00:00

abstract：:The arrangement of chromatin within interphase nuclei seems to be caused by topological constraints and related to gene expression depending on tissue and developmental stage. In yeast and animals it was found that homologous and heterologous chromatin association are required to realize faithful expression and DNA re...

journal_title：Frontiers in genetics

authors： Schubert V,Rudnik R,Schubert I

更新日期：2014-11-13 00:00:00

abstract：:In situ adaptation to climate change will be critical for the persistence of many ectotherm species due to their relative lack of dispersal capacity. Climate change is causing increases in both the mean and the variance of environmental temperature, each of which may act as agents of selection on different traits. Imp...

journal_title：Frontiers in genetics

authors： Logan ML,Cox CL

更新日期：2020-09-18 00:00:00

abstract：:The southern muriqui (Brachyteles arachnoides) is the largest neotropical primate. This species is endemic to Brazil and is currently critically endangered due to its habitat destruction. The genetic basis underlying adaptive traits of New World monkeys has been a subject of interest to several investigators, with sig...

journal_title：Frontiers in genetics

authors： Moreira DA,Lamarca AP,Soares RF,Coelho AMA,Furtado C,Scherer NM,Moreira MAM,Seuánez HN,Boroni M

更新日期：2020-07-31 00:00:00

abstract：:Cotton (Gossypium spp.) is the most important natural fiber crop in the world. The R2R3-MYB gene family is a large gene family involved in many plant functions including cotton fiber development. Although previous studies have reported its phylogenetic relationships, gene structures, and expression patterns in tetrapl...

journal_title：Frontiers in genetics

authors： Wang N,Ma Q,Ma J,Pei W,Liu G,Cui Y,Wu M,Zang X,Zhang J,Yu S,Ma L,Yu J

更新日期：2019-08-15 00:00:00

abstract：:Atrial fibrillation (AF) is the most common irregular heart rhythm which influence approximately 1-2% of the general population. As a potential factor for ischemic stroke, AF could also cause heart failure. The mechanisms behind AF pathogenesis is complex and remains elusive. As a new category of non-coding RNAs (ncRN...

journal_title：Frontiers in genetics

authors： Jiang S,Guo C,Zhang W,Che W,Zhang J,Zhuang S,Wang Y,Zhang Y,Liu B

更新日期：2019-06-13 00:00:00

abstract：:We evaluated differences in gene expression in pigs from the Porcine Reproductive and Respiratory Syndrome (PRRS) Host Genetics Consortium initiative showing a range of responses to PRRS virus infection. Pigs were allocated into four phenotypic groups according to their serum viral level and weight gain. RNA obtained ...

journal_title：Frontiers in genetics

authors： Arceo ME,Ernst CW,Lunney JK,Choi I,Raney NE,Huang T,Tuggle CK,Rowland RR,Steibel JP

更新日期：2013-01-16 00:00:00

abstract：:Since the turn of the century, researchers have sought to diagnose cancer based on gene expression signatures measured from the blood or biopsy as biomarkers. This task, known as classification, is typically solved using a suite of algorithms that learn a mathematical rule capable of discriminating one group ("cases")...

journal_title：Frontiers in genetics

authors： Quinn TP,Nguyen T,Lee SC,Venkatesh S

更新日期：2019-07-02 00:00:00

abstract：:The mammalian hearing organ is a regular array of two types of hair cells (HCs) surrounded by six types of supporting cells. Along the tonotopic axis, this conserved radial array of cell types shows longitudinal variations to enhance the tuning properties of basilar membrane. We present the current evidence supporting...

journal_title：Frontiers in genetics

authors： Booth KT,Azaiez H,Jahan I,Smith RJH,Fritzsch B

更新日期：2018-05-08 00:00:00

abstract：:Leukocyte telomere length is believed to measure cellular aging in humans, and short leukocyte telomere length is associated with increased risks of late onset diseases, including cardiovascular disease, dementia, etc. Many studies have shown that leukocyte telomere length is a heritable trait, and several candidate g...

journal_title：Frontiers in genetics

authors： Lee JH,Cheng R,Honig LS,Feitosa M,Kammerer CM,Kang MS,Schupf N,Lin SJ,Sanders JL,Bae H,Druley T,Perls T,Christensen K,Province M,Mayeux R

更新日期：2014-01-17 00:00:00

abstract：:Von Hippel-Lindau (VHL) disease is a rare autosomal-dominant inherited tumor syndrome. We aimed to analyze the correlations between frequent VHL mutations and phenotypes in Chinese VHL families. We screened 540 patients from 187 unrelated Chinese VHL families for 19 frequent VHL mutations. The penetrance and mean age ...

journal_title：Frontiers in genetics

authors： Hong B,Ma K,Zhou J,Zhang J,Wang J,Liu S,Zhang Z,Cai L,Zhang N,Gong K

更新日期：2019-09-18 00:00:00

abstract：:Over the past decade, neural networks have become one of the cutting-edge methods in various research fields, outshining specifically in complex classification problems. In this paper, we propose two main contributions: first, we conduct a methodological study of neural network modeling for classifying biological trai...

journal_title：Frontiers in genetics

authors： Wilentzik Müller R,Gat-Viks I

更新日期：2020-05-15 00:00:00

abstract：:Nutrition is the most important environmental factor that can influence early developmental processes through regulation of epigenetic mechanisms during pregnancy and neonatal periods. Maternal diets or nutritional compositions contribute to the establishment of the epigenetic profiles in the fetus that have a profoun...

journal_title：Frontiers in genetics

authors： Li Y

更新日期：2018-08-27 00:00:00

abstract：:Background: There is a continued debate and inconsistent findings in previous literature about the relationship of catechol-O-methyltransferase (COMT) and Parkinson's disease (PD) susceptibility as well as cognitive dysfunction. To substantiate this existing gap, we comprehensively examine COMT genotype effects on the...

journal_title：Frontiers in genetics

authors： Tang C,Wang W,Shi M,Zhang N,Zhou X,Li X,Ma C,Chen G,Xiang J,Gao D

更新日期：2019-07-12 00:00:00

abstract：:Our understanding of the biological role of N6-methyladenosine (m6A), a ubiquitous non-editing RNA modification, has increased greatly since 2011. More recently, work from several labs revealed that m6A methylation regulates several aspects of mRNA metabolism. The "writer" protein METTL3, known as MT-A70 in humans, Dm...

journal_title：Frontiers in genetics

authors： Rockwell AL,Hongay CF

更新日期：2019-11-12 00:00:00

abstract：:Searching for the Multiple Longest Common Subsequences (MLCS) of multiple sequences is a classical NP-hard problem, which has been used in many applications. One of the most effective exact approaches for the MLCS problem is based on dominant point graph, which is a kind of directed acyclic graph (DAG). However, the t...

journal_title：Frontiers in genetics

authors： Peng Z,Wang Y

更新日期：2017-08-09 00:00:00

abstract：:At least six different proteins of the spliceosome, including PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, and SNRNP200, are mutated in autosomal dominant retinitis pigmentosa (adRP). These proteins have recently been shown to localize to the base of the connecting cilium of the retinal photoreceptor cells, elucidating this fo...

journal_title：Frontiers in genetics

authors： Wheway G,Nazlamova L,Meshad N,Hunt S,Jackson N,Churchill A

更新日期：2019-03-22 00:00:00

abstract：:Aptamers are single-stranded nucleic acids that specifically recognize and bind tightly to their cognate targets due to their stable three-dimensional structure. Nucleic acid aptamers have been developed for various applications, including diagnostics, molecular imaging, biomarker discovery, target validation, therape...

journal_title：Frontiers in genetics

authors： Zhou J,Bobbin ML,Burnett JC,Rossi JJ

更新日期：2012-11-02 00:00:00

abstract：:Obesity has become a major public health issue which is caused by a combination of genetic and environmental factors. Genome-wide DNA methylation studies have identified that DNA methylation at Cytosine-phosphate-Guanine (CpG) sites are associated with obesity. However, subsequent functional validation of the results ...

journal_title：Frontiers in genetics

authors： Guo Q,Zheng R,Huang J,He M,Wang Y,Guo Z,Sun L,Chen P

更新日期：2018-12-19 00:00:00

abstract：:Hereditary spastic paraplegias (HSPs) is a rare heterogeneous group of neurodegenerative diseases, with upper and lower limb spasticity motor neuron disintegration leading to paraplegias. NT5C2 gene (OMIM: 600417) encode a hydrolase enzyme 5'-nucleotidase, cytosolic II play an important role in maintaining the balance...

journal_title：Frontiers in genetics

authors： Naseer MI,Abdulkareem AA,Pushparaj PN,Bibi F,Chaudhary AG

更新日期：2020-02-21 00:00:00

abstract：:mRNA-Seq is a precise and highly reproducible technique for measurement of transcripts levels and yields sequence information of a transcriptome at a single nucleotide base-level thus enabling us to determine splice junctions and alternative splicing events with high confidence. Often analysis of mRNA-Seq data does no...

journal_title：Frontiers in genetics

authors： Bhattacharjee M,Gupta R,Davuluri RV

更新日期：2012-11-27 00:00:00

abstract：:Colorectal cancer (CRC) is the third most commonly diagnosed type of cancer worldwide. The mechanisms leading to the progression of CRC are involved in both genetic and epigenetic regulations. In this study, we applied systems biology methods to identify potential biomarkers and conduct drug discovery in a computation...

journal_title：Frontiers in genetics

authors： Yeh SJ,Chen SW,Chen BS

更新日期：2020-03-06 00:00:00

abstract：:For the past several decades, research in understanding the molecular basis of human muscle aging has progressed significantly. However, the development of accessible tissue-specific biomarkers of human muscle aging that may be measured to evaluate the effectiveness of therapeutic interventions is still a major challe...

journal_title：Frontiers in genetics

authors： Mamoshina P,Volosnikova M,Ozerov IV,Putin E,Skibina E,Cortese F,Zhavoronkov A

更新日期：2018-07-12 00:00:00

abstract：BACKGROUND:Schizophrenia is a complex psychiatric disorder with a lifetime morbidity rate of 0.5-1.0%. The pathophysiology of schizophrenia still remains obscure. Accumulating evidence indicates that DNA methylation, which is the addition of a methyl group to the cytosine in a CpG dinucleotide, might play an important ...

journal_title：Frontiers in genetics

authors： Numata S,Ye T,Herman M,Lipska BK

更新日期：2014-08-26 00:00:00

abstract：PURPOSE:The multifactorial pathogenesis of coronary atherosclerotic lesion formation has been investigated in a swine model of high cholesterol diet induced atherogenesis and data processed by a systems approach. METHODS:Farm pigs were fed on standard or high cholesterol diet of 8 and 16 weeks duration. Plasma assessm...

journal_title：Frontiers in genetics

authors： Pelosi G,Rocchiccioli S,Cecchettini A,Viglione F,Puntoni M,Parodi O,Capobianco E,Trivella MG

更新日期：2014-04-07 00:00:00

abstract：:Livestock conservation practice is changing rapidly in light of policy developments, climate change and diversifying market demands. The last decade has seen a step change in technology and analytical approaches available to define, manage and conserve Farm Animal Genomic Resources (FAnGR). However, these rapid change...

journal_title：Frontiers in genetics

authors： Bruford MW,Ginja C,Hoffmann I,Joost S,Orozco-terWengel P,Alberto FJ,Amaral AJ,Barbato M,Biscarini F,Colli L,Costa M,Curik I,Duruz S,Ferenčaković M,Fischer D,Fitak R,Groeneveld LF,Hall SJ,Hanotte O,Hassan FU,Helsen

更新日期：2015-10-21 00:00:00

abstract：:Studies in rats and mice have established that maternal nutrition induces epigenetic modifications, sometimes permanently, that alter gene expression in the fetus, which in turn leads to phenotypic changes. However, limited data is available on the influence of maternal diet on epigenetic modifications and gene expres...

journal_title：Frontiers in genetics

authors： Lan X,Cretney EC,Kropp J,Khateeb K,Berg MA,Peñagaricano F,Magness R,Radunz AE,Khatib H

更新日期：2013-04-05 00:00:00

abstract：:Prolonged drug use causes long-lasting neuroadaptations in reward-related brain areas that contribute to addiction. Despite significant amount of research dedicated to understanding the underlying mechanisms of addiction, the molecular underpinnings remain unclear. At the same time, much of the pervasive transcription...

journal_title：Frontiers in genetics

authors： Sartor GC,St Laurent G 3rd,Wahlestedt C

更新日期：2012-06-22 00:00:00

abstract：:Bamboo is one of the fastest-growing non-timber forest plants. Moso bamboo (Phyllostachys edulis) is the most economically valuable bamboo in Asia, especially in China. With the release of the whole-genome sequence of moso bamboo, there are increasing demands for refined annotation of bamboo genes. Recently, large amo...

journal_title：Frontiers in genetics

authors： Ma X,Zhao H,Xu W,You Q,Yan H,Gao Z,Su Z

更新日期：2018-11-27 00:00:00

abstract：:The first breeding program in the world for durum wheat was conceived in Italy in the early 1900s. Over the decades, pressure exerted by natural and artificial selection could have progressively reduced the genetic diversity of the durum wheat germplasm. In the present study, a large panel of Italian durum wheat acces...

journal_title：Frontiers in genetics

authors： Taranto F,D'Agostino N,Rodriguez M,Pavan S,Minervini AP,Pecchioni N,Papa R,De Vita P

更新日期：2020-04-21 00:00:00