A benchmarking method to measure dietary absorption efficiency of chemicals by fish.


:Understanding the dietary absorption efficiency of chemicals in the gastrointestinal tract of fish is important from both a scientific and a regulatory point of view. However, reported fish absorption efficiencies for well-studied chemicals are highly variable. In the present study, the authors developed and exploited an internal chemical benchmarking method that has the potential to reduce uncertainty and variability and, thus, to improve the precision of measurements of fish absorption efficiency. The authors applied the benchmarking method to measure the gross absorption efficiency for 15 chemicals with a wide range of physicochemical properties and structures. They selected 2,2',5,6'-tetrachlorobiphenyl (PCB53) and decabromodiphenyl ethane as absorbable and nonabsorbable benchmarks, respectively. Quantities of chemicals determined in fish were benchmarked to the fraction of PCB53 recovered in fish, and quantities of chemicals determined in feces were benchmarked to the fraction of decabromodiphenyl ethane recovered in feces. The performance of the benchmarking procedure was evaluated based on the recovery of the test chemicals and precision of absorption efficiency from repeated tests. Benchmarking did not improve the precision of the measurements; after benchmarking, however, the median recovery for 15 chemicals was 106%, and variability of recoveries was reduced compared with before benchmarking, suggesting that benchmarking could account for incomplete extraction of chemical in fish and incomplete collection of feces from different tests.


Environ Toxicol Chem


Xiao R,Adolfsson-Erici M,Åkerman G,McLachlan MS,MacLeod M




Has Abstract


2013-12-01 00:00:00












  • Nanoecotoxicity assessment of graphene oxide and its relationship with humic acid.

    abstract::The risk assessment of nanomaterials is essential for regulatory purposes and for sustainable nanotechnological development. Although the application of graphene oxide has been widely exploited, its environmental risk is not well understood because several environmental conditions can affect its behavior and toxicity....

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Castro VL,Clemente Z,Jonsson C,Silva M,Vallim JH,de Medeiros AMZ,Martinez DST

    更新日期:2018-07-01 00:00:00

  • Effects of dietary uranium on reproductive endpoints--fecundity, survival, reproductive success--of the fish Danio rerio.

    abstract::Exposure to metal-contaminated water has been shown to result in a number of reproductive abnormalities in adult and larvae fish, such as failure of oocyte maturation and teratogenic effects. Recently, dietary uptake of metals by fish has been recognized as a critical route of exposure, however, the mechanisms of meta...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Simon O,Mottin E,Geffroy B,Hinton T

    更新日期:2011-01-01 00:00:00

  • How are trace elements mobilized during the postweaning fast in Northern elephant seals?

    abstract::Northern elephant seal (Mirounga angustirostris) pups undergo a substantial intertissue reorganization of protein, minerals, and other cellular components during their postweaning development, which might entail the mobilization of associated contaminants. The authors investigated the changes in concentrations of 11 e...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Habran S,Crocker DE,Debier C,Das K

    更新日期:2012-10-01 00:00:00

  • Effects and risk assessment of linear alkylbenzene sulfonates in agricultural soil. 5. Probabilistic risk assessment of linear alkylbenzene sulfonates in sludge-amended soils.

    abstract::Linear alkylbenzene sulfonates (LAS) can be found in high concentrations in sewage sludge and, hence, may enter the soil compartment as a result of sludge application. Here, LAS may pose a risk for soil-dwelling organisms. In the present probabilistic risk assessment, statistical extrapolation has been used to assess ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Jensen J,Løkke H,Holmstrup M,Krogh PH,Elsgaard L

    更新日期:2001-08-01 00:00:00

  • The effect of lead-contaminated soil from Canadian prairie skeet ranges on the neutral red retention assay and fecundity in the earthworm Eisenia fetida.

    abstract::The sublethal effects of lead (Pb) on the earthworm Eisenia fetida were evaluated in the laboratory using freshly spiked soil and soil collected from Canadian prairie skeet ranges. After a four-week exposure to soil spiked with lead acetate, earthworm neutral red retention time (NRRT). soil Pb concentrations, and eart...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Booth L,Palasz F,Darling C,Lanno R,Wickstrom M

    更新日期:2003-10-01 00:00:00

  • Acute and chronic toxicity of lead in water and diet to the amphipod Hyalella azteca.

    abstract::We evaluated the influence of waterborne and dietary lead (Pb) exposure on the acute and chronic toxicity of Pb to the amphipod Hyalella azteca. Test solutions were generated by a modified diluter with an extended (24-h) equilibration period. Acute (96-h) toxicity of Pb varied with water hardness in the range of 71 to...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Besser JM,Brumbaugh WG,Brunson EL,Ingersoll CG

    更新日期:2005-07-01 00:00:00

  • Toxicant- and response-specific comparisons of statistical methods for estimating effective concentrations.

    abstract::Standard U.S. Environmental Protection Agency (U.S. EPA) statistical analyses of whole effluent toxicity tests involve the estimation of the concentration associated with a specified level of inhibition relative to control responses. Current U.S. EPA estimation methods (linear interpolation or probit-based methods) ar...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Hughes MR,Bailer AJ,Denton DL

    更新日期:2001-06-01 00:00:00

  • Toxicity of substituted anilines to Pseudokirchneriella subcapitata and quantitative structure-activity relationship analysis for polar narcotics.

    abstract::This study evaluated the toxic effects of substituted anilines on Pseudokirchneriella subcapitata with the use of a closed algal toxicity testing technique with no headspace. Two response endpoints (i.e., dissolved oxygen production [DO] and algal growth rate) were used to evaluate the toxicity of anilines. Both DO an...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Chen CY,Ko CW,Lee PI

    更新日期:2007-06-01 00:00:00

  • The effects of zinc on the structure and functioning of a freshwater community: A microcosm experiment.

    abstract::A major problem with risk assessment of chemicals is the extrapolation of laboratory single-species toxicity tests, which oversimplify the actual field situation by ignoring species interactions, to natural communities. The authors tested if the bioavailability-normalized 5% hazardous concentration (HC5) estimated fro...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Van de Perre D,Roessink I,Janssen CR,Smolders E,Van Regenmortel T,Van Wichelen J,Vyverman W,Van den Brink PJ,De Schamphelaere KA

    更新日期:2016-11-01 00:00:00

  • Effects of metals on enantioselective toxicity and biotransformation of cis-bifenthrin in zebrafish.

    abstract::Co-occurrence of pyrethroids and metals in watersheds previously has been reported to pose great risk to aquatic species. Pyrethroids are a class of chiral insecticides that have been shown to have enantioselective toxicity and biotransformation. However, the influence of metals on enantioselectivity of pyrethroids ha...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Yang Y,Ji D,Huang X,Zhang J,Liu J

    更新日期:2017-08-01 00:00:00

  • Modeling the fate of polychlorinated biphenyls in the inner Oslofjord, Norway.

    abstract::A dynamic, segmented, multimedia fate and transport model has been developed, evaluated, and applied to gain insight regarding the behavior of seven polychlorinated biphenyl (PCB) congeners in the Inner Oslofjord (Norway). A comparison with a dated sediment core reveals that the model is not capable of reproducing som...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Breivik K,Bjerkeng B,Wania F,Helland A,Magnusson J

    更新日期:2004-10-01 00:00:00

  • Pyrethroid insecticide concentrations and toxicity in streambed sediments and loads in surface waters of the San Joaquin Valley, California, USA.

    abstract::Pyrethroid insecticide use in California, USA, is growing, and there is a need to understand the fate of these compounds in the environment. Concentrations and toxicity were assessed in streambed sediment of the San Joaquin Valley of California, one of the most productive agricultural regions of the United States. Con...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Domagalski JL,Weston DP,Zhang M,Hladik M

    更新日期:2010-04-01 00:00:00

  • Measuring the partitioning of silver to organic carbon using solubility enhancement.

    abstract::Ionic silver is toxic to aquatic organisms at low concentrations. However, complexation to binding sites on natural organic matter has been shown to reduce silver toxicity. Research indicates that there is a need to develop reliable methods for characterizing silver binding at very low silver ion concentrations where ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Rader KJ,Shadi TS,Mahony JD,Di Toro DM

    更新日期:2005-11-01 00:00:00

  • The chemical exposure toxicity space (CETS) model: Displaying exposure time, aqueous and organic concentration, activity, and onset of toxicity.

    abstract::A 1-compartment toxicokinetic model is used to characterize the chemical exposure toxicity space (CETS), providing a novel graphic tool that can aid in the design of aquatic toxicity tests for fish and for interpreting their results. The graph depicts the solution to the differential equation describing the uptake kin...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Mackay D,Celsie AKD,Parnis JM,McCarty LS,Arnot JA,Powell DE

    更新日期:2017-05-01 00:00:00

  • Vitellogenin induction by 17β-estradiol and 17α-ethynylestradiol in male Murray rainbowfish (Melanotaenia fluviatilis).

    abstract::Hepatic vitellogenin (VTG) mRNA and plasma protein assays were developed for the Murray rainbowfish (Melanotaenia fluviatilis), a native freshwater fish species in Australia. Adult male Murray rainbowfish were exposed to 17β-estradiol (E2) or 17α-ethynylestradiol (EE2) at 0, 1, 5, 10, 50, or 100 ng/L in a semistatic s...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Woods M,Kumar A

    更新日期:2011-11-01 00:00:00

  • Utility of in vitro test methods to assess the activity of xenoestrogens in fish.

    abstract::The results of the present study have demonstrated the utility of an estrogen receptor (ER) competitive ligand-binding assay, a hepatocyte vitellogenin (VTG) induction bioassay, and an ER reporter gene bioassay in characterizing the activity of model estrogen agonists (17beta-estradiol [E2], ethynylestradiol, and nony...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Marlatt VL,Hewitt LM,Van Der Kraak G

    更新日期:2006-12-01 00:00:00

  • Potentiation of the vitellogenic response to 17alpha-ethinylestradiol by cortisol in the fathead minnow Pimephales promelas.

    abstract::The effects of elevated plasma cortisol levels on vitellogenin (VTG) induction were examined in the fathead minnow (Pimephales promelas) in an attempt to evaluate the potential influence of stress on this commonly used biomarker of estrogenicity. Two separate experiments were conducted in which fish plasma cortisol wa...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Brodeur JC,Woodburn KB,Klecka GM

    更新日期:2005-05-01 00:00:00

  • Changes in growth and secondary sex characteristics of fathead minnows exposed to bleached sulfite mill effluent.

    abstract::Yellow perch captured downstream of a bleached sulfite mill had reduced gonad size and fecundity, and circulating steroid levels declined in goldfish exposed to final effluent for 21 d. To assess bleached sulfite mill (BSM) effluent, long-term fathead minnow (Pimephales promelas) growth and reproduction tests were car...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Parrott JL,Wood CS,Boutot P,Dunn S

    更新日期:2003-12-01 00:00:00

  • The influence of diet on the assimilation efficiency of 47 polychlorinated biphenyl congeners in Japanese koi (Cyprinus carpio).

    abstract::The influence of diet on polychlorinated biphenyl (PCB) assimilation was investigated by measuring dietary assimilation efficiencies (AEs) for 47 PCB congeners in juvenile koi (Cyprinus carpio) fed five experimental diets. Two of the diets were naturally contaminated and were obtained by collecting mayflies from Lake ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Liu J,Haffner GD,Drouillard KG

    更新日期:2010-02-01 00:00:00

  • Enhancement of aerobic microbial degradation of polychlorinated biphenyl in soil microcosms.

    abstract::This article reports the results of various biodegradation experiments on polychlorinated biphenyl (PCB)-contaminated sandy soil employing a mixed culture of acclimatized bacteria. Following the optimization of different variables without chemical pretreatment, the elimination rate achieved of Aroclor 1242 in slurry-p...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Manzano MA,Perales JA,Sales D,Quiroga JM

    更新日期:2003-04-01 00:00:00

  • Use of the Australian crimson-spotted rainbowfish (Melanotaenia fluviatilis) as a model test species for investigating the effects of endocrine disruptors.

    abstract::Few studies have investigated the potential reproductive effects of toxicants on Australian freshwater fish species. The present study uses the Australian rainbowfish (Melanotaenia fluviatilis) as a model for testing the potential effects of 17beta-estradiol. Groups of reproductively active rainbowfish were exposed to...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Pollino CA,Georgiades E,Holdway DA

    更新日期:2007-10-01 00:00:00

  • Simultaneous analysis of multiclass contaminants of emerging concern in sediments by liquid chromatography with tandem quadrupole mass spectrometry.

    abstract::A quick, easy, cheap, effective, rugged, and safe (QuEChERS)-based extraction and simultaneous dispersive solid-phase extraction (dSPE) clean-up method was developed for contaminants of emerging concern (CECs) in sediment samples. Hydration with a phosphate buffer (pH 2.0) and salting out with NaCl and MgSO4 facilitat...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Rashid A,Wang Y,Li Y,Yu CP,Sun Q

    更新日期:2019-07-01 00:00:00

  • Effects of diluted bitumen exposure on juvenile sockeye salmon: From cells to performance.

    abstract::Diluted bitumen (dilbit; the product of oil sands extraction) is transported through freshwater ecosystems critical to Pacific salmon. This is concerning, because crude oil disrupts cardiac development, morphology, and function in embryonic fish, and cardiac impairment in salmon can have major consequences on migrator...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Alderman SL,Lin F,Farrell AP,Kennedy CJ,Gillis TE

    更新日期:2017-02-01 00:00:00

  • Systems biology: leading the revolution in ecotoxicology.

    abstract::The rapid development of new technologies such as transcriptomics, proteomics, and metabolomics (Omics) are changing the way ecotoxicology is practiced. The data deluge has begun with genomes of over 65 different aquatic species that are currently being sequenced, and many times that number with at least some level of...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章,评审


    authors: Garcia-Reyero N,Perkins EJ

    更新日期:2011-02-01 00:00:00

  • Assessment of the levels of heavy metal pollution in roadside soils of Eskisehir, Turkey.

    abstract::A detailed study was conducted to determine the current status of the heavy metals Cd, Cu, Cr, Fe, Hg, Mn, Ni, Pb, and Zn in Eskisehir, Turkey. The 15 different locations (n =270) studied were specifically selected to identify the effects of soil pollution on the tramway, which has been in service since December 2004 ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Malkoc S,Yazıcı B,Savas Koparal A

    更新日期:2010-12-01 00:00:00

  • Correlation of Tetrahymena and Pimephales toxicity: evaluation of 100 additional compounds.

    abstract::In the summary/recommendations for the Ecotoxicology Session of TestSmart--A Humane and Efficient Approach to Screening Information Data Sets (SIDS) Data Workshop, it was recommended that more population growth impairment data using Tetrahymena be generated and compared with available lethality data for the fathead mi...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Sinks GD,Schultz TW

    更新日期:2001-04-01 00:00:00

  • Metabolism and distribution of p,p'-DDT during flight of the white-crowned sparrow, Zonotrichia leucophrys.

    abstract::This study evaluated the interactions of flight, fasting, and 1,1,1-trichloro-bis(4-chlorophenyl)ethane (p,p'-DDT) loading on residue metabolism and distribution in recently exposed white-crowned sparrows (Zonotrichia leucophrys). Female sparrows were dosed with 5 mg p,p'-DDT per kg body weight over 3 d. Following 1 d...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Scollon EJ,Carr JA,Rintoul DA,McMurry ST,Cobb GP

    更新日期:2012-02-01 00:00:00

  • Human pharmaceuticals in the marine environment: Focus on exposure and biological effects in animal species.

    abstract::Marine waters have been poorly investigated for the occurrence of pharmaceutical contamination. Recent data confirm that pharmaceuticals occur widely in marine and coastal environments; therefore, assessment of potential risk to marine species needs further efforts. The present study represents the first extensive rev...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章,评审


    authors: Fabbri E,Franzellitti S

    更新日期:2016-04-01 00:00:00

  • Acute, sublethal exposure to a pyrethroid insecticide alters behavior, growth, and predation risk in larvae of the fathead minnow (Pimephales promelas).

    abstract::The present study determined the effects of environmentally relevant, short-term (4-h) exposure to the pyrethroid insecticide esfenvalerate on mortality, food consumption, growth, swimming ability, and predation risk in larvae of the fathead minnow (Pimephales promelas). Acute effect concentrations were determined, an...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Floyd EY,Geist JP,Werner I

    更新日期:2008-08-01 00:00:00

  • Temperature and food concentration have limited influence on the mixture toxicity of copper and Microcystis aeruginosa to Daphnia magna.

    abstract::Standard ecotoxicity tests are conducted under constant and favorable experimental conditions. In natural communities, however, the toxicity of chemicals may be influenced by abiotic and biotic environmental factors. Firstly, the authors examined the influence of temperature and total food concentration on the nature ...

    journal_title:Environmental toxicology and chemistry

    pub_type: 杂志文章


    authors: Hochmuth JD,Janssen CR,De Schamphelaere KA

    更新日期:2016-03-01 00:00:00