Abstract:
OBJECTIVE:Recent genome wide association studies (GWASs) assessing the relationship between schizophrenia (SZ) and the ZNF804A gene, particularly the single nucleotide polymorphism (SNP) rs1344706, have yielded conflicting results. Schizophrenia is a heterogeneous disorder, so it is possible that an association may be restricted to specific SZ subtypes and that population heterogeneity may obscure a contribution of ZNF804A allelic variation to SZ risk. We thus evaluated the association between rs1344706 and different clinical SZ subtypes in a large Han Chinese patient population. METHOD:The rs1344706 genotype was determined in 1,025 SZ patients and 977 healthy controls using polymerase chain reaction restriction fragment length polymorphisms (PCR-RFLPs). The clinical SZ subtypes included paranoid, catatonic, disintegrated, and undifferentiated, diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition IV (DSM-IV). RESULTS:No significant differences in genotype and allele frequencies were found between controls and either the total SZ population (A > C, chi2 = 4.339, 2.994; p = 0.227, 0.087, respectively) or paranoid SZ patients (chi2 = 2.053, 0.002; p = 0.562, 0.973, respectively). However, there was a significant association between genotype frequency and SZ subtype (chi2 = 12.632, p = 0.049). CONCLUSIONS:We found no evidence that the ZNF804A SNP rs1344706 is a susceptibility locus for SZ. However, conflicting results from previous association studies may be due to genetic heterogeneity between different patient SZ subtypes.
journal_name
Int J Psychiatry Medjournal_title
International journal of psychiatry in medicineauthors
Yang Y,Li W,Yang G,Xiao B,Wang X,Ding M,Zhao J,Song X,Yue W,Zhang D,Zhang H,Lv Ldoi
10.2190/PM.45.3.fsubject
Has Abstractpub_date
2013-01-01 00:00:00pages
269-78issue
3eissn
0091-2174issn
1541-3527journal_volume
45pub_type
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journal_title:International journal of psychiatry in medicine
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journal_title:International journal of psychiatry in medicine
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journal_title:International journal of psychiatry in medicine
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journal_title:International journal of psychiatry in medicine
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pub_type: 杂志文章,评审
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journal_title:International journal of psychiatry in medicine
pub_type: 杂志文章,评审
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doi:10.1177/0091217417703290
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journal_title:International journal of psychiatry in medicine
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更新日期:2009-01-01 00:00:00
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