Abstract:
:Iron overload increases the risk of osteoporosis, which leads to an increase in the incidences of bone fracture after menopause. In vitro studies have demonstrated that excess iron can inhibit osteoblast activity. Hepcidin, a central regulator of iron homeostasis, prevents iron overload, and thus, it is considered to have anti-osteoporosis effects. In this study, a zebrafish model was employed to investigate the therapeutic role of hepcidin in iron overload-induced inhibition of bone formation. Our results show that ferric ammonium citrate (FAC) treatment decreased osteoblast-specific gene expression (runx2a, runx2b, and bglap) and bone mineralization in the zebrafish embryo, accompanied with increased whole-body iron levels and oxidative stress. Bone mineralization and osteoblast-specific gene expression increased with the microinjection of hepcidin-flag Capped-mRNA into zebrafish embryos. Moreover, the whole-body iron content and oxidative stress in the iron-overloaded zebrafish embryos decreased when microinjection of hepcidin preceded the FAC treatment. Therefore, our study suggests that hepcidin could prevent and rescue reduced bone formation caused by FAC treatment by preventing iron absorption.
journal_name
Fish Physiol Biochemjournal_title
Fish physiology and biochemistryauthors
Jiang Y,Chen B,Yan Y,Zhu GXdoi
10.1007/s10695-018-0568-zsubject
Has Abstractpub_date
2019-02-01 00:00:00pages
365-374issue
1eissn
0920-1742issn
1573-5168pii
10.1007/s10695-018-0568-zjournal_volume
45pub_type
杂志文章abstract::Teleosts have many spawning strategies and the hormonal control of gametogenesis is not well defined among the species or even, between sexes. To increase the knowledge of gonadotropin hormones, we studied the trend by gene expression of gonadotropin receptors in the follicles and testis at different maturity stages i...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-018-0479-z
更新日期:2018-06-01 00:00:00
abstract::The yellow catfish Pelteobagrus fulvidraco with initial average weight 16.6 ± 0.17 g were fed three extruded diets for 56 days. Fish meal (FM) diet was formulated as the normal control with 380 g FM and 200 g soybean meal (SBM) kg-1 diet. The SBM diet was prepared with 220 g FM and 360 g SBM kg-1 diet without Lys or M...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10695-017-0437-1
更新日期:2018-02-01 00:00:00
abstract::The effects of paraquat (PQ; 1,1'-dimethyl-4,4'-bipyridylium dichloride) treatment were investigated in carp, silver carp and wels. The serum glutamic-oxalacetic transaminase (GOT; L-aspartate: 2-oxoglutarate aminotransferase, EC 2.6.1.1.) level was enhanced by 50% at 1 ppm exposure and by 100% at 10 ppm exposure in a...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF00004434
更新日期:1990-01-01 00:00:00
abstract::In teleosts, cortisol is one of the key factors regulating the adaptation to environmental challenges, such as salinity changes. This paper compares interrenal function between fully adapted freshwater (FW) and sea water (SW) specimens of the euryhaline teleost Oreochromis mossambicus (tilapia), combining morphometric...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF00004289
更新日期:1995-02-01 00:00:00
abstract::Zinc pyrithione (ZPT) is a broad-spectrum antibacterial and antifungal agent; therefore, it is widely used in industry and civilian life. It is discharged into the aquatic environment with industrial and civilian waste water. Carassius sp. is one of the most widely distributed and farmed fish in China. The effects of ...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-016-0262-y
更新日期:2017-02-01 00:00:00
abstract::The aims of the present study are to determine whether triiodothyronine (T3) and/or thyroxine (T4) in tilapia larvae is gifted through the mother, and to investigate the change profiles of thyrotropin (TSH), thyroid follicular cells and type I deiodinase (D1) gene expression following larval development. T3 and T4 con...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-014-9950-7
更新日期:2014-10-01 00:00:00
abstract::Selected biochemical parameters were measured in the plasma of both underyearling anadromous steelhead trout (Salmo gairdneri) and underyearling residentS. gairdneri. The analyses were conducted in an effort to determine whether or not there might be changes which could be associated with the parr-smolt transformation...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF01874727
更新日期:1988-03-01 00:00:00
abstract::The trace element composition of the fish otolith is an indicator of biomineralization. In contrast to other skeletal tissue, the otolith retains its entire original structure and does not absorb any elements after the fish dies. Because otoliths in carp degrade very slowly in the dead body, the information it provide...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-008-9294-2
更新日期:2010-03-01 00:00:00
abstract::Glutathione (GSH) concentration, the activity of its metabolizing enzymes, glutathione transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR), and the antioxidant enzyme catalase (CAT) in O. niloticus ovary and testis were examined. GSH concentration of O. niloticus testis exhibited high concentra...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-015-0143-9
更新日期:2016-02-01 00:00:00
abstract::Three pepsinogens (PG1, PG2, and PG3) were highly purified from the stomach of freshwater fish rice field eel (Monopterus albus Zuiew) by ammonium sulfate fractionation and chromatographies on DEAE-Sephacel, Sephacryl S-200 HR. The molecular masses of the three purified PGs were all estimated as 36 kDa using SDS-PAGE....
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-010-9456-x
更新日期:2011-09-01 00:00:00
abstract::Individual differences in behaviour and physiological responses to stress are associated with evolutionary adaptive variation and thus raw material for evolution. In farmed animals, the interest in consistent trait associations, i.e. coping styles, has increased dramatically over the last years. However, one of limita...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-016-0231-5
更新日期:2016-10-01 00:00:00
abstract::The large yellow croaker (Larimichthys crocea) is a marine fish that is economically important to Chinese fisheries, and its reproductive and developmental biology have been extensively investigated. However, the molecular mechanism of oogenesis in L. crocea is not clear. Here, we investigated the multiple vitellogeni...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-018-0569-y
更新日期:2019-06-01 00:00:00
abstract::The stress response transmitted by the HPA axis is one of the best examples of neuroendocrine-immune interactions that are critical for survival. Analogous to the situation in mammals, the stress response in fish is characterized by the activation of the hypothalamo-pituitary-interrenal axis (HPI). Effects of cortisol...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-015-0084-3
更新日期:2015-10-01 00:00:00
abstract::The objective of this study was to determine the effect of two levels of inclusion of xylan oligosaccharides (XOS) extracted from corncob on growth, feed utilization, immune status and disease resistance of Mediterranean sea bass (Dicentrarchus labrax) fingerlings. Specimens of 4.75 ± 0.69 g at initial density of 2.7 ...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-015-0110-5
更新日期:2015-12-01 00:00:00
abstract::Bacillus circulans PB7, isolated from the intestine of Catla catla, was evaluated for use as a probiotic supplement in the feeds for the fingerlings of Catla catla. The effect of supplement on the growth performance, feed utilization efficiency, and immune response was evaluated. Catla fingerlings (ave. wt. 6.48 +/- 0...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-008-9272-8
更新日期:2009-08-01 00:00:00
abstract::This study describes the digestible protein (DP) and digestible energy (DE) utilization in juvenile mulloway, and determined the requirements for maintenance. This was achieved by feeding triplicate groups of fish weighing 40 or 129 g held at two temperatures (20 or 26 degrees C), on a commercial diet (21.4 g DP mJ DE...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-008-9296-0
更新日期:2010-03-01 00:00:00
abstract::High-mobility group box 2 (HMGB2) is a nonhistone architectural protein that plays important roles in many biological processes. In this study, we cloned a homologue of the HMGB2 from the lymphocyte-like cells of Lampetra japonica (L. japonica). Sequence analysis reveals that L. japonica HMGB2 contains two highly cons...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-013-9871-x
更新日期:2014-04-01 00:00:00
abstract::Drinking in freshwater juvenile salmon was investigated in response to vasodilation by sodium nitroprusside (SNP), a nitric oxide donor, which significantly increased blood vessel diameter in Atlantic salmon alevins. Atlantic salmon fry (1-3 g), as previously shown, drank at a significant rate in fresh water which dou...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF01874839
更新日期:1996-02-01 00:00:00
abstract::This review discusses the new biotechnological tools that are arising and promising for conservation and enhancement of fish production, mainly regarding the endangered and the most economically important species. Two main techniques, in particular, are available to avoid extinction of endangered fish species and to i...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1007/s10695-018-0506-0
更新日期:2018-12-01 00:00:00
abstract::The effects of acclimation temperature (15, 20, 25 °C) on routine oxygen consumption and post-exercise maximal oxygen consumption rates (MO2) were measured in juvenile shortnose sturgeon (Acipenser brevirostrum LeSueur, 1818). The routine MO2 of shortnose sturgeon increased significantly from 126.75 mg O2 h-1 kg-1 at ...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-017-0368-x
更新日期:2017-10-01 00:00:00
abstract::The involvement of the freshwater fish gill chloride cells (CCs) in trans-branchial calcium uptake (JinCa(2+)) was investigated. This was accomplished by assessing the interspecific relationships between the apical surface area of CCs exposed to the external environment and JinCa(2+). Three species of freshwater teleo...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF00004482
更新日期:1992-12-01 00:00:00
abstract::This study compared Amur sturgeon (Acipenser schrenckii) and Chinese sturgeon (Acipenser sinensis) on several biochemical parameters including glucose (GLU), urea, lactate dehydrogenase (LDH-L), activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), direct bilirubin (D.BILI), alkaline phosphat...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-006-7134-9
更新日期:2006-03-01 00:00:00
abstract::The cDNAs of the α-subunit of the pituitary gonadotrophic hormones (GTHα) of fish of the order Osteoglossiformes or the superorder Osteoglossomorpha have never been sequenced. For a better understanding the phylogenetic diversity and evolution of PGHα in fish and for future biotechnological synthesis of the gonadotrop...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-012-9730-1
更新日期:2013-06-01 00:00:00
abstract::Muscle tissues contribute 34-48 % of the total body mass in fish. Proteomic analysis enables better understanding of the skeletal muscle physiology and metabolism. A proteome map reflects the general fingerprinting of the fish species and has the potential to identify novel proteins which could serve as biomarkers for...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-015-0046-9
更新日期:2015-06-01 00:00:00
abstract::Due to rapid depletion of wild stocks, the necessity to cultivate fish is eminent. Current fish farming practices seek to improve flesh quality. The notion that white muscles are the main target of the fishing industry is emphasized. A novel approach is suggested based on the development of white muscles in wild fish ...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-011-9501-4
更新日期:2011-06-01 00:00:00
abstract::The toxic effects of thyroxine (T4F), levothyroxine (L-T4), and thyroxine complexed into β-cyclodextrin (β-CD-T4) on the biological parameters of tambaqui (Colossoma macropomum) were evaluated. The animals were exposed to a chronic toxicity test based on concentrations of influent (60 ng/L) for 2 months. Weight, total...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-019-00630-9
更新日期:2019-06-01 00:00:00
abstract::Goldfish,Carassius auratus, were acclimated for 2 to 3.5 weeks to three temperature regimes: [1] temporally-constant (10, 20 and 30°C), [2] diurnally-cycling (20 ± 10°C) and [3] randomly-fluctuating (± 2°C at approximately 2h intervals between extremes of 10 and 30°C). No significant differences in hematocrit were evi...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF00004327
更新日期:1994-12-01 00:00:00
abstract::Gilthead sea bream larvae (Sparus aurata) aged 47 days post hatching (dph) (11.6-12.8 mg in wet weight) were exposed to several sublethal concentrations of Cd(2+) (0.1, 5 and 10 mg/L) during 6 days in order to investigate the effects of this heavy metal on the expression of selected genes involved in detoxification (m...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/s10695-012-9727-9
更新日期:2013-06-01 00:00:00
abstract::The tilapia prolactin (PRL) cell responds rapidly (10-20 min) to small physiological changes in medium osmotic pressure (OP), releasing increasing quantities of hormone as medium OP is reduced. This release is rapidly (≤ 10 min) inhibited by somatostatin (SRIF). There is now extensive evidence that tilapia PRL cell fu...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF00004685
更新日期:1989-06-01 00:00:00
abstract::Immunoglobulin M (IgM) is known as a main factor in the humoral immune system of teleosts. In the present study, the effect of cortisol on plasma IgM concentrations was investigated using a specific antibody to IgM in masu salmon (Oncorhynchus masou). Cortisol was orally administered each day for 2 weeks at a dose of ...
journal_title:Fish physiology and biochemistry
pub_type: 杂志文章
doi:10.1007/BF00004118
更新日期:1994-05-01 00:00:00