Abstract：
OBJECTIVES:To gather all published information about the stability of drugs commonly used in Intensive Care Units (ICU); evaluate the methodology of published data; and generate a compatibility table. DESIGN:i) A systematic review was conducted searching the following databases: Medline, Stabilis, Handbook of Injectable Drugs and Micromedex. Articles published from 1990 to 2017 in English, Spanish and French were included. ii) Article quality was analyzed according to the stability studies practice guidelines. iii) A compatibility table was produced with data for 44 binary combinations of drugs frequently used in the ICU. SCOPE:Spanish and international hospital ICU. RESULTS:The systematic review included 29 studies (27 originals, 2 reviews). None of the included studies followed all the methodological requirements. However, 93% guaranteed correct reproducibility. Accordingly, drug stability knowledge was available for 50.3% of the studied admixtures, in which 77.1% of the binary combinations proved compatible and 16.8% proved incompatible. CONCLUSIONS:This review provides new reliable evidence about the physicochemical stability of drugs commonly used in the critical care setting. The study contributes to the safe administration of intravenous drugs in critical patients with a view to avoiding adverse events in this frail population.
journal_name
Med Intensivajournal_title
Medicina intensivaauthors
Castells Lao G,Rodríguez Reyes M,Roura Turet J,Prat Dot M,Soy Muner D,López Cabezas Cdoi
10.1016/j.medin.2018.08.004subject
Has Abstractpub_date
2020-03-01 00:00:00pages
80-87issue
2eissn
0210-5691issn
1578-6749pii
S0210-5691(18)30243-2journal_volume
44pub_type
杂志文章abstract：:This syndrome was described in 1990. It is characterized by chest pain that simulates an acute coronary syndrome (ACS), with alterations in the ECG, but with normal coronary arteries. We present 16 patients admitted in our ICU, who met the criteria of transient left ventricular dysfunction syndrome (TLVDS). All but 1 ...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2010.09.010
更新日期：2011-06-01 00:00:00
abstract：AIM:A study is made of the influence of alcohol and/or drug abuse upon traumatismo recurrence, with an analysis of the influence of such abuse upon the time to appearance of first injury in patients without antecedents of trauma. DESIGN:A prospective observational study was made. SETTING:Trauma patients admitted to t...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2012.04.010
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:Assessment of health related quality of life (HRQOL) before and 12 months after discharge from a mixed intensive care unit (ICU) according to diagnostic category and the relationship between both instruments. DESIGN:Prospective observational study. SETTING:The combined medical/surgical ICU in a secondary un...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/s0210-5691(08)70942-2
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:An evaluation is made of the hospital mortality predicting capacity of the main predictive scoring systems. DESIGN:A 2-year retrospective cohort study was carried out. SETTING:A third level ICU with surgical and medical patients. PATIENTS:All patients with multiorgan failure during the first day in the ICU...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2015.03.005
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVES:1) To assess the prevalence of pain during nursing care procedures, and 2) to evaluate the usefulness of certain vital signs and the bispectral index (BIS) in detecting pain. METHODS:A prospective, observational analytical study was made of procedures (endotracheal aspiration and mobilization with turning) ...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2015.03.004
更新日期：2016-03-01 00:00:00
abstract：:Pain is a problem in critically ill patients. The diagnosis of the intensity of is more simple when the patient is conscious (using ad hoc scales) than in unconscious or sedated patients. In these cases the study of the physiological responses to pain can be the best way of pain monitoring. The pain management in ICU ...
journal_title：Medicina intensiva
pub_type： 杂志文章,实务指引
doi：
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVES:To analyze the nutritional management practices in Intensive Care (ICU) to detect the need for improvement actions. Re-evaluate the process after implementation of improvement actions. DESIGN:Prospective observational study in 3 phases: 1) observation; 2) analysis, proposal development and dissemination; 3)...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2015.04.010
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:The optimal blood management after cardiac surgery remains controversial. Moreover, blood transfusions may have an impact on long-term outcomes. OBJECTIVE:The aim of this study is to characterize the impact of liberal red blood cell transfusions on Health-Related Quality of life (HRQoL) after cardiac surger...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2018.01.014
更新日期：2019-04-01 00:00:00
abstract：:After an introduction that summarizes the new definitions and risk classification of acute kidney injury, along with the consequences on its epidemiology, available evidence in the literature is reviewed in order to compare intermittent and continuous renal replacement therapy in terms of survival, renal function reco...
journal_title：Medicina intensiva
pub_type： 杂志文章,评审
doi：10.1016/s0210-5691(09)70688-6
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVE:This article reviews the utility and applicability of available systems in order to calculate general and quality costs in clinical services settings. METHODS:Review of techniques to calculate costs in Intensive Care Units (ICUs) according to analytical accounting approaches. RESULTS:The methodological deve...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/s0210-5691(06)74498-9
更新日期：2006-05-01 00:00:00
abstract：:Tuberculosis miliar is a very rare complication of bacillus Calmette-Guérin (BCG) immunotherapy that is associated to high mortality. Thus, early diagnosis and treatment is essential. At present, there is a polymerase chain reaction technique (PCR) which is a rapid diagnostic method with elevated sensitivity. Treatmen...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/s0210-5691(06)74485-0
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVE:To describe the factors associated to morbidity-mortality in pediatric patients with severe head injury (SHI). MATERIAL AND METHOD:A review was made of the patients admitted to the Pediatric Intensive Care Unit (PICU) with SHI between July 1983 and December 2009. RESULTS:Of the 389 patients with head injuri...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2011.02.006
更新日期：2011-08-01 00:00:00
abstract：:The intensive care units must be prepared for a possible disaster, whether internal or external, in case it becomes necessary to evacuate the in-patients. They must have an Emergency and Self-protection Plan that includes the patient evacuation criteria and this must be known by all the personnel who work in the servi...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2009.05.005
更新日期：2010-04-01 00:00:00
abstract：OBJECTIVE:To analyze the management and progression of the critical trauma patient. DESIGN:A retrospective, descriptive analysis. SETTING:The ICU in the province of Toledo. PATIENTS:All patients with traumatic injury admitted during the 2001-2007 period (7 years). MAIN VARIABLES OF INTEREST:These include the variab...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2010.02.002
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:To analyze the efficacy of negative fluid balance in hypoxemic patients with an elevated extravascular lung water index (EVLWI). DESIGN:A retrospective observational study was made. SETTING:Intensive Care Unit of Virgen de las Nieves Hospital (Spain). PARTICIPANTS:Forty-four patients participated in the st...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2014.07.008
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVE:Analyze the utility and safety of MARS therapy applied with the CRRT monitor. DESIGN:Prospective study of cohorts. SCOPE:Polyvalent ICU in tertiary university hospital with hepatic transplantation program. PATIENTS:Thirty one patients: 9 (22.6%) with acute liver failure (ALF) (1 hepatic surgery, 1 primary ...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/s0210-5691(07)74841-6
更新日期：2007-10-01 00:00:00
abstract：:Both acute myocardial infarction and pulmonary thromboembolism are responsible for a great number of cardiac arrests. Both present high rates of mortality. Thrombolysis has proved to be an effective treatment for acute myocardial infarction and pulmonary thromboembolism with shock. It would be worth considering whethe...
journal_title：Medicina intensiva
pub_type： 杂志文章,评审
doi：10.1016/s0210-5691(06)74470-9
更新日期：2006-03-01 00:00:00
abstract：:This article is based on the strategic reflection and discussion that took place on occasion of the first conference on innovation and technology transfer in the health sciences organized by the REGIC-ENS-FENIN-SEMICYUC and held in Madrid in the Instituto de Salud Carlos III on May 7th, 2013, with the aim of promoting...
journal_title：Medicina intensiva
pub_type：
doi：10.1016/j.medin.2014.04.012
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:To assess the impact of gender upon the prognosis and medical care in a regional acute ST-elevation myocardial infarction management network. DESIGN:An observational study was made of consecutive patients entered in a prospective database. SCOPE:The Catalan acute ST-elevation myocardial infarction managemen...
journal_title：Medicina intensiva
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medin.2016.06.008
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:Apply a sedoanalgesic (SA) protocol for invasive procedures (PI) in pediatric patients and evaluate its effectiveness and safety. DESIGN:Prospective observational study. SCOPE:Pediatric Intensive Care Unit (PICU) of third level hospital. PATIENTS:A total of 110 children subjected to invasive procedures und...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/s0210-5691(07)74851-9
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:Multicenter study oriented at establishing the incidence and prognosis of acute kidney failure (AKF) in the ICU of our country. MATERIAL AND METHODS:Prospective study of adult patients admitted over 8 months in 43 Spanish ICUs to detect AKF defined as creatinine>or=2 mg/dl or diuresis<400 ml/24 hours (in chr...
journal_title：Medicina intensiva
pub_type： 杂志文章,多中心研究
doi：10.1016/s0210-5691(06)74522-3
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVE:To describe the incidence and main clinical characteristics of barotrauma during open lung ventilation (OLV). DESIGN:A retrospective, observational, descriptive study was made of 100 patients with acute respiratory failure and bilateral pulmonary infiltrates. INTERVENTIONS:1) A lung recruitment maneuver (LR...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2011.10.011
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:A comparison was made of the oxidative stress (OS) levels of patients with either viral or bacterial severe community-acquired pneumonia (sCAP) and of patients without infection (healthy volunteers (HV) and patients with acute myocardial infarction (AMI)). DESIGN:A prospective observational study was made. ...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2013.01.004
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVE:To detect donor characteristics related to graft function after orthotopic liver transplantation (OLT). DESIGN:Retrospective cohort study. CONTEXT:Polyvalent intensive care unit. PATIENTS:145 liver transplant recipients and their respective donors. INTERVENTIONS:None. MAIN VARIABLES OF INTEREST:In donors...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/s0210-5691(08)75708-5
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVE:Describe the frequency of high degree atrioventricular block (HDAVB) in patients with unstable angina (UA), analyze the variables associated with their appearance and evaluate whether HDAVB is independently associated with increased mortality or increased length of ICU stay. DESIGN:Retrospective descriptive ...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/s0210-5691(06)74566-1
更新日期：2006-12-01 00:00:00
abstract：AIM:To determine the risk of microbiological contamination with hospital use high- and low-flow bubbling humidifiers. METHODS:A systematic literature review was carried out in 6 databases. Observational or experimental studies published between 1990 and 2016 were selected, written in English or Spanish, and in which m...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2017.11.003
更新日期：2019-01-01 00:00:00
abstract：:Extracorporeal membrane oxygenation (ECMO) support is indicated in patients who are refractory to treatment, those with cardiogenic shock or respiratory failure and those with exacerbations eligible for heart and lung transplantation. Physician experience and quantity of necessary resources are reasons why regionaliza...
journal_title：Medicina intensiva
pub_type： 杂志文章,评审
doi：10.1016/j.medin.2018.01.004
更新日期：2019-03-01 00:00:00
abstract：:Most patients who require mechanical ventilation for longer than 24 hours, and who improve the condition leading to the indication of ventilatory support, can be weaned after passing a first spontaneous breathing test. The challenge is to improve the weaning of patients who fail that first test. We have methods that c...
journal_title：Medicina intensiva
pub_type： 杂志文章,评审
doi：10.1016/j.medin.2012.08.008
更新日期：2013-12-01 00:00:00
abstract：:With the aim of analyzing the current state of the educational objectives in the training of medical residents in solid organ transplantation (SOT), we conducted a review of the status of the official programs of the specialities involved in SOT, focusing particularly on lung transplantation. A survey of medical resid...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2012.03.012
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:Before deciding increases in the number or capacitance of Intensive Care Units (ICUs), or the regionalization of Units, it is essential to know their present effectiveness. OBJECTIVE:To analyze the daily occupancy rate of ICUs in Catalonia (Spain) and the frequency of denied admission due to lack of capacit...
journal_title：Medicina intensiva
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medin.2014.11.002
更新日期：2015-12-01 00:00:00
