Oxidative stress in immunocompetent patients with severe community-acquired pneumonia. A pilot study.


OBJECTIVE:A comparison was made of the oxidative stress (OS) levels of patients with either viral or bacterial severe community-acquired pneumonia (sCAP) and of patients without infection (healthy volunteers (HV) and patients with acute myocardial infarction (AMI)). DESIGN:A prospective observational study was made. PATIENTS:Critically ill patients with sCAP. VARIABLES:The TBARS level was measured as an index of oxidative injury. SOD, CAT and redox glutathione system (GSH, GSSG, GR, GPx) activities were measured as reflecting antioxidant capacity. Severity of illness was assessed by the APACHE II, SOFA and SIRS scores. RESULTS:Thirty-seven subjects were included: 15 patients with CAP (12 of bacterial origin [BCAP] and 3 due to 2009 A/H1N1 virus [VCAP]), 10 HV and 12 AMI patients. Intensive care CAP mortality was 26.7% (n=4). Plasmatic TBARS levels were higher in CAP patients than in HV, but similar to those recorded in AMI patients. In contrast, VCAP was associated with lower TBARS levels, and some components of the glutathione redox system were higher in BCAP patients and HV. The OS levels did not differ between survivors and non-survivors. CONCLUSION:Our results suggest the occurrence of higher OS in sCAP patients compared with HV. In contrast, lower TBARS levels were observed in VCAP patients, suggesting an increase of antioxidant activity related to the redox glutathione system. However, further research involving a larger cohort is needed in order to confirm these findings.


Med Intensiva


Medicina intensiva


Trefler S,Rodríguez A,Martín-Loeches I,Sanchez V,Marín J,Llauradó M,Romeu M,Díaz E,Nogués R,Giralt M




Has Abstract


2014-03-01 00:00:00














  • [Tako-tsubo syndrome. Transient left ventricular dyskinesia. Presentation of our casuistics].

    abstract::This syndrome was described in 1990. It is characterized by chest pain that simulates an acute coronary syndrome (ACS), with alterations in the ECG, but with normal coronary arteries. We present 16 patients admitted in our ICU, who met the criteria of transient left ventricular dysfunction syndrome (TLVDS). All but 1 ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Del Nogal Sáez F,Meyer García-Sípido E,Villar Molina M,Blasco Navalpotro MA,Díaz Abad R,Grande Ingelmo JM

    更新日期:2011-06-01 00:00:00

  • [Absence of benefit with triple antiaggregation in acute non persistent ST segment elevation myocardial infarction in patients not subjected to early interventionism].

    abstract:OBJECTIVE:To assess the efficacy and safety of a treatment with clopidogrel when associated or not to the treatment with tirofiban and aspirin for high-risk non-ST segment elevation myocardial infarction (non-STEMI), without early angioplasty. SETTING:Intensive Care and Coronary Unit (ICCU), in a center with no Hemody...

    journal_title:Medicina intensiva

    pub_type: 临床试验,杂志文章


    authors: Blancas Gómez-Casero R,Nevado Losada E,López Matamala B,Martínez Díaz C,Serrano Castañeda J,Yáñez Parareda E,González Manzanares JL,Chana García M,Martín Delgado C

    更新日期:2007-05-01 00:00:00

  • Efficacy of an extravascular lung water-driven negative fluid balance protocol.

    abstract:OBJECTIVE:To analyze the efficacy of negative fluid balance in hypoxemic patients with an elevated extravascular lung water index (EVLWI). DESIGN:A retrospective observational study was made. SETTING:Intensive Care Unit of Virgen de las Nieves Hospital (Spain). PARTICIPANTS:Forty-four patients participated in the st...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Díaz-Rubia L,Ramos-Sáez S,Vázquez-Guillamet R,Guerrero-López F,Pino-Sánchez F,García-Delgado M,Gómez-Jiménez FJ,Fernández-Mondéjar E

    更新日期:2015-08-01 00:00:00

  • [Intermittent versus continuous renal replacement techniques: pro intermittent].

    abstract::After an introduction that summarizes the new definitions and risk classification of acute kidney injury, along with the consequences on its epidemiology, available evidence in the literature is reviewed in order to compare intermittent and continuous renal replacement therapy in terms of survival, renal function reco...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审


    authors: Barrio V

    更新日期:2009-03-01 00:00:00

  • Compatibility of drugs administered as Y-site infusion in intensive care units: A systematic review.

    abstract:OBJECTIVES:To gather all published information about the stability of drugs commonly used in Intensive Care Units (ICU); evaluate the methodology of published data; and generate a compatibility table. DESIGN:i) A systematic review was conducted searching the following databases: Medline, Stabilis, Handbook of Injectab...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Castells Lao G,Rodríguez Reyes M,Roura Turet J,Prat Dot M,Soy Muner D,López Cabezas C

    更新日期:2020-03-01 00:00:00

  • [Organ preservation].

    abstract::Maintaining organ viability from extraction to transplantation is crucial to ensure the function and survival of the graft. In recent years, maintaining organ viability has become more challenging because the shortage of donors has led to broader criteria for donor acceptability and consequently to organs with greater...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Cobo JL,Del Río Gallegos F

    更新日期:2009-08-01 00:00:00

  • [Indicators of quality in the critical patient].

    abstract::The utility of using quality indicators as a tool to measure the common practice and evaluate efficacy of measures established to improve quality has been demonstrated, making it possible to identify and make known the improvements carried out. The project "Quality indicators in the critical patient" has been conducte...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Martín MC,Cabré L,Ruiz J,Blanch L,Blanco J,Castillo F,Galdós P,Roca J,Saura RM,Grupos de trabajo de la Sociedad Española de Medicina Intensiva Crítica y Unidades Coronarias (SEMICYUC), Sociedad Española de Enfermería Intensiva y Unidad

    更新日期:2008-01-01 00:00:00

  • [Diagnosis of brain death by multislice CT scan: angioCT scan and brain perfusion].

    abstract::BD was diagnosed by clinical examination, electroencephalogram (EEG), Transcranial Doppler (TCD) and multislice CT of 64 detectors. Initially, a brain perfusion study was performed. This was followed by supra-aortic trunk and brain artery angiography with acquisition of images using 0.5 mm slices, from the origin of t...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Escudero D,Otero J,Vega P,Gil A,Roger RL,Gonzalo JA,Muñiz G,Taboada F

    更新日期:2007-08-01 00:00:00

  • Prognostic factors associated with mortality in patients with severe trauma: from prehospital care to the Intensive Care Unit.

    abstract:OBJECTIVE:To identify factors related to mortality in adult trauma patients, analyzing the clinical, epidemiological and therapeutic characteristics at the pre-hospital levels, in the Emergency Care Department and in Intensive Care. DESIGN:A retrospective, longitudinal descriptive study was carried out. Statistical an...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: González-Robledo J,Martín-González F,Moreno-García M,Sánchez-Barba M,Sánchez-Hernández F

    更新日期:2015-10-01 00:00:00

  • Management of accidental hypothermia: A narrative review.

    abstract::A narrative review is presented on the diagnosis, treatment and management of accidental hypothermia. Although all these processes form a continuum, for descriptive purposes in this manuscript the recommendations are organized into the prehospital and in-hospital settings. At prehospital level, it is advised to: a) pe...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审


    authors: Avellanas Chavala ML,Ayala Gallardo M,Soteras Martínez Í,Subirats Bayego E

    更新日期:2019-12-01 00:00:00

  • Innovation and technology transfer in the health sciences: a cross-sectional perspective.

    abstract::This article is based on the strategic reflection and discussion that took place on occasion of the first conference on innovation and technology transfer in the health sciences organized by the REGIC-ENS-FENIN-SEMICYUC and held in Madrid in the Instituto de Salud Carlos III on May 7th, 2013, with the aim of promoting...

    journal_title:Medicina intensiva



    authors: Blanch L,Guerra L,Lanuza A,Palomar G

    更新日期:2014-11-01 00:00:00

  • Blood purification in the critically ill patient. Prescription tailored to the indication (including the pediatric patient).

    abstract::We maintain a dynamic position on extracorporeal blood purification therapies (EBPT). Continuous therapies are of choice in the hemodynamically unstable patient. We recommend their early introduction in the course of the disease, and starting with a dose of 30-35mL/kg/h. Above all, however, daily re-evaluation is requ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Sanchez-Izquierdo Riera JA,Montoiro Allué R,Tomasa Irriguible T,Palencia Herrejón E,Cota Delgado F,Pérez Calvo C

    更新日期:2016-10-01 00:00:00

  • [MARS (Molecular Absorbent Recirculating System) as hepatic extracorporeal care in serious acute liver failure of alcoholic etiology].

    abstract::Acute liver failure with criteria of seriousness and alcoholic etiology is a picture of worldwide distribution, with an elevated mortality, of approximately 50%, that requires admission to the ICU. Acute serious alcoholic hepatitis is defined by a Maddrey score value > 32 and/or spontaneous encephalopathy. Together wi...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Mora JM,Olmedo R,Curiel E,Muñoz J,Herrera M,Séller G

    更新日期:2006-11-01 00:00:00

  • [Does decompressive craniectomy improve other parameters besides ICP? Effects of the decompressive craniectomy on tissular pressure?].

    abstract::Second level therapeutic maneuvres for controlling intracranial hypertension (ICH) proposed by the European Brain Injury Consortium and the American Association of Neurological Surgeons include barbiturates, moderate hypothermia and more recently the decompressive craniectomy (DC).In most patients, ICP can be maintain...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Lubillo S,Blanco J,López P,Domínguez J,Ruiz C,Molina I,Morera J

    更新日期:2011-04-01 00:00:00

  • The American-European Consensus Conference definition of the acute respiratory distress syndrome is dead, long live positive end-expiratory pressure!

    abstract::In 1994, an American-European Consensus Conference (AECC) formalized the criteria for the diagnosis of the acute respiratory distress syndrome (ARDS). Although that definition is simple to apply in the clinical setting, it has been challenged over the years in several studies since the assessment of the oxygenation de...

    journal_title:Medicina intensiva

    pub_type: 共识发展会议,杂志文章


    authors: Villar J,Kacmarek RM

    更新日期:2012-11-01 00:00:00

  • [Atrioventricular block in unstable angina. Results of the ARIAM registry].

    abstract:OBJECTIVE:Describe the frequency of high degree atrioventricular block (HDAVB) in patients with unstable angina (UA), analyze the variables associated with their appearance and evaluate whether HDAVB is independently associated with increased mortality or increased length of ICU stay. DESIGN:Retrospective descriptive ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Ruiz-Bailén M,Pola Gallego MD,Expósito Ruiz M,Pintor Mármol A,Issa-Khozouz Z,Aguayo De Hoyos E,Rucabado-Aguilar L,Castillo-Rivera AM,Morante-Valle A,Rodríguez-Puche JA,García-Alcántara A,Gómez Jiménez FJ,Grupo ARIAM.

    更新日期:2006-12-01 00:00:00

  • [Liver transplantation: influence of donor-related factors].

    abstract:OBJECTIVE:To detect donor characteristics related to graft function after orthotopic liver transplantation (OLT). DESIGN:Retrospective cohort study. CONTEXT:Polyvalent intensive care unit. PATIENTS:145 liver transplant recipients and their respective donors. INTERVENTIONS:None. MAIN VARIABLES OF INTEREST:In donors...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Seller-Pérez G,Herrera-Gutiérrez ME,Lebrón-Gallardo M,Moreno-Quintana J,Banderas-Bravo E,Quesada-García G

    更新日期:2008-11-01 00:00:00

  • [Guidelines for specialized nutritional and metabolic support in the critically ill-patient. Update. Consensus of the Spanish Society of Intensive Care Medicine and Coronary Units-Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-SENPE): sever

    abstract::Severe acute pancreatitis (SAP) causes local and systemic complications leading to high catabolic, hypermetabolic and hyperdynamic stress states with marked morbidity and mortality. In the last decade, nutritional support has become a key element in the treatment of SAP. Thus, specialized nutrition is indicated from a...

    journal_title:Medicina intensiva

    pub_type: 共识发展会议,杂志文章,实务指引


    authors: Bordejé Laguna L,Lorencio Cárdenas C,Acosta Escribano J,Spanish Society of Intensive Care Medicine and Coronary Units-Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-SENPE).

    更新日期:2011-11-01 00:00:00

  • [MELAS: diagnostic keys and treatment in the Intensive Care Unit].

    abstract::Cerebrovascular accident in young adults is not rare and the most common causes are: cardiac embolism, arterial dissection and migraine. The unknown etiology, in spite of extensive studies, is described in the literature in about one third of patients under 45 years of age. The mitochondrial encephalomyopathy, lactic ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Gómez Seijo A,Castro Orjales MJ,Pastor Benavent JA

    更新日期:2008-04-01 00:00:00

  • Perioperative management in thoracic surgery.

    abstract::Thoracic surgery has undergone significant advances in recent years related to anesthetic and surgical techniques and the prevention and management of complications related to the procedure. This has allowed improvements in patient clinical outcomes in surgeries of this kind. Despite the above, thoracic surgery, espec...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Muñoz de Cabo C,Hermoso Alarza F,Cossio Rodriguez AM,Martín Delgado MC

    更新日期:2020-04-01 00:00:00

  • [Results of an artificial airway management protocol in critical patients subjected to mechanical ventilation].

    abstract:OBJECTIVE:To determine the results of the implementation of a protocol in an intensive care unit (ICU) referred to critically ill patients requiring a prolonged artificial airway. DESIGN:A prospective, observational cohort study was carried out. INTERVENTION:Management strategies were established on the airway by end...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Prieto-González M,López-Messa JB,Moradillo-González S,Franzón-Laz ZM,Ortega-Sáez M,Poncela-Blanco M,Alonso-Castañeira I,Andrés-de Llano J

    更新日期:2013-08-01 00:00:00

  • [Epidemiology of acute kidney failure in Spanish ICU. Multicenter prospective study FRAMI].

    abstract:OBJECTIVE:Multicenter study oriented at establishing the incidence and prognosis of acute kidney failure (AKF) in the ICU of our country. MATERIAL AND METHODS:Prospective study of adult patients admitted over 8 months in 43 Spanish ICUs to detect AKF defined as creatinine>or=2 mg/dl or diuresis<400 ml/24 hours (in chr...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,多中心研究


    authors: Herrera-Gutiérrez ME,Seller-Pérez G,Maynar-Moliner J,Sánchez-Izquierdo-Riera JA,Grupo de trabajo \Estado actual del fracaso renal agudo y de las técnicas de reemplazo renal en UCI. Estudio FRAMI\.

    更新日期:2006-08-01 00:00:00

  • [Evaluation of pain during mobilization and endotracheal aspiration in critical patients].

    abstract:OBJECTIVES:1) To assess the prevalence of pain during nursing care procedures, and 2) to evaluate the usefulness of certain vital signs and the bispectral index (BIS) in detecting pain. METHODS:A prospective, observational analytical study was made of procedures (endotracheal aspiration and mobilization with turning) ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Robleda G,Roche-Campo F,Membrilla-Martínez L,Fernández-Lucio A,Villamor-Vázquez M,Merten A,Gich I,Mancebo J,Català-Puigbó E,Baños JE

    更新日期:2016-03-01 00:00:00

  • [Thrombolysis in cardiac arrest].

    abstract::Both acute myocardial infarction and pulmonary thromboembolism are responsible for a great number of cardiac arrests. Both present high rates of mortality. Thrombolysis has proved to be an effective treatment for acute myocardial infarction and pulmonary thromboembolism with shock. It would be worth considering whethe...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审


    authors: Ruiz Bailén M,Rucabado Aguilar L,Morante Valle A,Castillo Rivera A

    更新日期:2006-03-01 00:00:00

  • [Safety and effectiveness of the sedoanalgesia with fentanyl and propofol. Experience in a pediatric intensive medicine unit].

    abstract:OBJECTIVE:Apply a sedoanalgesic (SA) protocol for invasive procedures (PI) in pediatric patients and evaluate its effectiveness and safety. DESIGN:Prospective observational study. SCOPE:Pediatric Intensive Care Unit (PICU) of third level hospital. PATIENTS:A total of 110 children subjected to invasive procedures und...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: López JM,Valerón M,Pérez O,Consuegra E,Urquía L,Morón A,González R

    更新日期:2007-11-01 00:00:00

  • Hemodynamic resuscitation with fluids bolus and norepinephrine increases severity of lung damage in an experimental model of septic shock.

    abstract:OBJECTIVE:Hemodynamic resuscitation is considered a cornerstone of the initial treatment of septic shock. However, there is growing concern about its side effects. Our objective was to assess the relationship between fluid administration and norepinephrine infusion and the development of lung injury. DESIGN:Randomized...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Guijo Gonzalez P,Gracia Romero MA,Gil Cano A,Garcia Rojo M,Cecconi M,Monge Garcia IM

    更新日期:2020-07-24 00:00:00

  • Occupancy of the Departments of Intensive Care Medicine in Catalonia (Spain): A prospective, analytical cohort study.

    abstract:BACKGROUND:Before deciding increases in the number or capacitance of Intensive Care Units (ICUs), or the regionalization of Units, it is essential to know their present effectiveness. OBJECTIVE:To analyze the daily occupancy rate of ICUs in Catalonia (Spain) and the frequency of denied admission due to lack of capacit...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,多中心研究


    authors: Fernandez R,Clinical Management Working Group of the Societat Catalana de Medicina Intensiva i Crítica.

    更新日期:2015-12-01 00:00:00

  • [Safety and efficacy of the MARS therapy applied by continuous renal replacement therapy (CRRT) monitors].

    abstract:OBJECTIVE:Analyze the utility and safety of MARS therapy applied with the CRRT monitor. DESIGN:Prospective study of cohorts. SCOPE:Polyvalent ICU in tertiary university hospital with hepatic transplantation program. PATIENTS:Thirty one patients: 9 (22.6%) with acute liver failure (ALF) (1 hepatic surgery, 1 primary ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Herrera-Gutiérrez ME,Seller-Pérez G,Lebrón-Gallardo M,Jiménez-Pérez M,Moreno-López JM,Muñoz-López A

    更新日期:2007-10-01 00:00:00

  • [Changes observed in three quality indicators after the implementation of improvement strategies in the respiratory intensive care unit].

    abstract:OBJECTIVE:To compare the results of quality monitoring after the implementation of improvement strategies in the respiratory intensive care unit (RICU). DESIGN:A prospective, comparative, longitudinal and interventional study was carried out. SETTING:The RICU of Hospital General de México (Mexico). PATIENTS:All pati...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Álvarez Maldonado P,Cueto Robledo G,Cicero Sabido R

    更新日期:2015-04-01 00:00:00

  • Incidents related to critical patient safety during in-hospital transfer.

    abstract:OBJECTIVE:To analyze the incidents related to patient safety (IRSP) and their risk factors during in-hospital transfer (IHT) of critical patients after the application of a protocol, and to evaluate safety during transfer using quality indicators. DESIGN:A prospective, observational and non-intervention cohort study w...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Catalán-Ibars RM,Martín-Delgado MC,Puigoriol-Juvanteny E,Zapater-Casanova E,Lopez-Alabern M,Lopera-Caballero JL,González de Velasco JP,Coll-Solà M,Juanola-Codina M,Roger-Casals N

    更新日期:2020-07-15 00:00:00