Oxidative stress in immunocompetent patients with severe community-acquired pneumonia. A pilot study.


OBJECTIVE:A comparison was made of the oxidative stress (OS) levels of patients with either viral or bacterial severe community-acquired pneumonia (sCAP) and of patients without infection (healthy volunteers (HV) and patients with acute myocardial infarction (AMI)). DESIGN:A prospective observational study was made. PATIENTS:Critically ill patients with sCAP. VARIABLES:The TBARS level was measured as an index of oxidative injury. SOD, CAT and redox glutathione system (GSH, GSSG, GR, GPx) activities were measured as reflecting antioxidant capacity. Severity of illness was assessed by the APACHE II, SOFA and SIRS scores. RESULTS:Thirty-seven subjects were included: 15 patients with CAP (12 of bacterial origin [BCAP] and 3 due to 2009 A/H1N1 virus [VCAP]), 10 HV and 12 AMI patients. Intensive care CAP mortality was 26.7% (n=4). Plasmatic TBARS levels were higher in CAP patients than in HV, but similar to those recorded in AMI patients. In contrast, VCAP was associated with lower TBARS levels, and some components of the glutathione redox system were higher in BCAP patients and HV. The OS levels did not differ between survivors and non-survivors. CONCLUSION:Our results suggest the occurrence of higher OS in sCAP patients compared with HV. In contrast, lower TBARS levels were observed in VCAP patients, suggesting an increase of antioxidant activity related to the redox glutathione system. However, further research involving a larger cohort is needed in order to confirm these findings.


Med Intensiva


Medicina intensiva


Trefler S,Rodríguez A,Martín-Loeches I,Sanchez V,Marín J,Llauradó M,Romeu M,Díaz E,Nogués R,Giralt M




Has Abstract


2014-03-01 00:00:00














  • Occupancy of the Departments of Intensive Care Medicine in Catalonia (Spain): A prospective, analytical cohort study.

    abstract:BACKGROUND:Before deciding increases in the number or capacitance of Intensive Care Units (ICUs), or the regionalization of Units, it is essential to know their present effectiveness. OBJECTIVE:To analyze the daily occupancy rate of ICUs in Catalonia (Spain) and the frequency of denied admission due to lack of capacit...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,多中心研究


    authors: Fernandez R,Clinical Management Working Group of the Societat Catalana de Medicina Intensiva i Crítica.

    更新日期:2015-12-01 00:00:00

  • Enteral nutrition in the hemodynamically unstable critically ill patient.

    abstract::The benefit of enteral nutrition in critically ill patients has been demonstrated by several studies, especially when it is started early, in the first 24-48h of stay in the Intensive Care Unit, and this practice is currently advised by the main clinical guidelines. The start of enteral nutrition is controversial in p...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审


    authors: Flordelís Lasierra JL,Pérez-Vela JL,Montejo González JC

    更新日期:2015-01-01 00:00:00

  • Gender gap in medical care in ST segment elevation myocardial infarction networks: Findings from the Catalan network Codi Infart.

    abstract:OBJECTIVE:To assess the impact of gender upon the prognosis and medical care in a regional acute ST-elevation myocardial infarction management network. DESIGN:An observational study was made of consecutive patients entered in a prospective database. SCOPE:The Catalan acute ST-elevation myocardial infarction managemen...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,多中心研究


    authors: Fernández-Rodríguez D,Regueiro A,Cevallos J,Bosch X,Freixa X,Trilla M,Brugaletta S,Martín-Yuste V,Sabaté M,Bosa-Ojeda F,Masotti M,en representación de los investigadores del Registro Codi Infart.

    更新日期:2017-03-01 00:00:00

  • Main information requests of family members of patients in Intensive Care Units.

    abstract:OBJECTIVE:To compile an inventory of information requests prioritized by the family members, to find out which professionals them consider able to respond these requests, and to explore the differences in perception between family members and professionals. DESIGN:Qualitative analysis of content validation and descrip...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,多中心研究


    authors: Velasco Bueno JM,Alonso-Ovies A,Heras La Calle G,Zaforteza Lallemand C,Equipo de investigación del Proyecto HUCI (Humanizando los Cuidados Intensivos).

    更新日期:2018-01-01 00:00:00

  • [Latin American survey on delirium in critical patients].

    abstract:OBJECTIVES:This study has aimed to establish the intensivist physician's concepts and practices in this region regarding the diagnosis, management and prevention of delirium in intensive care units (ICU). DESIGN:A survey was distributed among the FEPIMCTI member societies for distribution among its medical members. R...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Ceraso DH,Dueñas-Castel C,Raimondi N,Celis E,Carrillo R,Ugarte Ubiergo S,Rodriguez F

    更新日期:2010-11-01 00:00:00

  • [MARS (Molecular Absorbent Recirculating System) as hepatic extracorporeal care in serious acute liver failure of alcoholic etiology].

    abstract::Acute liver failure with criteria of seriousness and alcoholic etiology is a picture of worldwide distribution, with an elevated mortality, of approximately 50%, that requires admission to the ICU. Acute serious alcoholic hepatitis is defined by a Maddrey score value > 32 and/or spontaneous encephalopathy. Together wi...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Mora JM,Olmedo R,Curiel E,Muñoz J,Herrera M,Séller G

    更新日期:2006-11-01 00:00:00

  • [Mitochondrial dysfunction during sepsis, impact and possible regulating role of hypoxia-inducible factor-1alpha].

    abstract::There is a direct correlation between the development of the multiple organ dysfunction syndrome (MODS) and the elevated mortality associated with sepsis. The mechanisms responsible for MODS development are being studied, however, the main efforts regarding MODS evaluation have focused on oxygen delivery optimization ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审


    authors: Regueira T,Andresen M,Djafarzadeh S

    更新日期:2009-11-01 00:00:00

  • [Does decompressive craniectomy improve other parameters besides ICP? Effects of the decompressive craniectomy on tissular pressure?].

    abstract::Second level therapeutic maneuvres for controlling intracranial hypertension (ICH) proposed by the European Brain Injury Consortium and the American Association of Neurological Surgeons include barbiturates, moderate hypothermia and more recently the decompressive craniectomy (DC).In most patients, ICP can be maintain...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Lubillo S,Blanco J,López P,Domínguez J,Ruiz C,Molina I,Morera J

    更新日期:2011-04-01 00:00:00

  • Efficacy of an extravascular lung water-driven negative fluid balance protocol.

    abstract:OBJECTIVE:To analyze the efficacy of negative fluid balance in hypoxemic patients with an elevated extravascular lung water index (EVLWI). DESIGN:A retrospective observational study was made. SETTING:Intensive Care Unit of Virgen de las Nieves Hospital (Spain). PARTICIPANTS:Forty-four patients participated in the st...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Díaz-Rubia L,Ramos-Sáez S,Vázquez-Guillamet R,Guerrero-López F,Pino-Sánchez F,García-Delgado M,Gómez-Jiménez FJ,Fernández-Mondéjar E

    更新日期:2015-08-01 00:00:00

  • Cranioplasty with bandaging. New forms of limitation of life support and organ donation.

    abstract::Most of transplanted organs are obtained from brain death (BD) donors. In neurocritical patients with catastrophic injuries and decompressive craniectomy (DC), which show a dreadful development in spite of this treatment, DC could be a futile tool to avoid natural progress to BD. We propose if cranial compressive band...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Escudero D,Cofiño L,Gracia D,Palacios M,Casares M,Cabré L,Simón P,Miranda P,Martínez K,Iribarren S,Saralegui I,Simó RM,de León B,Español V

    更新日期:2013-04-01 00:00:00

  • [Indicators of quality in the critical patient].

    abstract::The utility of using quality indicators as a tool to measure the common practice and evaluate efficacy of measures established to improve quality has been demonstrated, making it possible to identify and make known the improvements carried out. The project "Quality indicators in the critical patient" has been conducte...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Martín MC,Cabré L,Ruiz J,Blanch L,Blanco J,Castillo F,Galdós P,Roca J,Saura RM,Grupos de trabajo de la Sociedad Española de Medicina Intensiva Crítica y Unidades Coronarias (SEMICYUC), Sociedad Española de Enfermería Intensiva y Unidad

    更新日期:2008-01-01 00:00:00

  • Quality of anthropometric measurements in Spanish Intensive Care Units (The CAMIES Study).

    abstract:INTRODUCTION:Real body weight and height are essential data to be obtained in all critically ill patients (CIP), due to their influence in the designing of therapies and monitoring. Visual estimation is a very inaccurate practice. No precise descriptions of anthropometric measurements among CIP are available in the cli...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,多中心研究


    authors: García-Martínez MA,Cherednichenko T,Hidalgo Encinas Y,Catalá Espinosa AI,Arrascaeta Llanes A,Acosta Escribano JA

    更新日期:2018-01-01 00:00:00

  • Perioperative management in thoracic surgery.

    abstract::Thoracic surgery has undergone significant advances in recent years related to anesthetic and surgical techniques and the prevention and management of complications related to the procedure. This has allowed improvements in patient clinical outcomes in surgeries of this kind. Despite the above, thoracic surgery, espec...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Muñoz de Cabo C,Hermoso Alarza F,Cossio Rodriguez AM,Martín Delgado MC

    更新日期:2020-04-01 00:00:00

  • [Differential characteristics of patients with acute coronary syndrome without ST-segment elevation compared to those with transient ST-segment elevation].

    abstract:OBJECTIVE:To evaluate different characteristics of patients with acute coronary syndrome (ACS) without ST-segment elevation compared with transient St-segment elevation. DESIGN:An observational, prospective study. SETTING:A 12-bed coronary care unit. PATIENTS:Consecutive patients of ACS without persistent ST-segment...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Arroyo Úcar E,Domínguez-Rodríguez A,Juárez Prera R,Blanco Palacios G,Hernández García C,Carrillo-Pérez Tome M,Abreu-González P

    更新日期:2011-06-01 00:00:00

  • Advances in immunosuppression after lung transplantation.

    abstract::Immunosuppression in transplantation has experienced changes in recent years as a result of the introduction of new drugs that act upon the different pathways of the host immune response with the purpose of securing more individualized immune suppression, with fewer side effects. Although following in the steps of oth...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Borro JM

    更新日期:2013-01-01 00:00:00

  • [Incidence, characteristics and outcome of barotrauma during open lung ventilation].

    abstract:OBJECTIVE:To describe the incidence and main clinical characteristics of barotrauma during open lung ventilation (OLV). DESIGN:A retrospective, observational, descriptive study was made of 100 patients with acute respiratory failure and bilateral pulmonary infiltrates. INTERVENTIONS:1) A lung recruitment maneuver (LR...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Gil Cano A,Monge García MI,Gracia Romero M,Díaz Monrové JC

    更新日期:2012-06-01 00:00:00

  • [Safety and effectiveness of the sedoanalgesia with fentanyl and propofol. Experience in a pediatric intensive medicine unit].

    abstract:OBJECTIVE:Apply a sedoanalgesic (SA) protocol for invasive procedures (PI) in pediatric patients and evaluate its effectiveness and safety. DESIGN:Prospective observational study. SCOPE:Pediatric Intensive Care Unit (PICU) of third level hospital. PATIENTS:A total of 110 children subjected to invasive procedures und...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: López JM,Valerón M,Pérez O,Consuegra E,Urquía L,Morón A,González R

    更新日期:2007-11-01 00:00:00

  • [Hormone modulation of organ donor. Utility of the steroids].

    abstract::Recently, the work group made up of the National Transplant Organization (Organización Nacional de Trasplantes, ONT), Spanish Society of Intensive, Critical Medicine and Coronary Units (Sociedad Española de Medicina Intensiva, Crítica y de Unidades Coronarias, SEMICYUC) and other Scientific Societies have recommended ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审


    authors: Michelena JC,Chamorro C,Falcón JA,Garcés S

    更新日期:2009-06-01 00:00:00

  • [Brain death diagnosis].

    abstract::Brain death has been recognized by the scientific community as the person's death, and accepted in the legislation of different countries. Brain death is defined as the irreversible ending of the functions of all the intracranial neurological structure in both the brain and brain stem. This clinical situation appears ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审


    authors: Escudero D

    更新日期:2009-05-01 00:00:00

  • [Results of an artificial airway management protocol in critical patients subjected to mechanical ventilation].

    abstract:OBJECTIVE:To determine the results of the implementation of a protocol in an intensive care unit (ICU) referred to critically ill patients requiring a prolonged artificial airway. DESIGN:A prospective, observational cohort study was carried out. INTERVENTION:Management strategies were established on the airway by end...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Prieto-González M,López-Messa JB,Moradillo-González S,Franzón-Laz ZM,Ortega-Sáez M,Poncela-Blanco M,Alonso-Castañeira I,Andrés-de Llano J

    更新日期:2013-08-01 00:00:00

  • Prognostic factors associated with mortality in patients with severe trauma: from prehospital care to the Intensive Care Unit.

    abstract:OBJECTIVE:To identify factors related to mortality in adult trauma patients, analyzing the clinical, epidemiological and therapeutic characteristics at the pre-hospital levels, in the Emergency Care Department and in Intensive Care. DESIGN:A retrospective, longitudinal descriptive study was carried out. Statistical an...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: González-Robledo J,Martín-González F,Moreno-García M,Sánchez-Barba M,Sánchez-Hernández F

    更新日期:2015-10-01 00:00:00

  • [Southern European intensive care nurses' knowledge of evidence-based guidelines for preventing ventilator-associated pneumonia].

    abstract:OBJECTIVES:To assess Southern European intensive care unit nurses' knowledge about evidence-based guidelines for the prevention of ventilator-associated pneumonia and to compare these findings with a pan-European perspective. DESIGN:A sub-analysis from an observational study performed using a 9-questions, multiple-cho...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Llauradó M,Labeau S,Vandijck D,Rello J,Rosa A,Riera A,Gallart E,Moreno R,Vandewoude K,Piñer R,Benítez ML,Blot S,Investigadores del Estudio EVIDENCE.,Colaboradores del PROCORNEU (Programa Corporativo Neumonía CIBERES).

    更新日期:2011-01-01 00:00:00

  • [Takotsubo cardiomyopathy: transient apical dysfunction of the left ventricle].

    abstract::Transient apical dysfunction syndrome, ballooning or Takotsubo cardiomyopathy is a recently described syndrome. It is a disease with a partially known mechanism, characterized by the morphology adopted by the left ventricle secondary to hypokinesis and dyskinesis of the apical segments and hypercontractibility of the ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审


    authors: Obón Azuara B,Ortas Nadal MR,Gutiérrez Cía I,Villanueva Anadón B

    更新日期:2007-04-01 00:00:00

  • [Evaluation of pain during mobilization and endotracheal aspiration in critical patients].

    abstract:OBJECTIVES:1) To assess the prevalence of pain during nursing care procedures, and 2) to evaluate the usefulness of certain vital signs and the bispectral index (BIS) in detecting pain. METHODS:A prospective, observational analytical study was made of procedures (endotracheal aspiration and mobilization with turning) ...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Robleda G,Roche-Campo F,Membrilla-Martínez L,Fernández-Lucio A,Villamor-Vázquez M,Merten A,Gich I,Mancebo J,Català-Puigbó E,Baños JE

    更新日期:2016-03-01 00:00:00

  • [Use of neuromuscular blockers in the critical patient].

    abstract::The use of neuromuscular blockers (NMB) is a frequent practice in Intensive Care Units. However most of the experience with the use of these agents come from the operating room used to deal with patients with different characteristics from those admitted in the ICU. Recent advances on neuromonitoring and the commercia...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审


    authors: Sandiumenge A,Anglés R,Martínez-Melgar JL,Torrado H,Grupo de Trabajo de Analgesia y Sedación de la SEMICYUC.

    更新日期:2008-02-01 00:00:00

  • The American-European Consensus Conference definition of the acute respiratory distress syndrome is dead, long live positive end-expiratory pressure!

    abstract::In 1994, an American-European Consensus Conference (AECC) formalized the criteria for the diagnosis of the acute respiratory distress syndrome (ARDS). Although that definition is simple to apply in the clinical setting, it has been challenged over the years in several studies since the assessment of the oxygenation de...

    journal_title:Medicina intensiva

    pub_type: 共识发展会议,杂志文章


    authors: Villar J,Kacmarek RM

    更新日期:2012-11-01 00:00:00

  • [Diagnosis of brain death by multislice CT scan: angioCT scan and brain perfusion].

    abstract::BD was diagnosed by clinical examination, electroencephalogram (EEG), Transcranial Doppler (TCD) and multislice CT of 64 detectors. Initially, a brain perfusion study was performed. This was followed by supra-aortic trunk and brain artery angiography with acquisition of images using 0.5 mm slices, from the origin of t...

    journal_title:Medicina intensiva

    pub_type: 杂志文章


    authors: Escudero D,Otero J,Vega P,Gil A,Roger RL,Gonzalo JA,Muñiz G,Taboada F

    更新日期:2007-08-01 00:00:00

  • [Intermittent versus continuous renal replacement techniques: pro intermittent].

    abstract::After an introduction that summarizes the new definitions and risk classification of acute kidney injury, along with the consequences on its epidemiology, available evidence in the literature is reviewed in order to compare intermittent and continuous renal replacement therapy in terms of survival, renal function reco...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审


    authors: Barrio V

    更新日期:2009-03-01 00:00:00

  • Comparison of values in critically ill patients for global end-diastolic volume and extravascular lung water measured by transcardiopulmonary thermodilution: a meta-analysis of the literature.

    abstract:INTRODUCTION:Hemodynamic parameters such as the global end-diastolic volume index (GEDVI) and extravascular lung water index (EVLWI), derived by transpulmonary thermodilution, have gained increasing interest for guiding fluid therapy in critically ill patients. The proposed normal values (680-800ml/m(2) for GEDVI and 3...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,meta分析


    authors: Eichhorn V,Goepfert MS,Eulenburg C,Malbrain ML,Reuter DA

    更新日期:2012-10-01 00:00:00

  • Weaning from mechanical ventilation: why are we still looking for alternative methods?

    abstract::Most patients who require mechanical ventilation for longer than 24 hours, and who improve the condition leading to the indication of ventilatory support, can be weaned after passing a first spontaneous breathing test. The challenge is to improve the weaning of patients who fail that first test. We have methods that c...

    journal_title:Medicina intensiva

    pub_type: 杂志文章,评审


    authors: Frutos-Vivar F,Esteban A

    更新日期:2013-12-01 00:00:00