Abstract:
OBJECTIVE:A comparison was made of the oxidative stress (OS) levels of patients with either viral or bacterial severe community-acquired pneumonia (sCAP) and of patients without infection (healthy volunteers (HV) and patients with acute myocardial infarction (AMI)). DESIGN:A prospective observational study was made. PATIENTS:Critically ill patients with sCAP. VARIABLES:The TBARS level was measured as an index of oxidative injury. SOD, CAT and redox glutathione system (GSH, GSSG, GR, GPx) activities were measured as reflecting antioxidant capacity. Severity of illness was assessed by the APACHE II, SOFA and SIRS scores. RESULTS:Thirty-seven subjects were included: 15 patients with CAP (12 of bacterial origin [BCAP] and 3 due to 2009 A/H1N1 virus [VCAP]), 10 HV and 12 AMI patients. Intensive care CAP mortality was 26.7% (n=4). Plasmatic TBARS levels were higher in CAP patients than in HV, but similar to those recorded in AMI patients. In contrast, VCAP was associated with lower TBARS levels, and some components of the glutathione redox system were higher in BCAP patients and HV. The OS levels did not differ between survivors and non-survivors. CONCLUSION:Our results suggest the occurrence of higher OS in sCAP patients compared with HV. In contrast, lower TBARS levels were observed in VCAP patients, suggesting an increase of antioxidant activity related to the redox glutathione system. However, further research involving a larger cohort is needed in order to confirm these findings.
journal_name
Med Intensivajournal_title
Medicina intensivaauthors
Trefler S,Rodríguez A,Martín-Loeches I,Sanchez V,Marín J,Llauradó M,Romeu M,Díaz E,Nogués R,Giralt Mdoi
10.1016/j.medin.2013.01.004subject
Has Abstractpub_date
2014-03-01 00:00:00pages
73-82issue
2eissn
0210-5691issn
1578-6749pii
S0210-5691(13)00007-7journal_volume
38pub_type
杂志文章abstract:OBJECTIVE:To detect donor characteristics related to graft function after orthotopic liver transplantation (OLT). DESIGN:Retrospective cohort study. CONTEXT:Polyvalent intensive care unit. PATIENTS:145 liver transplant recipients and their respective donors. INTERVENTIONS:None. MAIN VARIABLES OF INTEREST:In donors...
journal_title:Medicina intensiva
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abstract:OBJECTIVE:To analyze the current evidence on glycemic control with insulin therapy in the critically ill. RECENT FINDINGS:Stress hyperglycemia in critically ill patients has been associated with increased morbidity and mortality. Furthermore, current evidence suggests that glucose variability has a predictive value fo...
journal_title:Medicina intensiva
pub_type: 杂志文章,评审
doi:10.1016/j.medin.2009.10.003
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abstract:OBJECTIVE:To describe the factors associated to morbidity-mortality in pediatric patients with severe head injury (SHI). MATERIAL AND METHOD:A review was made of the patients admitted to the Pediatric Intensive Care Unit (PICU) with SHI between July 1983 and December 2009. RESULTS:Of the 389 patients with head injuri...
journal_title:Medicina intensiva
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journal_title:Medicina intensiva
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journal_title:Medicina intensiva
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abstract:OBJECTIVE:To assess the impact of gender upon the prognosis and medical care in a regional acute ST-elevation myocardial infarction management network. DESIGN:An observational study was made of consecutive patients entered in a prospective database. SCOPE:The Catalan acute ST-elevation myocardial infarction managemen...
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pub_type: 杂志文章,多中心研究
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更新日期:2017-03-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章
doi:10.1016/j.medin.2012.12.008
更新日期:2013-04-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章,实务指引
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journal_title:Medicina intensiva
pub_type: 杂志文章
doi:10.1016/j.medin.2015.01.006
更新日期:2016-01-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章
doi:10.1016/j.medin.2014.07.008
更新日期:2015-08-01 00:00:00
abstract::Acute liver failure with criteria of seriousness and alcoholic etiology is a picture of worldwide distribution, with an elevated mortality, of approximately 50%, that requires admission to the ICU. Acute serious alcoholic hepatitis is defined by a Maddrey score value > 32 and/or spontaneous encephalopathy. Together wi...
journal_title:Medicina intensiva
pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章
doi:10.1016/j.medin.2010.09.011
更新日期:2011-04-01 00:00:00
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journal_title:Medicina intensiva
pub_type:
doi:10.1016/j.medin.2014.04.012
更新日期:2014-11-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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更新日期:2012-06-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章,多中心研究
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更新日期:2015-08-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 共识发展会议,杂志文章,实务指引
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更新日期:2007-12-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章,评审
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journal_title:Medicina intensiva
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journal_title:Medicina intensiva
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章,实务指引
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更新日期:2018-01-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 共识发展会议,杂志文章,实务指引
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更新日期:2011-11-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章
doi:10.1016/j.medin.2019.07.005
更新日期:2020-03-01 00:00:00
abstract::Maintaining organ viability from extraction to transplantation is crucial to ensure the function and survival of the graft. In recent years, maintaining organ viability has become more challenging because the shortage of donors has led to broader criteria for donor acceptability and consequently to organs with greater...
journal_title:Medicina intensiva
pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章,评审
doi:10.1016/j.medin.2012.08.008
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:No data are available on blood caspase-8 concentrations (the initiator caspase in the extrinsic apoptosis pathway) in septic patients. The present study thus describes the blood caspase-8 concentrations in survivors and non-survivors, and examines the possible association between blood caspase-8 concentration...
journal_title:Medicina intensiva
pub_type: 杂志文章
doi:10.1016/j.medin.2020.06.016
更新日期:2020-08-22 00:00:00
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journal_title:Medicina intensiva
pub_type: 杂志文章
doi:10.1016/j.medin.2010.11.002
更新日期:2011-01-01 00:00:00