Abstract：
OBJECTIVE:No data are available on blood caspase-8 concentrations (the initiator caspase in the extrinsic apoptosis pathway) in septic patients. The present study thus describes the blood caspase-8 concentrations in survivors and non-survivors, and examines the possible association between blood caspase-8 concentrations and mortality in septic patients. DESIGN:A prospective observational study was carried out. SETTING:Three Spanish Intensive Care Units. PATIENTS:Septic patients. INTERVENTIONS:Serum caspase-8 concentrations were determined at the diagnosis of sepsis. MAIN VARIABLE OF INTEREST:Mortality after 30 days. RESULTS:Patients not surviving at day 30 (n=81) compared to surviving patients (n=140) showed higher serum caspase-8 levels (p<0.001). Multiple logistic regression analysis found an association between serum caspase-8 levels>43.5ng/ml and mortality (OR=3.306; 95%CI=1.619-6.753; p=0.001). The area under the curve (AUC) for mortality predicted by serum caspase-8 levels was 67% (95% CI=60-73%; p<0.001). CONCLUSIONS:The novel findings of our study were that blood caspase-8 concentrations are higher in non-survivors than in survivors, and that there is an association between blood caspase-8 concentrations and mortality in septic patients.
journal_name
Med Intensivajournal_title
Medicina intensivaauthors
Lorente L,Martín MM,Ortiz-López R,González-Rivero AF,Pérez-Cejas A,Martín M,Gonzalez V,Pérez A,Rodin M,Jiménez Adoi
10.1016/j.medin.2020.06.016subject
Has Abstractpub_date
2020-08-22 00:00:00eissn
0210-5691issn
1578-6749pii
S0210-5691(20)30246-1pub_type
杂志文章abstract：:Maintaining organ viability from extraction to transplantation is crucial to ensure the function and survival of the graft. In recent years, maintaining organ viability has become more challenging because the shortage of donors has led to broader criteria for donor acceptability and consequently to organs with greater...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/S0210-5691(09)72196-5
更新日期：2009-08-01 00:00:00
abstract：:Sepsis is a major public health problem and a leading cause of death in the world, where delay in the beginning of treatment, along with clinical guidelines non-adherence have been proved to be associated with higher mortality. Machine Learning is increasingly being adopted in developing innovative Clinical Decision S...
journal_title：Medicina intensiva
pub_type： 杂志文章,评审
doi：10.1016/j.medin.2020.04.003
更新日期：2020-05-29 00:00:00
abstract：:Transient apical dysfunction syndrome, ballooning or Takotsubo cardiomyopathy is a recently described syndrome. It is a disease with a partially known mechanism, characterized by the morphology adopted by the left ventricle secondary to hypokinesis and dyskinesis of the apical segments and hypercontractibility of the ...
journal_title：Medicina intensiva
pub_type： 杂志文章,评审
doi：10.1016/s0210-5691(07)74793-9
更新日期：2007-04-01 00:00:00
abstract：OBJECTIVE:To assess the impact of gender upon the prognosis and medical care in a regional acute ST-elevation myocardial infarction management network. DESIGN:An observational study was made of consecutive patients entered in a prospective database. SCOPE:The Catalan acute ST-elevation myocardial infarction managemen...
journal_title：Medicina intensiva
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medin.2016.06.008
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:To analyze the efficacy of negative fluid balance in hypoxemic patients with an elevated extravascular lung water index (EVLWI). DESIGN:A retrospective observational study was made. SETTING:Intensive Care Unit of Virgen de las Nieves Hospital (Spain). PARTICIPANTS:Forty-four patients participated in the st...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2014.07.008
更新日期：2015-08-01 00:00:00
abstract：PURPOSE:Streptococcus pneumoniae and Neisseria meningitidis are major causes of severe invasive bacterial infections in some individuals. Apparently the genetic is a major susceptibility determinant to these infectious diseases. We study if the functional polymorphisms within genes of the innate immune system (TLR2-TLR...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2013.08.006
更新日期：2014-08-01 00:00:00
abstract：:Immunosuppression in transplantation has experienced changes in recent years as a result of the introduction of new drugs that act upon the different pathways of the host immune response with the purpose of securing more individualized immune suppression, with fewer side effects. Although following in the steps of oth...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2012.05.011
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVES:To analyze the nutritional management practices in Intensive Care (ICU) to detect the need for improvement actions. Re-evaluate the process after implementation of improvement actions. DESIGN:Prospective observational study in 3 phases: 1) observation; 2) analysis, proposal development and dissemination; 3)...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2015.04.010
更新日期：2015-12-01 00:00:00
abstract：:Acute liver failure with criteria of seriousness and alcoholic etiology is a picture of worldwide distribution, with an elevated mortality, of approximately 50%, that requires admission to the ICU. Acute serious alcoholic hepatitis is defined by a Maddrey score value > 32 and/or spontaneous encephalopathy. Together wi...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/s0210-5691(06)74556-9
更新日期：2006-11-01 00:00:00
abstract：:Extracorporeal membrane oxygenation (ECMO) support is indicated in patients who are refractory to treatment, those with cardiogenic shock or respiratory failure and those with exacerbations eligible for heart and lung transplantation. Physician experience and quantity of necessary resources are reasons why regionaliza...
journal_title：Medicina intensiva
pub_type： 杂志文章,评审
doi：10.1016/j.medin.2018.01.004
更新日期：2019-03-01 00:00:00
abstract：:Recently, the work group made up of the National Transplant Organization (Organización Nacional de Trasplantes, ONT), Spanish Society of Intensive, Critical Medicine and Coronary Units (Sociedad Española de Medicina Intensiva, Crítica y de Unidades Coronarias, SEMICYUC) and other Scientific Societies have recommended ...
journal_title：Medicina intensiva
pub_type： 杂志文章,评审
doi：10.1016/s0210-5691(09)71760-7
更新日期：2009-06-01 00:00:00
abstract：:The diagnosis of influenza A/H1N1 is mainly clinical, particularly during peak or seasonal flu outbreaks. A diagnostic test should be performed in all patients with fever and flu symptoms that require hospitalization. The respiratory sample (nasal or pharyngeal exudate or deeper sample in intubated patients) should be...
journal_title：Medicina intensiva
pub_type： 杂志文章,实务指引
doi：10.1016/j.medin.2011.11.020
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Before deciding increases in the number or capacitance of Intensive Care Units (ICUs), or the regionalization of Units, it is essential to know their present effectiveness. OBJECTIVE:To analyze the daily occupancy rate of ICUs in Catalonia (Spain) and the frequency of denied admission due to lack of capacit...
journal_title：Medicina intensiva
pub_type： 杂志文章,多中心研究
doi：10.1016/j.medin.2014.11.002
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:To determine the clinical characteristics and prognostic factors of patients with severe sepsis/septic shock admitted to the Intensive Care Unit of Donostia University Hospital (Guipuzcoa, Spain). DESIGN:A prospective, observational study was carried out during a consecutive 6-year period (1st February 2008-...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2015.01.006
更新日期：2016-01-01 00:00:00
abstract：:Technology and insertion techniques for cardiac temporary internal pacing have experienced a remarkable development over the last few years. Despite this fact, the procedure continues to have potentially fatal associated complications. Temporary internal pacing is indicated for the treatment of bradyarrhythmias or tac...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2014.02.006
更新日期：2014-12-01 00:00:00
abstract：:The benefit of enteral nutrition in critically ill patients has been demonstrated by several studies, especially when it is started early, in the first 24-48h of stay in the Intensive Care Unit, and this practice is currently advised by the main clinical guidelines. The start of enteral nutrition is controversial in p...
journal_title：Medicina intensiva
pub_type： 杂志文章,评审
doi：10.1016/j.medin.2014.04.002
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:Hemodynamic resuscitation is considered a cornerstone of the initial treatment of septic shock. However, there is growing concern about its side effects. Our objective was to assess the relationship between fluid administration and norepinephrine infusion and the development of lung injury. DESIGN:Randomized...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2020.05.011
更新日期：2020-07-24 00:00:00
abstract：OBJECTIVE:An evaluation is made of the hospital mortality predicting capacity of the main predictive scoring systems. DESIGN:A 2-year retrospective cohort study was carried out. SETTING:A third level ICU with surgical and medical patients. PATIENTS:All patients with multiorgan failure during the first day in the ICU...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2015.03.005
更新日期：2016-04-01 00:00:00
abstract：:We maintain a dynamic position on extracorporeal blood purification therapies (EBPT). Continuous therapies are of choice in the hemodynamically unstable patient. We recommend their early introduction in the course of the disease, and starting with a dose of 30-35mL/kg/h. Above all, however, daily re-evaluation is requ...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2016.05.009
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVE:Assessment of health related quality of life (HRQOL) before and 12 months after discharge from a mixed intensive care unit (ICU) according to diagnostic category and the relationship between both instruments. DESIGN:Prospective observational study. SETTING:The combined medical/surgical ICU in a secondary un...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/s0210-5691(08)70942-2
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:To evaluate different characteristics of patients with acute coronary syndrome (ACS) without ST-segment elevation compared with transient St-segment elevation. DESIGN:An observational, prospective study. SETTING:A 12-bed coronary care unit. PATIENTS:Consecutive patients of ACS without persistent ST-segment...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2011.01.007
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:To describe the main factors associated with proper recognition and management of patient-ventilator asynchrony (PVA). DESIGN:An analytical cross-sectional study was carried out. SETTING:An international study conducted in 20 countries through an online survey. PARTICIPANTS:Physicians, respiratory therapis...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2019.09.004
更新日期：2019-10-23 00:00:00
abstract：:Burned patients may need prolonged admissions in the Intensive Care Service, both for initial care and for the pre and postoperative treatment of the multiple surgeries they require. The initial resuscitation of critically burned patients requires adequate monitoring to calculate the fluid therapy necessary to repleni...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2019.07.005
更新日期：2020-03-01 00:00:00
abstract：AIM:A study is made of the influence of alcohol and/or drug abuse upon traumatismo recurrence, with an analysis of the influence of such abuse upon the time to appearance of first injury in patients without antecedents of trauma. DESIGN:A prospective observational study was made. SETTING:Trauma patients admitted to t...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2012.04.010
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVES:1) To assess the prevalence of pain during nursing care procedures, and 2) to evaluate the usefulness of certain vital signs and the bispectral index (BIS) in detecting pain. METHODS:A prospective, observational analytical study was made of procedures (endotracheal aspiration and mobilization with turning) ...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2015.03.004
更新日期：2016-03-01 00:00:00
abstract：:Second level therapeutic maneuvres for controlling intracranial hypertension (ICH) proposed by the European Brain Injury Consortium and the American Association of Neurological Surgeons include barbiturates, moderate hypothermia and more recently the decompressive craniectomy (DC).In most patients, ICP can be maintain...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2010.09.011
更新日期：2011-04-01 00:00:00
abstract：OBJECTIVE:To determine the results of the implementation of a protocol in an intensive care unit (ICU) referred to critically ill patients requiring a prolonged artificial airway. DESIGN:A prospective, observational cohort study was carried out. INTERVENTION:Management strategies were established on the airway by end...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2012.07.003
更新日期：2013-08-01 00:00:00
abstract：:Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emergent coronavirus, that was first recognized in Wuhan, China, in December 2019. Currently, the World Health Organization (WHO) has defined the infection as a global pandemic and there is a health and social emergency for the mana...
journal_title：Medicina intensiva
pub_type： 共识发展会议,杂志文章,实务指引
doi：10.1016/j.medin.2020.03.005
更新日期：2020-10-01 00:00:00
abstract：:Cerebrovascular accident in young adults is not rare and the most common causes are: cardiac embolism, arterial dissection and migraine. The unknown etiology, in spite of extensive studies, is described in the literature in about one third of patients under 45 years of age. The mitochondrial encephalomyopathy, lactic ...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/s0210-5691(08)70925-2
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVES:To assess Southern European intensive care unit nurses' knowledge about evidence-based guidelines for the prevention of ventilator-associated pneumonia and to compare these findings with a pan-European perspective. DESIGN:A sub-analysis from an observational study performed using a 9-questions, multiple-cho...
journal_title：Medicina intensiva
pub_type： 杂志文章
doi：10.1016/j.medin.2010.07.012
更新日期：2011-01-01 00:00:00
