Biliary complications after orthotopic liver transplantation: the Hungarian experience.

Abstract:

:Biliary complications (BC) significantly affect morbidity and mortality after orthotopic liver transplantation (OLT). The aim of this study was to analyze the incidence and types of biliary complications after OLT in Hungary. We retrospectively analyzed data of 471 adult liver transplant recipients between 1995 and 2011. Biliary complications occurred in 28% of patients. The most frequent BCs were bile duct stricture, stenosis (19%), biliary leakage (12%), and necrosis (BN: 6.4%). Biliary complications were associated with the incidence of acute rejection (51% vs 31%; P = .003), hepatic artery thrombosis (43% vs 11%; P < .001), and hepatic artery stenosis (26% vs 11%; P = .002). When cold ischemic time was longer than 12 hours, leakage (10% vs 3%; P = .043), ischemic type biliary lesion (20% vs 3.4%; P = .05), and BN (12% vs 3%; P = .067) were more often diagnosed post-OLT. Most of the biliary complications were treated by radiologic interventions (70%). Bile duct necrosis was associated with lower graft and patient survival. In conclusion, acute rejection, hepatic artery thrombosis/stenosis and cold ischemic time longer than 12 hours increase the incidence of BCs. Successful management of these risk factors can reduce the incidence of biliary complications and improve mortality.

journal_name

Transplant Proc

authors

Gámán G,Gelley F,Doros A,Zádori G,Görög D,Fehérvári I,Kóbori L,Nemes B

doi

10.1016/j.transproceed.2013.10.009

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

3695-7

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(13)00987-1

journal_volume

45

pub_type

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