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MRI-compatible positioning device for guiding a focused ultrasound system for transrectal treatment of prostate cancer.

Abstract：

BACKGROUND:High-intensity focused ultrasound (HIFU) is a promising treatment method for many common cancers, including prostate cancer. Magnetic resonance image (MRI) guidance of HIFU permits targeting and monitoring of therapy. A prototype MRI-compatible positioning device that navigates a HIFU transducer was designed, fabricated and tested. MATERIALS AND METHODS:The positioning device has two PC-controlled and one manually driven stage that allow endorectal access to the prostate. The positioning device was constructed using a 3-D rapid prototype manufacturing device. Software was developed that controls the motion of the positioning device and enables activation of a HIFU transducer. In vitro testing of the system was performed in a 1.5T MRI scanner using ex vivo turkey tissue. Optical encoders were employed to enhance the accuracy of this positioning device. RESULT:The positioning device was successfully tested for MRI compatibility. The movement error of the positioning device is approximately 20 [Formula: see text]m. The robot has the ability to accurately move the transducer for creation of discrete and overlapping lesions. CONCLUSION:An MRI-compatible HIFU positioning system was developed that has the ability to create thermal lesions with MRI guidance for endorectal treatment of prostate cancer.

journal_name

Int J Comput Assist Radiol Surg

journal_title

International journal of computer assisted radiology and surgery

authors

Yiallouras C,Mylonas N,Damianou C

doi

10.1007/s11548-013-0964-x

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

745-53

issue

4

eissn

1861-6410

issn

1861-6429

journal_volume

9

pub_type

杂志文章

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