Abstract：
BACKGROUND:We have previously reported that 35% CO2 challenge induced myocardial ischemia in 81% of coronary artery disease (CAD) patients with comorbid panic disorder (PD) and previous positive nuclear exercise stress tests. However, it is yet unclear whether this is the case among CAD patients with PD and normal nuclear exercise stress test results. We hypothesized that a potent mental stressor such as a panic challenge among CAD patients with PD would also induce ischemia in patients with normal exercise stress tests. METHODS:Forty-one coronary artery disease patients with normal nuclear exercise stress tests (21 patients with PD and 20 without PD) were submitted to a well-established panic challenge test (with 1 vital capacity inhalation of a gas mixture containing 35% CO2 and 65% O2) and injected with Tc-99m-tetrofosmin (Myoview), upon inhalation. Single photon emission computed tomography imaging was used to assess per-panic challenge reversible myocardial ischemia and HR, BP, and a 12 lead ECG was continuously measured during the procedure. RESULTS:Fifty-eight percent of panic disorder patients (12/21) had a panic attack during the panic challenge vs 15% (3/20) of controls (p=0.005). Only 10% of patients in each group displayed myocardial ischemia per panic challenge. CONCLUSIONS:These findings suggest that panic attacks among panic disorder patients with lower-risk coronary artery disease may not confer a risk for myocardial ischemia.
journal_name
J Psychosom Resjournal_title
Journal of psychosomatic researchauthors
Fleet R,Foldes-Busque G,Grégoire J,Harel F,Laurin C,Burelle D,Lavoie Kdoi
10.1016/j.jpsychores.2013.08.003subject
Has Abstractpub_date
2014-01-01 00:00:00pages
41-5issue
1eissn
0022-3999issn
1879-1360pii
S0022-3999(13)00307-3journal_volume
76pub_type
杂志文章abstract：OBJECTIVE:This prospective study investigated associations between maternal stress exposure and maternal psychological stress measures during pregnancy with obstetric and neonatal outcomes. We also tested whether any observed associations would be moderated by increasing glucose levels, as increased glycaemia is also a...
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journal_title：Journal of psychosomatic research
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pub_type： 杂志文章,多中心研究
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更新日期：2017-08-01 00:00:00
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