Differences in prognosis and efficacy of chemotherapy by p53 expression in triple-negative breast cancer.

abstract：:Since our previous findings had indicated that the androgenic steroid medroxyprogesterone acetate (MPA) exerts potent inhibitory effects on 7,12-dimethylbenz(a)anthracene (DMBA)-induced tumor growth, we have studied the effect of low doses of MPA released from Depo-Provera and from 50:50 poly[DL-lactide-co-glycolide] ...

journal_title：Breast cancer research and treatment

authors： Li S,Lepage M,Mérand Y,Bélanger A,Labrie F

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:CIPN is a common, debilitating, and dose-limiting side effect of chemotherapy. Here, we describe characteristics of patients with CIPN using both patient-reported outcomes (PRO) and quantitative sensory testing (QST). METHODS:Breast cancer survivors with persistent moderate to severe CIPN defined by a rating o...

journal_title：Breast cancer research and treatment

authors： Zhi WI,Chen P,Kwon A,Chen C,Harte SE,Piulson L,Li S,Patil S,Mao JJ,Bao T

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:Estrogen exposure is involved in both breast cancer susceptibility and the prognosis in patients with breast cancer. Aromatase is involved in the production of estrogens, and altered expression of it might be associated with the prognosis. The aim of this study was to examine the effect of single nucleotide pol...

journal_title：Breast cancer research and treatment

authors： Fasching PA,Loehberg CR,Strissel PL,Lux MP,Bani MR,Schrauder M,Geiler S,Ringleff K,Oeser S,Weihbrecht S,Schulz-Wendtland R,Hartmann A,Beckmann MW,Strick R

更新日期：2008-11-01 00:00:00

abstract：:Treatment decisions in oncology are based on a balance between the efficacy of therapy and its side effects. Patients with metastases and patients with a limited prognosis are a particular challenge, since communication about the disease situation and the expected therapeutic benefit is difficult not only for patients...

journal_title：Breast cancer research and treatment

authors： Lux MP,Bayer CM,Loehberg CR,Fasching PA,Schrauder MG,Bani MR,Häberle L,Engel A,Heusinger K,Tänzer T,Radosavac D,Scharl A,Bauerfeind I,Gesslein J,Schulte H,Overbeck-Schulte B,Beckmann MW,Hein A

更新日期：2013-06-01 00:00:00

abstract：AIMS:Anthracyclines-taxanes containing regimens are widely used for breast cancer treatment both in neoadjuvant-adjuvant setting and in metastatic disease. Recently high-dose chemotherapy (HDC) with autologous stem cell support has been introduced as adjuvant treatment for high-risk primary breast cancer and for select...

journal_title：Breast cancer research and treatment

authors： Zambelli A,Robustelli della Cuna FS,Ponchio L,Ucci G,Da Prada GA,Robustelli della Cuna G

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:The anatomy of the nipple has become clinically relevant. Diagnostic techniques access the breast through nipple ducts and surgeons offer nipple-sparing mastectomy. There is variation in the number of ducts reported and little is known about the spatial location of ducts, their size, and their relationship t...

journal_title：Breast cancer research and treatment

authors： Rusby JE,Brachtel EF,Michaelson JS,Koerner FC,Smith BL

更新日期：2007-12-01 00:00:00

abstract：:Loss of heterozygosity (LOH) in loci of the 10q23 region that harbor the PTEN gene and mutations in the sequence of this gene have been found in several primary human tumors including breast carcinomas, suggesting that this gene could be implicated in their pathogenesis. We investigated allelic losses in microsatellit...

journal_title：Breast cancer research and treatment

authors： Garcia JM,Silva JM,Dominguez G,Gonzalez R,Navarro A,Carretero L,Provencio M,España P,Bonilla F

更新日期：1999-10-01 00:00:00

abstract：:The glycolytic phenotype is a widespread phenomenon in solid cancer forms, including breast cancer. Dichloroacetate (DCA) has recently been proposed as a novel and relatively non-toxic anti-cancer agent that can reverse the glycolytic phenotype in cancer cells through the inhibition of pyruvate dehydrogenase kinase. W...

journal_title：Breast cancer research and treatment

authors： Sun RC,Fadia M,Dahlstrom JE,Parish CR,Board PG,Blackburn AC

更新日期：2010-02-01 00:00:00

abstract：:Obesity is a risk factor for the development of new cases of breast cancer and also affects survival in women who have already been diagnosed with breast cancer. Early studies of obesity and breast cancer survival have been summarised in two meta-analyses, but the latest of these only included studies that recruited w...

journal_title：Breast cancer research and treatment

authors： Protani M,Coory M,Martin JH

更新日期：2010-10-01 00:00:00

abstract：:Cell migration is essential in many diverse processes ranging from embryonic development to wound healing and immune response. Cancer cells have recently been shown to utilize chemoattraction mechanisms mediated by chemokines and their respective receptors, e.g., the CXCL12/CXCR4 pathway normally found in leukocytes. ...

journal_title：Breast cancer research and treatment

authors： Schmid BC,Rezniczek GA,Fabjani G,Yoneda T,Leodolter S,Zeillinger R

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:Fiber rich foods and dairy products have been suggested to be associated with breast cancer prognosis, though existing research is limited and either report on pre- or post-diagnostic dietary intake in relation to breast cancer prognosis. We investigated the associations between intake of whole grain (WG) and d...

journal_title：Breast cancer research and treatment

authors： Andersen JLM,Hansen L,Thomsen BLR,Christiansen LR,Dragsted LO,Olsen A

更新日期：2020-02-01 00:00:00

abstract：:Sex Hormone-Binding Globulin (SHBG), the plasma carrier for androgens and estradiol, inhibits the estradiol-induced proliferation of breast cancer cells through its membrane receptor, cAMP, and PKA. In addition, the SHBG membrane receptor is preferentially expressed in estrogen-dependent (ER+/PR+) breast cancers which...

journal_title：Breast cancer research and treatment

authors： Becchis M,Frairia R,Ferrera P,Fazzari A,Ondei S,Alfarano A,Coluccia C,Biglia N,Sismondi P,Fortunati N

更新日期：1999-03-01 00:00:00

abstract：:We calculated hazard rates for recurrence in patients with primary breast cancer (stage I, II; no adjuvant therapy). Previous publications have indicated a peak in hazard rates for recurrence (or death) at approximately 2-3 years after diagnosis of primary breast cancer. However, there have been conflicting reports co...

journal_title：Breast cancer research and treatment

authors： Jatoi I,Tsimelzon A,Weiss H,Clark GM,Hilsenbeck SG

更新日期：2005-01-01 00:00:00

abstract：:Our previous studies have shown that social housing conditions can significantly alter the growth rate of the Shionogi mouse mammary carcinoma (SC115). The present study extended our investigations to the molecular level by examining stressor effects on the expression of a group of stress-responsive proteins, the heat...

journal_title：Breast cancer research and treatment

authors： Andrews HN,Kerr LR,Strange KS,Emerman JT,Weinberg J

更新日期：2000-02-01 00:00:00

abstract：:Elevated levels of circulating estrogens and androgens are linked to higher breast cancer risk among postmenopausal women; however, little is known about hormone levels within the breast. Hormone concentrations within the breast may not be reflected in the blood and are likely important contributors to breast carcinog...

journal_title：Breast cancer research and treatment

authors： Falk RT,Gentzschein E,Stanczyk FZ,Garcia-Closas M,Figueroa JD,Ioffe OB,Lissowska J,Brinton LA,Sherman ME

更新日期：2012-01-01 00:00:00

abstract：:The Save Our Sisters Project builds on the roles of 95 "natural helpers" to increase mammography screening among older African American women in a NC county. Natural helpers are lay people to whom others naturally turn for advice, emotional support, and tangible aid. Findings from 14 focus group interviews showed that...

journal_title：Breast cancer research and treatment

authors： Eng E,Smith J

更新日期：1995-07-01 00:00:00

abstract：:The transcriptome of breast cancers have been extensively screened with microarrays and large sets of genes associated with clinical features have been established. The aim of this study was to validate original gene sets on a large cohort of raw breast cancer microarray data with known clinical follow-up. We recovere...

journal_title：Breast cancer research and treatment

authors： Györffy B,Schäfer R

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:Eribulin methylate (eribulin) improved the overall survival (OS) of HER2-negative advanced breast cancer (HER2-ABC) patients; however, the mechanism underlying the OS improvement has not been clarified. Several reports suggest that eribulin promotes antitumor immunity via tumor micro-environment conditioning. R...

journal_title：Breast cancer research and treatment

authors： Watanabe J,Saito M,Horimoto Y,Nakamoto S

更新日期：2020-05-01 00:00:00

abstract：:The complexity of breast cancer biology makes it challenging to analyze large datasets of clinicopathologic and molecular attributes, toward identifying the key prognostic features and producing systems capable of predicting which patients are likely to relapse. We applied machine-learning techniques to analyze a set ...

journal_title：Breast cancer research and treatment

authors： Asgarian N,Hu X,Aktary Z,Chapman KA,Lam L,Chibbar R,Mackey J,Greiner R,Pasdar M

更新日期：2010-06-01 00:00:00

abstract：INTRODUCTION:Axillary node fine needle aspiration cytology (FNAC) has the potential to triage women with operable breast cancer to initial nodal surgical procedure. Because of variability in the reported accuracy of this test its role and clinical utility in pre-operative staging remains controversial. METHODS:We retr...

journal_title：Breast cancer research and treatment

authors： Ciatto S,Brancato B,Risso G,Ambrogetti D,Bulgaresi P,Maddau C,Turco P,Houssami N

更新日期：2007-05-01 00:00:00

abstract：:Kinase suppressor of Ras 1 (KSR1) has been implicated in tumorigenesis in multiple cancers, including skin, pancreatic and lung carcinomas. However, our recent study revealed a role of KSR1 as a tumour suppressor in breast cancer, the expression of which is potentially correlated with chemotherapy response. Here, we a...

journal_title：Breast cancer research and treatment

authors： Zhang H,Angelopoulos N,Xu Y,Grothey A,Nunes J,Stebbing J,Giamas G

更新日期：2015-06-01 00:00:00

abstract：:The clinical and pathological heterogeneity of breast cancer has instigated efforts to stratify breast cancer sub-types according to molecular profiles. These profiling efforts are now being augmented by large-scale functional screening of breast tumour cell lines, using approaches such as RNA interference. We have de...

journal_title：Breast cancer research and treatment

authors： Sims D,Bursteinas B,Gao Q,Jain E,MacKay A,Mitsopoulos C,Zvelebil M

更新日期：2010-11-01 00:00:00

abstract：:Whether wide excision with margins ≥1 cm is sufficient treatment for small low- or intermediate-grade ductal carcinoma in situ (DCIS) is unclear. This is an updated analysis of a phase II, single-arm, prospective trial testing this hypothesis. A total of 158 patients with low- or intermediate-grade DCIS who underwent ...

journal_title：Breast cancer research and treatment

authors： Wong JS,Chen YH,Gadd MA,Gelman R,Lester SC,Schnitt SJ,Sgroi DC,Silver BJ,Smith BL,Troyan SL,Harris JR

更新日期：2014-01-01 00:00:00

abstract：:WWOX is a cancer gene, spanning the common chromosomal fragile site 16D. Genomic and expression aberrations affecting this gene and locus are common in various neoplasias including breast cancer. The aim of the present study was to evaluate the relationship between WWOX expression at the protein level with respect to ...

journal_title：Breast cancer research and treatment

authors： Nunez MI,Ludes-Meyers J,Abba MC,Kil H,Abbey NW,Page RE,Sahin A,Klein-Szanto AJ,Aldaz CM

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Myeloperoxidase (MPO) is an enzyme secreted by neutrophil granulocytes as a result of phagocytosis during inflammation. In colorectal cancer, tumour infiltration by MPO expressing cells has been shown to be independently associated with a favourable prognosis. In this study, we explored the role of MPO-positive...

journal_title：Breast cancer research and treatment

authors： Zeindler J,Angehrn F,Droeser R,Däster S,Piscuoglio S,Ng CKY,Kilic E,Mechera R,Meili S,Isaak A,Weber WP,Muenst S,Soysal SD

更新日期：2019-10-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFr) levels were analyzed in 140 primary breast cancer specimens by immunohistochemical assay (ICA), competitive binding assay (BA), or enzyme immunoassay (EIA). Thirty-nine of 118 specimens (33.1%) were scored as positive by ICA, 30 of 116 (25.9%; cut-off level 10 fmol/mg protein) b...

journal_title：Breast cancer research and treatment

authors： Iwase H,Kobayashi S,Itoh Y,Kuzushima T,Yamashita H,Iwata H,Naito A,Yamashita T,Itoh K,Masaoka A

更新日期：1993-12-01 00:00:00

abstract：:Approximately 15-20% of all breast cancers are human epidermal growth factor receptor 2 (HER2) positive, with clinical studies having validated the HER2 receptor tyrosine kinase pathway as an important therapeutic target. Presently, two HER2-targeted therapies are approved by the Food and Drug Administration for treat...

journal_title：Breast cancer research and treatment

authors： Ahn ER,Vogel CL

更新日期：2012-01-01 00:00:00

abstract：:Histological grading of 160 primary infiltrating breast carcinomas showed that both oestrogen and progesterone receptor status are strongly related to grade, tumours that are receptor positive tending to be of lower grade than the receptor negative. The nuclear factors used in grading were those that determined this a...

journal_title：Breast cancer research and treatment

authors： Thoresen S,Thorsen T,Tangen M,Hartveit F

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:The Ki67 proliferation index is a prognostic and predictive marker in breast cancer. Manual scoring is prone to inter- and intra-observer variability. The aims of this study were to clinically validate digital image analysis (DIA) of Ki67 using virtual dual staining (VDS) on whole tissue sections and to assess ...

journal_title：Breast cancer research and treatment

authors： Koopman T,Buikema HJ,Hollema H,de Bock GH,van der Vegt B

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:Younger women diagnosed with breast cancer have poorer prognoses and higher mortality compared to older women. Young black women have higher incidence rates of breast cancer and more aggressive subtypes than women of other races/ethnicities. In this study, we examined recent trends and variations in breast canc...

journal_title：Breast cancer research and treatment

authors： Shoemaker ML,White MC,Wu M,Weir HK,Romieu I

更新日期：2018-06-01 00:00:00