Sex steroid hormone levels in breast adipose tissue and serum in postmenopausal women.

abstract：:The article Reducing chemotherapy use in clinically high-risk, genomically low-risk pN0 and pN1 early breast cancer patients: five-year data from the prospective, randomised phase 3 West German Study Group (WSG) PlanB trial, written by Ulrike Nitz, Oleg Gluz, Matthias Christgen, Ronald E. Kates, Michael Clemens, Wolfr...

journal_title：Breast cancer research and treatment

authors： Nitz U,Gluz O,Christgen M,Kates RE,Clemens M,Malter W,Nuding B,Aktas B,Kuemmel S,Reimer T,Stefek A,Lorenz-Salehi F,Krabisch P,Just M,Augustin D,Liedtke C,Chao C,Shak S,Wuerstlein R,Kreipe HH,Harbeck N

更新日期：2019-05-01 00:00:00

abstract：:Partner and localizer of BRCA2 (PALB2), plays an important functional role in DNA damage repair. Recent studies indicate that germline mutations in PALB2 predispose individuals to a high risk of developing familial breast cancer. Therefore, comprehensive identification of PALB2 germline mutations is potentially import...

journal_title：Breast cancer research and treatment

authors： Downs B,Kim YC,Xiao F,Snyder C,Chen P,Fleissner EA,Becirovic D,Wen H,Sherman S,Cowan KH,Lynch HT,Wang SM

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:Cyclin D1 has a central role in cell cycle control and is an important component of estrogen regulation of cell cycle progression. We have previously shown that high cyclin D expression is related to aggressive features of ER-positive but not ER-negative breast cancer. The aims of the present study were to vali...

journal_title：Breast cancer research and treatment

authors： Ahlin C,Lundgren C,Embretsén-Varro E,Jirström K,Blomqvist C,Fjällskog M-

更新日期：2017-08-01 00:00:00

abstract：:The biological and clinical significance of circulating tumor cells (CTC) in the peripheral blood of breast cancer patients is not known. To study this question, we used a direct visualization assay to correlate the number of CTC with disease stage and progression. The CTC were enriched from the nucleated cell fractio...

journal_title：Breast cancer research and treatment

authors： Kahn HJ,Presta A,Yang LY,Blondal J,Trudeau M,Lickley L,Holloway C,McCready DR,Maclean D,Marks A

更新日期：2004-08-01 00:00:00

abstract：:Estrogen receptor beta (ERbeta) is widely expressed in mammary epithelium. ERbeta expression is reported to decline during carcinogenesis of the breast and other tissues. In this study, we examined the consequences of a loss of ERbeta expression in mammary epithelial cells. We knocked down ERbeta transcript levels in ...

journal_title：Breast cancer research and treatment

authors： Treeck O,Lattrich C,Springwald A,Ortmann O

更新日期：2010-04-01 00:00:00

abstract：:Although high mammographic density is a risk factor for postmenopausal breast cancer, its etiology remains unclear. We examined whether serum and dietary cholesterol, which increase breast cancer risk and are involved in endogenous estrogen formation, were associated with increased mammographic density. We conducted a...

journal_title：Breast cancer research and treatment

authors： Tamburrini AL,Woolcott CG,Boyd NF,Yaffe MJ,Terry T,Yasui Y,Jones CA,Patten SB,Courneya KS,Friedenreich CM

更新日期：2011-01-01 00:00:00

abstract：:We have qualitatively evaluated the retention of the fluorescent dye rhodamine 123 by malignant or non-malignant breast epithelial cells in passively-infused fresh surgical specimens. Our findings demonstrate a microscopically-visible increase in the ability of primary and metastatic tumor cells to retain the dye, as ...

journal_title：Breast cancer research and treatment

authors： Dairkee SH,Hackett AJ

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Paget's disease of the nipple is a rare form of breast cancer characterised by the presence of intraepidermal tumour cells. It is often associated with ductal carcinoma in situ (DCIS) and/or invasive cancer in the breast parenchyma. We have studied the presentation and symptoms of Paget's disease, local cont...

journal_title：Breast cancer research and treatment

authors： Dalberg K,Hellborg H,Wärnberg F

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:Little is known about racial variations in the financial impact of cancer care. Using data from a national survey of racially diverse patients with metastatic breast cancer, we examined racial/ethnic patterns in employment and cost-management (i.e., financial coping) behaviors. METHODS:We conducted an online s...

journal_title：Breast cancer research and treatment

authors： Samuel CA,Spencer JC,Rosenstein DL,Reeder-Hayes KE,Manning ML,Sellers JB,Wheeler SB

更新日期：2020-01-01 00:00:00

abstract：:Paraneoplastic neurological syndromes are a rare complication of breast cancer. Nevertheless, they may be clinically relevant leading to neurological impairment. Clinicians should be aware that these neurological disorders could even precede the diagnosis of breast cancer. Here we present the case of a female patient ...

journal_title：Breast cancer research and treatment

authors： Minisini AM,Pauletto G,Bergonzi P,Fasola G

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:Neutropenia is the most common toxicity of CDK4/6 inhibitors, causing frequent dose interruptions. However, CDK4/6 inhibitor-induced neutropenia shows a benign clinical course in contrast to that caused by chemotherapy. Here, we investigated the safety of a new dose scheme for palbociclib, which avoids dose del...

journal_title：Breast cancer research and treatment

authors： Ham A,Kim MH,Kim GM,Kim JH,Kim JY,Park HS,Park S,Cho YU,Park BW,Kim SI,Sohn J

更新日期：2020-08-01 00:00:00

abstract：:Tamoxifen citrate is a synthetic antiestrogen that provides survival benefit when given as adjuvant treatment in postmenopausal women with breast cancer. Venous thrombophlebitis may complicate tamoxifen treatment at a rate of approximately one per 800 treatment-years. To explore the possible procoagulant effects assoc...

journal_title：Breast cancer research and treatment

authors： Mamby CC,Love RR,Feyzi JM

更新日期：1994-01-01 00:00:00

abstract：:Irreversible electroporation (IRE) is a therapeutic technology for the ablation of soft tissues using electrodes to deliver intense but short electric pulses across a cell membrane, creating nanopores that lead to cell death. This phenomenon only affects the cell membrane, leaving the extracellular matrix and sensitiv...

journal_title：Breast cancer research and treatment

authors： Neal RE 2nd,Singh R,Hatcher HC,Kock ND,Torti SV,Davalos RV

更新日期：2010-08-01 00:00:00

abstract：:We analyzed the p53 mutational status, mRNA and protein expression in 24 human breast carcinoma cell lines. Following measurement of their DNA content with flow cytometry, we ascertained the copy numbers of the centromere of chromosome 17 (cen17) and p53 with fluorescence in situ hybridization (FISH). A functional yea...

journal_title：Breast cancer research and treatment

authors： Concin N,Zeillinger C,Tong D,Stimpfl M,König M,Printz D,Stonek F,Schneeberger C,Hefler L,Kainz C,Leodolter S,Haas OA,Zeillinger R

更新日期：2003-05-01 00:00:00

abstract：:The proportional hazards model is frequently used in analyzing the results of clinical trials, when it is often the case that the outcomes are right-censored. This model allows one to measure treatment effects and simultaneously identify and adjust for prognostic factors that might influence the outcome. In this paper...

journal_title：Breast cancer research and treatment

authors： Hastie T,Sleeper L,Tibshirani R

更新日期：1992-01-01 00:00:00

abstract：:This study analyzes the relationship between coxsackie-adenovirus receptor (CAR) expression (transmembrane and soluble isoforms) and hormone sensitivity in 95 breast cancers. Furthermore, prognostic significance of the expression of the various CAR isoforms was investigated. In addition, inducibility of CAR expression...

journal_title：Breast cancer research and treatment

authors： Auer D,Reimer D,Porto V,Fleischer M,Roessler J,Wiedemair A,Marth C,Müller-Holzner E,Daxenbichler G,Zeimet AG

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:We studied which, age of the patient or density of the breast accounts for the sensitivity of mammography and ultrasonography (US). Furthermore we studied whether the overall impression on the density of the breast or the density in tumour area accounts for the sensitivity of mammography and ultrasonography. M...

journal_title：Breast cancer research and treatment

authors： Saarenmaa I,Salminen T,Geiger U,Heikkinen P,Hyvärinen S,Isola J,Kataja V,Kokko ML,Kokko R,Kumpulainen E,Kärkkäinen A,Pakkanen J,Peltonen P,Piironen A,Salo A,Talviala ML,Haka M

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Several recent epidemiologic studies examined the association between breast cancer risk and an inherited, single-nucleotide polymorphism in the HER2 gene, codon 655 G to A, which leads to an amino acid substitution of Ile to Val. Results of previous studies have been mixed, with most studies showing no asso...

journal_title：Breast cancer research and treatment

authors： Millikan R,Eaton A,Worley K,Biscocho L,Hodgson E,Huang WY,Geradts J,Iacocca M,Cowan D,Conway K,Dressler L

更新日期：2003-06-01 00:00:00

abstract：:Although a wealth of research has focused on the influence of diet on breast cancer risk, the relationships between dietary factors and tumor characteristics of breast cancer, like estrogen receptor (ER) status, are not well characterized. In a case-case study, we evaluated self-reported dietary intake for five indivi...

journal_title：Breast cancer research and treatment

authors： Jakovljevic J,Touillaud MS,Bondy ML,Singletary SE,Pillow PC,Chang S

更新日期：2002-09-01 00:00:00

abstract：:We compared levels of erbB-2 oncoprotein among three groups: Group I included 60 asymptomatic women; Group II had 51 women with benign breast biopsies; and Group III had 67 women with node-negative breast cancer. Serological levels of erbB-2 protein were measured in all participants; tumor levels were measured for Gro...

journal_title：Breast cancer research and treatment

authors： Breuer B,Smith S,Thor A,Edgerton S,Osborne MP,Minick R,Cody HS 3rd,Nowak E,Cortese A,Simmons RM,Carney WP,Brandt-Rauf PW

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:This study examined the influence of knowledge of clinical information on the accuracy of mammography in women referred for investigation of breast symptoms. METHODS:Subjects were sampled from all women consecutively attending a symptomatic breast clinic and aged 25-55 years. This included all 240 women show...

journal_title：Breast cancer research and treatment

authors： Houssami N,Irwig L,Simpson JM,McKessar M,Blome S,Noakes J

更新日期：2004-06-01 00:00:00

abstract：:Estrogen receptor (ER) α is essential for estrogen-dependent growth, and its level of expression is a crucial determinant of response to endocrine therapy and prognosis in ERα-positive breast cancer. Breast cancer patients show a wide range of ERα expression levels and the levels of expression in individual patients c...

journal_title：Breast cancer research and treatment

authors： Yoshimoto N,Toyama T,Takahashi S,Sugiura H,Endo Y,Iwasa M,Fujii Y,Yamashita H

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:The malignant upgrade rate of flat epithelial atypia (FEA) diagnosed on core needle biopsy varies between 0 and 30%. Excision versus observation with radiological follow-up for these lesions remains controversial. We hypothesize that the local rate of FEA is low and that close radiological surveillance is a rea...

journal_title：Breast cancer research and treatment

authors： DiPasquale A,Silverman S,Farag E,Peiris L

更新日期：2020-01-01 00:00:00

abstract：:Several population-based and family-based studies have demonstrated that germline mutations of the PALB2 gene (Partner and Localizer of BRCA2) are associated with an increased risk of breast cancer. Distinct mutation frequencies and spectrums have been described depending on the population studied. Here we describe th...

journal_title：Breast cancer research and treatment

authors： Damiola F,Schultz I,Barjhoux L,Sornin V,Dondon MG,Eon-Marchais S,Marcou M,GENESIS Study Investigators.,Caron O,Gauthier-Villars M,de Pauw A,Luporsi E,Berthet P,Delnatte C,Bonadona V,Maugard C,Pujol P,Lasset C,Longy M

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Tumour budding (TB) is an adverse histological feature in many epithelial cancers. It is thought to represent epithelial-mesenchymal transition, a key step in the metastatic process. The significance of TB in breast carcinoma (BC) remains unclear. The aim of this study is to investigate the relationship between...

journal_title：Breast cancer research and treatment

authors： Lloyd AJ,Ryan ÉJ,Boland MR,Elwahab SA,Malone C,Sweeney KJ,Barry KM,McLaughlin R,Kerin MJ,Lowery AJ

更新日期：2020-10-01 00:00:00

abstract：:To increase the ability of ultrasonographic (US) technology for the differential diagnosis of solid breast tumors, we describe a novel computer-aided diagnosis (CADx) system using data mining with decision tree for classification of breast tumor to increase the levels of diagnostic confidence and to provide the immedi...

journal_title：Breast cancer research and treatment

authors： Kuo WJ,Chang RF,Chen DR,Lee CC

更新日期：2001-03-01 00:00:00

abstract：:The widespread use of mammography has resulted in the detection of an increasing number of small invasive breast cancers, i.e. those that are 1cm and smaller. Patients with these small cancers generally have a low incidence of axillary lymph node metastases, and this has led some to question the routine use of axillar...

journal_title：Breast cancer research and treatment

authors： Chen YY,Schnitt SJ

更新日期：1998-01-01 00:00:00

abstract：:We determined the expression of two transcriptional variants of thyroid hormone receptor alpha (THRα1 and THRα2) in samples from a cohort of breast cancer patients and correlated expression levels with survival. 130 women who were diagnosed with invasive breast carcinoma between 2007 and 2008 were included. Representa...

journal_title：Breast cancer research and treatment

authors： Jerzak KJ,Cockburn J,Pond GR,Pritchard KI,Narod SA,Dhesy-Thind SK,Bane A

更新日期：2015-01-01 00:00:00

abstract：AIMS:To examine the frequency of axillary lymph node (ALN) invasion of operable breast cancers by their combined oestrogen receptor (ER), progesterone receptor (PR) and HER-2 status. METHODS:2227 recently operated cases in one centre were retrieved from the Multidisciplinary Breast Centre database and stratified accor...

journal_title：Breast cancer research and treatment

authors： Van Calster B,Vanden Bempt I,Drijkoningen M,Pochet N,Cheng J,Van Huffel S,Hendrickx W,Decock J,Huang HJ,Leunen K,Amant F,Berteloot P,Paridaens R,Wildiers H,Van Limbergen E,Weltens C,Timmerman D,Van Gorp T,Smeets A,V

更新日期：2009-01-01 00:00:00

abstract：:Axillary evaluation in women with ductal carcinoma in situ (DCIS) is increasing; however, this may introduce additional morbidity with unclear benefit. Our objective was to examine the morbidity and mortality associated with axillary evaluation in DCIS. We conducted a retrospective cohort study of 10,504 women aged 65...

journal_title：Breast cancer research and treatment

authors： Coromilas EJ,Wright JD,Huang Y,Feldman S,Neugut AI,Hillyer GC,Chen L,Hershman DL

更新日期：2016-07-01 00:00:00