Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode.

Abstract:

:Irreversible electroporation (IRE) is a therapeutic technology for the ablation of soft tissues using electrodes to deliver intense but short electric pulses across a cell membrane, creating nanopores that lead to cell death. This phenomenon only affects the cell membrane, leaving the extracellular matrix and sensitive structures intact, making it a promising technique for the treatment many types of tumors. In this paper, we present the first in vivo study to achieve tumor regression using a translatable, clinically relevant single needle electrode for treatment administration. Numerical models of the electric field distribution for the protocol used suggest that a 1000 V/cm field threshold is sufficient to treat a tumor, and that the electric field distribution will slightly decrease if the same protocol were used on a tumor deep seated within a human breast. Tumor regression was observed in 5 out of 7 MDA-MB231 human mammary tumors orthotopically implanted in female Nu/Nu mice, with continued growth in controls.

authors

Neal RE 2nd,Singh R,Hatcher HC,Kock ND,Torti SV,Davalos RV

doi

10.1007/s10549-010-0803-5

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

295-301

issue

1

eissn

0167-6806

issn

1573-7217

journal_volume

123

pub_type

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