Distribution and significance of caveolin 2 expression in normal breast and invasive breast cancer: an immunofluorescence and immunohistochemical analysis.

abstract：INTRODUCTION:Breast cancer (BC) is the leading cause of cancer death in Caribbean women. Across the Caribbean islands, the prevalence of hereditary breast cancer among unselected breast cancer patients ranges from 5 to 25%. Moreover, the prevalence of BC among younger women and the high mortality in the Caribbean regio...

journal_title：Breast cancer research and treatment

authors： Donenberg T,George S,Ali J,Bravo G,Hernandez K,Sookar N,Ashing KT,Narod SA,Akbari MR,Hurley J

更新日期：2019-04-01 00:00:00

abstract：:Angiosarcoma of the breast (AB) is a rare entity: its overall incidence is estimated at between 0.002% and 0.005% per year. Some potential risk factors have been described, mainly previous irradiation of the breast. We report the experience of the European Institute of Oncology with this unusual disease from January 1...

journal_title：Breast cancer research and treatment

authors： Luini A,Gatti G,Diaz J,Botteri E,Oliveira E,Cecilio Sahium de Almeida R,Veronesi P,Intra M,Pagani G,Naninato P,Viale G

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:Despite numerous studies on the utility of GATA-3 as breast cancer marker, its comparison with other breast markers, its concordance between primary and metastatic tumors and its expression in primary cancers from sites with frequent breast metastases remains unclear. METHODS:To address these questions, totall...

journal_title：Breast cancer research and treatment

authors： Ni YB,Tsang JYS,Shao MM,Chan SK,Cheung SY,Tong J,To KF,Tse GM

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Gemcitabine (G) and vinorelbine (V) have favorable safety profile and antitumor activity in metastatic breast cancer. To exploit their different mechanism of action and lack of overlapping toxicity, we performed a phase I and II study of G and V in combination. PATIENTS AND METHODS:Fifty-three patients with...

journal_title：Breast cancer research and treatment

authors： Mariani G,Tagliabue P,Zucchinelli P,Brambilla C,Demicheli R,Villa E,Marchianò A,Valagussa P,Bonadonna G,Gianni L

更新日期：2001-12-01 00:00:00

abstract：PURPOSE:Chronic upper extremity disability (UED) is common after breast cancer treatment but under-identified and under-treated. Although UED has been linked to quality of life (QoL), the role of UED as mediator between contemporary treatment practices and QoL has not been quantified. This investigation describes UED i...

journal_title：Breast cancer research and treatment

authors： Chrischilles EA,Riley D,Letuchy E,Koehler L,Neuner J,Jernigan C,Gryzlak B,Segal N,McDowell B,Smith B,Sugg SL,Armer JM,Lizarraga IM

更新日期：2019-06-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) is expressed in benign and malignant breast epithelium. The EGFR, when mutated or over-expressed in the presence of its ligand, is transforming in other tissues or cell types. It is therefore of major interest in the pathogenesis of human breast cancer to understand the role...

journal_title：Breast cancer research and treatment

authors： Harris AL

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:The homeobox (HOX) family consists of 39 genes whose expressions are tightly controlled and coordinated within the family, during development. We performed a comprehensive analysis of this gene family in cancer settings. METHODS:Gene correlation analysis was performed using breast cancer data available in T...

journal_title：Breast cancer research and treatment

authors： Nakashoji A,Hayashida T,Yamaguchi S,Kawai Y,Kikuchi M,Yokoe T,Nagayama A,Seki T,Takahashi M,Kitagawa Y

更新日期：2021-01-18 00:00:00

abstract：:The site of several lectin receptors in human mammary tumors and stroma was studied with the electron microscope. The advantage of the ultrastructural over light microscopic study was that lectin receptors could be localized with precision on the different cell types of the tumor and stroma. Eighteen human mammary car...

journal_title：Breast cancer research and treatment

authors： Calafat J,Janssen H

更新日期：1984-01-01 00:00:00

abstract：:Interleukin-6 (IL-6) and interleukin-11 (IL-11) are frequently produced by breast cancer cells. These interleukins promote osteoclast formation and may mediate osteolysis at the site of breast cancer bone metastases. Transforming growth factor-beta (TGF-beta), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1b...

journal_title：Breast cancer research and treatment

authors： Suarez-Cuervo C,Harris KW,Kallman L,Väänänen HK,Selander KS

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:To investigate the correlation among some of the commonly used clinical, pathological factors and newer biological indicators, and to identify the independent predictors of distant metastasis at presentation in patients with breast cancer. METHODS:The pathological specimens from 73 patients with breast canc...

journal_title：Breast cancer research and treatment

authors： Bozcuk H,Uslu G,Peştereli E,Samur M,Ozdoğan M,Karaveli S,Sargin F,Savaş B

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:Nuclear factor E2-related factor 2 (NRF2) is a transcription factor that plays a major role in the regulation of intracellular antioxidant response. The effect of NRF2 overexpression in many malignancies is still unclear and recent meta-analysis correlated NRF2 overexpression with poor prognosis in a variety of...

journal_title：Breast cancer research and treatment

authors： Almeida M,Soares M,Ramalhinho AC,Moutinho JF,Breitenfeld L,Pereira L

更新日期：2020-02-01 00:00:00

abstract：:Clinical evidence indicates that higher levels of estrogen receptor beta (ERbeta) predicts improved disease-free and overall survival in patients treated with adjuvant tamoxifen therapy. To better understand the mechanisms in which ERbeta can modulate breast cancer therapies, we introduced ERbeta under an inducible pr...

journal_title：Breast cancer research and treatment

authors： Hodges-Gallagher L,Valentine CD,El Bader S,Kushner PJ

更新日期：2008-05-01 00:00:00

abstract：:Tumor necrosis factor-α (TNF-α) is an important pro-inflammatory cytokine in the development and progress in human cancer. TNF-α polymorphisms have been confirmed to influence the risk for several types of cancer, however, the associations between TNF-α polymorphisms and breast cancer (BC) remain controversial and amb...

journal_title：Breast cancer research and treatment

authors： Yang Y,Feng R,Bi S,Xu Y

更新日期：2011-09-01 00:00:00

abstract：:Resveratrol is a natural polyphenolic compound and has been shown to exhibit cardio-protective as well as anti-neoplastic effects on various types of cancers. However, the exact mechanism of its anti-tumor effect is not clearly defined. Resveratrol has been shown to have strong hypolipidemic effect on normal adipocyte...

journal_title：Breast cancer research and treatment

authors： Pandey PR,Okuda H,Watabe M,Pai SK,Liu W,Kobayashi A,Xing F,Fukuda K,Hirota S,Sugai T,Wakabayashi G,Koeda K,Kashiwaba M,Suzuki K,Chiba T,Endo M,Fujioka T,Tanji S,Mo YY,Cao D,Wilber AC,Watabe K

更新日期：2011-11-01 00:00:00

abstract：:Clinical evidence regarding the value of MRI for therapy responses assessment in breast cancer is increasing. The objective of this study is to compare the diagnostic capability of diffusion-weighted MR imaging (DW-MRI) and contrast-enhanced MR imaging (CE-MRI) to evaluate and predict pathological response in breast c...

journal_title：Breast cancer research and treatment

authors： Wu LM,Hu JN,Gu HY,Hua J,Chen J,Xu JR

更新日期：2012-08-01 00:00:00

abstract：:Gene fusions have long been considered principally as the oncogenic events of hematologic malignancies, but have recently gained wide attention in solid tumors due to several milestone discoveries and the advancement of deep sequencing technologies. With the progress in deep sequencing studies of breast cancer transcr...

journal_title：Breast cancer research and treatment

authors： Veeraraghavan J,Ma J,Hu Y,Wang XS

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:Whether young age at diagnosis of breast cancer is an independent risk factor for death remains controversial, and the question whether young age should be considered in treatment decisions is still to be answered. METHODS:From a population-based cohort of 22,017 women with breast cancer, all women <35 years (...

journal_title：Breast cancer research and treatment

authors： Fredholm H,Magnusson K,Lindström LS,Garmo H,Fält SE,Lindman H,Bergh J,Holmberg L,Pontén F,Frisell J,Fredriksson I

更新日期：2016-11-01 00:00:00

abstract：:A model for a more precise prognosis of the risk of relapse is needed to avoid overtreatment of lymph node-negative breast cancer patients. A large derivation data set (n = 684) was generated by pooling three independent breast cancer expression microarray data sets. Two major prognostic factors, proliferation and imm...

journal_title：Breast cancer research and treatment

authors： Oh E,Choi YL,Park T,Lee S,Nam SJ,Shin YK

更新日期：2012-04-01 00:00:00

abstract：:Tumor formation can result from a decrease in cell death, as well as an increase in cell proliferation. In spite of the high incidence of mammary gland tumors (MGTs) in female dogs, the understanding of its etiology is still poor. Consistent with several proto-oncogenes (such as Wnt) for the mammary gland, sFRP2 is ex...

journal_title：Breast cancer research and treatment

authors： Lee JL,Chang CJ,Chueh LL,Lin CT

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:The selective treatment of internal mammary lymph nodes (IMNs) in breast cancer is controversial. The purpose of this research was to determine the subpopulation patients with high risk of internal mammary lymph nodes metastasis who received extended radical mastectomy without any preoperative treatment from 19...

journal_title：Breast cancer research and treatment

authors： Huang O,Wang L,Shen K,Lin H,Hu Z,Liu G,Wu J,Lu J,Shao Z,Han Q,Shen Z

更新日期：2008-02-01 00:00:00

abstract：PURPOSE:Peripheral blood lymphopenia and elevated neutrophil-to-lymphocyte ratio (NLR) have been associated with poor outcomes in various malignancies. However, existing literature has largely focused on baseline parameters. The aim of this study is to assess the impact of radiation therapy (RT) and chemotherapy on abs...

journal_title：Breast cancer research and treatment

authors： Patel DA,Xi J,Luo J,Hassan B,Thomas S,Ma CX,Campian JL

更新日期：2019-04-01 00:00:00

abstract：:Circulating CA 15-3 antigen levels were evaluated in patients with benign diseases and breast cancer patients with no clinical evidence of disease after surgery (NED). Patients with breast cancer NED were followed for tumor recurrence or death during a median of 12.9 months (range 1 to 25 months). CA 15-3 and carcinoe...

journal_title：Breast cancer research and treatment

authors： Colomer R,Ruibal A,Genollá J,Rubio D,Del Campo JM,Bodi R,Salvador L

更新日期：1989-03-01 00:00:00

abstract：:We have evaluated tandem cycles of a tri-drug combination, termed CVP (cyclophosphamide, etoposide [VP-16], and cisplatin [Platinol]), at four levels in more than 300 patients with various types of tumors. Tandem CVP appears to be at least therapeutically equivalent to alternatives. A second potentially non-cross-resi...

journal_title：Breast cancer research and treatment

authors： Spitzer G,Adkins D,Dunphy F,Petruska P,Spencer V,Velasquez W

更新日期：1993-01-01 00:00:00

abstract：:Conflicting opinions exist concerning clinical and pathological presentation, as well as evolution and prognosis, of breast cancer in young women. The roles of associated pregnancy and lactation on these parameters is also unclear. These two conditions are studied in the present work through the comparison of two brea...

journal_title：Breast cancer research and treatment

authors： Tabbane F,el May A,Hachiche M,Bahi J,Jaziri M,Cammoun M,Mourali N

更新日期：1985-01-01 00:00:00

abstract：:To evaluate the prognostic relevance of Ki-67 and topoisomerase IIalpha expression in relation to tumor stage, grade, and hormone receptor content, 942 ductal infiltrating carcinomas of the breast were examined by means of the monoclonal antibodies Ki-S11 (Ki-67) and Ki-S4 (topoisomerase IIalpha). pS2, c-erbB2, and p5...

journal_title：Breast cancer research and treatment

authors： Rudolph P,MacGrogan G,Bonichon F,Frahm SO,de Mascarel I,Trojani M,Durand M,Avril A,Coindre JM,Parwaresch R

更新日期：1999-05-01 00:00:00

abstract：:Several prognostic signatures have been identified for breast cancer. However, these signatures vary extensively in their gene compositions, and the poor concordance of the risk groups defined by the prognostic signatures hinders their clinical applicability. Breast cancer risk prediction was refined with a novel appr...

journal_title：Breast cancer research and treatment

authors： Huang CC,Tu SH,Lien HH,Huang CS,Huang CJ,Lai LC,Tsai MH,Chuang EY

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:Breast cancer is the most common cancer and leading cause of cancer death in women. Body composition parameters, especially those related to muscle, have become a growing focus of cancer research. In this review, we summarize the literature on breast cancer and muscle parameters as well as combine their outcome...

journal_title：Breast cancer research and treatment

authors： Aleixo GFP,Williams GR,Nyrop KA,Muss HB,Shachar SS

更新日期：2019-10-01 00:00:00

abstract：:Detection of disseminated tumour cells (DTCs) in bone marrow by immunocytochemistry (ICC) includes morphological evaluation of cytokeratin immunopositive cells. The aim of this study was to disclose the prognostic significance of different morphological categories of ICC-positive cells according to treatment status an...

journal_title：Breast cancer research and treatment

authors： Synnestvedt M,Borgen E,Schlichting E,Schirmer CB,Renolen A,Giercksky KE,Nesland JM,Naume B

更新日期：2013-04-01 00:00:00

abstract：:Feulgen-stained samples from 460 small (pT1) primary breast cancers were investigated by means of an image analysis system. Several DNA, morphometrical and textural parameters were evaluated for each patient, and the prognostic meaning of these parameters was then investigated by the Cox regression analysis. As progno...

journal_title：Breast cancer research and treatment

authors： Aubele M,Auer G,Falkmer U,Voss A,Rodenacker K,Rutquist LE,Höfler H

更新日期：1995-01-01 00:00:00

abstract：:Kinase suppressor of Ras 1 (KSR1) has been implicated in tumorigenesis in multiple cancers, including skin, pancreatic and lung carcinomas. However, our recent study revealed a role of KSR1 as a tumour suppressor in breast cancer, the expression of which is potentially correlated with chemotherapy response. Here, we a...

journal_title：Breast cancer research and treatment

authors： Zhang H,Angelopoulos N,Xu Y,Grothey A,Nunes J,Stebbing J,Giamas G

更新日期：2015-06-01 00:00:00