Dual HER2-targeted approaches in HER2-positive breast cancer.

abstract：:Over the past two decades, the simple model for control of breast cancer growth involving one or two factors acting directly or indirectly via endocrine pathways has turned into a complex model implicating numerous interacting factors and the diverse cell populations constituting breast tumors. Current approaches to b...

journal_title：Breast cancer research and treatment

authors： Freiss G,Prébois C,Vignon F

更新日期：1993-01-01 00:00:00

abstract：INTRODUCTION:The use of scalp cooling for the prevention of chemotherapy-induced alopecia (CIA) is increasing. Cold caps are placed onto the hair-bearing areas of the scalp for varying time periods before, during, and after cytotoxic chemotherapy. Although not yet reported, improper application procedures could result ...

journal_title：Breast cancer research and treatment

authors： Belum VR,de Barros Silva G,Laloni MT,Ciccolini K,Goldfarb SB,Norton L,Sklarin NT,Lacouture ME

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:The main objectives of this study were to identify risk factors for local in-breast tumor recurrence after breast-conservation and to evaluate the impact of IBTR (in-breast tumor recurrence) on overall survival. METHODS:A total of 335 consecutive patients with 346 invasive and in situ breast cancers were treat...

journal_title：Breast cancer research and treatment

authors： Mechera R,Viehl CT,Oertli D

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:The use of adjuvant radiotherapy (RT) in the management of ductal carcinoma in situ (DCIS) is increasing. Left-sided breast irradiation may involve exposure of the heart to ionising radiation, increasing the risk of ischemic heart disease (IHD). We examined the incidence of IHD in a population-based cohort of w...

journal_title：Breast cancer research and treatment

authors： Wadsten C,Wennstig AK,Garmo H,Nilsson G,Blomqvist C,Holmberg L,Fredriksson I,Wärnberg F,Sund M

更新日期：2018-08-01 00:00:00

abstract：:The taxanes and anthracyclines have emerged as the most active agents for treating women with advanced breast cancer. As such, investigation of the two drug classes in combination regimens has been eagerly pursued. The rationale for combining docetaxel with an anthracycline includes high clinical activity of each indi...

journal_title：Breast cancer research and treatment

authors： Nabholtz JM

更新日期：2003-01-01 00:00:00

abstract：:Medroxyprogesterone acetate (MPA) is well recognized to have beneficial effects for the treatment of advanced breast cancer which are comparable to those achieved with other forms of endocrine therapy. Using mammary tumors induced in the rat by dimethylbenz(a)anthracene (DMBA) as a model, we have studied the possibili...

journal_title：Breast cancer research and treatment

authors： Labrie F,Li S,Bélanger A,Côté J,Mérand Y,Lepage M

更新日期：1993-01-01 00:00:00

abstract：:The possible role of personality patterns and psychosocial factors in breast cancer has been studied extensively, through both human and animal experiments. The data are conflicting, and the conclusions controversial. This review will serve two purposes. First, we present evidence that behavioral patterns most commonl...

journal_title：Breast cancer research and treatment

authors： Hilakivi-Clarke L

更新日期：1997-11-01 00:00:00

abstract：:The high potency and selectivity of new aromatase inhibitors has translated to greater efficacy and improved tolerability in comparison with established second-line hormonal agents for advanced breast cancer in phase III clinical trials. Two pharmacological studies are reported which assess the use of one of these inh...

journal_title：Breast cancer research and treatment

authors： Dowsett M,Doody D,Miall S,Howes A,English J,Coombes RC

更新日期：1999-07-01 00:00:00

abstract：:To report on a highly unusual case of a 20-year-old woman who presented with multifocal metaplastic breast cancer and was subsequently found to carry deleterious germline mutations in both BRCA1 and p53. Genetic testing was requested on an expedited basis to assist in surgical decision-making and BRCA1/2 and p53 genet...

journal_title：Breast cancer research and treatment

authors： Bell K,Hodgson N,Levine M,Sadikovic B,Zbuk K

更新日期：2014-07-01 00:00:00

abstract：:In contrast to antigen-specific alphabeta-T cells (adaptive immune system), gammadelta-T cells can recognize and lyse malignantly transformed cells almost immediately upon encounter in a manner that does not require the recognition of tumor-specific antigens (innate immune system). Given the well-documented capacity o...

journal_title：Breast cancer research and treatment

authors： Beck BH,Kim HG,Kim H,Samuel S,Liu Z,Shrestha R,Haines H,Zinn K,Lopez RD

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:The American Society of Clinical Oncology recommends concurrent palliative care (PC) for patients with metastatic cancer. Recent data show benefits of early PC (at least 90 days before death). However, little is known about PC among patients who die from metastatic breast cancer. METHODS:Patients with metastat...

journal_title：Breast cancer research and treatment

authors： Rabow M,Small R,Jow A,Majure M,Chien A,Melisko M,Belkora J,Esserman LJ,Rugo H

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:This trial studied the disease-free survival after high-dose chemotherapy in patients in complete remission of metastatic breast cancer. PATIENTS AND METHODS:Thirty women, mean age 42.2 years (range 33-55) with metastatic breast cancer, received high-dose chemotherapy in a phase II study. Patients were elig...

journal_title：Breast cancer research and treatment

authors： de Vries EG,Rodenhuis S,Schouten HC,Hupperets PS,Dolsma WV,Lebesque JV,Blijham GH,Bontenbal M,Mulder NH

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Differences in tumor biology, genomic architecture, and health care delivery patterns contribute to the breast cancer mortality gap between White and Black patients in the US. Although this gap has been well documented in previous literature, it remains uncertain how large the actual effect size of race is for ...

journal_title：Breast cancer research and treatment

authors： Zhao F,Copley B,Niu Q,Liu F,Johnson JA,Sutton T,Khramtsova G,Sveen E,Yoshimatsu TF,Zheng Y,Ibraheem A,Jaskowiak N,Nanda R,Fleming GF,Olopade OI,Huo D

更新日期：2020-10-27 00:00:00

abstract：:Although new chemotherapeutic drugs for metastatic breast cancer (MBC) have been approved over the past decade, it is unclear whether this has changed the overall outcome of patients. This study assessed the clinical and economic impacts of these drugs. We retrospectively studied MBC patients receiving chemotherapy in...

journal_title：Breast cancer research and treatment

authors： Galy G,Labidi-Galy SI,Perol D,Bachelot T,Ray-Coquard I,Tredan O,Biron P,Latour JF,Blay JY,Guastalla JP,Favier B

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:The aims of this study were to define the distribution of caveolin 2 (CAV2) in frozen and formalin fixed, paraffin embedded (FFPE) normal breast samples and the significance of CAV2 expression in breast cancer. METHODS:Caveolin 2 distribution in frozen and paraffin-embedded whole tissue sections of normal b...

journal_title：Breast cancer research and treatment

authors： Savage K,Leung S,Todd SK,Brown LA,Jones RL,Robertson D,James M,Parry S,Rodrigues Pinilla SM,Huntsman D,Reis-Filho JS

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate whether young age at onset of breast cancer is an independent prognostic factor in patients from the Japanese Breast Cancer Registry, after adjustment of known clinicopathological prognostic factors. METHODS:Of the 53,670 patients registered between 2004 and 2006 and su...

journal_title：Breast cancer research and treatment

authors： Kataoka A,Iwamoto T,Tokunaga E,Tomotaki A,Kumamaru H,Miyata H,Niikura N,Kawai M,Anan K,Hayashi N,Masuda S,Tsugawa K,Aogi K,Ishida T,Masuoka H,Iijima K,Kinoshita T,Nakamura S,Tokuda Y

更新日期：2016-11-01 00:00:00

abstract：:The rate of contralateral prophylactic mastectomy (CPM) is rising rapidly, despite limited evidence about the procedure's relative benefits and harms. The objective of this study is to examine the impact of CPM on life expectancy (LE) and quality-adjusted life expectancy (QALE) in women with sporadic unilateral breast...

journal_title：Breast cancer research and treatment

authors： Lester-Coll NH,Lee JM,Gogineni K,Hwang WT,Schwartz JS,Prosnitz RG

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Extending adjuvant endocrine therapy (ET) beyond 5 years has been shown to improve outcomes in breast cancer; however, limited data are available about if and why women pursue extended ET. The primary objective was to estimate the proportion of women who were willing to receive extended ET if recommended by the...

journal_title：Breast cancer research and treatment

authors： Kadakia KC,Kidwell KM,Barton DL,Schott AF,Hayes DF,Griggs JJ,Henry NL

更新日期：2019-05-01 00:00:00

abstract：:The epidermal growth factor system is a well characterized growth factor receptor pathway, the deregulation of which has been be associated with neoplastic growth. Overexpression or amplification of the epidermal growth factor receptor (EGFR) or one of its ligands has been linked with the malignant transformation of c...

journal_title：Breast cancer research and treatment

authors： Rae JM,Lippman ME

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:A number of studies have tested the hypothesis that breast cancer patients with low-activity CYP2D6 genotypes achieve inferior benefit from tamoxifen treatment, putatively due to lack of metabolic activation to endoxifen. Studies have provided conflicting data, and meta-analyses suggest a small but significant ...

journal_title：Breast cancer research and treatment

authors： Hertz DL,Kidwell KM,Hilsenbeck SG,Oesterreich S,Osborne CK,Philips S,Chenault C,Hartmaier RJ,Skaar TC,Sikora MJ,Rae JM

更新日期：2017-11-01 00:00:00

abstract：:Obesity is associated with an increased risk of breast cancer (BC) and poorer outcome. We assessed the impact of body mass index (BMI) on pathological complete response (pCR), disease-free (DFS), and overall survival (OS), according to BC subtypes in patients with primary BC treated with neoadjuvant chemotherapy. 8,87...

journal_title：Breast cancer research and treatment

authors： Fontanella C,Lederer B,Gade S,Vanoppen M,Blohmer JU,Costa SD,Denkert C,Eidtmann H,Gerber B,Hanusch C,Hilfrich J,Huober J,Schneeweiss A,Paepke S,Jackisch C,Mehta K,Nekljudova V,Untch M,Neven P,von Minckwitz G,Loibl

更新日期：2015-02-01 00:00:00

abstract：:The potential advantage of using quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) methodology to detect metastasis in sentinel lymph nodes (SLNs) of breast cancer (BC) patients was evaluated in this prospective study. We measured the expression of relevant gene transcripts in SLNs using an innova...

journal_title：Breast cancer research and treatment

authors： Wallwiener CW,Wallwiener M,Kurth RR,Röhm C,Neubauer H,Banys MJ,Staebler A,Schönfisch B,Meuer SC,Giese T,Fehm TN

更新日期：2011-12-01 00:00:00

abstract：:Mammographic density is a strong and independent risk factor for breast cancer and is considered an intermediate marker of risk. The major predictors of premenopausal mammographic density, however, have yet to be fully elucidated. To test the hypothesis that urinary estrogen metabolism profiles are associated with mam...

journal_title：Breast cancer research and treatment

authors： Bertrand KA,Eliassen AH,Hankinson SE,Gierach GL,Xu X,Rosner B,Ziegler RG,Tamimi RM

更新日期：2012-11-01 00:00:00

abstract：:The mitochondrial DNA (mtDNA) 4977-bp deletion (DeltamtDNA(4977) mutation) is one of the most frequently observed mtDNA mutations in human tissues and may play a role in carcinogenesis. Only a few studies have evaluated DeltamtDNA(4977) mutation in breast cancer tissue, and the findings have been inconsistent, which m...

journal_title：Breast cancer research and treatment

authors： Ye C,Shu XO,Wen W,Pierce L,Courtney R,Gao YT,Zheng W,Cai Q

更新日期：2008-04-01 00:00:00

abstract：:The population-based Ontario Breast Screening Program (OBSP) provides two-yearly screening by both nurse examiner clinical breast examination (CBE) and two-view mammography to women aged 50 to 69. CBE alone accounts for about 5% of cancer detection. The purpose of this study was to determine whether CBE information af...

journal_title：Breast cancer research and treatment

authors： Knight JA,Libstug AR,Moravan V,Boyd NF

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:The national guidelines recommend more intensive screening for breast cancer for women with a family history of breast or ovarian cancer. Using the data from the 2000 National Health Interview Survey (NHIS), we examined factors related to the underuse of mammogram in this population. METHOD:The study subject...

journal_title：Breast cancer research and treatment

authors： Wu H,Zhu K,Jatoi I,Shah M,Shriver CD,Potter J

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:In order to better define the breast cancer (BC) genetic risk factors in men, a germline investigation was carried out on 81 Male BC cases by screening the 24 genes involved in BC predisposition, genome stability maintenance and DNA repair mechanisms by next-generation sequencing. METHODS:Germline DNAs were te...

journal_title：Breast cancer research and treatment

authors： Scarpitta R,Zanna I,Aretini P,Gambino G,Scatena C,Mei B,Ghilli M,Rossetti E,Roncella M,Congregati C,Bonci F,Naccarato AG,Palli D,Caligo MA

更新日期：2019-12-01 00:00:00

abstract：:Knowledge of the family history of cancer may significantly influence diagnosis and surgical management. Hereditary breast cancer (HBC) is common and accounts for approximately 9% of the total breast cancer burden. The pattern of HBC's natural history, including age of onset, increased incidence of bilaterality, integ...

journal_title：Breast cancer research and treatment

authors： Lynch HT,Conway T,Fitzgibbons R Jr,Schreiman J,Watson P,Marcus J,Fitzsimmons ML,Lynch JF

更新日期：1988-12-01 00:00:00

abstract：:Chylous fistulas in cases treated surgically for breast cancer only, are rare. We encountered four chylous fistula cases after breast cancer operations out of a total of 851 cases, all of which involved the left breast. Chylous fistulas were confirmed by axillary white fluid and were unrelated to obesity, surgical met...

journal_title：Breast cancer research and treatment

authors： Nakajima E,Iwata H,Iwase T,Murai H,Mizutani M,Miura S,Kato H

更新日期：2004-01-01 00:00:00

abstract：:This retrospective study investigates the correlation of intra-individual HER2 status between primary breast cancers and corresponding recurrences in a population derived cohort. The REMARK criteria were used as reference. In 151 breast cancer patients, primary tumors were analyzed for HER2 status on histopathology se...

journal_title：Breast cancer research and treatment

authors： Wilking U,Karlsson E,Skoog L,Hatschek T,Lidbrink E,Elmberger G,Johansson H,Lindström L,Bergh J

更新日期：2011-01-01 00:00:00