[Neurological disorders and glaucoma - an overview].

Abstract:

:Due to the anatomic location of the N. opticus to the brain and its embryological development as a "bulging part of the brain", a close connection between the opticoneuropathy and certain neurological diseases exists. Glaucoma is a chronic neurodegenerative disorder and many cellular and molecular mechanisms of the chronic neurodegenerative diseases are common in the brain. For example, elevated levels of multiple biomarkers of Alzheimer's disease were found in the aqueous humor of patients with primary open-angle glaucoma. Also a decreased cerebrospinal fluid pressure (CSFP) has been demonstrated in patients with glaucoma and Alzheimer's disease. The resulting translaminar pressure difference is seen as one of the pathogenic mechanisms of the formation of the optic neuropathy in both diseases. Other hypotheses, such as the influence of oxidative stress, excitotoxicity, mitochondrial dysfunction, genetic factors and vascular factors play additional roles in the pathogenesis of the different diseases. Experimental studies have shown that dopaminergic amacrine cells are present in the retina. The dopamine in the retina is necessary for the light adaptation and the signal processing in the rods and cones. Parkinson's disease is characterised by a loss of dopaminergic neurons in the basal ganglia-substantia nigra pars compacta of the midbrain. These decreased levels of dopamine also have an effect on the eye and the afferent signal processing. So there are reductions in visual acuity, disturbances in colour vision and contrast sensitivity and reduction of the retinal nerve fiber layer in patients affected with Parkinson's disease. With the examples of Alzheimer's disease, Parkinson's disease and the chronic inflammatory disease multiple sclerosis, we demonstrate the association between the neurological diseases and the opticoneuropathy in primary open-angle glaucoma.

journal_name

Klin Monbl Augenheilkd

authors

Göbel K,Erb C

doi

10.1055/s-0033-1360316

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

130-5

issue

2

eissn

0023-2165

issn

1439-3999

journal_volume

231

pub_type

杂志文章,评审
  • [Chemical and thermal eye burns in the residential area of RWTH Aachen. Analysis of accidents in 1 year using a new automated documentation of findings].

    abstract:BACKGROUND:Until now there were no statistical data on the incidence and the prevalence of eye burns. Therefore we studied all patients coming to our hospital from the area of Aachen with eye burns during the time from September 1990 until August 1991. PATIENTS AND METHODS:All patients underwent a standardized examina...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1045646

    authors: Kuckelkorn R,Luft I,Kottek AA,Schrage NF,Makropoulos W,Reim M

    更新日期:1993-07-01 00:00:00

  • [Combined phacoemulsification with trabecular aspiration with differing outcomes in pseudoexfoliative glaucoma - a retrospective study].

    abstract:INTRODUCTION:The aim of this study was to differentiate the pressure-reducing results following trabecular aspiration combined with small incision cataract surgery in eyes with pseudoexfoliation depending on preoperative pressure and medication score. PATIENTS AND METHODS:A retrospective analysis was made of 104 exfol...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0031-1282014

    authors: Dinslage S,Rosentreter A,Schild AM,Jordan JF,Widder R,Dietlein TS

    更新日期:2012-06-01 00:00:00

  • [Spot-like to reticular pigment displacement in a patient with pseudoxanthoma elasticum (Grönblad-Strandberg syndrome)].

    abstract::The authors report a rare observation of leopard spot-like and reticular pigmentary patterns in a patient with pseudoxanthoma elasticum (PXE). Characteristic fundus changes associated with PXE have been described as angioid streaks, subretinal neovascularization membranes, peau d'orange, focal retinal pigment epitheli...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046124

    authors: Zürcher M,Schipper I

    更新日期:1990-01-01 00:00:00

  • [The 30 prism test].

    abstract::The 30-prism-test is a relatively quick and simple method for many-sided testing binocular behaviour in near distance in patients with reading difficulties and asthenopic symptoms, respecting well known and assumed causes of the disturbances. Therefore indications for treatment are given. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035556

    authors: Safra D

    更新日期:1994-05-01 00:00:00

  • [Peripheral exudative haemorrhagic chorioretinopathy: clinical and angiographic findings].

    abstract:BACKGROUND:Peripheral exudative haemorrhagic chorioretinopathy (PEHCR) is a degenerative disease of the peripheral retina and choroid in the elderly. Although PEHCR is often seen by clinicians, this entity is underrepresented in the ophthalmological literature. This may be due to inconsistent naming. PATIENTS:We prese...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0028-1109376

    authors: Mirshahi A,Höhn F,Baatz H,Müller M,Hattenbach LO

    更新日期:2009-08-01 00:00:00

  • [Biometry of the anterior chamber of the eye in Nd:YAG laser iridectomy].

    abstract::In a prospective clinical study covering 41 eyes (28 patients) with narrow-angle glaucoma the central and peripheral anterior chamber depths were determined biomicroscopically before and after Nd:YAG laser iridectomy. In 29 eyes the central anterior chamber depth was also measured by ultrasonography. In contrast to th...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046142

    authors: Schrems W,Hofmann G,Krieglstein GK

    更新日期:1990-03-01 00:00:00

  • [On the clinical picture and therapy of arachnitis optico-chiasmatica (author's transl)].

    abstract::From 20 cases of arachnitis optico-chiasmatica (a. o.) the symptoms of this relatively rare but pathologico-anatomically proved disuse of the brain base involving the optic nerves are described. In this description newer methods of investigation are mentioned which allow a differentiation of the clinical picture of o....

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Fuchs J

    更新日期:1977-12-01 00:00:00

  • [Local anesthesia with accidental perforation of the eye--an acute emergency?].

    abstract::A report on 3 instances of accidental injection of lidocaine into the eye. Among the immediate reactions were (1) development of corneal edema due to an abrupt rise in intraocular pressure, (2) dilatation and paralysis of the pupil, (3) decrease of visual acuity to light perception. In 2 of the patients pupillary reac...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050595

    authors: Lincoff H,Kreissig I

    更新日期:1986-02-01 00:00:00

  • [Intrabulbar and peribulbar reactive lymphoid hyperplasia].

    abstract::Report on a 69-year-old woman with a choroidal and a large peribulbar tumor. A scan ultrasonography of the peribulbar mass revealed a homogeneous structure of the lymphoma/sarcoma/pseudo-tumor type. Histological examination disclosed a reactive lymphoid hyperplasia without "Dutcher bodies", and consistent with a benig...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057457

    authors: Haddad R,Slezak H,Till P

    更新日期:1980-02-01 00:00:00

  • [Medallion lenses, 500 implantations].

    abstract::A report is given on the implantation of 500 Medallion lenses, most of which were implanted after intracapsular cataract operation (88%) and were kept under observation for between 3 and 88 months (average 22 months). In 1.2% a severe keratopathy resulted from an operation that was too traumatic, from decentration of ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054737

    authors: Fechner PU

    更新日期:1983-02-01 00:00:00

  • [II: Difference plots or scattergram--when to use which?].

    abstract::Sometimes the statistical comparison of diagnostic measurement methods or subsequent measurement series in the same individuals is based on bivariate scattergrams; correlation coefficients and linear regression lines are provided in addition. However, this strategy for data representation must be considered inappropri...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2002-35165

    authors: Krummenauer F

    更新日期:2002-09-01 00:00:00

  • Intravitreal triamcinolone injection for unresponsive cystoid macular oedema in probable Behçet's disease as an additional therapy.

    abstract:BACKGROUND:We present the description of a successful outcome of intravitreal triamcinolone injection (IVTA) in a patient with cystoid macular oedema (CME) and severe retinal vasculitis suggestive of ocular Behçet's disease. HISTORY AND SIGNS:A healthy 32 year-old Caucasian man presented initially with right retinal v...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1027351

    authors: Oueghlani E,Pavésio CE

    更新日期:2008-05-01 00:00:00

  • [Secondary ocular syphilis with chorioretinitis of the posterior pole - a case report].

    abstract:BACKGROUND:Diagnosis of syphilis is often very difficult due to the absence of typical organ manifestation. In addition syphilis has the ability to imitate any ocular inflammation. This may result in misdiagnosis and delay of appropriate antimicrobial therapy. Up to now the first choice therapy is penicillin. CASE REP...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2001-17141

    authors: Stübiger N,Denk PO,Kötter I,Zierhut M

    更新日期:2001-08-01 00:00:00

  • [Arteriovenous malformation of the orbit].

    abstract::Arteriovenous malformation is a rare vascular disease of the orbit that has to be differentiated from arteriovenous fistulas (e.g., of the carotid sinus), arterial aneurysms, the varices and the angiomas. It develops in the presence of an underlying constitutional maldifferentiation of the vascular bed but usually onl...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046343

    authors: Witschel H,Grannemann D

    更新日期:1989-02-01 00:00:00

  • [Local anesthetic effect and subjective tolerance of a single dose of 0.25% bupranolol in probands with healthy eyes. Randomized parallel double-blind study].

    abstract::.25% Bupranolol in an oily solution decreases corneal sensitivity statistically significant from the 3. to the 15. minute after the application. The maximum of decrease is found between the 6. and the 15. minute in contrast to beta-blockers in aqueous solution (1.-3. minute). The topical subjective compatibility of 0....

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1055/s-2008-1045923

    authors: Bastian B,Höh H

    更新日期:1991-01-01 00:00:00

  • [Intraocular solitary granuloma of toxocara canis (author's transl)].

    abstract::5 cases of intraocular Toxocara canis solitary granuloma are demonstrated. The coincidence of two different aspects of a disease: pseudocoloboma of the macula (toxoplasmosis) in the right and a toxocara solitary granuloma in the left eye of the same patient (case 5) perhaps will furnish proof possibility of foetal inf...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Huismans H

    更新日期:1976-08-01 00:00:00

  • [Familial cataract in plasma galactitol increase without known enzyme defect].

    abstract:BACKGROUND:Several enzyme defects of the galactose pathway may lead to cataract formation. We report on a family with familiar cataract. PATIENTS:A 2-year-old Turkish girl (daughter of first cousins) presented with dense cortical and subcapsular opacifications and mature cataract respectively. Bilateral phacectomy, pl...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034710

    authors: Budde M,Gusek-Schneider GC,Jünemann A,Jansen F,Shin YS

    更新日期:1999-10-01 00:00:00

  • [Vision Screening in Zurich].

    abstract:BACKGROUND:In the city of Zurich, vision screening is performed by school medical services as part of the legally compulsory preventive medical examinations. We retrospectively evaluated the results of the 2011-2012 school year. PATIENTS AND METHODS:Preventive medical examinations by the school medical services were p...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0041-111818

    authors: Sturm V,Heckmann J,Wandernoth P,Kunz A,Steffen T,Schmitt Oggier S

    更新日期:2016-04-01 00:00:00

  • [Management of childhood glaucoma associated with Sturge-Weber syndrome].

    abstract:PURPOSE:Sturge-Weber syndrome is a rare congenital disorder consisting of cutaneous, leptomeningeal and ocular vascular malformations. Glaucoma occurs in 30-70 % of patients. Treatment is challenging due to a high risk of severe complications such as expulsive haemorrhage, massive choroidal effusion and serous retinal ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-0032-1315217

    authors: Greslechner R,Helbig H,Oberacher-Velten IM

    更新日期:2012-10-01 00:00:00

  • [Ab externo sclerostomy with the Er:YAG laser: report of outcome after 2 years].

    abstract:OBJECT:Results over a period of 24 months of performing the Er:YAG laser ab externo sclerostomy. MATERIAL AND METHODS:The procedure was performed 81 times (chronic glaucoma with open angle (n = 55) and narrow angle (n = 15), 6 secondary glaucoma, 4 pigment glaucoma, 1 normal pressure glaucoma) in 74 eyes of 64 patient...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035199

    authors: Kampmeier J,Klafke M,Hibst R,Wierschin S,Schütte E,Steiner R

    更新日期:1996-04-01 00:00:00

  • [Relative discharge of tears by the upper and lower lacrimal ducts].

    abstract::Forty eyes were studied in order to establish the relative function of the upper and lower lacrimal ducts. Following artificial occlusion first of the upper and then of the lower lacrimal ducts. Schirmer's No. 1 test was performed. The wetting of the test strips was used as an indirect measure of tear discharge. Highe...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1054425

    authors: Vidic B,Schuhmann G,Auerbach B

    更新日期:1984-02-01 00:00:00

  • [Autophagy in visual cell renewal processes (author's transl)].

    abstract::The biological significance of autophagy in the metabolism of visual cells is discussed. In the process of autophagy, parts of the cytoplasm including cell organelles are surrounded by membranes. This formation is called an autophagic vacuole. Then, the contents of the vacuole are degraded by enzymes. Autophagy is a w...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Remé CE

    更新日期:1978-09-01 00:00:00

  • [Endophthalmitis after intra-oral block of the infraorbital nerve].

    abstract:BACKGROUND:Most penetrating needle puncture injuries occur in retro- or peribulbar anesthesia. Hereby only a small percentage of patients develop endophthalmitis. Ocular penetration after enoral infraorbital nerve block has not yet been reported in literature. HISTORY AND FINDINGS:In June 1995 a 74-year-old man presen...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035084

    authors: Weinand FS,Pavlovic S,Dick B

    更新日期:1997-06-01 00:00:00

  • [The circulatory disturbance of the optic nerve with special reference to the side distribution and other dispositional factors (author's transl)].

    abstract::We examined 38 patients with disturbed blood supply to the optic nerve. The observations suggest: 1. men are more frequently affected than women. 2. the first attack of apoplexia nervi optici occurs most often in the left eye. 3. diabetes mellitus and most probably arterial hypertension are risk factors. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Bastian GO

    更新日期:1979-01-01 00:00:00

  • [The Mannheim lens: a provisional cataract lens for one-eyed aphakic patients (author's transl)].

    abstract::Description of a tailor-made dressing with a built-in cataract lens which gives the one-eyed aphakic patient vision from the first postoperative day. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1057599

    authors: Werner W,Martus H,Liesenhoff H

    更新日期:1980-06-01 00:00:00

  • [Epidemiology of uveitis in juvenile idiopathic arthritis from a national paediatric rheumatologic and ophthalmologic database].

    abstract:BACKGROUND:Uveitis is a frequent and potentially vision-threatening manifestation of juvenile idiopathic arthritis (JIA). There are only a few population-based studies providing data on the frequency and severity of uveitis. METHODS:Documentation of patients with JIA was collected in a national database. An analysis o...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2005-858753

    authors: Heiligenhaus A,Niewerth M,Mingels A,Ganser G,Thon A,Pleyer U,Greiner K,Minden K

    更新日期:2005-12-01 00:00:00

  • [Radiotherapy of intraocular tumours (author's transl)].

    abstract::Ocular radiotherapy has considerably improved during the last 60 years. It allows very often, not only to save an eye, but also to maintain a useful function. But it is only one single element, although important, in our fight against intraocular tumors. ...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Gailloud C,Balmer A,Zografos L,Raimondi S

    更新日期:1979-06-01 00:00:00

  • [Flicker stimulation induces retinal vasodilation in man].

    abstract:BACKGROUND:Previous studies have demonstrated, in the cat, a vasodilatation of retinal vessels in response to neuronal activity induced by diffuse luminance flicker. The aim of this study was to determine whether a similar diameter variation is detectable in humans. MATERIALS AND METHODS:Nine normal subjects were expo...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034897

    authors: Formaz F,Riva CE,Geiser MH,Petrig BL

    更新日期:1998-05-01 00:00:00

  • [Pathology of the lacrimal apparatus].

    abstract::Following a brief survey of the subjects covered in this paper the author discusses the problem of lacrimal gland tumefactions. These can be divided into five groups: malignant lymphoma and leukemias, proliferative reactions of the lymphatic tissues, dacryoadenitis, secondary and metastatic tumors, and finally miscell...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1050952

    authors: Ducrey N

    更新日期:1985-06-01 00:00:00

  • [Endonasal dacryocystorhinostomy with transillumination of the lacrimal sac: implementation and results].

    abstract:PATIENTS:Since Mai 1991 we performed a total of 17 endonasal dacryocystorhinostomies under transillumination of the lacrimal sac on 15 patients with lacrimal obstruction aged 11 to 88 years. 11 patients with 12 operations were followed up between 40 and 393 days (mean of 5.6 months). RESULTS:In all cases the connectio...

    journal_title:Klinische Monatsblatter fur Augenheilkunde

    pub_type: 杂志文章

    doi:

    authors: von Büren M,Forrer A,Fiebach A

    更新日期:1994-05-01 00:00:00