当前位置： SCI文献检索 > JOURNAL OF PERIODONTOLOGY期刊下所有文献 > Association of simvastatin and hyperlipidemia with periodontal status and bone metabolism markers.

Association of simvastatin and hyperlipidemia with periodontal status and bone metabolism markers.

Abstract：

BACKGROUND:The objective of this study is to determine whether simvastatin consumption and hyperlipidemia are associated with a worse periodontal condition and specific bone activity biomarkers. METHODS:This cross-sectional and analytic study includes 73 patients divided into three groups: 1) simvastatin-treated patients with hyperlipidemia (n = 29); 2) patients with hyperlipidemia treated by diet alone (n = 28); and 3) normolipidemic patients (controls, n = 16). The periodontal clinical variables of all participants were gathered, a blood sample was drawn from each to determine the lipid profile (total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein), serum levels of acute-phase reactants (C-reactive protein), erythrocyte sedimentation rate, and bone metabolism markers (osteoprotegerin [OPG], osteocalcin, procollagen type I N-terminal propeptide, and C-terminal telopeptide of type I collagen). RESULTS:The mean ESR was higher in the diet-treated patients with hyperlipidemia than in the normolipidemic controls (P = 0.04). Serum OPG concentrations were significantly higher in the simvastatin-treated patients with hyperlipidemia than in the diet-treated patients with hyperlipidemia (P = 0.05). Multivariable linear regression analysis adjusted for age, sex, tobacco, and alcohol revealed that, compared with the normolipidemic patients, the simvastatin-treated patients with hyperlipidemia showed a mean reduction of 0.8 mm (95% confidence interval = -1.5 to 0.0, P = 0.05) in clinical attachment loss. CONCLUSIONS:Within the limits of this study, the findings suggest that the intake of simvastatin is associated with increasing serum OPG concentrations, and this could have a protective effect against bone breakdown and periodontal attachment loss. The baseline systemic inflammatory state of patients with hyperlipidemia is indicated by their increased erythrocyte sedimentation rate.

journal_name

J Periodontol

journal_title

Journal of periodontology

authors

Magán-Fernández A,Papay-Ramírez L,Tomás J,Marfil-Álvarez R,Rizzo M,Bravo M,Mesa F

doi

10.1902/jop.2014.130652

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

1408-15

issue

eissn

0022-3492

issn

1943-3670

journal_volume

pub_type

杂志文章

在线工具

Association of simvastatin and hyperlipidemia with periodontal status and bone metabolism markers.