Abstract:
:Alcohol intake is facilitated by its relationship with eating behavior and both processes are highly influenced by situations of stress and anxiety. The dysregulation of these processes can reach pathological situations such as anorexia, bulimia or obesity. The neurobiological elements which underlie this control are not completely clarified. The nucleus incertus (NI) in the pontine tegmentum is a common element in the food intake and alcoholism. NI is characterized by using the neuropeptide relaxin-3 (RLN3) as transmitter and its receptor RXFP3. In the present review, we will analyze the participation of the NI-RLN3-RXFP3 system in these behaviors under conditions of anxiety or stress in animal models. The activation of NI has a positive effect on intake (orexigenic) and generates a wide response in the amygdala modulating anxiety states. The activity of RLN3-RXFP3 in the amygdala could affect alcohol addiction since the application of the RXFP3 antagonist in extended amygdala attenuates the relapse to alcohol induced by stress. The neuroanatomical data indicate that the NI-RLN3-RXFP3 system acts on the feeding behavior and alcohol intake by means of projections parallel to the canonical mesolimbic pathways. Thus, data in animal models indicate that the NI-RLN3-RXFP3 system should be taken into account as a target in the future treatment of disorders of eating and alcohol addictive behaviors. TITLE:Un nuevo agente en los mecanismos de la adiccion al alcohol y la ingesta: el nucleo incertus y el neuropeptido relaxina-3. :La ingesta de alcohol esta facilitada por la relacion con la conducta alimentaria, y ambas conductas estan altamente influidas por situaciones de estres y ansiedad. La desregulacion de estos procesos puede llegar a situaciones patologicas, como la anorexia, la bulimia o la obesidad. Los elementos neurobiologicos que subyacen a este control no estan completamente esclarecidos. El nucleo incertus (NI) en el tegmento pontino constituye un elemento comun a la ingesta y a la adiccion al alcohol. Las neuronas del NI utilizan como señalizacion el neuropeptido relaxina-3 (RLN3) y su receptor RXFP3. En esta revision se analiza la participacion del sistema NI-RLN3-RXFP3 en estas conductas bajo condiciones de ansiedad o estres en modelos animales. La activacion del NI tiene un efecto positivo sobre la ingesta (orexigeno) y desarrolla una respuesta amplia en la amigdala, donde se modulan los estados de ansiedad. La actividad de RLN3-RXFP3 en la amigdala podria afectar a la adiccion al alcohol, ya que la aplicacion del antagonista de RXFP3 en la amigdala extendida atenua la recaida al alcohol inducida por el estres. Los datos neuroanatomicos indican que el sistema NI-RLN3-RXFP3 actua sobre la conducta de ingesta y adiccion al alcohol mediante proyecciones paralelas a las vias canonicas mesolimbicas. Con ello, los datos en modelos animales indican que el sistema NI-RLN3-RXFP3 deberia tenerse en cuenta como diana en el tratamiento futuro de trastornos de las conductas alimentarias y adictivas.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Nova-Marques JA,Garcia-Diaz C,Olucha-Bordonau FEsubject
Has Abstractpub_date
2018-09-01 00:00:00pages
175-186issue
5eissn
0210-0010issn
1576-6578pii
rn2017454journal_volume
67pub_type
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