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Human papillomavirus genotype prevalence in invasive vaginal cancer from a registry-based population.

Abstract：

OBJECTIVE:To describe the human papillomavirus (HPV) genotype distribution in invasive vaginal cancers diagnosed before the introduction of the HPV vaccine and evaluate if survival differed by HPV status. METHODS:Four population-based registries and three residual tissue repositories provided formalin-fixed, paraffin-embedded tissue from microscopically confirmed primary vaginal cancer cases diagnosed between 1994 and 2005 that were tested by L1 consensus polymerase chain reaction with type-specific hybridization in a central laboratory. Clinical, demographic, and all-cause survival data were assessed by HPV status. RESULTS:Sixty cases of invasive vaginal cancer were included. Human papillomavirus was detected in 75% (45) and 25% (15) were HPV-negative. HPV 16 was most frequently detected (55% [33/60]) followed by HPV 33 (18.3% [11/60]). Only one case was positive for HPV 18 (1.7%) Multiple types were detected in 15% of the cases. Vaginal cancers in women younger than 60 years were more likely to be HPV 16- or HPV 18-positive (HPV 16 and 18) than older women, 77.3% compared with 44.7% (P=.038). The median age at diagnosis was younger in the HPV 16 and 18 (59 years) group compared with other HPV-positive (68 years) and no HPV (77 years) (P=.003). The HPV distribution did not significantly vary by race or ethnicity or place of residence. The 5-year unadjusted all-cause survival was 57.4% for women with HPV-positive vaginal cancers compared with 35.7% among those with HPV-negative tumors (P=.243). CONCLUSION:Three fourths of all vaginal cancers in the United States had HPV detected, much higher than previously found, and 57% could be prevented by current HPV vaccines.

journal_name

Obstet Gynecol

journal_title

Obstetrics and gynecology

authors

Sinno AK,Saraiya M,Thompson TD,Hernandez BY,Goodman MT,Steinau M,Lynch CF,Cozen W,Saber MS,Peters ES,Wilkinson EJ,Copeland G,Hopenhayn C,Watson M,Lyu C,Unger ER

doi

10.1097/AOG.0000000000000171

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

817-21

issue

eissn

0029-7844

issn

1873-233X

pii

00006250-201404000-00014

journal_volume

123

pub_type

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Human papillomavirus genotype prevalence in invasive vaginal cancer from a registry-based population.